Micro-Computed Tomography Comparison of Preterminal Bronchioles in Centrilobular and Panlobular Emphysema.

abstract：:We investigated whether exposure to ozone (O(3)) 24 hours after an allergen challenge test would increase airway eosinophilia induced by allergen in subjects with mild asthma with late airway response. Twelve subjects with mild atopic asthma participated in a randomized, single-blind study. Subjects underwent allergen...

journal_title：American journal of respiratory and critical care medicine

authors： Vagaggini B,Taccola M,Cianchetti S,Carnevali S,Bartoli ML,Bacci E,Dente FL,Di Franco A,Giannini D,Paggiaro PL

更新日期：2002-10-15 00:00:00

abstract：RATIONALE:Bronchiolitis is the most common lower respiratory infection in infants; however, it remains unclear which infants with bronchiolitis will develop severe illness. In addition, although emerging evidence indicates associations of the upper-airway microbiome with bronchiolitis severity, little is known about th...

journal_title：American journal of respiratory and critical care medicine

authors： Stewart CJ,Mansbach JM,Wong MC,Ajami NJ,Petrosino JF,Camargo CA Jr,Hasegawa K

更新日期：2017-10-01 00:00:00

abstract：RATIONALE:Lack of health insurance maybe an independent risk factor for mortality and differential treatment in critical illness. OBJECTIVES:To determine whether uninsured critically ill patients had differences in 30-day mortality and critical care service use compared with those with private insurance and to determi...

journal_title：American journal of respiratory and critical care medicine

authors： Lyon SM,Benson NM,Cooke CR,Iwashyna TJ,Ratcliffe SJ,Kahn JM

更新日期：2011-10-01 00:00:00

abstract：:Controversy exists regarding the clinical utility of pleural fluid pH, lactate dehydrogenase (LDH), and glucose for identifying complicated parapneumonic effusions that require drainage. In this report, we performed a meta-analysis of pertinent studies, using receiver operating characteristic (ROC) techniques, to asse...

journal_title：American journal of respiratory and critical care medicine

authors： Heffner JE,Brown LK,Barbieri C,DeLeo JM

更新日期：1995-06-01 00:00:00

abstract：:Despite extensive research into the etiology and treatment of severe sepsis, little is known about its epidemiology in children. We sought to determine the age- and sex-adjusted incidence, outcome, and associated hospital costs of severe sepsis in United States children using 1995 hospital discharge and population dat...

journal_title：American journal of respiratory and critical care medicine

authors： Watson RS,Carcillo JA,Linde-Zwirble WT,Clermont G,Lidicker J,Angus DC

更新日期：2003-03-01 00:00:00

abstract：RATIONALE:Epidemiological studies in older individuals have found an association between the use of angiotensin-converting enzyme (ACE) inhibition (ACE-I) therapy and preserved locomotor muscle mass, strength, and walking speed. ACE-I therapy might therefore have a role in the context of pulmonary rehabilitation (PR). ...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis KJ,Meyrick VM,Mehta B,Haji GS,Li K,Montgomery H,Man WD,Polkey MI,Hopkinson NS

更新日期：2016-12-01 00:00:00

abstract：:Tracheal and lung parenchymal SP-LI (substance P-like immunoreactivity) and VIP-LI (vasoactive intestinal peptide-like immunoreactivity) content was measured in HPLC-purified tissue extracts from patients with and without asthma. We detected significantly less SP-LI in tracheal tissue from asthmatic than from nonasthm...

journal_title：American journal of respiratory and critical care medicine

authors： Lilly CM,Bai TR,Shore SA,Hall AE,Drazen JM

更新日期：1995-02-01 00:00:00

abstract：:Fibrosing alveolitis in systemic sclerosis is histologically identical to lone cryptogenic fibrosing alveolitis (CFA) (idiopathic pulmonary fibrosis). The inflammatory cell content of bronchoalveolar lavage (BAL) samples has been used as a guide to prognosis and treatment in CFA. In this study, the relationship was ex...

