Titration of tidal volume and induced hypercapnia in acute respiratory distress syndrome.

abstract：RATIONALE:Pulmonary complications (PCs) cause significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HCT). Shifts in gut microbiota have been linked to HCT outcomes; however, their effect on PCs is unknown. OBJECTIVES:To investigate whether changes in gut microbiota are associate...

journal_title：American journal of respiratory and critical care medicine

authors： Harris B,Morjaria SM,Littmann ER,Geyer AI,Stover DE,Barker JN,Giralt SA,Taur Y,Pamer EG

更新日期：2016-08-15 00:00:00

abstract：RATIONALE:The CD40 protein plays important roles in cell-mediated and humoral immune responses, especially in immunoglobulin class-switching to IgE. OBJECTIVES:We tested the association of CD40 polymorphisms with the risk of asthma and the level of serum IgE and investigated the functional effect of associated polymor...

journal_title：American journal of respiratory and critical care medicine

authors： Park JH,Chang HS,Park CS,Jang AS,Park BL,Rhim TY,Uh ST,Kim YH,Chung IY,Shin HD

更新日期：2007-04-15 00:00:00

abstract：RATIONALE:Epidemiological studies in older individuals have found an association between the use of angiotensin-converting enzyme (ACE) inhibition (ACE-I) therapy and preserved locomotor muscle mass, strength, and walking speed. ACE-I therapy might therefore have a role in the context of pulmonary rehabilitation (PR). ...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis KJ,Meyrick VM,Mehta B,Haji GS,Li K,Montgomery H,Man WD,Polkey MI,Hopkinson NS

更新日期：2016-12-01 00:00:00

abstract：:We examined the influence of gender on the polysomnographic features of obstructive sleep apnea (OSA) in a retrospective study of 830 patients with OSA diagnosed by overnight polysomnography (PSG). The severity of OSA was determined from the apnea- hypopnea index (AHI) for total sleep time (AHI(TST)), and was classifi...

journal_title：American journal of respiratory and critical care medicine

authors： O'Connor C,Thornley KS,Hanly PJ

更新日期：2000-05-01 00:00:00

abstract：:Burkholderia gladioli has been reported as colonizing the airways of patients with cystic fibrosis (CF) but has not previously been associated with adverse outcome. We describe six patients with CF in whom the same strain of B. gladioli, on the basis of ribotyping and biochemical characteristics, was grown in their sp...

journal_title：American journal of respiratory and critical care medicine

authors： Wilsher ML,Kolbe J,Morris AJ,Welch DF

更新日期：1997-04-01 00:00:00

abstract：RATIONALE:E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and flavorings. However, the long-term health effects of exposing lungs to vaped e-liquids are unknown. OBJECTIVES:To determine the effects of chronic vaping on pulmonary epithelia. METHODS:We performed research bronchoscopies on h...

journal_title：American journal of respiratory and critical care medicine

authors： Ghosh A,Coakley RC,Mascenik T,Rowell TR,Davis ES,Rogers K,Webster MJ,Dang H,Herring LE,Sassano MF,Livraghi-Butrico A,Van Buren SK,Graves LM,Herman MA,Randell SH,Alexis NE,Tarran R

更新日期：2018-07-01 00:00:00

abstract：:We investigated 116 Italian atopic families (560 individuals) for linkage with 13 DNA markers on chromosome 12. All the subjects were phenotyped for asthma, total serum IgE, bronchial hyperresponsiveness, skin-prick positivity to common aeroallergens, and atopy. A relative location map of the markers was prepared from...

journal_title：American journal of respiratory and critical care medicine

authors： Malerba G,Lauciello MC,Scherpbier T,Trabetti E,Galavotti R,Cusin V,Pescollderungg L,Zanoni G,Martinati LC,Boner AL,Levitt RC,Pignatti PF

更新日期：2000-10-01 00:00:00

abstract：:Sensitive measures of lung function applicable to young subjects are needed to detect early cystic fibrosis (CF) lung disease. Forty children with CF aged 2 to 5 years and 37 age-matched healthy control subjects performed multiple-breath inert gas washout, plethysmography, and spirometry. Thirty children in each group...

journal_title：American journal of respiratory and critical care medicine

authors： Aurora P,Bush A,Gustafsson P,Oliver C,Wallis C,Price J,Stroobant J,Carr S,Stocks J,London Cystic Fibrosis Collaboration.

