Effects of rSP-C surfactant on oxygenation and histology in a rat-lung-lavage model of acute lung injury.

abstract：:An imbalance of proinflammatory cytokines such as TNF-alpha, IL-1 beta, and the neutrophil chemotactic factor IL-8 and inhibitors (e.g., soluble TNF receptors and IL-1ra) in the lung during the first week of life may contribute to prolonged pulmonary inflammation and fibrosis in bronchopulmonary dysplasia (BPD). Disod...

journal_title：American journal of respiratory and critical care medicine

authors： Viscardi RM,Hasday JD,Gumpper KF,Taciak V,Campbell AB,Palmer TW

更新日期：1997-11-01 00:00:00

abstract：RATIONALE:Because of high mortality, end-of-life care is an important component of intensive care. OBJECTIVES:We evaluated the effectiveness of a quality-improvement intervention to improve intensive care unit (ICU) end-of-life care. METHODS:We conducted a cluster-randomized trial randomizing 12 hospitals. The interv...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis JR,Nielsen EL,Treece PD,Downey L,Dotolo D,Shannon SE,Back AL,Rubenfeld GD,Engelberg RA

更新日期：2011-02-01 00:00:00

abstract：RATIONALE:New vaccines are urgently needed to protect the vulnerable from bacterial pneumonia. Clinical trials of pneumonia vaccines are slow and costly, requiring tens of thousands of patients. Studies of pneumococcal vaccine efficacy against colonization have been proposed as a novel method to down-select between vac...

journal_title：American journal of respiratory and critical care medicine

authors： Collins AM,Wright AD,Mitsi E,Gritzfeld JF,Hancock CA,Pennington SH,Wang D,Morton B,Ferreira DM,Gordon SB

更新日期：2015-10-01 00:00:00

abstract：:Current evidence suggests that patients with obstructive sleep apnea (OSA) may have augmented pharyngeal dilator muscle activity during wakefulness, to compensate for deficient anatomy. However, the isolated effect of sleep on the activity of these muscles (comparing OSA patients with controls) has not been studied. W...

journal_title：American journal of respiratory and critical care medicine

authors： Mezzanotte WS,Tangel DJ,White DP

更新日期：1996-06-01 00:00:00

abstract：RATIONALE:Patent foramen ovale (PFO) may be disadvantageous in chronic obstructive pulmonary disease (COPD). It is unknown whether right-to-left shunting through PFO increases during exercise impairing exercise performance. OBJECTIVES:To determine whether (1) PFO prevalence is greater in hypoxemic versus less hypoxemi...

journal_title：American journal of respiratory and critical care medicine

authors： Shaikh ZF,Kelly JL,Shrikrishna D,de Villa M,Mullen MJ,Hopkinson NS,Morrell MJ,Polkey MI

更新日期：2014-03-01 00:00:00

abstract：RATIONALE:Inhaled human insulin (INH; Exubera [human insulin (recombinant DNA origin) Inhalation Powder]) causes small changes in pulmonary function and increases in insulin antibodies compared with subcutaneous (SC) insulin. OBJECTIVES:To investigate the relationship between changes in pulmonary function and insulin ...

journal_title：American journal of respiratory and critical care medicine

authors： Teeter JG,Riese RJ

更新日期：2006-06-01 00:00:00

abstract：:In order to determine the long-term sequelae of prune belly syndrome (PBS) and whether the absence of abdominal wall musculature impairs exercise performance we studied nine patients 6 to 31 yr of age with PBS. Conventional spirometry, lung volumes, DLCO, and respiratory muscle strength were measured. A progressive 1-...

journal_title：American journal of respiratory and critical care medicine

authors： Ewig JM,Griscom NT,Wohl ME

更新日期：1996-04-01 00:00:00

abstract：:Background: This document provides clinical recommendations for the pharmacologic treatment of chronic obstructive pulmonary disease (COPD). It represents a collaborative effort on the part of a panel of expert COPD clinicians and researchers along with a team of methodologists under the guidance of the American Thora...

