Fibrosing alveolitis in systemic sclerosis. Bronchoalveolar lavage findings in relation to computed tomographic appearance.

abstract：RATIONALE:The rapid diagnosis of pulmonary tuberculosis (TB) is difficult when acid fast bacilli (AFB) cannot be detected in sputum smears. OBJECTIVES:Following a proof of principle study, we examined in routine clinical practice whether individuals with sputum AFB smear-negative TB can be discriminated from those wit...

journal_title：American journal of respiratory and critical care medicine

authors： Jafari C,Thijsen S,Sotgiu G,Goletti D,Domínguez Benítez JA,Losi M,Eberhardt R,Kirsten D,Kalsdorf B,Bossink A,Latorre I,Migliori GB,Strassburg A,Winteroll S,Greinert U,Richeldi L,Ernst M,Lange C,Tuberculosis Network Eu

更新日期：2009-10-01 00:00:00

abstract：:We review recent advances in the use of corticosteroids (CS) in pediatric lung disease. CS are frequently used, systemically or by inhalation. Their mechanisms of action in pulmonary diseases are ill defined. CS exert direct inhibitory effects on many inflammatory cells through genomic mechanisms. There is a time lag ...

journal_title：American journal of respiratory and critical care medicine

authors： de Benedictis FM,Bush A

更新日期：2012-01-01 00:00:00

abstract：:The present study was undertaken to assess the relationship between health-related quality of life (HRQOL) and bronchiolitis obliterans syndrome (BOS), as both represent important parameters of outcome after lung transplantation. HRQOL was measured both cross-sectionally and longitudinally by standardized patient self...

journal_title：American journal of respiratory and critical care medicine

authors： van Den BERG JW,Geertsma A,van Der BIJ W,Koëter GH,de BOER WJ,Postma DS,ten VERGERT EM

更新日期：2000-06-01 00:00:00

abstract：RATIONALE:Ipsilateral recurrence rates of spontaneous pneumothorax after video-assisted thoracoscopic surgery are higher than rates after open thoracotomy. OBJECTIVES:This study was conducted to determine whether additional minocycline pleurodesis would be effective in diminishing recurrence after video-assisted thora...

journal_title：American journal of respiratory and critical care medicine

authors： Chen JS,Hsu HH,Chen RJ,Kuo SW,Huang PM,Tsai PR,Lee JM,Lee YC

更新日期：2006-03-01 00:00:00

abstract：:The intestinal immune system discriminates between potentially harmful and harmless foreign proteins. The basis for this differential response may be related to the conditions of antigen presentation by antigen-presenting cells, as determined by their phenotype or activation state. How these conditions affect specific...

journal_title：American journal of respiratory and critical care medicine

authors： Smith KM,Eaton AD,Finlayson LM,Garside P

更新日期：2000-10-01 00:00:00

abstract：:Lung transplantation with its attendant life-long immunosuppression contributes to bone loss and its sequelae, fractures and kyphosis, in patients with lung disease, many of whom already suffer from severe osteoporosis. Patients with cystic fibrosis (CF) are one of the most severely affected groups. We conducted a con...

journal_title：American journal of respiratory and critical care medicine

authors： Aris RM,Lester GE,Renner JB,Winders A,Denene Blackwood A,Lark RK,Ontjes DA

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Because of high mortality, end-of-life care is an important component of intensive care. OBJECTIVES:We evaluated the effectiveness of a quality-improvement intervention to improve intensive care unit (ICU) end-of-life care. METHODS:We conducted a cluster-randomized trial randomizing 12 hospitals. The interv...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis JR,Nielsen EL,Treece PD,Downey L,Dotolo D,Shannon SE,Back AL,Rubenfeld GD,Engelberg RA

更新日期：2011-02-01 00:00:00

abstract：RATIONALE:In clinical trials, patients with cystic fibrosis and a G551D mutation who received ivacaftor experienced improvements in pulmonary and nutritional outcomes. However, whether these improvements reflect a change in disease trajectory cannot be determined without longer-term analyses with an appropriate compara...

