Lactoperoxidase and hydrogen peroxide metabolism in the airway.

abstract：RATIONALE:Extracellular nucleotides have recently been identified as proinflammatory mediators involved in asthma pathogenesis by signaling via purinergic receptors, but the role of the purinergic receptor type 6 (P2Y6R) has not been previously investigated. OBJECTIVES:To investigate the role of P2Y6R in asthma pathog...

journal_title：American journal of respiratory and critical care medicine

authors： Vieira RP,Müller T,Grimm M,von Gernler V,Vetter B,Dürk T,Cicko S,Ayata CK,Sorichter S,Robaye B,Zeiser R,Ferrari D,Kirschbaum A,Zissel G,Virchow JC,Boeynaems JM,Idzko M

更新日期：2011-07-15 00:00:00

abstract：:The number of alveoli is a key structural determinant of lung architecture. A design-based stereologic approach was used for the direct and unbiased estimation of alveolar number in the human lung. The principle is based on two-dimensional topology in three-dimensional space and is free of assumptions on the shape, si...

journal_title：American journal of respiratory and critical care medicine

authors： Ochs M,Nyengaard JR,Jung A,Knudsen L,Voigt M,Wahlers T,Richter J,Gundersen HJ

更新日期：2004-01-01 00:00:00

abstract：RATIONALE:Defining the biogeography of bacterial populations in human body habitats is a high priority for understanding microbial-host relationships in health and disease. The healthy lung was traditionally considered sterile, but this notion has been challenged by emerging molecular approaches that enable comprehensi...

journal_title：American journal of respiratory and critical care medicine

authors： Charlson ES,Bittinger K,Haas AR,Fitzgerald AS,Frank I,Yadav A,Bushman FD,Collman RG

更新日期：2011-10-15 00:00:00

abstract：:Quality of life has been found to be impaired both in patients with asthma and in patients with allergic rhinitis, but the relative burden of these diseases has not been investigated. We analyzed answers to the SF-36 questionnaire from 850 subjects recruited in two French centers participating in the European Communit...

journal_title：American journal of respiratory and critical care medicine

authors： Leynaert B,Neukirch C,Liard R,Bousquet J,Neukirch F

更新日期：2000-10-01 00:00:00

abstract：:Patients with pulmonary Mycobacterium avium complex (MAC) infection occasionally have neither past histories of pulmonary diseases nor underlying immunodeficiency conditions. Therefore, we hypothesized that MAC may be linked with a disease-susceptibility gene and determined human leukocyte-associated antigens (HLA) in...

journal_title：American journal of respiratory and critical care medicine

authors： Takahashi M,Ishizaka A,Nakamura H,Kobayashi K,Nakamura M,Namiki M,Sekita T,Okajima S

更新日期：2000-07-01 00:00:00

abstract：:Lung transplant (LTx) recipients have a low peak work rate, peak oxygen consumption (V O2peak), and early lactate threshold on incremental exercise. We hypothesized that LTx recipients have reduced oxidative function and altered fiber type proportion in peripheral skeletal muscle. Seven stable LTx recipients and seven...

journal_title：American journal of respiratory and critical care medicine

authors： Wang XN,Williams TJ,McKenna MJ,Li JL,Fraser SF,Side EA,Snell GI,Walters EH,Carey MF

更新日期：1999-07-01 00:00:00

abstract：KEYWORDS:Children as young as 6 years old can perform spirometry, yet the relationship between current asthma, lung function, and bronchial responsiveness has not been described at this age; 2,537 children from a community-based birth cohort were assessed at 6 years of age, with history (n = 2,141), physical examinatio...

journal_title：American journal of respiratory and critical care medicine

authors： Joseph-Bowen J,de Klerk NH,Firth MJ,Kendall GE,Holt PG,Sly PD

更新日期：2004-04-01 00:00:00

abstract：RATIONALE:Asthma commonly originates in early life in association with impaired lung function, which tracks to adulthood. OBJECTIVES:Within the context of a prospective birth cohort study, we investigated the association between single nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) ge...

