Pulmonary vascular abnormalities and ventilation-perfusion relationships in mild chronic obstructive pulmonary disease.

abstract：:Many persons say that they "don't know" whether they snore. The purpose of this study was to investigate the prevalence and correlates of such responses in an elderly population. Subjects were 1715 members (1,155 men, 560 women) of a previously defined cohort (Western Group Collaborative Study) followed prospectively ...

journal_title：American journal of respiratory and critical care medicine

authors： Bliwise DL,Swan GE,Carmelli D,La Rue A

更新日期：1999-12-01 00:00:00

abstract：RATIONALE:Activin-A is up-regulated in various respiratory disorders. However, its precise role in pulmonary pathophysiology has not been adequately substantiated in vivo. OBJECTIVES:To investigate in vivo the consequences of dysregulated Activin-A expression in the lung and identify key Activin-A-induced processes th...

journal_title：American journal of respiratory and critical care medicine

authors： Apostolou E,Stavropoulos A,Sountoulidis A,Xirakia C,Giaglis S,Protopapadakis E,Ritis K,Mentzelopoulos S,Pasternack A,Foster M,Ritvos O,Tzelepis GE,Andreakos E,Sideras P

更新日期：2012-02-15 00:00:00

abstract：:Important features of both stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) are skeletal muscle weakness and wasting. Limb muscle dysfunction during an exacerbation has been linked to various adverse outcomes, including prolonged hospitalization, readmission, and mortality. The contributin...

journal_title：American journal of respiratory and critical care medicine

authors： Abdulai RM,Jensen TJ,Patel NR,Polkey MI,Jansson P,Celli BR,Rennard SI

更新日期：2018-02-15 00:00:00

abstract：:The management of children with drug-resistant tuberculosis (DR-TB) is challenging, and it is likely that in many places, the roll-out of molecular diagnostic testing will lead to more children being diagnosed. There is a limited evidence base to guide optimal treatment and follow-up in the pediatric population; in ex...

journal_title：American journal of respiratory and critical care medicine

authors： Seddon JA,Furin JJ,Gale M,Del Castillo Barrientos H,Hurtado RM,Amanullah F,Ford N,Starke JR,Schaaf HS,Sentinel Project on Pediatric Drug-Resistant Tuberculosis.

更新日期：2012-11-15 00:00:00

abstract：:E-selectin, an early mediator of leukocyte-endothelial adhesion, is expressed on activated endothelium. Soluble E-selectin is present in the supernatant of cytokine-activated endothelial cells and elevated serum levels are found in a variety of inflammatory conditions. We documented elevated E-selectin serum levels in...

journal_title：American journal of respiratory and critical care medicine

authors： Cummings CJ,Sessler CN,Beall LD,Fisher BJ,Best AM,Fowler AA 3rd

更新日期：1997-08-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease that persists even during adequate therapy and asymptomatic episodes. We questioned whether "silent" chronic allergen exposure can induce and maintain airway inflammation and whether this still occurs during regular treatment with inhaled steroids. Twenty-six patients with hous...

journal_title：American journal of respiratory and critical care medicine

authors： de Kluijver J,Evertse CE,Schrumpf JA,van der Veen H,Zwinderman AH,Hiemstra PS,Rabe KF,Sterk PJ

更新日期：2002-08-01 00:00:00

abstract：RATIONALE:T-bet (TBX21 or T-box 21) is a critical regulator of T-helper 1 lineage commitment and IFN-gamma production. Knockout mice lacking T-bet develop airway hyperresponsiveness (AHR) to methacholine, peribronchial eosinophilic and lymphocytic inflammation, and increased type III collagen deposition below the bronc...

journal_title：American journal of respiratory and critical care medicine

authors： Raby BA,Hwang ES,Van Steen K,Tantisira K,Peng S,Litonjua A,Lazarus R,Giallourakis C,Rioux JD,Sparrow D,Silverman EK,Glimcher LH,Weiss ST

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive syndromes is a significant determinant of short- and long-term outcomes. Although remarkable progress has been made in the understanding of RV function and failure since the meeting of the NIH Working Group on Cellular and Molecula...