journal_title：American journal of respiratory and critical care medicine

authors： Sawicki GS,McKone EF,Pasta DJ,Millar SJ,Wagener JS,Johnson CA,Konstan MW

更新日期：2015-10-01 00:00:00

abstract：:Critical illness is not a discrete disease state or syndrome. It is the culmination of a multiplicity of heterogeneous disease states and their varied health trajectories leading to extreme illness that requires advanced life support in a distinct geographic location in the hospital. It is a marker of newly acquired o...

journal_title：American journal of respiratory and critical care medicine

authors： Herridge MS

更新日期：2017-12-01 00:00:00

abstract：:To investigate whether the magnitude of blood flow contributes to ventilator-induced lung injury, 14 sets of isolated rabbit lungs were randomized for perfusion at either 300 (Group A: n = 7) or 900 ml/ min (Group B: n = 7) while ventilated with 30 cm H2O peak static pressure. Control lungs (Group C: n = 7) were venti...

journal_title：American journal of respiratory and critical care medicine

authors： Broccard AF,Hotchkiss JR,Kuwayama N,Olson DA,Jamal S,Wangensteen DO,Marini JJ

更新日期：1998-06-01 00:00:00

abstract：RATIONALE:Biomass exposure is an important risk factor for chronic obstructive pulmonary disease (COPD). However, the time-course behavior of FEV1 in subjects exposed to biomass is unknown. OBJECTIVES:We undertook this study to determine the FEV1 rate decline in subjects exposed to biomass. METHODS:Pulmonary function...

journal_title：American journal of respiratory and critical care medicine

authors： Ramírez-Venegas A,Sansores RH,Quintana-Carrillo RH,Velázquez-Uncal M,Hernandez-Zenteno RJ,Sánchez-Romero C,Velazquez-Montero A,Flores-Trujillo F

更新日期：2014-11-01 00:00:00

abstract：RATIONALE:Long-term intermittent hypoxia (LTIH) exposure in adult mice, modeling oxygenation patterns of moderate-severe obstructive sleep apnea, results in lasting hypersomnolence and is associated with nitration and oxidation injuries in many brain regions, including wake-active regions. OBJECTIVES:We sought to dete...

journal_title：American journal of respiratory and critical care medicine

authors： Zhan G,Fenik P,Pratico D,Veasey SC

更新日期：2005-06-15 00:00:00

abstract：:Lung transplant (LTx) recipients have a low peak work rate, peak oxygen consumption (V O2peak), and early lactate threshold on incremental exercise. We hypothesized that LTx recipients have reduced oxidative function and altered fiber type proportion in peripheral skeletal muscle. Seven stable LTx recipients and seven...

journal_title：American journal of respiratory and critical care medicine

authors： Wang XN,Williams TJ,McKenna MJ,Li JL,Fraser SF,Side EA,Snell GI,Walters EH,Carey MF

更新日期：1999-07-01 00:00:00

abstract：:Rationale: Mathematical modeling is used to understand disease dynamics, forecast trends, and inform public health prioritization. We conducted a comparative analysis of tuberculosis (TB) epidemiology and potential intervention effects in California, using three previously developed epidemiologic models of TB.Objectiv...

journal_title：American journal of respiratory and critical care medicine

authors： Menzies NA,Parriott A,Shrestha S,Dowdy DW,Cohen T,Salomon JA,Marks SM,Hill AN,Winston CA,Asay GR,Barry P,Readhead A,Flood J,Kahn JG,Shete PB

更新日期：2020-02-01 00:00:00

abstract：RATIONALE:Previous studies have demonstrated a high prevalence of sleep apnea (SA) in patients with chronic heart failure (HF), which is associated with higher rates of morbidity, mortality, and health care use. OBJECTIVES:To investigate the reported incidence, treatment, outcomes, and economic cost of SA in new-onset...

