Neuropeptide content of lungs from asthmatic and nonasthmatic patients.

abstract：:This prospective and controlled pilot study evaluates the long-term effects of nocturnal oxygen therapy (NOT) on exercise endurance, hematology variables, quality of life, and survival of 23 adult patients (mean age, 32 +/- 6 yr) with post-tricuspid congenital heart defects (ventricular septal defect = 10; patent duct...

journal_title：American journal of respiratory and critical care medicine

authors： Sandoval J,Aguirre JS,Pulido T,Martinez-Guerra ML,Santos E,Alvarado P,Rosas M,Bautista E

更新日期：2001-11-01 00:00:00

abstract：:The six-minute walk test is a submaximal exercise test that can be performed even by a patient with heart failure not tolerating maximal exercise testing. To elucidate the clinical significance and prognostic value of the six-minute walk test in patients with primary pulmonary hypertension (PPH), we sought (1) to asse...

journal_title：American journal of respiratory and critical care medicine

authors： Miyamoto S,Nagaya N,Satoh T,Kyotani S,Sakamaki F,Fujita M,Nakanishi N,Miyatake K

更新日期：2000-02-01 00:00:00

abstract：:To study whether the individual inflammatory response to ozone was reproducible, dose-dependent, and time-dependent, we performed two exposures to 250 ppb ozone, one to 125 ppb and one to filtered air, each for 3 h of intermittent exercise and separated by at least 1 wk. Twenty-one healthy and 15 asthmatic subjects pa...

journal_title：American journal of respiratory and critical care medicine

authors： Holz O,Jörres RA,Timm P,Mücke M,Richter K,Koschyk S,Magnussen H

更新日期：1999-03-01 00:00:00

abstract：:Preventing, treating, and promoting recovery from critical illness due to pulmonary disease are foundational goals of the critical care community and the National Heart, Lung, and Blood Institute. Decades of clinical research in acute respiratory distress syndrome, acute respiratory failure, pneumonia, and sepsis have...

journal_title：American journal of respiratory and critical care medicine

authors： Semler MW,Bernard GR,Aaron SD,Angus DC,Biros MH,Brower RG,Calfee CS,Colantuoni EA,Ferguson ND,Gong MN,Hopkins RO,Hough CL,Iwashyna TJ,Levy BD,Martin TR,Matthay MA,Mizgerd JP,Moss M,Needham DM,Self WH,Seymour CW,

更新日期：2020-03-09 00:00:00

abstract：RATIONALE:The allergen inhalation challenge is used in clinical trials to test the efficacy of new treatments in attenuating the late-phase asthmatic response (LAR) and associated airway inflammation in subjects with allergic asthma. However, not all subjects with allergic asthma develop the LAR after allergen inhalati...

journal_title：American journal of respiratory and critical care medicine

authors： Singh A,Shannon CP,Kim YW,Yang CX,Balshaw R,Cohen Freue GV,Gauvreau GM,FitzGerald JM,Boulet LP,O'Byrne PM,Tebbutt SJ

更新日期：2018-02-15 00:00:00

abstract：:Successful bronchodilator therapy with a metered-dose inhaler (MDI) in intubated, mechanically ventilated patients requires adequate delivery of aerosol to the lower respiratory tract. We determined the effect of ventilator mode, inspiratory flow pattern, humidity, and spontaneous respiratory effort on albuterol deliv...

journal_title：American journal of respiratory and critical care medicine

authors： Fink JB,Dhand R,Duarte AG,Jenne JW,Tobin MJ

更新日期：1996-08-01 00:00:00

abstract：:Stenotrophomonas maltophilia is a gram-negative bacterium that has been cultured with increasing prevalence from the sputum of patients with cystic fibrosis (CF). We conducted a cohort study, using the Cystic Fibrosis Foundation Registry, to assess the effect of S. maltophilia on survival. We studied all patients in t...