journal_title：American journal of respiratory and critical care medicine

authors： Wells AU,Hansell DM,Rubens MB,Cullinan P,Haslam PL,Black CM,Du Bois RM

更新日期：1994-08-01 00:00:00

abstract：:Pulmonary emphysema and periodontal disease are each characterized by the uncontrolled proteolysis of connective tissue proteins by proteinases derived from human neutrophils. Although these diseases would not appear to be related in terms of the initial insult to individual tissues, the ultimate result in each diseas...

journal_title：American journal of respiratory and critical care medicine

authors： Travis J,Pike R,Imamura T,Potempa J

更新日期：1994-12-01 00:00:00

abstract：:Two distinct types of tumor necrosis factor receptors (TNF-R) have been identified (TNF-R55 and TNF-R75). Both TNF-R also exist in soluble forms (TNF-sR), resulting from the release of the extracellular domains (TNF-sR55 and TNF-sR75). TNF-sR may play an important role in vivo as they can bind to TNF alpha and prevent...

journal_title：American journal of respiratory and critical care medicine

authors： Humbert M,Roux-Lombard P,Cerrina J,Magnan A,Simonneau G,Dartevelle P,Galanaud P,Dayer JM,Emilie D

更新日期：1994-06-01 00:00:00

abstract：:The predisposing factors and complications of unplanned extubation (UEX) in mechanically ventilated adult patients are not well recognized. We designed a prospective multicenter observational study to identify risk factors and describe the complications of UEX. We followed 426 ventilated patients over a 2-mo period. C...

journal_title：American journal of respiratory and critical care medicine

authors： Boulain T

更新日期：1998-04-01 00:00:00

abstract：:The aim of this study was to clarify the influence of gastroesophageal reflux (GER) on cough threshold in patients with digestive symptoms but free from respiratory involvement. Of 57 consecutive subjects referred for 24-h esophageal pH monitoring because of digestive reflux symptoms, 29 patients free from respiratory...

journal_title：American journal of respiratory and critical care medicine

authors： Ferrari M,Olivieri M,Sembenini C,Benini L,Zuccali V,Bardelli E,Bovo P,Cavallini G,Vantini I,Lo Cascio V

更新日期：1995-02-01 00:00:00

abstract：:Asthma in adults may be associated with chronic airflow obstruction, possibly resulting from airway disease in early life and/or a greater rate of decline in lung function in adult life compared with those with asthma. Treatment and cigarette smoking may also influence the rate of decline of lung function. The aim of ...

journal_title：American journal of respiratory and critical care medicine

authors： James AL,Palmer LJ,Kicic E,Maxwell PS,Lagan SE,Ryan GF,Musk AW

更新日期：2005-01-15 00:00:00

abstract：:The lobar and cephalocaudal distribution of aerated and nonaerated lung and of PEEP-induced alveolar recruitment is unknown in acute lung injury (ALI). Dimensions of the lungs and volumes of aerated and nonaerated parts of each pulmonary lobe were measured using a computerized tomographic quantitative analysis and com...

journal_title：American journal of respiratory and critical care medicine

authors： Puybasset L,Cluzel P,Chao N,Slutsky AS,Coriat P,Rouby JJ

更新日期：1998-11-01 00:00:00

abstract：:We reported that systemic keratinocyte growth factor (KGF) given before bone marrow transplantation (BMT) prevents allogeneic T cell-dependent lung inflammation assessed on Day 7 post-BMT, but the antiinflammatory effects of KGF were impaired in mice injected with both T cells and conditioning regimen of cyclophospham...

journal_title：American journal of respiratory and critical care medicine

authors： Yang S,Panoskaltsis-Mortari A,Ingbar DH,Matalon S,Zhu S,Resnik ER,Farrell CL,Lacey DL,Blazar BR,Haddad IY

