Rhinovirus disrupts the barrier function of polarized airway epithelial cells.

abstract：RATIONALE:Observational studies link statin therapy with improved outcomes in patients with severe sepsis. OBJECTIVES:To test whether atorvastatin therapy affects biologic and clinical outcomes in critically ill patients with severe sepsis. METHODS:Phase II, multicenter, prospective, randomized, double-blind, placebo...

journal_title：American journal of respiratory and critical care medicine

authors： Kruger P,Bailey M,Bellomo R,Cooper DJ,Harward M,Higgins A,Howe B,Jones D,Joyce C,Kostner K,McNeil J,Nichol A,Roberts MS,Syres G,Venkatesh B,ANZ-STATInS Investigators–ANZICS Clinical Trials Group.

更新日期：2013-04-01 00:00:00

abstract：RATIONALE:Colonization of lower airways by Staphylococcus aureus is a risk factor for the development of ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP). However, little is known about the virulence factors of methicillin-sensitive and -resistant S. aureus (MSSA and MRSA) that ma...

journal_title：American journal of respiratory and critical care medicine

authors： Stulik L,Malafa S,Hudcova J,Rouha H,Henics BZ,Craven DE,Sonnevend AM,Nagy E

更新日期：2014-11-15 00:00:00

abstract：:In mechanically ventilated neonates, the instrumental dead space is a major determinant of total minute ventilation. By flushing this dead space, continuous tracheal gas insufflation (CTGI) may allow reduction of the risk of overinflation. We conducted a randomized trial to evaluate the efficacy of CTGI in reducing ai...

journal_title：American journal of respiratory and critical care medicine

authors： Dassieu G,Brochard L,Benani M,Avenel S,Danan C

更新日期：2000-09-01 00:00:00

abstract：:Sensitive measures of lung function applicable to young subjects are needed to detect early cystic fibrosis (CF) lung disease. Forty children with CF aged 2 to 5 years and 37 age-matched healthy control subjects performed multiple-breath inert gas washout, plethysmography, and spirometry. Thirty children in each group...

journal_title：American journal of respiratory and critical care medicine

authors： Aurora P,Bush A,Gustafsson P,Oliver C,Wallis C,Price J,Stroobant J,Carr S,Stocks J,London Cystic Fibrosis Collaboration.

更新日期：2005-02-01 00:00:00

abstract：RATIONALE:Infection with Pneumocystis, an opportunistic fungal pathogen, can result in fulminant pneumonia in the clinical setting of patients with immunosuppression. In murine models, Pneumocystis has previously been shown to induce a CD4+ T cell-dependent eosinophilic response in the lung capable of providing protect...

journal_title：American journal of respiratory and critical care medicine

authors： Eddens T,Campfield BT,Serody K,Manni ML,Horne W,Elsegeiny W,McHugh KJ,Pociask D,Chen K,Zheng M,Alcorn JF,Wenzel S,Kolls JK

更新日期：2016-10-01 00:00:00

abstract：:Sepsis is the most common cause of death in patients in the intensive care unit. Genome-wide gene expression analysis can provide insights into the molecular alterations of sepsis. Total mRNA was extracted from the livers of 6 uninfected control mice and 60 septic mice after infusion of either live Escherichia coli or...

journal_title：American journal of respiratory and critical care medicine

authors： Yu SL,Chen HW,Yang PC,Peck K,Tsai MH,Chen JJ,Lin FY

更新日期：2004-05-15 00:00:00

abstract：:We used three-dimensional reconstructions obtained with spiral computed tomography to measure total diaphragm surface area (Adi), and the surface area of the dome (Ado) and of the zone of apposition (Aap) of the diaphragm in nine patients with single-lung transplantation (SLT) for emphysema and nine normal subjects ma...

