Clinical advances in the diagnosis and therapy of the interstitial lung diseases.

abstract：:In mechanically ventilated patients, pressure and flow tracings can be used to assess respiratory pump muscle activity or rest. When the ventilation is delivered through an endotracheal tube, the respiratory system can be considered a one-compartment model, and activation of the respiratory muscles results in deformat...

journal_title：American journal of respiratory and critical care medicine

authors： Jounieaux V,Parreira VF,Delguste P,Aubert G,Rodenstein DO

更新日期：1997-06-01 00:00:00

abstract：:Many persons say that they "don't know" whether they snore. The purpose of this study was to investigate the prevalence and correlates of such responses in an elderly population. Subjects were 1715 members (1,155 men, 560 women) of a previously defined cohort (Western Group Collaborative Study) followed prospectively ...

journal_title：American journal of respiratory and critical care medicine

authors： Bliwise DL,Swan GE,Carmelli D,La Rue A

更新日期：1999-12-01 00:00:00

abstract：RATIONALE:The incidence of influenza-associated acute respiratory failure is unknown. OBJECTIVES:To estimate the population-based incidence of influenza-associated acute respiratory failure hospitalizations. METHODS:This is a cohort study from January 2003 through March 2009 using hospitalization databases for Arizon...

journal_title：American journal of respiratory and critical care medicine

authors： Ortiz JR,Neuzil KM,Rue TC,Zhou H,Shay DK,Cheng PY,Cooke CR,Goss CH

更新日期：2013-09-15 00:00:00

abstract：RATIONALE:Corticosteroids are the antiinflammatory treatment of choice in asthma. Treatment guidelines are mainly symptom-driven but symptoms are not closely related to airway inflammation. The fraction of nitric oxide in exhaled air (FENO) is a marker of airway inflammation in asthma. OBJECTIVE:We evaluated whether t...

journal_title：American journal of respiratory and critical care medicine

authors： Pijnenburg MW,Bakker EM,Hop WC,De Jongste JC

更新日期：2005-10-01 00:00:00

abstract：:Knowledge of the local and regional doses of inhaled particulates is crucial for inhalation therapy and for understanding the progression of pulmonary disease. We studied the deposition pattern of radioactively tagged particles in rats with chronic bronchitis. Rats were exposed to sulfur dioxide (SO2; 236 +/- 14 ppm) ...

journal_title：American journal of respiratory and critical care medicine

authors： Sweeney TD,Skornik WA,Brain JD,Hatch V,Godleski JJ

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:HIV-1-induced interstitial pneumonitis (IP) is a serious complication of HIV-1 infection, characterized by inflammation and cellular infiltration in lungs, often leading to respiratory failure and death. The barrier function of the pulmonary endothelium is caused in part by tight junction (TJ) proteins, such ...

journal_title：American journal of respiratory and critical care medicine

authors： Li H,Singh S,Potula R,Persidsky Y,Kanmogne GD

更新日期：2014-07-01 00:00:00

abstract：:Cilomilast (Ariflo), a new oral phosphodiesterase-4 selective inhibitor, improves lung function in chronic obstructive pulmonary disease (COPD). We have evaluated its antiinflammatory effects in 59 patients with COPD randomized to receive cilomilast, 15 mg two times a day, or placebo for 12 weeks. Induced sputum diffe...

journal_title：American journal of respiratory and critical care medicine

authors： Gamble E,Grootendorst DC,Brightling CE,Troy S,Qiu Y,Zhu J,Parker D,Matin D,Majumdar S,Vignola AM,Kroegel C,Morell F,Hansel TT,Rennard SI,Compton C,Amit O,Tat T,Edelson J,Pavord ID,Rabe KF,Barnes NC,Jeffery PK

更新日期：2003-10-15 00:00:00

abstract：:In patients with chronic obstructive pulmonary disease (COPD) the intensity of aerobic training is limited by dyspnea. Improving strength of the inspiratory muscles could enhance aerobic exercise training by reducing exercise-related dyspnea. We examined effects of home-based inspiratory muscle training (IMT) and cycl...

journal_title：American journal of respiratory and critical care medicine

authors： Larson JL,Covey MK,Wirtz SE,Berry JK,Alex CG,Langbein WE,Edwards L

更新日期：1999-08-01 00:00:00

abstract：:Viral respiratory tract infections are associated with an acute increase in airway responsiveness in normal subjects and patients with asthma. Airway responsiveness is also increased at least transiently in animals during acute viral infections. In this article, we discuss possible mechanisms whereby viral infections ...

journal_title：American journal of respiratory and critical care medicine

authors： Hegele RG,Hayashi S,Hogg JC,Paré PD

更新日期：1995-05-01 00:00:00

abstract：:Sepsis is the most common cause of death in patients in the intensive care unit. Genome-wide gene expression analysis can provide insights into the molecular alterations of sepsis. Total mRNA was extracted from the livers of 6 uninfected control mice and 60 septic mice after infusion of either live Escherichia coli or...

