Familial correlation in the decline of forced expiratory volume in one second.

abstract：RATIONALE:Donor mesenchymal stromal/stem cell (MSC) expansion and fibrotic differentiation is associated with development of bronchiolitis obliterans syndrome (BOS) in human lung allografts. However, the regulators of fibrotic differentiation of these resident mesenchymal cells are not well understood. OBJECTIVES:This...

journal_title：American journal of respiratory and critical care medicine

authors： Walker NM,Badri LN,Wadhwa A,Wettlaufer S,Peters-Golden M,Lama VN

更新日期：2012-01-01 00:00:00

abstract：:The reaction of nitric oxide (NO) and superoxide anions (O(2)(-)) in the airway results in the formation of peroxynitrite, a highly reactive oxidant species. Peroxynitrite reacts with tyrosine residues in proteins to form the stable product nitrotyrosine. We investigated whether nitrotyrosine in exhaled breath condens...

journal_title：American journal of respiratory and critical care medicine

authors： Hanazawa T,Kharitonov SA,Barnes PJ

更新日期：2000-10-01 00:00:00

abstract：:The purpose of this study was to describe the nature of diaphragm injury, to quantify the injury and number of macrophages at the light microscopic level, and to determine their association with airflow obstruction in humans. Partial-thickness diaphragm biopsies were obtained from 21 subjects going for thoracotomy sur...

journal_title：American journal of respiratory and critical care medicine

authors： Macgowan NA,Evans KG,Road JD,Reid WD

更新日期：2001-06-01 00:00:00

abstract：RATIONALE:The clinical management of idiopathic pulmonary fibrosis (IPF) remains a major challenge due to lack of effective drug therapy or accurate indicators for disease progression. Fibrocytes are circulating mesenchymal cell progenitors that are involved in tissue repair and fibrosis. OBJECTIVES:To test the hypoth...

journal_title：American journal of respiratory and critical care medicine

authors： Moeller A,Gilpin SE,Ask K,Cox G,Cook D,Gauldie J,Margetts PJ,Farkas L,Dobranowski J,Boylan C,O'Byrne PM,Strieter RM,Kolb M

更新日期：2009-04-01 00:00:00

abstract：RATIONALE:Increasing epithelial repair and regeneration may hasten resolution of lung injury in patients with the acute respiratory distress syndrome (ARDS). In animal models of ARDS, keratinocyte growth factor (KGF) reduces injury and increases epithelial proliferation and repair. The effect of KGF in the human alveol...

journal_title：American journal of respiratory and critical care medicine

authors： Shyamsundar M,McAuley DF,Ingram RJ,Gibson DS,O'Kane D,McKeown ST,Edwards A,Taggart C,Elborn JS,Calfee CS,Matthay MA,O'Kane CM

更新日期：2014-06-15 00:00:00

abstract：:The inflection points of the pressure-volume curve have been used for setting mechanical ventilation in patients with acute lung injury. However, the lung status at these points has never been specifically addressed. In 12 patients with early lung injury we traced both limbs of the pressure-volume curve by means of a ...

journal_title：American journal of respiratory and critical care medicine

authors： Albaiceta GM,Taboada F,Parra D,Luyando LH,Calvo J,Menendez R,Otero J

更新日期：2004-11-15 00:00:00

abstract：:A group of male amateur cyclists was studied in the summer of 1991 in the east of the Netherlands. Lung function was measured before and after training sessions or competitive races on a number of occasions. Continuous heart rate monitors were employed to document exercise levels. Heart rate averaged 161 beats/min dur...

journal_title：American journal of respiratory and critical care medicine

authors： Brunekreef B,Hoek G,Breugelmans O,Leentvaar M

更新日期：1994-10-01 00:00:00

abstract：:Collections of sputum from 105 patients with newly diagnosed pulmonary tuberculosis were made before and at 1 and 2 d after the start of chemotherapy with isoniazid (INH) alone given to groups of patients in doses of 600 mg, 300 mg, 150 mg, 75 mg, 37.5 mg, 18.75 mg, and 9 mg daily, as well as from an untreated group. ...

journal_title：American journal of respiratory and critical care medicine

authors： Donald PR,Sirgel FA,Botha FJ,Seifart HI,Parkin DP,Vandenplas ML,Van de Wal BW,Maritz JS,Mitchison DA

更新日期：1997-09-01 00:00:00

abstract：:Knowledge of the local and regional doses of inhaled particulates is crucial for inhalation therapy and for understanding the progression of pulmonary disease. We studied the deposition pattern of radioactively tagged particles in rats with chronic bronchitis. Rats were exposed to sulfur dioxide (SO2; 236 +/- 14 ppm) ...

journal_title：American journal of respiratory and critical care medicine

authors： Sweeney TD,Skornik WA,Brain JD,Hatch V,Godleski JJ

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:In 1989, the United States embarked upon an ambitious path to eliminate tuberculosis (TB) nationwide. Although incidence rates of TB disease in the United States are declining, these cases represent only a tiny fraction of all TB infections. Understanding national trends in TB infection may be important in an...