journal_title：American journal of respiratory and critical care medicine

authors： Simpson A,Maniatis N,Jury F,Cakebread JA,Lowe LA,Holgate ST,Woodcock A,Ollier WE,Collins A,Custovic A,Holloway JW,John SL

更新日期：2005-07-01 00:00:00

abstract：RATIONALE:Cigarette smoke is the major risk factor in the development of chronic obstructive pulmonary disease (COPD). Lipidomics is a novel and emerging research field that may provide new insights in the origins of chronic inflammatory diseases, such as COPD. OBJECTIVES:To investigate whether expression of the sputu...

journal_title：American journal of respiratory and critical care medicine

authors： Telenga ED,Hoffmann RF,Ruben t'Kindt,Hoonhorst SJ,Willemse BW,van Oosterhout AJ,Heijink IH,van den Berge M,Jorge L,Sandra P,Postma DS,Sandra K,ten Hacken NH

更新日期：2014-07-15 00:00:00

abstract：:In 11 ventilator-dependent patients, we undertook a head-to-head comparison of patient-ventilator interaction during four ventilator modes: assist-control ventilation (ACV), intermittent mandatory ventilation (IMV), pressure support (PS), and a combination of IMV and PS. Progressive increases in IMV rate and PS level ...

journal_title：American journal of respiratory and critical care medicine

authors： Leung P,Jubran A,Tobin MJ

更新日期：1997-06-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with impaired renal function, but uncertainty exists over whether OSA treatment can influence renal outcomes. OBJECTIVES:To determine the effects of continuous positive airway pressure (CPAP) on renal function in subjects with coexisting OSA and cardiovascular dise...

journal_title：American journal of respiratory and critical care medicine

authors： Loffler KA,Heeley E,Freed R,Anderson CS,Brockway B,Corbett A,Chang CL,Douglas JA,Ferrier K,Graham N,Hamilton GS,Hlavac M,McArdle N,McLachlan J,Mukherjee S,Naughton MT,Thien F,Young A,Grunstein RR,Palmer LJ,Woodman

更新日期：2017-12-01 00:00:00

abstract：RATIONALE:End-tidal CO2 (EtCO2) is used to monitor cardiopulmonary resuscitation (CPR), but it can be affected by intrathoracic airway closure. Chest compressions induce oscillations in expired CO2, and this could reflect variable degrees of airway patency. OBJECTIVES:To understand the impact of airway closure during ...

journal_title：American journal of respiratory and critical care medicine

authors： Grieco DL,J Brochard L,Drouet A,Telias I,Delisle S,Bronchti G,Ricard C,Rigollot M,Badat B,Ouellet P,Charbonney E,Mancebo J,Mercat A,Savary D,Richard JM

更新日期：2019-03-15 00:00:00

abstract：:Although contraction of human isolated bronchi is mediated mainly by tachykinin NK2 receptors, NK1 receptors, via prostanoid release, contract small-size (approximately 1 mm in diameter) bronchi. Here, we have investigated the presence and biological responses of NK1 receptors in medium-size (2-5 mm in diameter) human...

journal_title：American journal of respiratory and critical care medicine

authors： Amadesi S,Moreau J,Tognetto M,Springer J,Trevisani M,Naline E,Advenier C,Fisher A,Vinci D,Mapp C,Miotto D,Cavallesco G,Geppetti P

更新日期：2001-04-01 00:00:00

abstract：RATIONALE:5-Hydroxytryptamine (5-HT) is involved in the pathogenesis of allergic airway inflammation (AAI). It is unclear, however, how 5-HT contributes to AAI and whether this depends on tryptophan hydroxylase (TPH) 1, the critical enzyme for peripheral 5-HT synthesis. OBJECTIVES:To elucidate the role of TPH1 and the...

journal_title：American journal of respiratory and critical care medicine

authors： Dürk T,Duerschmied D,Müller T,Grimm M,Reuter S,Vieira RP,Ayata K,Cicko S,Sorichter S,Walther DJ,Virchow JC,Taube C,Idzko M

更新日期：2013-03-01 00:00:00

abstract：:Decreases in gastric mucosal pH (pHi) are associated with splanchnic hypoxia in animals and with increased mortality in patients. In the present study we measured changes in gastric pHi with a tonometer in septic patients after a short-term infusion of dobutamine. These changes were compared with concurrent alteration...

