Ozone exposure increases eosinophilic airway response induced by previous allergen challenge.

abstract：:Obstructive sleep apnea (OSA) is traditionally diagnosed using overnight polysomnography. Decision rules may provide an alternative to polysomnography. A consecutive series of patients referred to a tertiary sleep center underwent prospective evaluation with the upper airway physical examination protocol, followed by ...

journal_title：American journal of respiratory and critical care medicine

authors： Tsai WH,Remmers JE,Brant R,Flemons WW,Davies J,Macarthur C

更新日期：2003-05-15 00:00:00

abstract：:We described here an original device for laser Doppler (LD) flowmetry measurements of gastric mucosal perfusion, which was used here in healthy volunteers. A modified nasogastric tube containing the LD probe was inserted. Aspiration via a catheter, fixed in parallel to the probe, held the probe against the gastric wal...

journal_title：American journal of respiratory and critical care medicine

authors： Duranteau J,Sitbon P,Vicaut E,Descorps-Declère A,Vigue B,Samii K

更新日期：1996-12-01 00:00:00

abstract：:The aim of this study was to clarify the influence of gastroesophageal reflux (GER) on cough threshold in patients with digestive symptoms but free from respiratory involvement. Of 57 consecutive subjects referred for 24-h esophageal pH monitoring because of digestive reflux symptoms, 29 patients free from respiratory...

journal_title：American journal of respiratory and critical care medicine

authors： Ferrari M,Olivieri M,Sembenini C,Benini L,Zuccali V,Bardelli E,Bovo P,Cavallini G,Vantini I,Lo Cascio V

更新日期：1995-02-01 00:00:00

abstract：:In 35 patients fulfilling the criteria of systemic inflammatory response syndrome (SIRS) of infectious origin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), tumor necrosis factor-soluble receptor (TNF-sR), and interleukin-12 (IL-12), C-reactive protein (CRP) levels and the Acute Physiology, and Chroni...

journal_title：American journal of respiratory and critical care medicine

authors： Presterl E,Staudinger T,Pettermann M,Lassnigg A,Burgmann H,Winkler S,Frass M,Graninger W

更新日期：1997-09-01 00:00:00

abstract：:Pharyngeal dilator muscle activation (GGEMG) during wakefulness is greater in patients with obstructive sleep apnea (OSA) than in healthy control subjects, representing a neuromuscular compensatory mechanism for a more collapsible airway. As previous work from our laboratory has demonstrated a close relationship betwe...

journal_title：American journal of respiratory and critical care medicine

authors： Fogel RB,Malhotra A,Pillar G,Edwards JK,Beauregard J,Shea SA,White DP

更新日期：2001-12-01 00:00:00

abstract：:Several studies have found that sleep deprivation reduces the hypercapnic ventilatory response (HCVR). Such results may have been affected by uncontrolled activities or environmental influences during the sleep deprivation period. The current study determined the "pure" effect of sleep deprivation on respiratory contr...

journal_title：American journal of respiratory and critical care medicine

authors： Spengler CM,Shea SA

更新日期：2000-04-01 00:00:00

abstract：:This study describes the natural history of atopic and wheezy disorders from birth to adult life in a cohort at risk of atopy. One hundred subjects born in Poole, England, were selected at birth in 1976 on the basis that at least one parent was atopic. Subjects were examined annually in the preschool years, and at the...

journal_title：American journal of respiratory and critical care medicine

authors： Rhodes HL,Thomas P,Sporik R,Holgate ST,Cogswell JJ

更新日期：2002-01-15 00:00:00

abstract：:The six-minute walk test is a submaximal exercise test that can be performed even by a patient with heart failure not tolerating maximal exercise testing. To elucidate the clinical significance and prognostic value of the six-minute walk test in patients with primary pulmonary hypertension (PPH), we sought (1) to asse...

journal_title：American journal of respiratory and critical care medicine

authors： Miyamoto S,Nagaya N,Satoh T,Kyotani S,Sakamaki F,Fujita M,Nakanishi N,Miyatake K

更新日期：2000-02-01 00:00:00

abstract：:Current guidelines recommend that the clinician, radiologist, and pathologist work together to establish a diagnosis of idiopathic interstitial pneumonia. Three clinicians, two radiologists, and two pathologists reviewed 58 consecutive cases of suspected idiopathic interstitial pneumonia. Each participant was provided...

journal_title：American journal of respiratory and critical care medicine

authors： Flaherty KR,King TE Jr,Raghu G,Lynch JP 3rd,Colby TV,Travis WD,Gross BH,Kazerooni EA,Toews GB,Long Q,Murray S,Lama VN,Gay SE,Martinez FJ

更新日期：2004-10-15 00:00:00

abstract：:Lung cancer is a significant disease with survival rates remaining poor despite numerous therapeutic advances during the last 30 years. Understanding lung cancer pathogenesis through murine modeling may improve future human therapies, and new data indicate that mutations within different endogenous stem cells situated...