journal_title：American journal of respiratory and critical care medicine

authors： Goss CH,Otto K,Aitken ML,Rubenfeld GD

更新日期：2002-08-01 00:00:00

abstract：:Thyroid transcription factor-1 (TTF-1) deficiency syndrome is characterized by neurologic, thyroidal, and pulmonary dysfunction. Children usually have mild-to-severe respiratory symptoms and occasionally die of respiratory failure. Herein, we describe an infant with a constitutional 14q12-21.3 haploid deletion encompa...

journal_title：American journal of respiratory and critical care medicine

authors： Galambos C,Levy H,Cannon CL,Vargas SO,Reid LM,Cleveland R,Lindeman R,deMello DE,Wert SE,Whitsett JA,Perez-Atayde AR,Kozakewich H

更新日期：2010-08-15 00:00:00

abstract：:Rationale: Noninvasive ventilation decreases the need for invasive mechanical ventilation and mortality among patients with chronic obstructive pulmonary disease but has not been well studied in asthma.Objectives: To assess the association between noninvasive ventilation and subsequent need for invasive mechanical ven...

journal_title：American journal of respiratory and critical care medicine

authors： Althoff MD,Holguin F,Yang F,Grunwald GK,Moss M,Vandivier RW,Ho PM,Kiser TH,Burnham EL

更新日期：2020-12-01 00:00:00

abstract：:Several studies have found that sleep deprivation reduces the hypercapnic ventilatory response (HCVR). Such results may have been affected by uncontrolled activities or environmental influences during the sleep deprivation period. The current study determined the "pure" effect of sleep deprivation on respiratory contr...

journal_title：American journal of respiratory and critical care medicine

authors： Spengler CM,Shea SA

更新日期：2000-04-01 00:00:00

abstract：RATIONALE:Protein kinase C zeta (PKCζ) has been reported to act as a tumor suppressor. Deletion of PKCζ in experimental cancer models has been shown to increase tumor growth. However, the mechanisms of PKCζ down-regulation in cancerous cells have not been previously described. OBJECTIVES:To determine the molecular mec...

journal_title：American journal of respiratory and critical care medicine

authors： Queisser MA,Dada LA,Deiss-Yehiely N,Angulo M,Zhou G,Kouri FM,Knab LM,Liu J,Stegh AH,DeCamp MM,Budinger GR,Chandel NS,Ciechanover A,Iwai K,Sznajder JI

更新日期：2014-09-15 00:00:00

abstract：:Although there is abundant clinical evidence of asthmatic responses to indoor aeroallergens, the symptomatic impacts of other common indoor air pollutants from gas stoves, fireplaces, and environmental tobacco smoke have been less well characterized. These combustion sources produce a complex mixture of pollutants, ma...

journal_title：American journal of respiratory and critical care medicine

authors： Ostro BD,Lipsett MJ,Mann JK,Wiener MB,Selner J

更新日期：1994-06-01 00:00:00

abstract：:Clinically, the spread of infectious agents between subjects undergoing spirometry is quite uncommon. There is almost no documentation in the medical literature on this subject. We studied the retrieval of nonpathogenic Escherichia coli after aerosolizing organisms into standard pulmonary function tubing of a type tha...

journal_title：American journal of respiratory and critical care medicine

authors： Hiebert T,Miles J,Okeson GC

更新日期：1999-02-01 00:00:00

abstract：:We produced ovalbumin (OVA)-sensitized rats as an animal model of nasal allergy. Intranasal instillation of OVA induced hypertrophic and metaplastic changes of goblet cells in nasal epithelium of OVA- sensitized rats. Intraepithelial mucosubstance in nasal mucosa increased significantly at 24 h after 3 or 7 d of OVA i...

journal_title：American journal of respiratory and critical care medicine

authors： Shimizu T,Hirano H,Majima Y,Sakakura Y

更新日期：2000-05-01 00:00:00

abstract：:Interpretation of incremental cardiopulmonary exercise tests (CPET) might be enhanced by considering the simultaneous rates of change of certain key variables, e.g., Delta oxygen uptake/Delta work rate (Delta VO(2)/Delta WR), Delta heart rate/Delta VO(2) (Delta HR/Delta VO(2)), Delta ventilation/Delta carbon dioxide p...