journal_title：American journal of respiratory and critical care medicine

authors： Nici L,Mammen MJ,Charbek E,Alexander PE,Au DH,Boyd CM,Criner GJ,Donaldson GC,Dreher M,Fan VS,Gershon AS,Han MK,Krishnan JA,Martinez FJ,Meek PM,Morgan M,Polkey MI,Puhan MA,Sadatsafavi M,Sin DD,Washko GR,Wedzicha

更新日期：2020-05-01 00:00:00

abstract：:Bacterial lipopolysaccharide (LPS) is known to induce the expression of inducible nitric oxide synthase (iNOS) in the lung and to lead to increased pulmonary nitric oxide (NO) production. The contribution of various pulmonary cells to this phenomenon remains unclear. In this study, we used gadolinium chloride, a block...

journal_title：American journal of respiratory and critical care medicine

authors： Fujii Y,Goldberg P,Hussain SN

更新日期：1998-05-01 00:00:00

abstract：RATIONALE:Studies in humans and rodents have indicated a causative role for CD8(+) T cells in IgE-mediated allergic inflammation, but their function is still controversial. OBJECTIVES:To analyze the role of allergen-specific CD8(+) T cells during the development of allergic airway inflammation in two parallel but dive...

journal_title：American journal of respiratory and critical care medicine

authors： Aguilar-Pimentel JA,Alessandrini F,Huster KM,Jakob T,Schulz H,Behrendt H,Ring J,de Angelis MH,Busch DH,Mempel M,Ollert M

更新日期：2010-01-01 00:00:00

abstract：RATIONALE:Despite intensive research, sepsis displays the most prevalent cause of death on intensive care units. The hallmark of sepsis is an overshooting T-cell death that reduces host defense mechanisms and that is associated with poor patient survival. Previous in vitro studies revealed that the expression of the tr...

journal_title：American journal of respiratory and critical care medicine

authors： Schmidt MV,Paulus P,Kuhn AM,Weigert A,Morbitzer V,Zacharowski K,Kempf VA,Brüne B,von Knethen A

更新日期：2011-07-01 00:00:00

abstract：:The mechanisms of exertional dyspnea relief in response to supplemental oxygen (O2) in chronic airflow limitation (CAL) are not precisely known and are likely multifactorial. To explore factors contributing to the relief of dyspnea after oxygen administration, 11 patients with severe CAL (FEV1.0 = 39 +/- 3% predicted,...

journal_title：American journal of respiratory and critical care medicine

authors： O'Donnell DE,Bain DJ,Webb KA

更新日期：1997-02-01 00:00:00

abstract：RATIONALE:There is consensus on the need to address social determinants of tuberculosis (TB) to achieve TB control, but evidence based on interventions is lacking. OBJECTIVES:We reanalyzed data from the sociomedical experiment performed at the Papworth Village Settlement in England, where the impact of stable employme...

journal_title：American journal of respiratory and critical care medicine

authors： Bhargava A,Pai M,Bhargava M,Marais BJ,Menzies D

更新日期：2012-09-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is used to ameliorate neutropenia in patients after antineoplastic treatment. It has also been suggested as an adjunct treatment in septic patients; however, the recruitment and priming of leukocytes by GM-CSF bears the hazard of a hyperinflammatory response. I...

journal_title：American journal of respiratory and critical care medicine

authors： Wollin L,Uhlig S,Nüsing R,Wendel A

更新日期：2001-02-01 00:00:00

abstract：:Secretory leukocyte protease inhibitor (SLPI) and elafin are structurally similar, low-molecular-weight antiproteases produced in the lung. We have developed a simple method for distinguishing the antiprotease activities of SLPI and elafin in lung lavage fluid from those of alpha 1-antitrypsin (alpha 1-AT) that is bas...

journal_title：American journal of respiratory and critical care medicine

authors： Nadziejko C,Finkelstein I,Balmes JR

更新日期：1995-11-01 00:00:00

abstract：:In animal models of endotoxemia, sepsis is associated with the accumulation of leukocytes and altered microvascular perfusion. In order to test the hypothesis that bacterial sepsis upregulates leukocyte-endothelial adhesion, we used intravital microscopy to examine the flow behavior of leukocytes in the postcapillary ...

