Cytokine profile and correlation to the APACHE III and MPM II scores in patients with sepsis.

abstract：RATIONALE:Statin use has been linked to improved lung health in asthma and chronic obstructive pulmonary disease. We hypothesize that statins inhibit allergic airway inflammation and reduce airway hyperreactivity via a mevalonate-dependent mechanism. OBJECTIVES:To determine whether simvastatin attenuates airway inflam...

journal_title：American journal of respiratory and critical care medicine

authors： Zeki AA,Franzi L,Last J,Kenyon NJ

更新日期：2009-10-15 00:00:00

abstract：:The epithelium of the paranasal sinuses produces nitric oxide (NO), which probably plays a major role in the nonspecific defense of these cavities through its bacteriostatic and cilia motility stimulation properties. Abundant eosinophils of nasal polyps potentially generate superoxide anion (O2-*), but NO and O2-* ina...

journal_title：American journal of respiratory and critical care medicine

authors： Pasto M,Serrano E,Urocoste E,Barbacanne MA,Guissani A,Didier A,Delisle MB,Rami J,Arnal JF

更新日期：2001-01-01 00:00:00

abstract：RATIONALE:Serum chitinases may be novel biomarkers of airway inflammation and remodeling, but less is known about factors regulating their levels. OBJECTIVES:To examine serum chitotriosidase activity and YKL-40 levels in patients with asthma and chronic obstructive pulmonary disease (COPD) and evaluate clinically rele...

journal_title：American journal of respiratory and critical care medicine

authors： James AJ,Reinius LE,Verhoek M,Gomes A,Kupczyk M,Hammar U,Ono J,Ohta S,Izuhara K,Bel E,Kere J,Söderhäll C,Dahlén B,Boot RG,Dahlén SE,BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway

更新日期：2016-01-15 00:00:00

abstract：:The relationships between mite and cat allergen levels in the home, skin test reactivity, and severity of asthma were explored in 120 asthmatic subjects, 57 in Vancouver and 63 in Winnipeg. Patients in the two cities were similar in age, gender distribution, and severity of asthma. Skin tests were performed using 13 c...

journal_title：American journal of respiratory and critical care medicine

authors： Chan-Yeung M,Manfreda J,Dimich-Ward H,Lam J,Ferguson A,Warren P,Simons E,Broder I,Chapman M,Platts-Mills T

更新日期：1995-12-01 00:00:00

abstract：:The blood beryllium lymphocyte proliferation test is used in medical surveillance to identify both beryllium sensitization and chronic beryllium disease. Approximately 50% of individuals with beryllium sensitization have chronic beryllium disease at the time of their initial clinical evaluation; however, the rate of p...

journal_title：American journal of respiratory and critical care medicine

authors： Newman LS,Mroz MM,Balkissoon R,Maier LA

更新日期：2005-01-01 00:00:00

abstract：:In order to examine the dose-dependence of the airway response to animal allergens we performed environmental challenges on 17 workers with documented IgE-mediated allergic reactions to laboratory rats. The 1-h environmental challenges were conducted in a vivarium during cage cleaning (high-allergen challenge), quiet ...

journal_title：American journal of respiratory and critical care medicine

authors： Eggleston PA,Ansari AA,Adkinson NF Jr,Wood RA

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Previous investigations have identified several potential predictors of outcomes from lung volume reduction surgery (LVRS). A concern regarding these studies has been their small sample size, which may limit generalizability. We therefore sought to examine radiographic and physiologic predictors of surgical o...

journal_title：American journal of respiratory and critical care medicine

authors： Washko GR,Martinez FJ,Hoffman EA,Loring SH,Estépar RS,Diaz AA,Sciurba FC,Silverman EK,Han MK,Decamp M,Reilly JJ,National Emphysema Treatment Trial Research Group.