journal_title：American journal of respiratory and critical care medicine

authors： Gutierrez G,Clark C,Brown SD,Price K,Ortiz L,Nelson C

更新日期：1994-08-01 00:00:00

abstract：:The mechanism responsible for the increased air-space permeability in cigarette smokers is unknown. The aim of this study was to assess the acute and chronic effects of cigarette smoking on epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Fourteen cigarette smokers underwent 99mT...

journal_title：American journal of respiratory and critical care medicine

authors： Morrison D,Rahman I,Lannan S,MacNee W

更新日期：1999-02-01 00:00:00

abstract：:This prospective and controlled pilot study evaluates the long-term effects of nocturnal oxygen therapy (NOT) on exercise endurance, hematology variables, quality of life, and survival of 23 adult patients (mean age, 32 +/- 6 yr) with post-tricuspid congenital heart defects (ventricular septal defect = 10; patent duct...

journal_title：American journal of respiratory and critical care medicine

authors： Sandoval J,Aguirre JS,Pulido T,Martinez-Guerra ML,Santos E,Alvarado P,Rosas M,Bautista E

更新日期：2001-11-01 00:00:00

abstract：:Rationale: The bHLH (basic helix-loop-helix) transcription factor TWIST1 (Twist-related protein 1) controls cell proliferation and differentiation in tissue development and disease processes. Recently, endothelial TWIST1 has been linked to pulmonary hypertension (PH) and endothelial-to-mesenchymal transition, yet the ...

journal_title：American journal of respiratory and critical care medicine

authors： Fan Y,Gu X,Zhang J,Sinn K,Klepetko W,Wu N,Foris V,Solymosi P,Kwapiszewska G,Kuebler WM

更新日期：2020-11-01 00:00:00

abstract：:The low-affinity IgG Fc receptor, FcgammaRIIB, displays inhibitory potential in experimental models such as autoimmune diseases. However, whether this receptor is involved in the onset of allergic diseases remains unknown. This study examines the role of FcgammaRIIB in the initiation of allergic rhinitis in mice. Repe...

journal_title：American journal of respiratory and critical care medicine

authors： Watanabe T,Okano M,Hattori H,Yoshino T,Ohno N,Ohta N,Sugata Y,Orita Y,Takai T,Nishizaki K

更新日期：2004-01-01 00:00:00

abstract：:Noninvasive and invasive diagnostic techniques have been shown to achieve comparable performances in the evaluation of suspected ventilator-associated pneumonia (VAP). We studied the impact of both approaches on outcome in a prospective, open, and randomized study in three intensive care units (ICUs) of a 1,000-bed te...

journal_title：American journal of respiratory and critical care medicine

authors： Ruiz M,Torres A,Ewig S,Marcos MA,Alcón A,Lledó R,Asenjo MA,Maldonaldo A

更新日期：2000-07-01 00:00:00

abstract：RATIONALE:Respiratory syncytial virus (RSV) is the leading cause of childhood lower respiratory infection, yet viable therapies are lacking. Two major challenges have stalled antiviral development: ethical difficulties in performing pediatric proof-of-concept studies and the prevailing concept that the disease is immun...

journal_title：American journal of respiratory and critical care medicine

authors： DeVincenzo JP,Wilkinson T,Vaishnaw A,Cehelsky J,Meyers R,Nochur S,Harrison L,Meeking P,Mann A,Moane E,Oxford J,Pareek R,Moore R,Walsh E,Studholme R,Dorsett P,Alvarez R,Lambkin-Williams R

更新日期：2010-11-15 00:00:00

abstract：:Daily symptom, peak expiratory flow rate (PEFR), and medication diaries are often used in clinical trials of treatments for asthma on the assumption that they provide a better estimate of clinical status than does a questionnaire completed in the clinic. We conducted a study with the aim of comparing the measurement p...