journal_title：American journal of respiratory and critical care medicine

authors： Cassart M,Verbandt Y,de Francquen P,Gevenois PA,Estenne M

更新日期：1999-06-01 00:00:00

abstract：:Mechanical ventilation may promote overdistension-induced pulmonary lesions in patients with acute respiratory distress syndrome (ARDS). The static pressure-volume (P-V) curve of the respiratory system can be used to determine the lung volume and corresponding static airway pressure at which lung compliance begins to ...

journal_title：American journal of respiratory and critical care medicine

authors： Roupie E,Dambrosio M,Servillo G,Mentec H,el Atrous S,Beydon L,Brun-Buisson C,Lemaire F,Brochard L

更新日期：1995-07-01 00:00:00

abstract：:We have previously reported differential impairment of pulmonary and systemic vascular contractility in hyperdynamic sepsis. The objectives of this study were (1) to determine whether the magnitude of this phenomenon depends on the control group chosen for comparison, and (2) to examine the role of nitric oxide (NO) i...

journal_title：American journal of respiratory and critical care medicine

authors： Yaghi A,Paterson NA,McCormack DG

更新日期：1995-03-01 00:00:00

abstract：:Cyclophosphamide-induced lung toxicity may be difficult to recognize because of the presence of confounding variables such as concomitant use of other cytotoxic drugs, opportunistic infections, diffuse pulmonary malignancy, radiation pneumonitis, and oxygen toxicity. The purpose of this retrospective analysis was to i...

journal_title：American journal of respiratory and critical care medicine

authors： Malik SW,Myers JL,DeRemee RA,Specks U

更新日期：1996-12-01 00:00:00

abstract：RATIONALE:Immunophenotypes of antiviral responses, and their relationship with asthma, allergy, and lower respiratory tract infections, are poorly understood. OBJECTIVES:We characterized multiple cytokine responses of peripheral blood mononuclear cells to rhinovirus stimulation, and their relationship with clinical ou...

journal_title：American journal of respiratory and critical care medicine

authors： Custovic A,Belgrave D,Lin L,Bakhsoliani E,Telcian AG,Solari R,Murray CS,Walton RP,Curtin J,Edwards MR,Simpson A,Rattray M,Johnston SL

更新日期：2018-05-15 00:00:00

abstract：:Short-term increases in particulate air pollution are associated with increased incidence of cardiovascular events. Previously, we showed that intratracheally instilled diesel exhaust particles (DEPs) are prothrombotic. Here, we investigated the time course and the mechanisms. At 1, 6, and 24 hours after instillation ...

journal_title：American journal of respiratory and critical care medicine

authors： Nemmar A,Nemery B,Hoet PH,Vermylen J,Hoylaerts MF

更新日期：2003-12-01 00:00:00

abstract：:Cell death is intertwined with life in development, homeostasis, pathology, and aging. Until recently, apoptosis was the best known form of programmed cell death, whereas necrosis was for a long time considered accidental owing to physicochemical injury. However, identification of crucial signaling and execution molec...

journal_title：American journal of respiratory and critical care medicine

authors： Moreno-Gonzalez G,Vandenabeele P,Krysko DV

更新日期：2016-08-15 00:00:00

abstract：:The Child Health Questionnaire (CHQ-PF50) is one of several recent efforts to gauge pediatric, health-related quality of life from the patient's (or parent's) perspective. Although tested extensively with healthy children, more information is needed about CHQ performance among children with chronic conditions such as ...

journal_title：American journal of respiratory and critical care medicine

authors： Asmussen L,Olson LM,Grant EN,Landgraf JM,Fagan J,Weiss KB

更新日期：2000-10-01 00:00:00

abstract：:The incidence of mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in children with intermediate sweat chloride levels is unknown. The results of 2,349 sweat tests performed at two Belgian university hospitals were reviewed. Intermediate chloride concentrations were observed in 98 subjec...