journal_title：American journal of respiratory and critical care medicine

authors： Khan K,Wang J,Hu W,Bierman A,Li Y,Gardam M

更新日期：2008-02-15 00:00:00

abstract：:Serum concentrations of neuron-specific enolase (NSE) were measured in 135 patients with benign pulmonary diseases who also underwent a clinical, laboratory, and radiologic evaluation. Eleven percent of the patients as a whole and 27.3% of those who were tuberculous had abnormal serum levels of NSE. Significant differ...

journal_title：American journal of respiratory and critical care medicine

authors： Collazos J,Esteban C,Fernández A,Genollá J

更新日期：1994-07-01 00:00:00

abstract：:The six-minute walk test is a submaximal exercise test that can be performed even by a patient with heart failure not tolerating maximal exercise testing. To elucidate the clinical significance and prognostic value of the six-minute walk test in patients with primary pulmonary hypertension (PPH), we sought (1) to asse...

journal_title：American journal of respiratory and critical care medicine

authors： Miyamoto S,Nagaya N,Satoh T,Kyotani S,Sakamaki F,Fujita M,Nakanishi N,Miyatake K

更新日期：2000-02-01 00:00:00

abstract：:Induced sputum using hypertonic saline (HS) is a useful research tool to study airway inflammation (AI). HS provocation testing can also be used to measure airway hyperresponsiveness (AHR). A combined HS challenge and sputum induction procedure has been developed to permit assessment of AI and AHR in a single test. Th...

journal_title：American journal of respiratory and critical care medicine

authors： Jones PD,Hankin R,Simpson J,Gibson PG,Henry RL

更新日期：2001-10-01 00:00:00

abstract：:Systemic inflammation is present in chronic obstructive pulmonary disease (COPD), which has been linked to cardiovascular morbidity and mortality. We determined the effects of oral and inhaled corticosteroids on serum markers of inflammation in patients with stable COPD. We recruited 41 patients with mild to moderate ...

journal_title：American journal of respiratory and critical care medicine

authors： Sin DD,Lacy P,York E,Man SF

更新日期：2004-10-01 00:00:00

abstract：:In asthma, the acute increment of airway responsiveness caused by exposure to allergen is associated with influx of eosinophils into the airways. The relationship between chronic airway hyperresponsiveness and airway inflammation is unclear, as they do not change consistently following long-term anti-inflammatory trea...

journal_title：American journal of respiratory and critical care medicine

authors： Crimi E,Spanevello A,Neri M,Ind PW,Rossi GA,Brusasco V

更新日期：1998-01-01 00:00:00

abstract：RATIONALE:Implementation of intervention strategies to prevent lung damage in early cystic fibrosis (CF) requires objective outcome measures that capture and track lung disease. OBJECTIVES:To define the utility of the Lung Clearance Index (LCI), measured by multiple breath washout, as a means to track disease progress...

journal_title：American journal of respiratory and critical care medicine

authors： Stanojevic S,Davis SD,Retsch-Bogart G,Webster H,Davis M,Johnson RC,Jensen R,Pizarro ME,Kane M,Clem CC,Schornick L,Subbarao P,Ratjen FA

更新日期：2017-05-01 00:00:00

abstract：:We found that continuous eosinophilic inflammation after repeated antigen instillation into the nose was observed only in A/J mice, not in three other strains. Histologic analysis of tissues from A/J mice revealed features typical of airway remodeling, i.e., airway wall thickening and increased collagen depositions we...

journal_title：American journal of respiratory and critical care medicine

authors： Shinagawa K,Kojima M

更新日期：2003-10-15 00:00:00

abstract：:The rise in childhood asthma prevalence suggests a role for environmental factors in the etiology of this evolving epidemic; however, genetics also influence the occurrence of asthma. Glutathione S-transferase (GST) M1 may play a role in asthma and wheezing occurrence among those exposed to tobacco smoke, as it functi...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Li YF,Dubeau L,Berhane K,Avol E,McConnell R,Gauderman WJ,Peters JM

更新日期：2002-08-15 00:00:00

abstract：:This study aimed to estimate exposure-response relationships for mesothelioma and environmental exposure to crocidolite. All 4,659 former residents of Wittenoom, Western Australia (WA) who lived there between 1943 and 1993 for at least 1 mo and were not directly employed in the crocidolite industry, were followed-up t...

journal_title：American journal of respiratory and critical care medicine

authors： Hansen J,de Klerk NH,Musk AW,Hobbs MS

更新日期：1998-01-01 00:00:00

abstract：:The lobar and cephalocaudal distribution of aerated and nonaerated lung and of PEEP-induced alveolar recruitment is unknown in acute lung injury (ALI). Dimensions of the lungs and volumes of aerated and nonaerated parts of each pulmonary lobe were measured using a computerized tomographic quantitative analysis and com...

journal_title：American journal of respiratory and critical care medicine

authors： Puybasset L,Cluzel P,Chao N,Slutsky AS,Coriat P,Rouby JJ

更新日期：1998-11-01 00:00:00

abstract：:Airway hyperresponsiveness in asthma has been attributed to impaired ability of deep inspiration (DI) to stretch airway smooth muscle. We have retested this hypothesis by comparing the responses to methacholine of 10 asthmatic and 10 control subjects. After each dose subjects breathed tidally without deep inspiration ...