journal_title：American journal of respiratory and critical care medicine

authors： Neder JA,Nery LE,Peres C,Whipp BJ

更新日期：2001-10-15 00:00:00

abstract：RATIONALE:In San Francisco, 70% of the tuberculosis cases occur among foreign-born persons, mainly from China, the Philippines, and Mexico. We postulate that there are differences in the characteristics and risk factors for tuberculosis among these populations. OBJECTIVES:To determine the clinical, epidemiological and...

journal_title：American journal of respiratory and critical care medicine

authors： Suwanpimolkul G,Jarlsberg LG,Grinsdale JA,Osmond D,Kawamura LM,Hopewell PC,Kato-Maeda M

更新日期：2013-05-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrotic disorder underlain by aberrant wound healing of repeated lung injury. Environmental triggers and genetic background are likely to act as modifiers of the fibrotic response. Erythrocyte complement receptor 1 is a membrane protein mediating the transport of immu...

journal_title：American journal of respiratory and critical care medicine

authors： Zorzetto M,Ferrarotti I,Trisolini R,Lazzari Agli L,Scabini R,Novo M,De Silvestri A,Patelli M,Martinetti M,Cuccia M,Poletti V,Pozzi E,Luisetti M

更新日期：2003-08-01 00:00:00

abstract：:The aim of the study was to investigate the effect of addition of montelukast to inhaled fluticasone propionate (FP) therapy, compared with FP therapy alone (100 microg twice a day) on airway immunopathology in individuals with mild asthma. Twenty-eight subjects received FP (100 microg twice a day) or FP (100 microg t...

journal_title：American journal of respiratory and critical care medicine

authors： O'Sullivan S,Akveld M,Burke CM,Poulter LW

更新日期：2003-03-01 00:00:00

abstract：RATIONALE:Studies in humans and rodents have indicated a causative role for CD8(+) T cells in IgE-mediated allergic inflammation, but their function is still controversial. OBJECTIVES:To analyze the role of allergen-specific CD8(+) T cells during the development of allergic airway inflammation in two parallel but dive...

journal_title：American journal of respiratory and critical care medicine

authors： Aguilar-Pimentel JA,Alessandrini F,Huster KM,Jakob T,Schulz H,Behrendt H,Ring J,de Angelis MH,Busch DH,Mempel M,Ollert M

更新日期：2010-01-01 00:00:00

abstract：:Clinicians are frequently faced with patients in whom the radiographic resolution of community-acquired pneumonia seems delayed. Previous studies of radiographic resolution of the disease have yielded conflicting results. We prospectively assessed the radiographic resolution of pneumonia in 81 non-immuno-compromised p...

journal_title：American journal of respiratory and critical care medicine

authors： Mittl RL Jr,Schwab RJ,Duchin JS,Goin JE,Albeida SM,Miller WT

更新日期：1994-03-01 00:00:00

abstract：:In normal airways, invasion of small numbers of pathogenic bacteria will not give rise to injury or local colonization. In chronic obstructive pulmonary disease, however, local conditions are changed, which may impair local defense systems and facilitate infection. These include: (1) factors promoting bacterial adhere...

journal_title：American journal of respiratory and critical care medicine

authors： Jansen HM,Sachs AP,van Alphen L

更新日期：1995-06-01 00:00:00

abstract：:The effects of conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFO) on intraalveolar expression of the tumor necrosis factor-alpha (TNF-alpha) gene were studied in surfactant-depleted rabbits. After lung lavage with saline, 13 rabbits were administered either CMV (n = 6) or HFO (n...

journal_title：American journal of respiratory and critical care medicine

authors： Takata M,Abe J,Tanaka H,Kitano Y,Doi S,Kohsaka T,Miyasaka K

更新日期：1997-07-01 00:00:00

abstract：:Rationale: Mathematical modeling is used to understand disease dynamics, forecast trends, and inform public health prioritization. We conducted a comparative analysis of tuberculosis (TB) epidemiology and potential intervention effects in California, using three previously developed epidemiologic models of TB.Objectiv...