journal_title：American journal of respiratory and critical care medicine

authors： Lebecque P,Leal T,De Boeck C,Jaspers M,Cuppens H,Cassiman JJ

更新日期：2002-03-15 00:00:00

abstract：RATIONALE:Previous investigations have identified several potential predictors of outcomes from lung volume reduction surgery (LVRS). A concern regarding these studies has been their small sample size, which may limit generalizability. We therefore sought to examine radiographic and physiologic predictors of surgical o...

journal_title：American journal of respiratory and critical care medicine

authors： Washko GR,Martinez FJ,Hoffman EA,Loring SH,Estépar RS,Diaz AA,Sciurba FC,Silverman EK,Han MK,Decamp M,Reilly JJ,National Emphysema Treatment Trial Research Group.

更新日期：2010-03-01 00:00:00

abstract：RATIONALE:Secondhand tobacco smoke (SHS) and traffic-related air pollutants are associated with asthma and allergy. Diesel exhaust particles (DEPs) and SHS can interact with allergens in exacerbating allergic airway diseases through generation of reactive oxygen species. Glutathione S-transferases (GSTs) metabolize rea...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Li YF,Gong H Jr,Diaz-Sanchez D

更新日期：2006-12-15 00:00:00

abstract：RATIONALE:Hyponatremia is associated with decompensated heart failure and poor prognosis in patients with left ventricular systolic dysfunction. OBJECTIVES:We sought to determine if hyponatremia is associated with right heart failure and worse prognosis in patients with pulmonary arterial hypertension (PAH). METHODS:...

journal_title：American journal of respiratory and critical care medicine

authors： Forfia PR,Mathai SC,Fisher MR,Housten-Harris T,Hemnes AR,Champion HC,Girgis RE,Hassoun PM

更新日期：2008-06-15 00:00:00

abstract：RATIONALE:The around-the-clock presence of an in-house attending critical care physician (24/7 coverage) is purported to be associated with improved outcomes among high-risk children with critical illness. OBJECTIVES:To evaluate the association of 24/7 in-house coverage with outcomes in children with critical illness....

journal_title：American journal of respiratory and critical care medicine

authors： Gupta P,Rettiganti M,Rice TB,Wetzel RC

更新日期：2016-12-15 00:00:00

abstract：:Thyroid transcription factor-1 (TTF-1) deficiency syndrome is characterized by neurologic, thyroidal, and pulmonary dysfunction. Children usually have mild-to-severe respiratory symptoms and occasionally die of respiratory failure. Herein, we describe an infant with a constitutional 14q12-21.3 haploid deletion encompa...

journal_title：American journal of respiratory and critical care medicine

authors： Galambos C,Levy H,Cannon CL,Vargas SO,Reid LM,Cleveland R,Lindeman R,deMello DE,Wert SE,Whitsett JA,Perez-Atayde AR,Kozakewich H

更新日期：2010-08-15 00:00:00

abstract：:The relationship of sleep-disordered breathing (SOB) to neuropsychological deficits was investigated with cross-sectional data from the Wisconsin Sleep Cohort Study, a population-based study of the natural history of SDB. A sample of 841 employed men and women ages 30 to 60 yr was studied by overnight polysomnography ...

journal_title：American journal of respiratory and critical care medicine

authors： Kim HC,Young T,Matthews CG,Weber SM,Woodward AR,Palta M

更新日期：1997-12-01 00:00:00

abstract：:Collapsibility of the active pharynx, where active contraction of the upper airway muscles is evident, was previously reported to be higher in children with obstructive sleep apnea (OSA) than in those with primary snoring during sleep. Contribution of neuromuscular and anatomic factors to the increased collapsibility,...

journal_title：American journal of respiratory and critical care medicine

authors： Isono S,Shimada A,Utsugi M,Konno A,Nishino T

更新日期：1998-04-01 00:00:00

abstract：:Mechanical ventilation can worsen morbidity and mortality by causing ventilator-associated lung injury, especially where adverse ventilatory strategies are employed. Adverse strategies commonly involve hyperventilation, which frequently results in hypocapnia. Although hypocapnia is associated with significant lung alt...