journal_title：American journal of respiratory and critical care medicine

authors： Giangreco A,Groot KR,Janes SM

更新日期：2007-03-15 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is hypothesized to be influenced by genes within pathways involved with obesity, craniofacial development, inflammation, and ventilatory control. OBJECTIVES:We conducted the first candidate gene study of OSA using family data from European Americans and African Americans, select...

journal_title：American journal of respiratory and critical care medicine

authors： Larkin EK,Patel SR,Goodloe RJ,Li Y,Zhu X,Gray-McGuire C,Adams MD,Redline S

更新日期：2010-10-01 00:00:00

abstract：:Human T lymphotropic virus type I (HTLV-I) is the etiological agent of adult T cell leukemia, and reports suggest that several other clinical conditions are associated with HTLV-I infection, including myelopathy and inflammatory pulmonary diseases. However, the clinical entity of HTLV-I-associated lung disease remains...

journal_title：American journal of respiratory and critical care medicine

authors： Kawakami K,Miyazato A,Iwakura Y,Saito A

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:Exacerbation of chronic obstructive pulmonary disease commonly causes hospitalization. The change in lung mechanics during exacerbation and its relationship to symptoms in spontaneously breathing individuals has not been described. OBJECTIVE:We hypothesized that changes in both airflow and lung volumes would...

journal_title：American journal of respiratory and critical care medicine

authors： Stevenson NJ,Walker PP,Costello RW,Calverley PM

更新日期：2005-12-15 00:00:00

abstract：RATIONALE:Inhaled corticosteroids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD). OBJECTIVES:To examine whether these medications might be associated with an excess risk of pneumonia. METHODS:We conducted a nested case-control study within a cohort of patients with COPD from Que...

journal_title：American journal of respiratory and critical care medicine

authors： Ernst P,Gonzalez AV,Brassard P,Suissa S

更新日期：2007-07-15 00:00:00

abstract：:We derived reference values for slow vital capacity (VC) and flow-volume curve indexes (FVC, FEV(1), and flows) from the 1,185 tracings provided by 1,039 "normal" subjects who participated in one or both cross-sectional surveys of the Po River Delta study in 1980-1982 and in 1988-1991. Definition of "normal" was based...

journal_title：American journal of respiratory and critical care medicine

authors： Pistelli F,Bottai M,Viegi G,Di Pede F,Carrozzi L,Baldacci S,Pedreschi M,Giuntini C

更新日期：2000-03-01 00:00:00

abstract：:Alkaline phosphatase (ALP) in lung lavage fluids is a marker of tissue damage and type II cell proliferation. Type II pneumocytes are extensively involved in fibrosis. The aim of our study was to verify whether local ALP activity can be held as a marker of fibrosis in chronic interstitial lung disorders. ALP was deter...

journal_title：American journal of respiratory and critical care medicine

authors： Capelli A,Lusuardi M,Cerutti CG,Donner CF

更新日期：1997-01-01 00:00:00

abstract：:There is a growing understanding of the effects and potential pathophysiological role of the ETs in asthma and several of the criteria required to strongly implicate ET-1 as a mediator in this disease have been fulfilled. However, some of the information is preliminary, equivocal and requires confirmation. Furthermore...

journal_title：American journal of respiratory and critical care medicine

authors： Hay DW,Henry PJ,Goldie RG

更新日期：1996-12-01 00:00:00

abstract：:The length of time that blood remains in the pulmonary capillary is an important variable in gas exchange. We have investigated the distribution of capillary transit times in isolated rabbit lungs perfused with a bicarbonate-free buffer. The time course of gas exchange was monitored by enclosing the lungs in a plethys...

journal_title：American journal of respiratory and critical care medicine

authors： Klocke RA,Schünemann HJ,Grant BJ

更新日期：1995-12-01 00:00:00

abstract：:We investigated ventilation inhomogeneity in patients with chronic obstructive pulmonary disease (COPD) through use of the multiple breath N2 washout test (MBW). From an alveolar slope analysis throughout the MBW, we derived two indices, S(cond) and S(acin), as a measure of ventilation inhomogeneity in conductive and ...

journal_title：American journal of respiratory and critical care medicine

authors： Verbanck S,Schuermans D,Van Muylem A,Melot C,Noppen M,Vincken W,Paiva M

更新日期：1998-05-01 00:00:00

abstract：:Cryptogenic fibrosing alveolitis has been reported to be associated with an increased risk of lung cancer. However, it has recently become apparent that cigarette smoking may be a risk factor for cryptogenic fibrosing alveolitis as well as for lung cancer, and so may confound the association between these conditions. ...

journal_title：American journal of respiratory and critical care medicine

authors： Hubbard R,Venn A,Lewis S,Britton J

更新日期：2000-01-01 00:00:00

abstract：RATIONALE:Community-acquired pneumonia (CAP) accounts for a major proportion of intensive care unit (ICU) admissions for respiratory failure and sepsis. Diagnostic uncertainty complicates case management, which may delay appropriate cause-specific treatment. OBJECTIVES:To characterize the blood genomic response in pat...