journal_title：American journal of respiratory and critical care medicine

authors： Piper RD,Pitt-Hyde ML,Anderson LA,Sibbald WJ,Potter RF

更新日期：1998-01-01 00:00:00

abstract：:Asthma and chronic bronchitis are inflammatory diseases with extracellular matrix (ECM) remodeling and collagen deposition. Collagen homeostasis is controlled by metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). We evaluated MMP and TIMP balance in induced sputum of 10 control, 31 untreate...

journal_title：American journal of respiratory and critical care medicine

authors： Vignola AM,Riccobono L,Mirabella A,Profita M,Chanez P,Bellia V,Mautino G,D'accardi P,Bousquet J,Bonsignore G

更新日期：1998-12-01 00:00:00

abstract：RATIONALE:Smoking is a primary risk factor for chronic bronchitis, emphysema, and chronic obstructive pulmonary disease, but since not all smokers develop disease, it has been suggested that some individuals may be more susceptible to exogenous factors, such as smoking, and that this susceptibility could be genetically...

journal_title：American journal of respiratory and critical care medicine

authors： Hallberg J,Dominicus A,Eriksson UK,Gerhardsson de Verdier M,Pedersen NL,Dahlbäck M,Nihlén U,Higenbottam T,Svartengren M

更新日期：2008-03-01 00:00:00

abstract：RATIONALE:Pulmonary infection in cystic fibrosis (CF) is polymicrobial and it is possible that anaerobic bacteria, not detected by routine aerobic culture methods, reside within infected anaerobic airway mucus. OBJECTIVES:To determine whether anaerobic bacteria are present in the sputum of patients with CF. METHODS:S...

journal_title：American journal of respiratory and critical care medicine

authors： Tunney MM,Field TR,Moriarty TF,Patrick S,Doering G,Muhlebach MS,Wolfgang MC,Boucher R,Gilpin DF,McDowell A,Elborn JS

更新日期：2008-05-01 00:00:00

abstract：RATIONALE:Cytomegalovirus (CMV), which is one of the most common infections after lung transplantation, is associated with chronic lung allograft dysfunction and worse post-transplantation survival. Current approaches for at-risk patients include a fixed duration of antiviral prophylaxis despite the associated cost and...

journal_title：American journal of respiratory and critical care medicine

authors： Snyder LD,Chan C,Kwon D,Yi JS,Martissa JA,Copeland CA,Osborne RJ,Sparks SD,Palmer SM,Weinhold KJ

更新日期：2016-01-01 00:00:00

abstract：RATIONALE:Fibroblast growth factor receptor-1alpha(IIIc) [FGF-R1alpha(IIIc)] regulates recovery of neonatal rat lung growth, after 95% oxygen-mediated growth arrest. Its role in normal postnatal alveologenesis is unknown. OBJECTIVE:To determine if FGF-R1alpha(IIIc) regulates normal postnatal alveologenesis. METHODS:T...

journal_title：American journal of respiratory and critical care medicine

authors： Yi M,Belcastro R,Shek S,Luo D,Post M,Tanswell AK

更新日期：2006-09-01 00:00:00

abstract：:The role of immunoglobulin E (IgE) in the development and course of impaired ventilatory function and chronic obstructive pulmonary disease (COPD) required further study. This role has been examined in the longitudinal Tucson Epidemiological Study of Airways Obstructive Disease, which started in 1972. The association ...

journal_title：American journal of respiratory and critical care medicine

authors： Sherrill DL,Lebowitz MD,Halonen M,Barbee RA,Burrows B

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:There is growing evidence that resident cells, such as fibroblasts and epithelial cells, can drive the persistent accumulation of dendritic cells (DCs) in chronically inflamed tissue, leading to the organization and the maintenance of ectopic lymphoid aggregates. This phenomenon, occurring through a chemokine...

journal_title：American journal of respiratory and critical care medicine

authors： Marchal-Sommé J,Uzunhan Y,Marchand-Adam S,Kambouchner M,Valeyre D,Crestani B,Soler P