journal_title：American journal of respiratory and critical care medicine

authors： Yu SL,Chen HW,Yang PC,Peck K,Tsai MH,Chen JJ,Lin FY

更新日期：2004-05-15 00:00:00

abstract：:Respiratory system compliance (Crs) in infants with cystic fibrosis (CF) has been reported as decreased or not different compared with healthy control subjects; however, the reported measurements of Crs were "quasi-static" or by the single-breath occlusion technique, with all measurements limited to tidal lung volume,...

journal_title：American journal of respiratory and critical care medicine

authors： Tepper RS,Weist A,Williams-Nkomo T,Kisling J

更新日期：2004-09-01 00:00:00

abstract：:Previous work from our laboratory has indicated that mechanoreceptor feedback from the respiratory muscles may play an important role in arousal and apnea termination in obstructive sleep apnea (OSA). Other studies have pointed to a prominent role for chemoreceptor stimuli. We postulated that mechanoreceptor stimuli f...

journal_title：American journal of respiratory and critical care medicine

authors： Kimoff RJ,Cheong TH,Olha AE,Charbonneau M,Levy RD,Cosio MG,Gottfried SB

更新日期：1994-03-01 00:00:00

abstract：:Recent studies suggest that a nitric oxide (NO) deficiency and elevated arginase activity may play a role in the pathogenesis of asthma. Although much attention has been directed toward measurements of exhaled NO in asthma, no studies to date have evaluated levels of plasma arginase or arginine, the substrate for NO p...

journal_title：American journal of respiratory and critical care medicine

authors： Morris CR,Poljakovic M,Lavrisha L,Machado L,Kuypers FA,Morris SM Jr

更新日期：2004-07-15 00:00:00

abstract：:Short-term increases in particulate air pollution are associated with increased incidence of cardiovascular events. Previously, we showed that intratracheally instilled diesel exhaust particles (DEPs) are prothrombotic. Here, we investigated the time course and the mechanisms. At 1, 6, and 24 hours after instillation ...

journal_title：American journal of respiratory and critical care medicine

authors： Nemmar A,Nemery B,Hoet PH,Vermylen J,Hoylaerts MF

更新日期：2003-12-01 00:00:00

abstract：:We measured in rats the effects of 48 h of mechanical ventilation on the weight, contractile properties, and enzymatic profile of the diaphragm, the soleus and the extensor digitorium longus (EDL) muscles. Eighteen animals were randomly divided into a mechanically ventilated (MV, n = 9) group or a control (C, n = 9) g...

journal_title：American journal of respiratory and critical care medicine

authors： Le Bourdelles G,Viires N,Boczkowski J,Seta N,Pavlovic D,Aubier M

更新日期：1994-06-01 00:00:00

abstract：:In a prospective, controlled, and randomized clinical trial, we examined the effects of treatment with vitamin D (1,000 IU/d), calcium (1 g/d), and ethane-1-hydroxy-1,1-diphosphonate (EHDP; 7.5 mg/kg body weight) on vertebral bone mass in fourteen asthmatics undergoing long-term treatment with systemically applied cor...

journal_title：American journal of respiratory and critical care medicine

authors： Worth H,Stammen D,Keck E

更新日期：1994-08-01 00:00:00

abstract：:We have undertaken this retrospective study to determine factors associated with in-hospital mortality and morbidity in 80 adult patients with severe Streptococcus pneumoniae meningitis. Clinical characteristics at admission of patients infected with susceptible (n = 54) and nonsusceptible (n = 17) strains to penicill...

journal_title：American journal of respiratory and critical care medicine

authors： Auburtin M,Porcher R,Bruneel F,Scanvic A,Trouillet JL,Bédos JP,Régnier B,Wolff M

更新日期：2002-03-01 00:00:00

abstract：RATIONALE:Lack of health insurance maybe an independent risk factor for mortality and differential treatment in critical illness. OBJECTIVES:To determine whether uninsured critically ill patients had differences in 30-day mortality and critical care service use compared with those with private insurance and to determi...

journal_title：American journal of respiratory and critical care medicine

authors： Lyon SM,Benson NM,Cooke CR,Iwashyna TJ,Ratcliffe SJ,Kahn JM

更新日期：2011-10-01 00:00:00

abstract：:Lung transplantation with its attendant life-long immunosuppression contributes to bone loss and its sequelae, fractures and kyphosis, in patients with lung disease, many of whom already suffer from severe osteoporosis. Patients with cystic fibrosis (CF) are one of the most severely affected groups. We conducted a con...

journal_title：American journal of respiratory and critical care medicine

authors： Aris RM,Lester GE,Renner JB,Winders A,Denene Blackwood A,Lark RK,Ontjes DA

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Cystic fibrosis (CF) lung disease is caused by the loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) combined with hyperactivation of the epithelial sodium channel (ENaC). In the lung, ENaC is responsible for movement of sodium. Hyperactivation of ENaC, which creates an osmoti...

journal_title：American journal of respiratory and critical care medicine

authors： Scott DW,Walker MP,Sesma J,Wu B,Stuhlmiller TJ,Sabater JR,Abraham WM,Crowder TM,Christensen DJ,Tarran R