更新日期：2005-02-01 00:00:00

abstract：:Several epidemiologic studies have demonstrated a consistent association between levels of particulate matter (PM) in the ambient air with increases in cardiovascular and respiratory mortality and morbidity. Diesel exhaust (DE), in addition to generating other pollutants, is a major contributor to PM pollution in most...

journal_title：American journal of respiratory and critical care medicine

authors： Salvi S,Blomberg A,Rudell B,Kelly F,Sandström T,Holgate ST,Frew A

更新日期：1999-03-01 00:00:00

abstract：RATIONALE:Data on hemoptysis of unknown origin (i.e., "cryptogenic") are scarce and the outcome of patients affected is controversial. OBJECTIVES:To describe the clinical spectrum and course of patients with cryptogenic hemoptysis, as well as pathologic findings when surgery is performed. METHODS:A cohort of 81 patie...

journal_title：American journal of respiratory and critical care medicine

authors： Savale L,Parrot A,Khalil A,Antoine M,Théodore J,Carette MF,Mayaud C,Fartoukh M

更新日期：2007-06-01 00:00:00

abstract：:The purpose of the present study is twofold: to evaluate alterations in total phospholipid content and individual phospholipid classes of the surfactant, and to detect markers of inflammatory reaction in bronchoalveolar lavage (BAL) from patients with hydrostatic pulmonary edema (HPE). Mechanically ventilated patients...

journal_title：American journal of respiratory and critical care medicine

authors： Nakos G,Pneumatikos J,Tsangaris I,Tellis C,Lekka M

更新日期：1997-03-01 00:00:00

abstract：:Damage to the airway epithelium is one prominent feature of chronic asthma. Corticosteroids induce apoptosis in inflammatory cells, which in part explains their ability to suppress airway inflammation. However, corticosteroid therapy does not necessarily reverse epithelial damage. We hypothesized that corticosteroids ...

journal_title：American journal of respiratory and critical care medicine

authors： Dorscheid DR,Wojcik KR,Sun S,Marroquin B,White SR

更新日期：2001-11-15 00:00:00

abstract：:Small airway disease is thought to contribute significantly to functional impairment caused by asthma. Functional evidence of airway-parenchyma uncoupling in asthma, such as loss of deep breath bronchodilator effect in bronchoconstrictive episodes and enhanced airway closure, has been previously demonstrated. Elastic ...

journal_title：American journal of respiratory and critical care medicine

authors： Mauad T,Silva LF,Santos MA,Grinberg L,Bernardi FD,Martins MA,Saldiva PH,Dolhnikoff M

更新日期：2004-10-15 00:00:00

abstract：:Erythromycin inhibits mucus glycoconjugate secretion from airway cells in vitro and may increase mucus clearance in patients with asthma or diffuse panbronchiolitis. Because mucus hypersecretion is common in purulent rhinitis, we questioned whether clarithromycin would change the properties of nasal mucus from subject...

journal_title：American journal of respiratory and critical care medicine

authors： Rubin BK,Druce H,Ramirez OE,Palmer R

更新日期：1997-06-01 00:00:00

abstract：RATIONALE:Inhaled corticosteroids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD). OBJECTIVES:To examine whether these medications might be associated with an excess risk of pneumonia. METHODS:We conducted a nested case-control study within a cohort of patients with COPD from Que...

journal_title：American journal of respiratory and critical care medicine

authors： Ernst P,Gonzalez AV,Brassard P,Suissa S

更新日期：2007-07-15 00:00:00

abstract：:Salbutamol inhibits neutropenia, increased airway resistance, and gas exchange abnormalities provoked by platelet-activating factor (PAF) challenge in normal persons. To further explore the intriguing dissociation between spirometric abnormalities and gas exchange defects shown in patients with asthma, we investigated...