更新日期：2000-11-01 00:00:00

abstract：RATIONALE:Superoxide dismutase (SOD) 3 inhibits oxidative fragmentation of lung matrix components collagen I, hyaluronan, and heparan sulfate. Inherited change in SOD3 expression or function could affect lung matrix homeostasis and influence pulmonary function. OBJECTIVES:To identify novel SOD3 polymorphisms that are ...

journal_title：American journal of respiratory and critical care medicine

authors： Dahl M,Bowler RP,Juul K,Crapo JD,Levy S,Nordestgaard BG

更新日期：2008-11-01 00:00:00

abstract：:The mechanism responsible for diminished exercise performance in cystic fibrosis (CF) is not clear. We hypothesized that reduced muscle size, rather than an intrinsic muscle defect, was the primary factor in such diminished exercise performance. Twenty-two subjects with CF (14 females and eight males, aged 6.5 to 17.7...

journal_title：American journal of respiratory and critical care medicine

authors： Moser C,Tirakitsoontorn P,Nussbaum E,Newcomb R,Cooper DM

更新日期：2000-11-01 00:00:00

abstract：:To determine whether the diagnostic yield of transbronchial needle aspiration (TBNA) improves over time and to obtain insights about factors influencing its performance, we reviewed our experience during a 3-yr period. After serial multifaceted educational interventions directed toward bronchoscopists and their techni...

journal_title：American journal of respiratory and critical care medicine

authors： Haponik EF,Cappellari JO,Chin R,Adair NE,Lykens M,Alford PT,Bowton DL

更新日期：1995-06-01 00:00:00

abstract：RATIONALE:Encephalitis caused by anti-N-methyl-d-aspartate receptor (NMDAR) antibodies is the leading cause of immune-mediated encephalitis. There are limited data on intensive care unit (ICU) management of these patients. OBJECTIVES:To identify prognostic factors of good neurologic outcome in patients admitted to an ...

journal_title：American journal of respiratory and critical care medicine

authors： de Montmollin E,Demeret S,Brulé N,Conrad M,Dailler F,Lerolle N,Navellou JC,Schwebel C,Alves M,Cour M,Engrand N,Tonnelier JM,Maury E,Ruckly S,Picard G,Rogemond V,Magalhaes É,Sharshar T,Timsit JF,Honnorat J,Sonnevil

更新日期：2017-02-15 00:00:00

abstract：:In animal models of endotoxemia, sepsis is associated with the accumulation of leukocytes and altered microvascular perfusion. In order to test the hypothesis that bacterial sepsis upregulates leukocyte-endothelial adhesion, we used intravital microscopy to examine the flow behavior of leukocytes in the postcapillary ...

journal_title：American journal of respiratory and critical care medicine

authors： Piper RD,Pitt-Hyde ML,Anderson LA,Sibbald WJ,Potter RF

更新日期：1998-01-01 00:00:00

abstract：:Although transbronchial lung biopsy (TBBx) is widely acknowledged as the "gold standard" for diagnosis of acute rejection, controversy exists regarding the need to perform follow-up procedures. Over a 5-yr period, we performed 1,142 TBBx of which 173 were follow-up TBBx in 99 patients with pulmonary allograft rejectio...

journal_title：American journal of respiratory and critical care medicine

authors： Aboyoun CL,Tamm M,Chhajed PN,Hopkins P,Malouf MA,Rainer S,Glanville AR

更新日期：2001-08-01 00:00:00

abstract：:The objective of this study was to evaluate the effectiveness of an asthma education program on morbidity, knowledge, and compliance with inhaled corticosteroid treatment using a prospective, randomized, controlled, one-year-before/one-year-after protocol. After rigorous optimization of asthma therapy under the care o...

journal_title：American journal of respiratory and critical care medicine

authors： Coté J,Cartier A,Robichaud P,Boutin H,Malo JL,Rouleau M,Fillion A,Lavallée M,Krusky M,Boulet LP

更新日期：1997-05-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) has recently been noted to function as a pulmotrophic factor for lung regeneration. The present study was conducted to determine if HGF would be induced in a rat model of pulmonary ischemia-reperfusion (IR) injury, which was established by occlusion of the left lung, and to examine the s...