journal_title：American journal of respiratory and critical care medicine

authors： Laffey JG,Engelberts D,Kavanagh BP

更新日期：2000-08-01 00:00:00

abstract：:To determine the status of activation of lymphocytes and the role of cytokines on the inflammatory response of the bronchial mucosa in toluene diisocyanate (TDI) asthma, we performed a quantitative analysis of bronchial biopsies obtained from 15 subjects with TDI-induced asthma and seven normal control subjects. Marke...

journal_title：American journal of respiratory and critical care medicine

authors： Maestrelli P,di Stefano A,Occari P,Turato G,Milani G,Pivirotto F,Mapp CE,Fabbri LM,Saetta M

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Childhood sleep-disordered breathing ranges in severity from primary snoring to obstructive sleep apnea and is associated with behavioral and neurocognitive deficits. It remains unknown why children with primary snoring, who do not experience peripheral oxygen desaturation or sleep fragmentation, experience s...

journal_title：American journal of respiratory and critical care medicine

authors： Tamanyan K,Walter LM,Weichard A,Davey MJ,Nixon GM,Biggs SN,Horne RSC

更新日期：2018-06-01 00:00:00

abstract：:The cost effectiveness of asthma care is the first topic of the National Asthma Education and Prevention Program Task Force Report on the Cost Effectiveness, Quality of Care, and Financing of Asthma Care. This working group characterized the role of health economics in understanding optimal asthma management strategie...

journal_title：American journal of respiratory and critical care medicine

authors： Sullivan S,Elixhauser A,Buist AS,Luce BR,Eisenberg J,Weiss KB

更新日期：1996-09-01 00:00:00

abstract：RATIONALE:Lack of health insurance maybe an independent risk factor for mortality and differential treatment in critical illness. OBJECTIVES:To determine whether uninsured critically ill patients had differences in 30-day mortality and critical care service use compared with those with private insurance and to determi...

journal_title：American journal of respiratory and critical care medicine

authors： Lyon SM,Benson NM,Cooke CR,Iwashyna TJ,Ratcliffe SJ,Kahn JM

更新日期：2011-10-01 00:00:00

abstract：:Interleukin-5 (IL-5) is a potent eosinophilopoietic factor implicated in the chronic inflammatory cell accumulation accompanying bronchial asthma. However, its role in stimulating eosinophil differentiation within the bone marrow following allergen exposure remains to be elucidated. The aims of our study were to deter...

journal_title：American journal of respiratory and critical care medicine

authors： Minshall EM,Schleimer R,Cameron L,Minnicozzi M,Egan RW,Gutierrez-Ramos JC,Eidelman DH,Hamid Q

更新日期：1998-09-01 00:00:00

abstract：RATIONALE:The degree to which chronic respiratory health effects caused by exposures to cotton dust and endotoxin is reversible after cessation of textile work is unknown. OBJECTIVES:To investigate changes in lung function and respiratory symptoms after cessation of textile work and to determine whether past exposure ...

journal_title：American journal of respiratory and critical care medicine

authors： Shi J,Hang JQ,Mehta AJ,Zhang HX,Dai HL,Su L,Eisen EA,Christiani DC

更新日期：2010-07-15 00:00:00

abstract：:Numerous in vitro and in vivo studies in both animals and patients with asthma have shown that interleukin (IL)-9 is an important inflammatory mediator in asthma. To examine the effects of IL-9 antagonism on airway inflammation, ovalbumin-sensitized BALB/c mice were intravenously given anti-IL-9 antibody or an isotype...

journal_title：American journal of respiratory and critical care medicine

authors： Cheng G,Arima M,Honda K,Hirata H,Eda F,Yoshida N,Fukushima F,Ishii Y,Fukuda T

更新日期：2002-08-01 00:00:00