journal_title：American journal of respiratory and critical care medicine

authors： Menzies NA,Parriott A,Shrestha S,Dowdy DW,Cohen T,Salomon JA,Marks SM,Hill AN,Winston CA,Asay GR,Barry P,Readhead A,Flood J,Kahn JG,Shete PB

更新日期：2020-02-01 00:00:00

abstract：:The clinical significance of minimal acute rejection (grade A1) in lung transplant recipients is unknown. We prospectively analyzed 1,159 transbronchial lung biopsies in 184 patients. Two hundred seventy-nine biopsies in 128 participants confirmed A1 histology at a mean postoperative day of 229 +/- 340. Sixty four of ...

journal_title：American journal of respiratory and critical care medicine

authors： Hopkins PM,Aboyoun CL,Chhajed PN,Malouf MA,Plit ML,Rainer SP,Glanville AR

更新日期：2004-11-01 00:00:00

abstract：:Loss of lung elastic recoil causing hyperinflation with increased TLC and decreased diffusing capacity and expiratory airflow are physiologic hallmarks of emphysema. We studied lung mechanics in 10 patients (seven men and three women) aged 69 +/- 9 yr (mean +/- SD) who had fixed, severe expiratory airflow limitation w...

journal_title：American journal of respiratory and critical care medicine

authors： Gelb AF,Zamel N,Hogg JC,Müller NL,Schein MJ

更新日期：1998-09-01 00:00:00

abstract：RATIONALE:Platelets may interact with the immune system in tuberculosis (TB) to regulate human inflammatory responses that lead to morbidity and spread of infection. OBJECTIVES:To identify a functional role of platelets in the innate inflammatory and matrix-degrading response in TB. METHODS:Markers of platelet activa...

journal_title：American journal of respiratory and critical care medicine

authors： Fox KA,Kirwan DE,Whittington AM,Krishnan N,Robertson BD,Gilman RH,López JW,Singh S,Porter JC,Friedland JS

更新日期：2018-07-15 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with impaired renal function, but uncertainty exists over whether OSA treatment can influence renal outcomes. OBJECTIVES:To determine the effects of continuous positive airway pressure (CPAP) on renal function in subjects with coexisting OSA and cardiovascular dise...

journal_title：American journal of respiratory and critical care medicine

authors： Loffler KA,Heeley E,Freed R,Anderson CS,Brockway B,Corbett A,Chang CL,Douglas JA,Ferrier K,Graham N,Hamilton GS,Hlavac M,McArdle N,McLachlan J,Mukherjee S,Naughton MT,Thien F,Young A,Grunstein RR,Palmer LJ,Woodman

更新日期：2017-12-01 00:00:00

abstract：:The failure of patients to adhere to physician-prescribed regimens, either pharmacologic or behavioral, has been well documented in medical literature. Poor adherence to asthma medication regimens has been repeatedly demonstrated in both children and adults, with rates of nonadherence commonly reported from 30 to 70%....

journal_title：American journal of respiratory and critical care medicine

authors： Rand CS,Wise RA

更新日期：1994-02-01 00:00:00

abstract：RATIONALE:Mechanical ventilation induces heterogeneous lung injury by mitogen-activated protein kinase (MAPK) and nuclear factor-κB. Mechanisms regulating regional injury and protective effects of prone positioning are unclear. OBJECTIVES:To determine the key regulators of the lung regional protective effects of prone...

journal_title：American journal of respiratory and critical care medicine

authors： Park MS,He Q,Edwards MG,Sergew A,Riches DW,Albert RK,Douglas IS

更新日期：2012-07-01 00:00:00

abstract：:Although hematopoietic stem cell transplantation (HSCT) can be curative in patients with certain malignancies, survival is poor if the recipient becomes critically ill. This prospective study examined the outcomes of 115 consecutive HSCT patients admitted to the medical intensive care unit (MICU) of a tertiary cancer ...

journal_title：American journal of respiratory and critical care medicine

authors： Price KJ,Thall PF,Kish SK,Shannon VR,Andersson BS

更新日期：1998-09-01 00:00:00