更新日期：2010-03-01 00:00:00

abstract：:We examined endotoxin exposure and wheezing episodes during the first year of life in a birth cohort of 499 infants with one or both parents having a history of asthma or allergy. We measured endotoxin in settled dust from the baby's bed, bedroom floor, family room, and kitchen floor within the first 3 mo after birth....

journal_title：American journal of respiratory and critical care medicine

authors： Park JH,Gold DR,Spiegelman DL,Burge HA,Milton DK

更新日期：2001-02-01 00:00:00

abstract：:Pharyngeal dilator muscle activation (GGEMG) during wakefulness is greater in patients with obstructive sleep apnea (OSA) than in healthy control subjects, representing a neuromuscular compensatory mechanism for a more collapsible airway. As previous work from our laboratory has demonstrated a close relationship betwe...

journal_title：American journal of respiratory and critical care medicine

authors： Fogel RB,Malhotra A,Pillar G,Edwards JK,Beauregard J,Shea SA,White DP

更新日期：2001-12-01 00:00:00

abstract：:DNA fingerprinting of Mycobacterium tuberculosis is used to study the epidemiology of tuberculosis, but the specificity of the widely used IS6110 technique has not been validated. Isolates from Denver, Colorado from December 1988 through June 1994 were fingerprinted with the IS6110 technique. Available records were re...

journal_title：American journal of respiratory and critical care medicine

authors： Burman WJ,Reves RR,Hawkes AP,Rietmeijer CA,Yang Z,el-Hajj H,Bates JH,Cave MD

更新日期：1997-03-01 00:00:00

abstract：:The Child Health Questionnaire (CHQ-PF50) is one of several recent efforts to gauge pediatric, health-related quality of life from the patient's (or parent's) perspective. Although tested extensively with healthy children, more information is needed about CHQ performance among children with chronic conditions such as ...

journal_title：American journal of respiratory and critical care medicine

authors： Asmussen L,Olson LM,Grant EN,Landgraf JM,Fagan J,Weiss KB

更新日期：2000-10-01 00:00:00

abstract：:To investigate the utility of testing all tuberculosis patients for HIV infection in Los Angeles, we prospectively evaluated 183 hospitalized patients with acid-fast smear-positive tuberculosis who gave no history of HIV infection. HIV serologic testing was performed, and the presence of risk factors for HIV infection...

journal_title：American journal of respiratory and critical care medicine

authors： Barnes PF,Silva C,Otaya M

更新日期：1996-04-01 00:00:00

abstract：:The demand for intensivists is increasing around the world, not only to meet the needs of a growing aging population, but also to fill positions in the intensive care unit now occupied by other specialists, since there is compelling evidence that the presence of critical care practitioners improves patient outcomes. N...

journal_title：American journal of respiratory and critical care medicine

authors： Estenssoro E,Valente Barbas CS,Briva A

更新日期：2013-01-15 00:00:00

abstract：:Patients in whom acid-fast bacilli smear-positive pulmonary tuberculosis was newly diagnosed were randomized to receive 400 mg moxifloxacin, 300 mg isonaizid, or 600 mg rifampin daily for 5 days. Sixteen-hour overnight sputa collections were made for the 2 days before and for 5 days of monotherapy. Bactericidal activi...

journal_title：American journal of respiratory and critical care medicine

authors： Gosling RD,Uiso LO,Sam NE,Bongard E,Kanduma EG,Nyindo M,Morris RW,Gillespie SH

更新日期：2003-12-01 00:00:00

abstract：:Measurement of cardiac output using thermodilution technique in mechanically ventilated patients is associated with significant morbidity. The goal of the present study was to assess the validity of cardiac output measurement using transesophageal Doppler in critically ill patients. Forty-six patients from three diffe...

journal_title：American journal of respiratory and critical care medicine

authors： Valtier B,Cholley BP,Belot JP,de la Coussaye JE,Mateo J,Payen DM

更新日期：1998-07-01 00:00:00

abstract：:To determine the factors contributing to tuberculosis incidence in the U.S.-born and foreign-born populations in San Francisco, California, and to assess the effectiveness of tuberculosis control efforts in these populations, we performed a population-based molecular epidemiologic study using 367 patients with strains...