更新日期：2017-09-15 00:00:00

abstract：RATIONALE:Dysregulation of cellular metabolism has been shown to participate in several pathologic processes. However, the role of metabolic reprogramming is not well appreciated in the pathogenesis of organ fibrosis. OBJECTIVES:To determine if glycolytic reprogramming participates in the pathogenesis of lung fibrosis...

journal_title：American journal of respiratory and critical care medicine

authors： Xie N,Tan Z,Banerjee S,Cui H,Ge J,Liu RM,Bernard K,Thannickal VJ,Liu G

更新日期：2015-12-15 00:00:00

abstract：RATIONALE:Platelets are essential for pulmonary leukocyte recruitment, airway hyperresponsiveness, and bronchial remodeling in animals with allergic inflammation and can be found in bronchoalveolar lavage of sensitized animals. No studies, however, have explored the direct migration of platelets to lungs. OBJECTIVES:T...

journal_title：American journal of respiratory and critical care medicine

authors： Pitchford SC,Momi S,Baglioni S,Casali L,Giannini S,Rossi R,Page CP,Gresele P

更新日期：2008-03-15 00:00:00

abstract：:Rationale: Sleep-disordered breathing (SDB) is associated with increased vascular resistance in children and adults. Persistent increased vascular resistance damages vascular endothelial cells-a marker of which is increased platelet activation.Objectives: This study compared whole-blood impedance platelet aggregation ...

journal_title：American journal of respiratory and critical care medicine

authors： Kontos A,Willoughby S,Lushington K,Martin J,Wabnitz D,Dorrian J,Kennedy D

更新日期：2020-12-01 00:00:00

abstract：RATIONALE:The inadequacy of effector T-cell response in containment of tubercle bacilli is believed to result in the development of disseminated forms of tuberculosis (TB), such as miliary tuberculosis (MTB). Regulatory T cells (Treg) plausibly play a critical role in the immunopathogenesis of disseminated TB by suppre...

journal_title：American journal of respiratory and critical care medicine

authors： Sharma PK,Saha PK,Singh A,Sharma SK,Ghosh B,Mitra DK

更新日期：2009-06-01 00:00:00

abstract：:The effects of glutathione-S-transferase (GST) M1, GSTT1, and GSTP1 genotypes on lung function growth were investigated in 1,940 children enrolled in the Children's Health Study as fourth graders (aged 8-11 years) in two cohorts during 1993 and 1996 and were followed annually over a 4-year period. Genotypes for GSTM1 ...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Gauderman WJ,Vora H,Rappaport E,Dubeau L

更新日期：2002-09-01 00:00:00

abstract：:Exposure to fine airborne particulate matter (PM(2.5)) is associated with cardiovascular events and mortality in older and cardiac patients. Potential physiologic effects of in-vehicle, roadside, and ambient PM(2.5) were investigated in young, healthy, nonsmoking, male North Carolina Highway Patrol troopers. Nine troo...

journal_title：American journal of respiratory and critical care medicine

authors： Riediker M,Cascio WE,Griggs TR,Herbst MC,Bromberg PA,Neas L,Williams RW,Devlin RB

更新日期：2004-04-15 00:00:00

abstract：:Pleural disease both before and after organ transplantation has important implications. Pleural effusions are common in candidates for heart, liver, and kidney transplantation. A thoracentesis is not mandatory in these patients, but it should be performed if clinical or radiologic features suggest that the effusion is...

journal_title：American journal of respiratory and critical care medicine

authors： Judson MA,Sahn SA

更新日期：1996-03-01 00:00:00

abstract：RATIONALE:Previous investigations have identified several potential predictors of outcomes from lung volume reduction surgery (LVRS). A concern regarding these studies has been their small sample size, which may limit generalizability. We therefore sought to examine radiographic and physiologic predictors of surgical o...

journal_title：American journal of respiratory and critical care medicine

authors： Washko GR,Martinez FJ,Hoffman EA,Loring SH,Estépar RS,Diaz AA,Sciurba FC,Silverman EK,Han MK,Decamp M,Reilly JJ,National Emphysema Treatment Trial Research Group.

更新日期：2010-03-01 00:00:00

abstract：:Reexpansion of collapsed lung creates intrapulmonary shear forces. In an earlier study we showed that application of a negative end-expiratory airway pressure (NEEP) to normal rabbit lungs in vivo produced tidal collapse and reexpansion with transient changes in compliance and gas exchange but no histologic damage. In...

journal_title：American journal of respiratory and critical care medicine

authors： Taskar V,John J,Evander E,Robertson B,Jonson B

更新日期：1997-01-01 00:00:00

abstract：:The Pulmonary Complications of HIV Infection Study is a prospective, multicenter, observational study evaluating pulmonary disease among HIV-infected persons. For approximately 52 mo, 1,182 HIV-infected subjects were followed. All participants were evaluated for pulmonary disease on a predetermined schedule. There wer...

journal_title：American journal of respiratory and critical care medicine

authors： Stansell JD,Osmond DH,Charlebois E,LaVange L,Wallace JM,Alexander BV,Glassroth J,Kvale PA,Rosen MJ,Reichman LB,Turner JR,Hopewell PC

更新日期：1997-01-01 00:00:00