Partial inhibition of the early and late asthmatic response by a single dose of salmeterol.

Abstract:

:The long-acting beta 2-agonist salmeterol has been suggested to have other pharmacologic activities, that is, antiinflammatory capacities, in addition to its bronchodilator properties. We investigated the protective effect of 50 micrograms salmeterol in a placebo-controlled study on house dust mite-induced early- and late-phase reactions in 19 atopic asthmatic subjects. FEV1 and methacholine airway reactivity (AR) were measured. Eosinophils and their activation markers in peripheral blood were counted as indirect parameters of inflammation. Corrections were made for confounding of bronchodilator effects by salmeterol and the spontaneous diurnal variation, using saline inhalation as a control. Salmeterol completely inhibited the fall in FEV1 up to 10 h after the house dust mite challenge. Nevertheless, after correction, a biphasic response was present in the salmeterol group. Salmeterol protected against the allergen-associated increase in AR 3 h after the challenge, but no protection was observed after 24 h. Salmeterol did not inhibit the allergen-induced changes in total number of eosinophils and their activation markers in peripheral blood. These data suggest that a single dose of salmeterol modifies allergen-induced airway responses, above all by sustained bronchodilation.

authors

Weersink EJ,Aalbers R,Koëter GH,Kauffman HF,De Monchy JG,Postma DS

doi

10.1164/ajrccm.150.5.7952550

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

1262-7

issue

5 Pt 1

eissn

1073-449X

issn

1535-4970

journal_volume

150

pub_type

临床试验,杂志文章
  • Lung cancer and lung stem cells: strange bedfellows?

    abstract::Lung cancer is a significant disease with survival rates remaining poor despite numerous therapeutic advances during the last 30 years. Understanding lung cancer pathogenesis through murine modeling may improve future human therapies, and new data indicate that mutations within different endogenous stem cells situated...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1164/rccm.200607-984PP

    authors: Giangreco A,Groot KR,Janes SM

    更新日期:2007-03-15 00:00:00

  • Effect of fibrous glass on rat pleural mesothelium. Histopathologic observations.

    abstract::Female Fisher 344 rats (n = 25) were inoculated intrapleurally with a single 20-mg dose of (JM-100) fibrous glass. The mean length (2.2 microns) and width (0.15 microns) of the fibrous glass particles was within respirable range. Following inoculation, the rats were killed at timed intervals ranging from 2 to 430 d fr...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.150.2.8049840

    authors: Fraire AE,Greenberg SD,Spjut HJ,Roggli VL,Dodson RF,Cartwright J,Williams G,Baker S

    更新日期:1994-08-01 00:00:00

  • Airway inflammation in mild intermittent and in persistent asthma.

    abstract::The severity of asthma can be graded from mild intermittent to severe persistent. Airway inflammation is a feature of persistent asthma. We compared several markers of inflammation in mucosal biopsies and bronchoalveolar lavage fluid (BAL fluid) from 12 healthy control subjects, 24 patients with intermittent asthma, a...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.157.2.96-08040

    authors: Vignola AM,Chanez P,Campbell AM,Souques F,Lebel B,Enander I,Bousquet J

    更新日期:1998-02-01 00:00:00

  • DNA and actin bind and inhibit interleukin-8 function in cystic fibrosis sputa: in vitro effects of mucolytics.

    abstract::Infection of the cystic fibrosis (CF) airways elicits an exaggerated, interleukin-8 (IL-8) mediated, neutrophil inflammatory response. Necrosing neutrophils release DNA and actin into the airways, increasing the viscoelasticity of airway secretions. Mucolytics aim to improve airway clearance by reducing this viscoelas...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.162.5.9908107

    authors: Perks B,Shute JK

    更新日期:2000-11-01 00:00:00

  • Heterogeneous increase in CD34-positive alveolar capillaries in idiopathic pulmonary fibrosis.