journal_title：American journal of respiratory and critical care medicine

authors： Yamada T,Hisanaga M,Nakajima Y,Mizuno S,Matsumoto K,Nakamura T,Nakano H

更新日期：2000-08-01 00:00:00

abstract：:Infection of the cystic fibrosis (CF) airways elicits an exaggerated, interleukin-8 (IL-8) mediated, neutrophil inflammatory response. Necrosing neutrophils release DNA and actin into the airways, increasing the viscoelasticity of airway secretions. Mucolytics aim to improve airway clearance by reducing this viscoelas...

journal_title：American journal of respiratory and critical care medicine

authors： Perks B,Shute JK

更新日期：2000-11-01 00:00:00

abstract：:REM-related oxygen desaturation occurs in advanced Duchenne muscular dystrophy (DMD) and might be an independent predictor of disease progression. We have followed 18 patients for 10 yr after an initial respiratory sleep study or until death or onset of nasal ventilation. We measured baseline spirometry, blood gas ten...

journal_title：American journal of respiratory and critical care medicine

authors： Phillips MF,Smith PE,Carroll N,Edwards RH,Calverley PM

更新日期：1999-07-01 00:00:00

abstract：:Tumor-associated angiogenesis is important for tumor growth and metastasis. Interleukin (IL)-8 was recently reported to be an important angiogenic factor both in vitro and in vivo. In this study we evaluated, for the first time, IL-8 messenger RNA (mRNA) expression in non-small-cell lung cancer (NSCLC), using real-tim...

journal_title：American journal of respiratory and critical care medicine

authors： Yuan A,Yang PC,Yu CJ,Chen WJ,Lin FY,Kuo SH,Luh KT

更新日期：2000-11-01 00:00:00

abstract：:Acute lung injury was produced in C57BL/6 mice by the intratracheal (i.t.) administration of bleomycin (BLM). Following injection of 0.1 U BLM, CD3+ lymphocytes and the production of the T-helper-1 (Th1) lymphokines interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) were increased in lung and lymph nodes. The produ...

journal_title：American journal of respiratory and critical care medicine

authors： Sharma SK,MacLean JA,Pinto C,Kradin RL

更新日期：1996-07-01 00:00:00

abstract：RATIONALE:Corticosteroids are the antiinflammatory treatment of choice in asthma. Treatment guidelines are mainly symptom-driven but symptoms are not closely related to airway inflammation. The fraction of nitric oxide in exhaled air (FENO) is a marker of airway inflammation in asthma. OBJECTIVE:We evaluated whether t...

journal_title：American journal of respiratory and critical care medicine

authors： Pijnenburg MW,Bakker EM,Hop WC,De Jongste JC

更新日期：2005-10-01 00:00:00

abstract：:This prospective and controlled pilot study evaluates the long-term effects of nocturnal oxygen therapy (NOT) on exercise endurance, hematology variables, quality of life, and survival of 23 adult patients (mean age, 32 +/- 6 yr) with post-tricuspid congenital heart defects (ventricular septal defect = 10; patent duct...

journal_title：American journal of respiratory and critical care medicine

authors： Sandoval J,Aguirre JS,Pulido T,Martinez-Guerra ML,Santos E,Alvarado P,Rosas M,Bautista E

更新日期：2001-11-01 00:00:00

abstract：:Monocyte deactivation has been identified as a major factor of immunosuppression in sepsis and is associated with a loss of surface human leukocyte antigen-DR (HLA-DR) expression on circulating monocytes. Using flow cytometry, quantitative reverse transcription-polymerase chain reaction, we investigated this phenomeno...

journal_title：American journal of respiratory and critical care medicine

authors： Le Tulzo Y,Pangault C,Amiot L,Guilloux V,Tribut O,Arvieux C,Camus C,Fauchet R,Thomas R,Drénou B

更新日期：2004-05-15 00:00:00