journal_title：American journal of respiratory and critical care medicine

authors： Lahm T,Douglas IS,Archer SL,Bogaard HJ,Chesler NC,Haddad F,Hemnes AR,Kawut SM,Kline JA,Kolb TM,Mathai SC,Mercier O,Michelakis ED,Naeije R,Tuder RM,Ventetuolo CE,Vieillard-Baron A,Voelkel NF,Vonk-Noordegraaf A,Hassou

更新日期：2018-08-15 00:00:00

abstract：:The lungs of newborn rats exposed to 60% oxygen for 14 days develop an injury that shares morphologic similarities to human bronchopulmonary dysplasia (BPD). Neutrophil influx into the lung, as part of an inflammatory response, may play a pivotal role in the development of BPD. A neutrophil chemokine, cytokine-induced...

journal_title：American journal of respiratory and critical care medicine

authors： Yi M,Jankov RP,Belcastro R,Humes D,Copland I,Shek S,Sweezey NB,Post M,Albertine KH,Auten RL,Tanswell AK

更新日期：2004-12-01 00:00:00

abstract：RATIONALE:The immune response in sepsis is characterized by overt immune dysfunction. Studies indicate immunostimulation represents a viable therapy for patients. One study suggests a potentially protective role for interleukin 5 (IL-5) in sepsis; however, the loss of eosinophils in this disease presents a paradox. OB...

journal_title：American journal of respiratory and critical care medicine

authors： Linch SN,Danielson ET,Kelly AM,Tamakawa RA,Lee JJ,Gold JA

更新日期：2012-08-01 00:00:00

abstract：:The timing and magnitude of airway narrowing in central apneas is unknown. We have developed a method of apnea classification that relies on the transmission of cardiac airflow oscillation to indicate airway patency. Using a theoretical model, we showed that the amplitude of the cardiac airflow oscillation is proporti...

journal_title：American journal of respiratory and critical care medicine

authors： Lemke RP,Idiong N,Al-Saedi S,Kwiatkowski K,Cates DB,Rigatto H

更新日期：1998-02-01 00:00:00

abstract：RATIONALE:Endobronchial ultrasound (EBUS) and electromagnetic navigation bronchoscopy (ENB) have increased the diagnostic yield of bronchoscopic diagnosis of peripheral lung lesions. However, the role of combining these modalities to overcome each individual technique's limitations and, consequently, to further increas...

journal_title：American journal of respiratory and critical care medicine

authors： Eberhardt R,Anantham D,Ernst A,Feller-Kopman D,Herth F

更新日期：2007-07-01 00:00:00

abstract：RATIONALE:Controlled mechanical ventilation (CMV) results in atrophy of the human diaphragm. The autophagy-lysosome pathway (ALP) contributes to skeletal muscle proteolysis, but its contribution to diaphragmatic protein degradation in mechanically ventilated patients is unknown. OBJECTIVES:To evaluate the autophagy pa...

journal_title：American journal of respiratory and critical care medicine

authors： Hussain SN,Mofarrahi M,Sigala I,Kim HC,Vassilakopoulos T,Maltais F,Bellenis I,Chaturvedi R,Gottfried SB,Metrakos P,Danialou G,Matecki S,Jaber S,Petrof BJ,Goldberg P

更新日期：2010-12-01 00:00:00

abstract：:Several modalities of ventilatory support have been proposed to gradually withdraw patients from mechanical ventilation, but their respective effects on the outcome of weaning from mechanical ventilation are not known. We conducted a randomized trial in three intensive care units in mechanically ventilated patients wh...

journal_title：American journal of respiratory and critical care medicine

authors： Brochard L,Rauss A,Benito S,Conti G,Mancebo J,Rekik N,Gasparetto A,Lemaire F

更新日期：1994-10-01 00:00:00

abstract：RATIONALE:Severe sepsis and septic shock are leading causes of intensive care unit (ICU) admission, morbidity, and mortality. The effect of compliance with sepsis management guidelines on outcomes is unclear. OBJECTIVES:To assess the effect on mortality of compliance with a severe sepsis and septic shock management bu...

journal_title：American journal of respiratory and critical care medicine

authors： Miller RR 3rd,Dong L,Nelson NC,Brown SM,Kuttler KG,Probst DR,Allen TL,Clemmer TP,Intermountain Healthcare Intensive Medicine Clinical Program.