    abstract::To elucidate the apparent contradictions in vascular remodeling in the lungs of patients with idiopathic pulmonary fibrosis, we evaluated alveolar vascularity in relation to the various degrees of fibrosis in surgically biopsied lungs of usual interstitial pneumonia. Alveolar capillary endothelial cells were intensely...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200308-1111OC

    authors: Ebina M,Shimizukawa M,Shibata N,Kimura Y,Suzuki T,Endo M,Sasano H,Kondo T,Nukiwa T

    更新日期:2004-06-01 00:00:00

  • Risks and routes for ventilator-associated pneumonia with Pseudomonas aeruginosa.

    abstract::In a prospective study, we screened specimens from 190 mechanically ventilated patients hospitalized in a surgical intensive care unit, and from the environment to assess risks and routes of colonization/infection. Specimens from various sites were collected on admission and once a week throughout each patient's stay....

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.157.3.9702096

    authors: Talon D,Mulin B,Rouget C,Bailly P,Thouverez M,Viel JF

    更新日期:1998-03-01 00:00:00

  • Cost-effectiveness of directly observed versus self-administered therapy for tuberculosis.

    abstract::Decision analysis was used to compare three alternative strategies for a 6-mo course of treatment for tuberculosis: directly observed drug therapy (DOT), self-administered fixed-dose combination drug therapy, and self-administered conventional individual drug therapy. Estimates of effectiveness were obtained from the ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.154.4.8887600

    authors: Moore RD,Chaulk CP,Griffiths R,Cavalcante S,Chaisson RE

    更新日期:1996-10-01 00:00:00

  • Indications and Effects of Plasma Transfusions in Critically Ill Children.

    abstract:RATIONALE:Plasma transfusions are frequently prescribed for critically ill children, although their indications lack a strong evidence base. Plasma transfusions are largely driven by physician conceptions of need, and these are poorly documented in pediatric intensive care patients. OBJECTIVES:To identify patient char...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1164/rccm.201503-0450OC

    authors: Karam O,Demaret P,Shefler A,Leteurtre S,Spinella PC,Stanworth SJ,Tucci M,Canadian Critical Care Trials Group (CCCTG).,Pediatric Acute Lung Injury and Sepsis Investigators (PALISI).,BloodNet.,PlasmaTV Investigators.

    更新日期:2015-06-15 00:00:00

  • Quantitative upper airway imaging with anatomic optical coherence tomography.

    abstract:BACKGROUND:Measurements of upper airway size and shape are important in investigating the pathophysiology of obstructive sleep apnea (OSA) and in devising, applying, and determining the effectiveness of treatment modalities. We describe an endoscopic optical technique (anatomic optical coherence tomography, aOCT) that ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200507-1148OC

    authors: Armstrong JJ,Leigh MS,Sampson DD,Walsh JH,Hillman DR,Eastwood PR

    更新日期:2006-01-15 00:00:00

  • Randomized trial of adjunctive interleukin-2 in adults with pulmonary tuberculosis.

    abstract::Interleukin (IL)-2 has a central role in regulating T cell responses to Mycobacterium tuberculosis. Adjunctive immunotherapy with recombinant human IL-2 was studied in a randomized, placebo-controlled, double-blinded trial in 110 human immunodeficiency virus-seronegative adults in whom smear-positive, drug-susceptible...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1164/rccm.200211-1359OC

    authors: Johnson JL,Ssekasanvu E,Okwera A,Mayanja H,Hirsch CS,Nakibali JG,Jankus DD,Eisenach KD,Boom WH,Ellner JJ,Mugerwa RD,Uganda-Case Western Reserve University Research Collaboration.