journal_title：American journal of respiratory and critical care medicine

authors： Javaheri S,Caref EB,Chen E,Tong KB,Abraham WT

更新日期：2011-02-15 00:00:00

abstract：:Because interleukin 8 (IL-8) is a potent neutrophil chemotactic and activating cytokine, we investigated IL-8 production in relation to neutrophil migration and elastase release in the human lung during unilateral community-acquired pneumonia (CAP). In 17 patients, the local response in the involved lung was compared ...

journal_title：American journal of respiratory and critical care medicine

authors： Boutten A,Dehoux MS,Seta N,Ostinelli J,Venembre P,Crestani B,Dombret MC,Durand G,Aubier M

更新日期：1996-01-01 00:00:00

abstract：:In many countries the majority of patients with asthma are now treated with inhaled beta 2-agonists as required and regular inhaled steroids. Compliance with asthma medication is poor, particularly for inhaled steroids, which do not give immediate relief of symptoms. An inhaler combining a beta 2-agonist and a steroid...

journal_title：American journal of respiratory and critical care medicine

authors： Barnes PJ,O'Connor BJ

更新日期：1995-04-01 00:00:00

abstract：:In 1976-1992 245 new cases of asthma induced by diisocyanates were diagnosed, caused by hexamethylene diisocyanate (HDI) in 39%, diphenylmethane diisocyanate (MDI) in 39%, and toluene diisocyanate (TDI) in 17% of the cases. Our aim was to study the clinical outcome of diisocyanate-induced asthma. A questionnaire was s...

journal_title：American journal of respiratory and critical care medicine

authors： Piirilä PL,Nordman H,Keskinen HM,Luukkonen R,Salo SP,Tuomi TO,Tuppurainen M

更新日期：2000-08-01 00:00:00

abstract：:The effects of conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFO) on intraalveolar expression of the tumor necrosis factor-alpha (TNF-alpha) gene were studied in surfactant-depleted rabbits. After lung lavage with saline, 13 rabbits were administered either CMV (n = 6) or HFO (n...

journal_title：American journal of respiratory and critical care medicine

authors： Takata M,Abe J,Tanaka H,Kitano Y,Doi S,Kohsaka T,Miyasaka K

更新日期：1997-07-01 00:00:00

abstract：RATIONALE:Very little is known about airways that are too small to be visible on thoracic multidetector computed tomography but larger than the terminal bronchioles. OBJECTIVES:To examine the structure of preterminal bronchioles located one generation proximal to terminal bronchioles in centrilobular and panlobular em...

journal_title：American journal of respiratory and critical care medicine

authors： Tanabe N,Vasilescu DM,McDonough JE,Kinose D,Suzuki M,Cooper JD,Paré PD,Hogg JC

更新日期：2017-03-01 00:00:00

abstract：:The factors that lead to increased production of specific IgG subclasses are still largely unknown. Recent studies suggest that increased IgG4 responses may be related to prolonged antigen exposure. We present data showing that increased IgG4 responses are found under conditions of chronic exposure to Aspergillus fumi...

journal_title：American journal of respiratory and critical care medicine

authors： Tomee JF,Dubois AE,Koëter GH,Beaumont F,van der Werf TS,Kauffman HF

更新日期：1996-06-01 00:00:00

abstract：:Rationale: To detect pulmonary arterial hypertension (PAH) at any early stage is a promising approach to optimize the outcome. Objectives: To investigate the impact of school ECG-based screening on detecting idiopathic or heritable (I/H)-PAH in the general pediatric population. Methods: This was a nationwide survey of...

journal_title：American journal of respiratory and critical care medicine

authors： Sawada H,Mitani Y,Nakayama T,Fukushima H,Kogaki S,Igarashi T,Ichida F,Ono Y,Nakanishi T,Doi S,Ishikawa S,Matsushima M,Yamada O,Saji T