更新日期：2013-07-01 00:00:00

abstract：RATIONALE:The temporal stability of adult asthma phenotypes identified using clustering methods has never been addressed. Longitudinal cluster-based methods may provide novel insights in the study of the natural history of asthma. OBJECTIVES:To compare the stability of cluster-based asthma phenotype structures a decad...

journal_title：American journal of respiratory and critical care medicine

authors： Boudier A,Curjuric I,Basagaña X,Hazgui H,Anto JM,Bousquet J,Bridevaux PO,Dupuis-Lozeron E,Garcia-Aymerich J,Heinrich J,Janson C,Künzli N,Leynaert B,de Marco R,Rochat T,Schindler C,Varraso R,Pin I,Probst-Hensch N,Sun

更新日期：2013-09-01 00:00:00

abstract：:In a prospective study, we screened specimens from 190 mechanically ventilated patients hospitalized in a surgical intensive care unit, and from the environment to assess risks and routes of colonization/infection. Specimens from various sites were collected on admission and once a week throughout each patient's stay....

journal_title：American journal of respiratory and critical care medicine

authors： Talon D,Mulin B,Rouget C,Bailly P,Thouverez M,Viel JF

更新日期：1998-03-01 00:00:00

abstract：:In humans, respiratory viral infections lead to increased airway responsiveness and exacerbations of asthma. In the present study, the role of interleukin-5 (IL-5) in virus-induced airway hyperresponsiveness and inflammation was examined in guinea pigs. In animals treated with control antibody, parainfluenza-3 virus s...

journal_title：American journal of respiratory and critical care medicine

authors： van Oosterhout AJ,van Ark I,Folkerts G,van der Linde HJ,Savelkoul HF,Verheyen AK,Nijkamp FP

更新日期：1995-01-01 00:00:00

abstract：RATIONALE:Pseudomonas aeruginosa is one of the leading causes of gram-negative ventilator-associated pneumonia (VAP) associated with a mortality rate of 34 to 68%. Recent evidence suggests that P. aeruginosa in patients with VAP may persist in the alveolar space despite adequate antimicrobial therapy. We hypothesized t...

journal_title：American journal of respiratory and critical care medicine

authors： El Solh AA,Akinnusi ME,Wiener-Kronish JP,Lynch SV,Pineda LA,Szarpa K

更新日期：2008-09-01 00:00:00

abstract：:The severity of asthma can be graded from mild intermittent to severe persistent. Airway inflammation is a feature of persistent asthma. We compared several markers of inflammation in mucosal biopsies and bronchoalveolar lavage fluid (BAL fluid) from 12 healthy control subjects, 24 patients with intermittent asthma, a...

journal_title：American journal of respiratory and critical care medicine

authors： Vignola AM,Chanez P,Campbell AM,Souques F,Lebel B,Enander I,Bousquet J

更新日期：1998-02-01 00:00:00

abstract：:Although all the well-recognized muscles of expiration are paralyzed after traumatic transection of the lower cervical cord, tetraplegic subjects can still empty their lungs actively by contracting the clavicular portion of the pectoralis major. It is not known, however, whether contraction of this muscle bundle may r...

journal_title：American journal of respiratory and critical care medicine

authors： Estenne M,Van Muylem A,Gorini M,Kinnear W,Heilporn A,De Troyer A

更新日期：1994-10-01 00:00:00

abstract：:CC-chemokine receptor 3 (CCR3)-stimulating chemokines are likely to have important in vivo roles in the regulation of eosinophil, basophil, and potentially helper T cell type 2 and mast cell recruitment. We have developed techniques to investigate the actions of eotaxin and other chemokines on multiple leukocyte popul...

journal_title：American journal of respiratory and critical care medicine

authors： Bryan SA,Jose PJ,Topping JR,Wilhelm R,Soderberg C,Kertesz D,Barnes PJ,Williams TJ,Hansel TT,Sabroe I

更新日期：2002-06-15 00:00:00

abstract：:Reduced diaphragm contractility has been described in normal subjects after whole body endurance exercise, and it indicates low frequency fatigue (LFF); it is unknown whether LFF is of clinical importance. We therefore studied the effect of treadmill exercise to exhaustion on diaphragm contractility in six patients wi...