journal_title：American journal of respiratory and critical care medicine

authors： Burns GP,Gibson GJ

更新日期：1998-07-01 00:00:00

abstract：RATIONALE:Little is known about the incidence of isoniazid-associated hepatitis in HIV-infected Africans who receive both isoniazid preventive therapy (IPT) and antiretroviral therapy (ART). OBJECTIVES:To assess the rate of and risk factors for isoniazid (INH)-associated hepatitis in persons living with HIV (PLWH) dur...

journal_title：American journal of respiratory and critical care medicine

authors： Tedla Z,Nyirenda S,Peeler C,Agizew T,Sibanda T,Motsamai O,Vernon A,Wells CD,Samandari T

更新日期：2010-07-15 00:00:00

abstract：RATIONALE:Transthoracic Doppler echocardiography is recommended for screening for the presence of pulmonary hypertension (PH). However, some recent studies have suggested that Doppler echocardiographic pulmonary artery pressure estimates may frequently be inaccurate. OBJECTIVES:Evaluate the accuracy of Doppler echocar...

journal_title：American journal of respiratory and critical care medicine

authors： Fisher MR,Forfia PR,Chamera E,Housten-Harris T,Champion HC,Girgis RE,Corretti MC,Hassoun PM

更新日期：2009-04-01 00:00:00

abstract：:Hydrogen peroxide (H2O2) is known to play an important role in airway homeostasis. For this reason its levels and thus its synthesis and consumption are important mechanisms for controlling airway functions. We have identified the major macromolecular consumer of H2O2 in sheep airway secretions to be lactoperoxidase (...

journal_title：American journal of respiratory and critical care medicine

authors： Conner GE,Salathe M,Forteza R

更新日期：2002-12-15 00:00:00

abstract：:Genetic factors may contribute to the variability of exhaled nitric oxide in healthy individuals. We studied exhaled nitric oxide and genetic variants in both neuronal and endothelial nitric oxide synthases in 105 healthy nonsmoking and smoking subjects. Genomic DNA was screened for a repeat polymorphism in intron 20 ...

journal_title：American journal of respiratory and critical care medicine

authors： Grasemann H,Storm van's Gravesande K,Buscher R,Drazen JM,Ratjen F

更新日期：2003-04-15 00:00:00

abstract：RATIONALE:FVC has emerged as a standard primary endpoint in clinical trials evaluating novel therapies for patients with idiopathic pulmonary fibrosis (IPF). However, it has recently been proposed that all-cause mortality or a composite comprised of all-cause mortality and all-cause nonelective hospitalization be adopt...

journal_title：American journal of respiratory and critical care medicine

authors： King TE Jr,Albera C,Bradford WZ,Costabel U,du Bois RM,Leff JA,Nathan SD,Sahn SA,Valeyre D,Noble PW

更新日期：2014-04-01 00:00:00

abstract：:Reduced bronchodilatation in response to deep inspiration (DI) has been demonstrated in asthmatics. We have previously shown that inhibition of DI for 10 min or more during methacholine inhalation increases airway narrowing in normals. We tested the hypothesis that inhibition of DIs during methacholine inhalation in a...

journal_title：American journal of respiratory and critical care medicine

authors： King GG,Moore BJ,Seow CY,Paré PD

更新日期：2001-07-15 00:00:00

abstract：:The stimuli controlling pharyngeal dilator muscles are poorly defined. Local mechanoreceptors are a leading possibility. To address this, we assessed the relationship between two dilator muscle electromyograms (EMGs, i.e., genioglossus [GG-an inspiratory phasic muscle], tensor palatini [TP-a tonically active muscle]) ...

journal_title：American journal of respiratory and critical care medicine

authors： Malhotra A,Pillar G,Fogel RB,Beauregard J,Edwards JK,Slamowitz DI,Shea SA,White DP

更新日期：2000-09-01 00:00:00

abstract：:Successful bronchodilator therapy with a metered-dose inhaler (MDI) in intubated, mechanically ventilated patients requires adequate delivery of aerosol to the lower respiratory tract. We determined the effect of ventilator mode, inspiratory flow pattern, humidity, and spontaneous respiratory effort on albuterol deliv...

journal_title：American journal of respiratory and critical care medicine

authors： Fink JB,Dhand R,Duarte AG,Jenne JW,Tobin MJ

更新日期：1996-08-01 00:00:00

abstract：:To elucidate the apparent contradictions in vascular remodeling in the lungs of patients with idiopathic pulmonary fibrosis, we evaluated alveolar vascularity in relation to the various degrees of fibrosis in surgically biopsied lungs of usual interstitial pneumonia. Alveolar capillary endothelial cells were intensely...

journal_title：American journal of respiratory and critical care medicine

authors： Ebina M,Shimizukawa M,Shibata N,Kimura Y,Suzuki T,Endo M,Sasano H,Kondo T,Nukiwa T

更新日期：2004-06-01 00:00:00