    更新日期:2003-07-15 00:00:00

  • Which index of peak expiratory flow is most useful in the management of stable asthma?

    abstract::Calculation of diurnal peak expiratory flow (PEF) variability using values before and after bronchodilator is no longer possible for many asthmatic patients because they now use beta-agonists "as needed" for symptoms rather than regularly. This study assesses the usefulness of a number of alternative PEF indices as ma...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.151.5.7735580

    authors: Reddel HK,Salome CM,Peat JK,Woolcock AJ

    更新日期:1995-05-01 00:00:00

  • Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada.

    abstract:RATIONALE:Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationsh...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1164/rccm.201006-0940OC

    authors: Olsson AC,Gustavsson P,Kromhout H,Peters S,Vermeulen R,Brüske I,Pesch B,Siemiatycki J,Pintos J,Brüning T,Cassidy A,Wichmann HE,Consonni D,Landi MT,Caporaso N,Plato N,Merletti F,Mirabelli D,Richiardi L,Jöckel KH,Ah

    更新日期:2011-04-01 00:00:00

  • Pneumonia in HIV-infected persons: increased risk with cigarette smoking and treatment interruption.

    abstract:RATIONALE:Bacterial pneumonia is a major cause of morbidity for HIV-infected persons and contributes to excess mortality in this population. OBJECTIVES:To evaluate the frequency and risk factors for occurrence of bacterial pneumonia in the present era of potent antiretroviral therapy. METHODS:We evaluated data from a...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1164/rccm.200804-617OC

    authors: Gordin FM,Roediger MP,Girard PM,Lundgren JD,Miro JM,Palfreeman A,Rodriguez-Barradas MC,Wolff MJ,Easterbrook PJ,Clezy K,Slater LN

    更新日期:2008-09-15 00:00:00

  • Transcriptomic analysis identifies phosphatases as novel targets for adenotonsillar hypertrophy of pediatric obstructive sleep apnea.

    abstract:RATIONALE:Obstructive sleep apnea (OSA) is a highly prevalent disorder in children, in which enlarged adenotonsillar tissues (AT) play a major pathophysiologic role. Mechanisms leading to the proliferation and hypertrophy of AT in children who subsequently develop OSA remain unknown, and surgical extirpation of AT is a...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200909-1398OC

    authors: Khalyfa A,Gharib SA,Kim J,Dayyat E,Snow AB,Bhattacharjee R,Kheirandish-Gozal L,Goldman JL,Gozal D

    更新日期:2010-05-15 00:00:00

  • Airway inflammation in childhood asthma.

    abstract::Airway pathology has been extensively investigated in adulthood asthma, whereas only few studies examined bronchial biopsies in childhood asthma. To evaluate the airway pathology in children with asthma, we analyzed bronchial biopsies obtained from 23 children undergoing bronchoscopy for clinical indications other tha...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200305-650OC

    authors: Barbato A,Turato G,Baraldo S,Bazzan E,Calabrese F,Tura M,Zuin R,Beghe B,Maestrelli P,Fabbri LM,Saetta M

    更新日期:2003-10-01 00:00:00

  • Molecular epidemiology of tuberculosis in foreign-born persons living in San Francisco.

    abstract:RATIONALE:In San Francisco, 70% of the tuberculosis cases occur among foreign-born persons, mainly from China, the Philippines, and Mexico. We postulate that there are differences in the characteristics and risk factors for tuberculosis among these populations. OBJECTIVES:To determine the clinical, epidemiological and...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201212-2239OC

    authors: Suwanpimolkul G,Jarlsberg LG,Grinsdale JA,Osmond D,Kawamura LM,Hopewell PC,Kato-Maeda M

    更新日期:2013-05-01 00:00:00

  • Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans.

    abstract:RATIONALE:Surfactant protein D (SP-D), a 43-kD collectin, is synthesized and secreted by airway epithelia as a dodecamer formed by assembly of four trimeric subunits. We have previously shown that the quaternary structure of SP-D can be altered during inflammatory lung injury through its modification by S-nitrosylation...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201004-0654OC

    authors: Atochina-Vasserman EN,Winkler C,Abramova H,Schaumann F,Krug N,Gow AJ,Beers MF,Hohlfeld JM