journal_title：American journal of respiratory and critical care medicine

authors： Díaz O,Barberà JA,Marrades R,Chung KF,Roca J,Rodriguez-Roisin R

更新日期：1997-07-01 00:00:00

abstract：RATIONALE:Platelets are essential for pulmonary leukocyte recruitment, airway hyperresponsiveness, and bronchial remodeling in animals with allergic inflammation and can be found in bronchoalveolar lavage of sensitized animals. No studies, however, have explored the direct migration of platelets to lungs. OBJECTIVES:T...

journal_title：American journal of respiratory and critical care medicine

authors： Pitchford SC,Momi S,Baglioni S,Casali L,Giannini S,Rossi R,Page CP,Gresele P

更新日期：2008-03-15 00:00:00

abstract：RATIONALE:When subclavian access is not possible, controversy exists between the internal jugular and femoral sites for the choice of central-venous access in intensive care unit patients. OBJECTIVES:To compare infection and colonization rates of short-term jugular and femoral catheters. METHODS:Using data from two m...

journal_title：American journal of respiratory and critical care medicine

authors： Timsit JF,Bouadma L,Mimoz O,Parienti JJ,Garrouste-Orgeas M,Alfandari S,Plantefeve G,Bronchard R,Troche G,Gauzit R,Antona M,Canet E,Bohe J,Herrault MC,Schwebel C,Ruckly S,Souweine B,Lucet JC

更新日期：2013-11-15 00:00:00

abstract：RATIONALE:There is conflicting information about the development and resolution of airway inflammation and airway hyperresponsiveness (AHR) after repeated airway exposure to allergen in sensitized mice. METHODS:Sensitized BALB/c and C57BL/6 mice were exposed to repeated allergen challenge on 3, 7, or 11 occasions. Air...

journal_title：American journal of respiratory and critical care medicine

authors： Koya T,Kodama T,Takeda K,Miyahara N,Yang ES,Taube C,Joetham A,Park JW,Dakhama A,Gelfand EW

更新日期：2006-01-01 00:00:00

abstract：:We evaluated ultrasonic examination as a diagnostic tool for catheter misplacement and pneumothorax after central venous catheter insertion. Physicians in the intensive care unit (ICU) performed the ultrasonic examinations, and the results were compared with those of chest radiography. Eighty-five central venous cathe...

journal_title：American journal of respiratory and critical care medicine

authors： Maury E,Guglielminotti J,Alzieu M,Guidet B,Offenstadt G

更新日期：2001-08-01 00:00:00

abstract：RATIONALE:There is growing evidence that alveolar cell apoptosis plays an important role in emphysema pathogenesis, a chronic inflammatory lung disease characterized by alveolar destruction. The association of alpha1-antitrypsin deficiency with the development of emphysema has supported the concept that protease/antipr...

journal_title：American journal of respiratory and critical care medicine

authors： Petrache I,Fijalkowska I,Zhen L,Medler TR,Brown E,Cruz P,Choe KH,Taraseviciene-Stewart L,Scerbavicius R,Shapiro L,Zhang B,Song S,Hicklin D,Voelkel NF,Flotte T,Tuder RM

更新日期：2006-06-01 00:00:00

abstract：:Short-term increases in particulate air pollution are associated with increased incidence of cardiovascular events. Previously, we showed that intratracheally instilled diesel exhaust particles (DEPs) are prothrombotic. Here, we investigated the time course and the mechanisms. At 1, 6, and 24 hours after instillation ...

journal_title：American journal of respiratory and critical care medicine

authors： Nemmar A,Nemery B,Hoet PH,Vermylen J,Hoylaerts MF

更新日期：2003-12-01 00:00:00

abstract：:The role of strain difference in the response to cigarette smoke was investigated in mice. Mice of the strains DBA/2 and C57BL/6J responded to acute cigarette smoke with a decrease of the antioxidant defenses of their bronchoalveolar lavage (BAL) fluids. On the other hand, under these conditions ICR mice increased the...