journal_title：American journal of respiratory and critical care medicine

authors： Chin DP,DeRiemer K,Small PM,de Leon AP,Steinhart R,Schecter GF,Daley CL,Moss AR,Paz EA,Jasmer RM,Agasino CB,Hopewell PC

更新日期：1998-12-01 00:00:00

abstract：RATIONALE:The immune response in sepsis is characterized by overt immune dysfunction. Studies indicate immunostimulation represents a viable therapy for patients. One study suggests a potentially protective role for interleukin 5 (IL-5) in sepsis; however, the loss of eosinophils in this disease presents a paradox. OB...

journal_title：American journal of respiratory and critical care medicine

authors： Linch SN,Danielson ET,Kelly AM,Tamakawa RA,Lee JJ,Gold JA

更新日期：2012-08-01 00:00:00

abstract：:Although all the well-recognized muscles of expiration are paralyzed after traumatic transection of the lower cervical cord, tetraplegic subjects can still empty their lungs actively by contracting the clavicular portion of the pectoralis major. It is not known, however, whether contraction of this muscle bundle may r...

journal_title：American journal of respiratory and critical care medicine

authors： Estenne M,Van Muylem A,Gorini M,Kinnear W,Heilporn A,De Troyer A

更新日期：1994-10-01 00:00:00

abstract：:Transbronchial biopsies (TBBs) are useful to diagnose acute rejection and infection in patients with lung transplants. The value of routine surveillance biopsies (S-TBBs) is not known, and such biopsies with a clinical indication are not without risk and are expensive. One hundred twenty-six 6-mo survivors of heart-lu...

journal_title：American journal of respiratory and critical care medicine

authors： Tamm M,Sharples LD,Higenbottam TW,Stewart S,Wallwork J

更新日期：1997-05-01 00:00:00

abstract：:We investigated ventilation inhomogeneity in patients with chronic obstructive pulmonary disease (COPD) through use of the multiple breath N2 washout test (MBW). From an alveolar slope analysis throughout the MBW, we derived two indices, S(cond) and S(acin), as a measure of ventilation inhomogeneity in conductive and ...

journal_title：American journal of respiratory and critical care medicine

authors： Verbanck S,Schuermans D,Van Muylem A,Melot C,Noppen M,Vincken W,Paiva M

更新日期：1998-05-01 00:00:00

abstract：RATIONALE:The contribution of interferon-gamma release assays (IGRAs) to appropriate risk stratification of active tuberculosis suspects has not been studied. OBJECTIVES:To determine whether the addition of quantitative IGRA results to a prediction model incorporating clinical criteria improves risk stratification of ...

journal_title：American journal of respiratory and critical care medicine

authors： Metcalfe JZ,Cattamanchi A,Vittinghoff E,Ho C,Grinsdale J,Hopewell PC,Kawamura LM,Nahid P

更新日期：2010-01-01 00:00:00

abstract：RATIONALE:Sarcoidosis is a granulomatous disease of unknown etiology, although M. tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in sarcoidosis is compartmentalized to involved organs. OBJECTIVES:To determine whether whole blood gene expression signatures reflect inflamm...

journal_title：American journal of respiratory and critical care medicine

authors： Koth LL,Solberg OD,Peng JC,Bhakta NR,Nguyen CP,Woodruff PG

更新日期：2011-11-15 00:00:00

abstract：:Despite extensive research into the etiology and treatment of severe sepsis, little is known about its epidemiology in children. We sought to determine the age- and sex-adjusted incidence, outcome, and associated hospital costs of severe sepsis in United States children using 1995 hospital discharge and population dat...