journal_title：American journal of respiratory and critical care medicine

authors： Scicluna BP,Klein Klouwenberg PM,van Vught LA,Wiewel MA,Ong DS,Zwinderman AH,Franitza M,Toliat MR,Nürnberg P,Hoogendijk AJ,Horn J,Cremer OL,Schultz MJ,Bonten MJ,van der Poll T

更新日期：2015-10-01 00:00:00

abstract：RATIONALE:Human metapneumovirus is a newly described virus isolated in 2001 from children with acute respiratory viral infection. It has subsequently been reported globally, although there are limited data in lung transplant recipients. OBJECTIVES:To prospectively analyze whether human metapneumovirus was circulating ...

journal_title：American journal of respiratory and critical care medicine

authors： Hopkins P,McNeil K,Kermeen F,Musk M,McQueen E,Mackay I,Sloots T,Nissen M

更新日期：2008-10-15 00:00:00

abstract：RATIONALE:Density-based morphometric studies have demonstrated decreased capillary density in infants with bronchopulmonary dysplasia (BPD) and in BPD-like animal models, leading to the prevailing view that microvascular development is disrupted in BPD. OBJECTIVE:To perform a comprehensive analysis of the early and la...

journal_title：American journal of respiratory and critical care medicine

authors： De Paepe ME,Mao Q,Powell J,Rubin SE,DeKoninck P,Appel N,Dixon M,Gundogan F

更新日期：2006-01-15 00:00:00

abstract：:Changes in dynamic lung compliance during inspiration and expiration cannot be modeled accurately with conventional algorithms. We developed a simple method to analyze pressure-volume (P/V) relationships under condition of nonlinearity (APVNL) and tested it in a lung model with known resistance and nonlinear P/V relat...

journal_title：American journal of respiratory and critical care medicine

authors： Nikischin W,Gerhardt T,Everett R,Bancalari E

更新日期：1998-10-01 00:00:00

abstract：RATIONALE:Little is known about human club cells, dome-shaped cells with dense cytoplasmic granules and microvilli that represent the major secretory cells of the human small airways (at least sixth-generation bronchi). OBJECTIVES:To define the ontogeny and biology of the human small airway epithelium club cell. METH...

journal_title：American journal of respiratory and critical care medicine

authors： Zuo WL,Shenoy SA,Li S,O'Beirne SL,Strulovici-Barel Y,Leopold PL,Wang G,Staudt MR,Walters MS,Mason C,Kaner RJ,Mezey JG,Crystal RG

更新日期：2018-12-01 00:00:00

abstract：:Hepatopulmonary syndrome (HPS) is characterized by intrapulmonary vascular dilatations and an increased alveoloarterial oxygen difference (AaPO(2)). These abnormalities are related to augmented pulmonary nitric oxide (NO) production, dependent primarily on increases in the expression and activity of inducible NO-synth...

journal_title：American journal of respiratory and critical care medicine

authors： Rabiller A,Nunes H,Lebrec D,Tazi KA,Wartski M,Dulmet E,Libert JM,Mougeot C,Moreau R,Mazmanian M,Humbert M,Hervé P

更新日期：2002-08-15 00:00:00

abstract：:In a prospective study, we screened specimens from 190 mechanically ventilated patients hospitalized in a surgical intensive care unit, and from the environment to assess risks and routes of colonization/infection. Specimens from various sites were collected on admission and once a week throughout each patient's stay....

journal_title：American journal of respiratory and critical care medicine

authors： Talon D,Mulin B,Rouget C,Bailly P,Thouverez M,Viel JF

更新日期：1998-03-01 00:00:00

abstract：RATIONALE:Sarcoidosis is known as a disease with high heterogeneity in clinical severity and inflammatory activity. On the basis of radiologic criteria, John Guyette Scadding developed a classification system, which is widely used, but is insufficient for clinical decision making. Therefore, biomarkers and genetic mark...

journal_title：American journal of respiratory and critical care medicine

authors： Prasse A,Katic C,Germann M,Buchwald A,Zissel G,Müller-Quernheim J

更新日期：2008-02-01 00:00:00

abstract：:Neutrophil infiltration is a major feature in the pathogenesis of the common cold, and respiratory viral infection is the major cause of asthma exacerbations. The factors regulating the neutrophil influx are unknown. Interleukin-8 (IL-8) is a potent neutrophil chemoattractant, which has been implicated in several infl...

journal_title：American journal of respiratory and critical care medicine

authors： Teran LM,Johnston SL,Schröder JM,Church MK,Holgate ST

更新日期：1997-04-01 00:00:00

abstract：:This study investigated the clinico-pathologic correlation of tumor angiogenesis in non-small-cell lung cancers. Formalin-fixed, paraffin-embedded surgical specimens of 55 consecutive patients with primary non-small-cell lung cancers were examined. Included were 26 squamous cell carcinomas and 29 adenocarcinomas. Twen...

journal_title：American journal of respiratory and critical care medicine

authors： Yuan A,Yang PC,Yu CJ,Lee YC,Yao YT,Chen CL,Lee LN,Kuo SH,Luh KT

更新日期：1995-12-01 00:00:00