journal_title：American journal of respiratory and critical care medicine

authors： Juniper EF,O'Byrne PM,Ferrie PJ,King DR,Roberts JN

更新日期：2000-10-01 00:00:00

abstract：:Acute lung injury was produced in C57BL/6 mice by the intratracheal (i.t.) administration of bleomycin (BLM). Following injection of 0.1 U BLM, CD3+ lymphocytes and the production of the T-helper-1 (Th1) lymphokines interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) were increased in lung and lymph nodes. The produ...

journal_title：American journal of respiratory and critical care medicine

authors： Sharma SK,MacLean JA,Pinto C,Kradin RL

更新日期：1996-07-01 00:00:00

abstract：RATIONALE:Smoking is the largest contributor to lung cancer risk, and those who continue to smoke after diagnosis have a worse survival. Screening for lung cancer with low-dose computed tomography (LDCT) reduces mortality in high-risk individuals. Smoking cessation is an essential component of a high-quality screening ...

journal_title：American journal of respiratory and critical care medicine

authors： Tanner NT,Kanodra NM,Gebregziabher M,Payne E,Halbert CH,Warren GW,Egede LE,Silvestri GA

更新日期：2016-03-01 00:00:00

abstract：RATIONALE:Cytomegalovirus (CMV), which is one of the most common infections after lung transplantation, is associated with chronic lung allograft dysfunction and worse post-transplantation survival. Current approaches for at-risk patients include a fixed duration of antiviral prophylaxis despite the associated cost and...

journal_title：American journal of respiratory and critical care medicine

authors： Snyder LD,Chan C,Kwon D,Yi JS,Martissa JA,Copeland CA,Osborne RJ,Sparks SD,Palmer SM,Weinhold KJ

更新日期：2016-01-01 00:00:00

abstract：:Used adjunctively during mechanical ventilation, tracheal gas insufflation (TGI) improves CO2 elimination, principally by decreasing effective anatomic dead space. Continuing lung deflation at end- expiration raises the end-expiratory C02 concentration within the proximal airway, and could theoretically reduce the eff...

journal_title：American journal of respiratory and critical care medicine

authors： Ravenscraft SA,Shapiro RS,Nahum A,Burke WC,Adams AB,Nakos G,Marini JJ

更新日期：1996-06-01 00:00:00

abstract：RATIONALE:Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors. OBJECTIVES:We sought to identify donor, recipient, and perioperative risk factors for PGD. METHODS:We performed a 10-center p...

journal_title：American journal of respiratory and critical care medicine

authors： Diamond JM,Lee JC,Kawut SM,Shah RJ,Localio AR,Bellamy SL,Lederer DJ,Cantu E,Kohl BA,Lama VN,Bhorade SM,Crespo M,Demissie E,Sonett J,Wille K,Orens J,Shah AS,Weinacker A,Arcasoy S,Shah PD,Wilkes DS,Ware LB,Palme

更新日期：2013-03-01 00:00:00

abstract：:The demand for intensivists is increasing around the world, not only to meet the needs of a growing aging population, but also to fill positions in the intensive care unit now occupied by other specialists, since there is compelling evidence that the presence of critical care practitioners improves patient outcomes. N...

journal_title：American journal of respiratory and critical care medicine

authors： Estenssoro E,Valente Barbas CS,Briva A

更新日期：2013-01-15 00:00:00

abstract：RATIONALE:Although frequent, little is known about early-onset pneumonia that occurs in the postresuscitation period. Although induced hypothermia is recommended as a method of improving neurological outcome, its influence on the occurrence of early-onset pneumonia is not well defined. OBJECTIVES:To describe the incid...

journal_title：American journal of respiratory and critical care medicine

authors： Perbet S,Mongardon N,Dumas F,Bruel C,Lemiale V,Mourvillier B,Carli P,Varenne O,Mira JP,Wolff M,Cariou A

更新日期：2011-11-01 00:00:00

abstract：:It has been nearly a century since the first suggestion that a soluble factor in plasma or serum might be responsible for the symptoms of allergic disease and asthma, and more than 30 yr since immunoglobulin E (IgE) was identified as the key molecule in mediating what are now described as type 1 hypersensitivity react...

journal_title：American journal of respiratory and critical care medicine

authors： Platts-Mills TA

更新日期：2001-10-15 00:00:00