journal_title：American journal of respiratory and critical care medicine

authors： Watson RS,Carcillo JA,Linde-Zwirble WT,Clermont G,Lidicker J,Angus DC

更新日期：2003-03-01 00:00:00

abstract：:The upper airway undergoes progressive changes during childhood. Using magnetic resonance imaging (MRI), we studied the growth relationships of the tissues surrounding the upper airway (bone and soft tissues) in 92 normal children (47% males; range, 1 to 11 yr) who underwent brain MRI. None had symptoms of sleep-disor...

journal_title：American journal of respiratory and critical care medicine

authors： Arens R,McDonough JM,Corbin AM,Hernandez ME,Maislin G,Schwab RJ,Pack AI

更新日期：2002-01-01 00:00:00

abstract：:Effective treatment of tuberculosis requires adherence to a minimum of 6 months treatment with multiple drugs. To improve adherence and cure rates, directly observed therapy is recommended for the treatment of pulmonary tuberculosis. We compared treatment outcomes among all culture-positive patients treated for active...

journal_title：American journal of respiratory and critical care medicine

authors： Jasmer RM,Seaman CB,Gonzalez LC,Kawamura LM,Osmond DH,Daley CL

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:The discovery that retinoic acid-related orphan receptor (Rora)-α is highly expressed in lungs of patients with COPD led us to hypothesize that Rora may contribute to the pathogenesis of emphysema. OBJECTIVES:To determine the role of Rora in smoke-induced emphysema. METHODS:Cigarette smoke extract in vitro ...

journal_title：American journal of respiratory and critical care medicine

authors： Shi Y,Cao J,Gao J,Zheng L,Goodwin A,An CH,Patel A,Lee JS,Duncan SR,Kaminski N,Pandit KV,Rosas IO,Choi AM,Morse D

更新日期：2012-09-01 00:00:00

abstract：:Sarcoidosis is a systemic granulomatous disease of unknown etiology that primarily affects the lungs. The etiology remains unclear; however, environmental, genetic, ethnic, and familial factors probably modify expression of the disease. As an example, African Americans are at greater risk of mortality and morbidity th...

journal_title：American journal of respiratory and critical care medicine

authors： Martin WJ 2nd,Iannuzzi MC,Gail DB,Peavy HH

更新日期：2004-09-01 00:00:00

abstract：:Although impairment of gas exchange caused by ventilation-perfusion (VA/Q) mismatch has been extensively analyzed, there have been no systematic studies focused on determining the distributions of diffusion properties in dose connection with those of VA/Q. We attempted to clarify the simultaneous distributions of VA/Q...

journal_title：American journal of respiratory and critical care medicine

authors： Yamaguchi K,Mori M,Kawai A,Takasugi T,Oyamada Y,Koda E

更新日期：1997-07-01 00:00:00

abstract：:Genetic factors may contribute to the variability of exhaled nitric oxide in healthy individuals. We studied exhaled nitric oxide and genetic variants in both neuronal and endothelial nitric oxide synthases in 105 healthy nonsmoking and smoking subjects. Genomic DNA was screened for a repeat polymorphism in intron 20 ...

journal_title：American journal of respiratory and critical care medicine

authors： Grasemann H,Storm van's Gravesande K,Buscher R,Drazen JM,Ratjen F

更新日期：2003-04-15 00:00:00

abstract：RATIONALE:Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors. OBJECTIVES:We sought to identify donor, recipient, and perioperative risk factors for PGD. METHODS:We performed a 10-center p...

journal_title：American journal of respiratory and critical care medicine

authors： Diamond JM,Lee JC,Kawut SM,Shah RJ,Localio AR,Bellamy SL,Lederer DJ,Cantu E,Kohl BA,Lama VN,Bhorade SM,Crespo M,Demissie E,Sonett J,Wille K,Orens J,Shah AS,Weinacker A,Arcasoy S,Shah PD,Wilkes DS,Ware LB,Palme

更新日期：2013-03-01 00:00:00