更新日期：2007-11-15 00:00:00

abstract：RATIONALE:The rate of progression of most interstitial lung diseases (ILD) is unpredictable. Fibrocytes are circulating bone marrow-derived cells that have been implicated in the pathogenesis of lung fibrosis. Hermansky-Pudlak syndrome (HPS), a genetic cause of ILD in early adulthood, allows for study of biomarkers of ...

journal_title：American journal of respiratory and critical care medicine

authors： Trimble A,Gochuico BR,Markello TC,Fischer R,Gahl WA,Lee JK,Kim Y,Burdick MD,Strieter RM,Mehrad B

更新日期：2014-12-15 00:00:00

abstract：:The present study was undertaken to determine if a synthetic peptide, KLLLLKLLLLKLLLLKLLLLK (KL4), in which K = lysine and L = leucine, in an aqueous dispersion of phospholipids (DPPC and POPG), would expand pulmonary alveoli and improve gas exchange in premature human infants with respiratory distress syndrome (RDS)....

journal_title：American journal of respiratory and critical care medicine

authors： Cochrane CG,Revak SD,Merritt TA,Heldt GP,Hallman M,Cunningham MD,Easa D,Pramanik A,Edwards DK,Alberts MS

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:Amplification of distal 3q is the most common genomic aberration in squamous lung cancer (SQC). SQC develops in a multistage progression from normal bronchial epithelium through dysplasia to invasive disease. Identifying the key driver events in the early pathogenesis of SQC will facilitate the search for pre...

journal_title：American journal of respiratory and critical care medicine

authors： McCaughan F,Pole JC,Bankier AT,Konfortov BA,Carroll B,Falzon M,Rabbitts TH,George PJ,Dear PH,Rabbitts PH

更新日期：2010-07-01 00:00:00

abstract：RATIONALE:Peroxisome proliferator-activated receptor (PPAR)-β/δ is a transcription factor that belongs to the PPAR nuclear hormone receptor family, but the role of PPAR-β/δ in sepsis is unknown. OBJECTIVES:We investigated the role of PPAR-β/δ in murine models of LPS-induced organ injury and dysfunction and cecal ligat...

journal_title：American journal of respiratory and critical care medicine

authors： Kapoor A,Shintani Y,Collino M,Osuchowski MF,Busch D,Patel NS,Sepodes B,Castiglia S,Fantozzi R,Bishop-Bailey D,Mota-Filipe H,Yaqoob MM,Suzuki K,Bahrami S,Desvergne B,Mitchell JA,Thiemermann C

更新日期：2010-12-15 00:00:00

abstract：:Two patients receiving low dose methotrexate, one with rheumatoid arthritis and the other with pityriasis rubra pilaris, developed disseminated histoplasmosis and Mycobacterium avium intracellulare pneumonia, respectively. Twenty-three cases of opportunistic infection in patients receiving low dose methotrexate have b...

journal_title：American journal of respiratory and critical care medicine

authors： LeMense GP,Sahn SA

更新日期：1994-07-01 00:00:00

abstract：:The present study was undertaken to assess the relationship between health-related quality of life (HRQOL) and bronchiolitis obliterans syndrome (BOS), as both represent important parameters of outcome after lung transplantation. HRQOL was measured both cross-sectionally and longitudinally by standardized patient self...

journal_title：American journal of respiratory and critical care medicine

authors： van Den BERG JW,Geertsma A,van Der BIJ W,Koëter GH,de BOER WJ,Postma DS,ten VERGERT EM

更新日期：2000-06-01 00:00:00

abstract：:We have studied intrasubject variability with respect to counts of immunostained inflammatory cells in snap frozen endobronchial biopsies from a group of patients with clinically mild to moderate stable asthma. Fiberoptic bronchoscopy was used to obtain endobronchial biopsies from the upper and lower lobes in 12 volun...

journal_title：American journal of respiratory and critical care medicine

authors： Richmond I,Booth H,Ward C,Walters EH

更新日期：1996-03-01 00:00:00