    更新日期:2011-04-01 00:00:00

  • Cytokine secretion by cystic fibrosis airway epithelial cells.

    abstract::It is controversial whether mutations in cystic fibrosis transmembrane conductance regulator intrinsically dysregulate inflammation. We characterized passage 2 human tracheobronchial epithelial cell cultures morphologically and physiologically and determined whether cytokine production or nuclear factor-kappaB activat...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200207-765OC

    authors: Becker MN,Sauer MS,Muhlebach MS,Hirsh AJ,Wu Q,Verghese MW,Randell SH

    更新日期:2004-03-01 00:00:00

  • Specific IgG4 responses during chronic and transient antigen exposure in aspergillosis.

    abstract::The factors that lead to increased production of specific IgG subclasses are still largely unknown. Recent studies suggest that increased IgG4 responses may be related to prolonged antigen exposure. We present data showing that increased IgG4 responses are found under conditions of chronic exposure to Aspergillus fumi...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.153.6.8665060

    authors: Tomee JF,Dubois AE,Koëter GH,Beaumont F,van der Werf TS,Kauffman HF

    更新日期:1996-06-01 00:00:00

  • The effect of nedocromil sodium on childhood asthma during the viral season.

    abstract::Viral-induced symptomatic respiratory infections (SRI) frequently cause exacerbations of asthma in children. This study investigated the protective effects of 0.5% nedocromil sodium nebulizer solution given three times a day in preventing asthma exacerbations associated with SRI. Ninety-three mild-moderate asthmatic c...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1164/ajrccm.152.6.8520750

    authors: König P,Eigen H,Ellis MH,Ellis E,Blake K,Geller D,Shapiro G,Welch M,Scott C

    更新日期:1995-12-01 00:00:00

  • Inhibition of PAF-induced gas exchange defects by beta-adrenergic agonists in mild asthma is not due to bronchodilation.

    abstract::Salbutamol inhibits neutropenia, increased airway resistance, and gas exchange abnormalities provoked by platelet-activating factor (PAF) challenge in normal persons. To further explore the intriguing dissociation between spirometric abnormalities and gas exchange defects shown in patients with asthma, we investigated...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1164/ajrccm.156.1.9610100

    authors: Díaz O,Barberà JA,Marrades R,Chung KF,Roca J,Rodriguez-Roisin R

    更新日期:1997-07-01 00:00:00

  • Role of the quorum-sensing system in experimental pneumonia due to Pseudomonas aeruginosa in rats.

    abstract::The virulence of Pseudomonas aeruginosa is partly controlled by the las quorum-sensing system. A rat model of acute pneumonia was used to investigate the pathophysiological impact of this system by comparing the virulence of the wild-type virulent laboratory strain PAO1 with that of its lasR-deleted mutant PAOR. In co...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200207-736BC

    authors: Lesprit P,Faurisson F,Join-Lambert O,Roudot-Thoraval F,Foglino M,Vissuzaine C,Carbon C

    更新日期:2003-06-01 00:00:00

  • Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis.

    abstract:RATIONALE:Interferon-gamma (IFN-gamma) is of central interest in the study of tuberculosis. A number of single-gene mutations have been identified in the IFN-gamma signaling pathway that predispose to severe mycobacterial disease, but the relevance of polymorphism within these genes to the common phenotype of tuberculo...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200601-088OC

    authors: Cooke GS,Campbell SJ,Sillah J,Gustafson P,Bah B,Sirugo G,Bennett S,McAdam KP,Sow O,Lienhardt C,Hill AV

    更新日期:2006-08-01 00:00:00

  • The affective dimension of laboratory dyspnea: air hunger is more unpleasant than work/effort.