journal_title：American journal of respiratory and critical care medicine

authors： Polkey MI,Kyroussis D,Keilty SE,Hamnegard CH,Mills GH,Green M,Moxham J

更新日期：1995-09-01 00:00:00

abstract：:The present study was undertaken to determine if a synthetic peptide, KLLLLKLLLLKLLLLKLLLLK (KL4), in which K = lysine and L = leucine, in an aqueous dispersion of phospholipids (DPPC and POPG), would expand pulmonary alveoli and improve gas exchange in premature human infants with respiratory distress syndrome (RDS)....

journal_title：American journal of respiratory and critical care medicine

authors： Cochrane CG,Revak SD,Merritt TA,Heldt GP,Hallman M,Cunningham MD,Easa D,Pramanik A,Edwards DK,Alberts MS

更新日期：1996-01-01 00:00:00

abstract：:Obstructive sleep apnea causes cardiovascular morbidity and premature death. Potential links between sleep apnea and cardiovascular complications are chronically elevated activity of the sympathetic nervous system and abnormal vascular function. To explore vascular function, we determined the reactive hyperemic blood ...

journal_title：American journal of respiratory and critical care medicine

authors： Imadojemu VA,Gleeson K,Quraishi SA,Kunselman AR,Sinoway LI,Leuenberger UA

更新日期：2002-04-01 00:00:00

abstract：RATIONALE:Genetic alterations on 8p22 have been implicated in multiple cancers, including lung cancer. In this region, genetic variants of the class A scavenger receptor (SR-A) gene have been associated with prostate cancer risk and have been highlighted as a potential susceptibility gene of cancer. OBJECTIVES:To dete...

journal_title：American journal of respiratory and critical care medicine

authors： Ben J,Jin G,Zhang Y,Ma B,Bai H,Chen J,Zhang H,Gong Q,Zhou X,Zhang H,Qian L,Zhu X,Li X,Yang Q,Hu Z,Xu Y,Shen H,Chen Q

更新日期：2012-10-15 00:00:00

abstract：:Long-term cognitive impairment is common among ICU survivors, but its natural history remains unclear. In this systematic review, we report the frequency of cognitive impairment in ICU survivors across various time points after ICU discharge that were extracted from 46 of the 3,350 screened records. Prior studies used...

journal_title：American journal of respiratory and critical care medicine

authors： Honarmand K,Lalli RS,Priestap F,Chen JL,McIntyre CW,Owen AM,Slessarev M

更新日期：2020-07-15 00:00:00

abstract：:The long-acting beta 2-agonist salmeterol has been suggested to have other pharmacologic activities, that is, antiinflammatory capacities, in addition to its bronchodilator properties. We investigated the protective effect of 50 micrograms salmeterol in a placebo-controlled study on house dust mite-induced early- and ...

journal_title：American journal of respiratory and critical care medicine

authors： Weersink EJ,Aalbers R,Koëter GH,Kauffman HF,De Monchy JG,Postma DS

更新日期：1994-11-01 00:00:00

abstract：:During Operation Everest III (Comex '97), to assess the consequences of altitude-induced hypoxia, eight volunteers were decompressed in a hypobaric chamber, with a decompression profile simulating the climb of Mount Everest. Cardiac function was assessed using a combination of M-mode and two-dimensional echocardiograp...

journal_title：American journal of respiratory and critical care medicine

authors： Boussuges A,Molenat F,Burnet H,Cauchy E,Gardette B,Sainty JM,Jammes Y,Richalet JP

更新日期：2000-01-01 00:00:00

abstract：:This is a study of the reliability of peak expiratory flow (PEF) monitoring using a portable computerized peak flow meter, the VMX Mini-log, in 17 subjects referred for suspected occupational asthma. Subjects were requested to monitor their PEF six times daily using the VMX Mini-Log for 2 wk at work and at least 10 d ...

journal_title：American journal of respiratory and critical care medicine

authors： Quirce S,Contreras G,Dybuncio A,Chan-Yeung M

更新日期：1995-09-01 00:00:00