更新日期：2019-06-01 00:00:00

abstract：:Most randomized trials in critical care report no mortality benefit; this may reflect competing pathogenic mechanisms, patient heterogeneity, or true ineffectiveness of interventions. We hypothesize that in acute respiratory distress syndrome (ARDS), randomizing only those patients who show a favorable physiological r...

journal_title：American journal of respiratory and critical care medicine

authors： Goligher EC,Kavanagh BP,Rubenfeld GD,Ferguson ND

更新日期：2015-12-15 00:00:00

abstract：:In patients with chronic obstructive pulmonary disease (COPD) the intensity of aerobic training is limited by dyspnea. Improving strength of the inspiratory muscles could enhance aerobic exercise training by reducing exercise-related dyspnea. We examined effects of home-based inspiratory muscle training (IMT) and cycl...

journal_title：American journal of respiratory and critical care medicine

authors： Larson JL,Covey MK,Wirtz SE,Berry JK,Alex CG,Langbein WE,Edwards L

更新日期：1999-08-01 00:00:00

abstract：:Smoking is the major risk factor for chronic respiratory symptoms, but dietary factors may also play a role. Most studies of diet and lung disease have been cross-sectional and conducted in populations with a Western-style diet. We analyzed the relation between dietary intake at baseline and new onset of cough with ph...

journal_title：American journal of respiratory and critical care medicine

authors： Butler LM,Koh WP,Lee HP,Yu MC,London SJ

更新日期：2004-08-01 00:00:00

abstract：:This study aimed to estimate exposure-response relationships for mesothelioma and environmental exposure to crocidolite. All 4,659 former residents of Wittenoom, Western Australia (WA) who lived there between 1943 and 1993 for at least 1 mo and were not directly employed in the crocidolite industry, were followed-up t...

journal_title：American journal of respiratory and critical care medicine

authors： Hansen J,de Klerk NH,Musk AW,Hobbs MS

更新日期：1998-01-01 00:00:00

abstract：:Comparison of the risk-benefit profiles of different inhaled glucocorticoids has been limited by inadequate information about the dose-response relationships for efficacy relative to side effects. Fluticasone propionate (FP) is twice as effective as budesonide (BUD), but the potency ratio of FP:BUD with respect to sup...

journal_title：American journal of respiratory and critical care medicine

authors： Donnelly R,Williams KM,Baker AB,Badcock CA,Day RO,Seale JP

更新日期：1997-12-01 00:00:00

abstract：RATIONALE:The inadequacy of effector T-cell response in containment of tubercle bacilli is believed to result in the development of disseminated forms of tuberculosis (TB), such as miliary tuberculosis (MTB). Regulatory T cells (Treg) plausibly play a critical role in the immunopathogenesis of disseminated TB by suppre...

journal_title：American journal of respiratory and critical care medicine

authors： Sharma PK,Saha PK,Singh A,Sharma SK,Ghosh B,Mitra DK

更新日期：2009-06-01 00:00:00

abstract：:Burkholderia gladioli has been reported as colonizing the airways of patients with cystic fibrosis (CF) but has not previously been associated with adverse outcome. We describe six patients with CF in whom the same strain of B. gladioli, on the basis of ribotyping and biochemical characteristics, was grown in their sp...

journal_title：American journal of respiratory and critical care medicine

authors： Wilsher ML,Kolbe J,Morris AJ,Welch DF

更新日期：1997-04-01 00:00:00

abstract：RATIONALE:No methodical assessment of the lung, cardiac, and sleep function of patients surviving an acute hypercapnic respiratory failure episode requiring admission to the intensive care unit (ICU) has been reported in the literature. OBJECTIVES:To prospectively investigate the prevalence and impact of comorbidities...

journal_title：American journal of respiratory and critical care medicine

authors： Adler D,Pépin JL,Dupuis-Lozeron E,Espa-Cervena K,Merlet-Violet R,Muller H,Janssens JP,Brochard L

更新日期：2017-07-15 00:00:00