    abstract:RATIONALE:It is hypothesized that the affective dimension of dyspnea (unpleasantness, emotional response) is not strictly dependent on the intensity of dyspnea. OBJECTIVES:We tested the hypothesis that the ratio of immediate unpleasantness (A(1)) to sensory intensity (SI) varies depending on the type of dyspnea. METH...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1164/rccm.200711-1675OC

    authors: Banzett RB,Pedersen SH,Schwartzstein RM,Lansing RW

    更新日期:2008-06-15 00:00:00

  • Prenatal cigarette smoke exposure attenuates recovery from hypoxemic challenge in preterm infants.

    abstract:RATIONALE:The effects of prenatal cigarette smoke (CS) exposure and hypoxemia on cardiorespiratory control have been investigated in full-term infants. However, few data are available in preterm infants, who form a particularly vulnerable population, with developmentally immature cardiorespiratory control. OBJECTIVES:...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200803-432OC

    authors: Schneider J,Mitchell I,Singhal N,Kirk V,Hasan SU

    更新日期:2008-09-01 00:00:00

  • Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide-induced pulmonary neutrophil influx.

    abstract::The influx of neutrophils into the lung is a sentinel event in LPS-induced acute lung inflammation. Previous studies have shown that systemic inhibition of p38 decreases LPS-induced neutrophil influx into the alveolar space but has no effect on pulmonary parenchymal neutrophil accumulation or on microvascular leak, in...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200406-712OC

    authors: Arndt PG,Young SK,Lieber JG,Fessler MB,Nick JA,Worthen GS

    更新日期:2005-05-01 00:00:00

  • Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study.

    abstract::The safety of sputum induction and the reproducibility of measurements in induced sputum in multicenter studies is unknown. We examined the safety of sputum induction in a two-visit, six-center study in 79 subjects with moderate to severe asthma (mean +/- SD FEV(1) 71 +/- 12% predicted, 67% taking inhaled corticostero...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1164/ajrccm.163.6.9901105

    authors: Fahy JV,Boushey HA,Lazarus SC,Mauger EA,Cherniack RM,Chinchilli VM,Craig TJ,Drazen JM,Ford JG,Fish JE,Israel E,Kraft M,Lemanske RF,Martin RJ,McLean D,Peters SP,Sorkness C,Szefler SJ,NHLBI Asthma Clinical Research Netw

    更新日期:2001-05-01 00:00:00

  • Persistent wheeze in grain elevator workers should not be ignored.

    abstract::We investigated the relationship between annual change in pulmonary function and changes in respiratory symptoms among male grain elevator workers who participated in a health surveillance program mandated by Labour Canada. The surveillance was conducted every 3 yr starting from the period 1978 to 1981. The 1,211 work...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.153.2.8564120

    authors: Senthilselvan A,Pahwa P,Wang P,McDuffie HH,Dosman JA

    更新日期:1996-02-01 00:00:00

  • Blood and bronchoalveolar lavage endothelin-1 levels in nocturnal asthma.

    abstract::Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that was recently shown to exhibit bronchoconstrictive properties in vitro. In asthmatic patients, the expression of ET-1 peptide was also shown to be increased in endobronchial biopsies. Thus, we postulated that ET-1 could be higher in subjects with nocturnal...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.149.4.8143060

    authors: Kraft M,Beam WR,Wenzel SE,Zamora MR,O'Brien RF,Martin RJ

    更新日期:1994-04-01 00:00:00

  • The severity of breathlessness during challenges with inhaled methacholine and hypertonic saline in atopic asthmatic subjects. The relationship with deep breath-induced bronchodilation.

    abstract::The severity of breathlessness at given degrees of airway obstruction varies between patients with asthma. It has been postulated that the symptoms during bronchoconstriction are determined in part by involvement of airway inflammation. We compared the severity of breathlessness at various degrees of acute airway obst...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1164/ajrccm.152.1.7599850

    authors: Sont JK,Booms P,Bel EH,Vandenbroucke JP,Sterk PJ

    更新日期:1995-07-01 00:00:00