journal_title：American journal of respiratory and critical care medicine

authors： Cavarra E,Bartalesi B,Lucattelli M,Fineschi S,Lunghi B,Gambelli F,Ortiz LA,Martorana PA,Lungarella G

更新日期：2001-09-01 00:00:00

abstract：:A continuously mixed series of microbial communities inhabits various points of the respiratory tract, with community composition determined by distance from colonization sources, colonization rates, and extinction rates. Ecology and evolution theory developed in the context of biogeography is relevant to clinical mic...

journal_title：American journal of respiratory and critical care medicine

authors： Whiteson KL,Bailey B,Bergkessel M,Conrad D,Delhaes L,Felts B,Harris JK,Hunter R,Lim YW,Maughan H,Quinn R,Salamon P,Sullivan J,Wagner BD,Rainey PB

更新日期：2014-06-01 00:00:00

abstract：:Lone cryptogenic fibrosing alveolitis (CFA) is a progressive interstitial lung disease, with a median survival of 3 to 6 yr from the onset of dyspnea. CFA can be subdivided into prognostically significant histopathologic patterns, including nonspecific interstitial pneumonia (NSIP). We reviewed 78 patients with a clin...

journal_title：American journal of respiratory and critical care medicine

authors： Nicholson AG,Colby TV,du Bois RM,Hansell DM,Wells AU

更新日期：2000-12-01 00:00:00

abstract：RATIONALE:Poor adherence is common in difficult-to-control asthma. Distinguishing patients with difficult-to-control asthma who respond to inhaled corticosteroids (ICS) from refractory asthma is an important clinical challenge. OBJECTIVES:Suppression of fractional exhaled nitric oxide (FeNO) with directly observed ICS...

journal_title：American journal of respiratory and critical care medicine

authors： Heaney LG,Busby J,Bradding P,Chaudhuri R,Mansur AH,Niven R,Pavord ID,Lindsay JT,Costello RW,Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK).

更新日期：2019-02-15 00:00:00

abstract：:In order to examine the dose-dependence of the airway response to animal allergens we performed environmental challenges on 17 workers with documented IgE-mediated allergic reactions to laboratory rats. The 1-h environmental challenges were conducted in a vivarium during cage cleaning (high-allergen challenge), quiet ...

journal_title：American journal of respiratory and critical care medicine

authors： Eggleston PA,Ansari AA,Adkinson NF Jr,Wood RA

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Although commonly used as the primary outcome measure of clinical trials in pulmonary arterial hypertension (PAH), the minimal important difference (MID) of the 6-minute walk test (6MWT) has not been well defined for this population of patients. OBJECTIVES:To estimate the MID in the 6MWT in patients with PAH...

journal_title：American journal of respiratory and critical care medicine

authors： Mathai SC,Puhan MA,Lam D,Wise RA

更新日期：2012-09-01 00:00:00

abstract：:Rationale: Viral infections are major drivers of exacerbations and clinical burden in patients with asthma and chronic obstructive pulmonary disease (COPD). IFN-β is a key component of the innate immune response to viral infection. To date, studies of inhaled IFN-β treatment have not demonstrated a significant effect ...

journal_title：American journal of respiratory and critical care medicine

authors： Watson A,Spalluto CM,McCrae C,Cellura D,Burke H,Cunoosamy D,Freeman A,Hicks A,Hühn M,Ostridge K,Staples KJ,Vaarala O,Wilkinson T

更新日期：2020-01-01 00:00:00

abstract：RATIONALE:Reactivation tuberculosis (TB) occurs as a result of reactivation of latent TB infection (LTBI), and was reported to occur in the United States at a rate of 0.10 to 0.16 cases per 100 person-years in the 1950s; it has not been measured since. OBJECTIVES:To calculate the rate of reactivation TB in a U.S. comm...

journal_title：American journal of respiratory and critical care medicine

authors： Horsburgh CR Jr,O'Donnell M,Chamblee S,Moreland JL,Johnson J,Marsh BJ,Narita M,Johnson LS,von Reyn CF

更新日期：2010-08-01 00:00:00