听力与言语-语言病理学

行为科学

医学伦理学

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  • Toward an Integrated View of Operational Tolerance in Human Renal Transplantation: A Systems Biology Perspective.

    abstract::Operational tolerance (OT) is the phenomenon occurring in human renal and liver transplantation in which the body does not reject the organ after discontinuing immunosuppression for at least a year. We revisited the data generated by The Brazilian Multicenter Study on Operational Tolerance involving different conceptu...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章

    doi:10.1615/CritRevImmunol.2020035040

    authors: Coelho V,Cabral A,Martins F,Arcuri H,Carmona P,Moraes-Vieira PMM,Lemos F,Fonseca SG,de Faria AC,Monteiro SM,Noronha I,Saitovitch D,Nakaya H,Ferreira LRP,Kalil J

    更新日期:2020-01-01 00:00:00

  • A Coordinated Dance of Effector and Regulatory T Cells that are Reactive to Different Determinants in Autoimmune Response Orchestration.

    abstract::This article is about my amazing immunological journey for more than a decade with Eli Sercarz as an achaarya, which in Sanskrit means enlightened mentor. My training and routine interactions with colleagues not only at Eli's laboratory but at University of California at Los Angeles, La Jolla Institute for Immunology,...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章

    doi:10.1615/CritRevImmunol.2020036239

    authors: Chaturvedi VK

    更新日期:2020-01-01 00:00:00

  • The Form of an Antigen and Its Molecular Context Do Matter: Infectious versus Attenuated Plasmodium Sporozoites.

    abstract::The physicochemical properties of an antigen (Ag) influence the type, specificity, as well as duration of emerging immune responses. Like immune responses arising to nominal protein Ags, reactivities to protozoan parasites, Plasmodium falciparum and P. berghei, the causative agents of human and mouse malaria, respecti...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章

    doi:10.1615/CritRevImmunol.2020034835

    authors: Krzych U,Althubaiti N

    更新日期:2020-01-01 00:00:00

  • Role of Treg/Th17 Imbalance, Microbiota and miRNAs in Pancreatic Cancer: Therapeutic Options.

    abstract::Pancreatic cancer is one of the most lethal kinds of cancer; numerous patients die from it every year all over the word. Fewer than 5% of people with pancreatic cancer survive death and recover. Recent evidence suggests that inflammation parameters, such as Th17 cells and Tregs, affect the progression and even the dia...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/CritRevImmunol.2020033631

    authors: Fu LQ,Yang X,Cai MH,Yao JY,Jin WW,Mou YP,Ma YY

    更新日期:2020-01-01 00:00:00

  • Beta-Adrenergic Signaling in Tumor Immunology and Immunotherapy.

    abstract::Communication between the nervous and immune systems is required for the body to regulate physiological homeostasis. Beta-adrenergic receptors expressed on immune cells mediate the modulation of immune response by neural activity. Activation of beta-adrenergic signaling results in suppression of antitumor immune respo...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/CritRevImmunol.2019031188

    authors: Wang W,Cao X

    更新日期:2019-01-01 00:00:00

  • The Human Immune System against Staphylococcus epidermidis.

    abstract::Staphylococcus epidermidis is one of the major causes of nosocomial infections in humans. This organism can exist as a commensal on the skin. However, it can also lead to severe infections. The immune system has evolved mechanisms to deal with microorganisms and has strategies to combat bacteria. The initial defense a...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/CritRevImmunol.2019031282

    authors: Rasoul M,Rokhsareh M,Mohammad SM,Sajad K,Ahmadreza M

    更新日期:2019-01-01 00:00:00

  • Pattern Recognition Receptors and Liver Failure.

    abstract::Liver failure is a clinical syndrome with many causes, a complicated pathogenesis, diverse clinical manifestations, and very high mortality. No effective treatment is yet available. Main pathological processes of liver failure include direct damage to parenchymal and nonparenchymal liver cells that might be caused by ...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/CritRevImmunol.2019031012

    authors: Wu J,Han M,Li J,Yang X,Zhen X,Schlaak JF,Yang D,Lu M

    更新日期:2019-01-01 00:00:00

  • Strategies to enhance NK cell function for the treatment of tumors and infections.

    abstract::Natural killer (NK) cells are innate immune cells equipped with the ability to rapidly kill stressed cells that are neoplastic or virally infected. These cells are especially important in settings where these stressed cells downregulate MHC class I molecules and evade recognition by cytotoxic T cells. However, the act...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/CritRevImmunol.2018025248

    authors: Freund-Brown J,Chirino L,Kambayashi T

    更新日期:2018-01-01 00:00:00

  • IL-33 in Tumor Immunity: Nothing to Sneeze At.

    abstract::Although immunotherapy has been at the forefront of cancer therapy for the last several years, better clinical responses are still desired. Interleukin-33 is perhaps one of the most overlooked antitumor cytokines. Its ability to promote type 1 immune responses, which control tumor growth in preclinical animal models i...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/CritRevImmunol.2018026335

    authors: Dominguez D,Zhang Y,Zhang B

    更新日期:2018-01-01 00:00:00

  • Roles of Steroid Receptor Coactivator 3 in Host Defense Against Bacterial Pathogens.

    abstract::Steroid receptor coactivator 3 (SRC-3) is a transcriptional coactivator that interacts with nuclear receptors such as the estrogen receptor and the androgen receptor and several other transcription factors to enhance their effects on target gene expression. SRC-3 plays important roles in many developmental, physiologi...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/CritRevImmunol.2018026300

    authors: Chen W,Mo P,Yu C

    更新日期:2018-01-01 00:00:00

  • Functions of IL-4 and Control of Its Expression.

    abstract::IL-4 has been called the "prototypic immunoregulatory cytokine." Like many cytokines, it can affect a variety of target cells in multiple ways. IL-4 has an important role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. It is produced only by a subset...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/CritRevImmunol.v37.i2-6.30

    authors: Brown MA,Hural J

    更新日期:2017-01-01 00:00:00

  • T Cell Activation Pathways: B7, LFA-3, and ICAM-1 Shape Unique T Cell Profiles.

    abstract::Two signals are required for induction of cell proliferation and cytokine production in resting T cells. Occupancy of the T cell receptor by antigen/MHC complexes delivers the first signal to the T cell, while the second signal is provided by interaction with costimulatory ligands on APC. CD2, LFA-1, and CD28 are the ...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/CritRevImmunol.v37.i2-6.130

    authors: Wingren AG,Parra E,Varga M,Kalland T,Sjogren HO,Hedlund G,Dohlsten M

    更新日期:2017-01-01 00:00:00

  • Role in Allergic Diseases of Immunological Cross-Reactivity between Allergens and Homologues of Parasite Proteins.

    abstract::Implied under the rubric of the hygiene hypothesis is that helminth infection can protect against allergic disease. It is well known that helminths induce processes associated with type 2 immune responses, but they also induce important regulatory responses that can modulate these type 2-associated responses-modulatio...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/CritRevImmunol.2016016545

    authors: Santiago Hda C,Nutman TB

    更新日期:2016-01-01 00:00:00

  • Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks.

    abstract::Ribosomal proteins have long been known to serve critical roles in facilitating the biogenesis of the ribosome and its ability to synthesize proteins. However, evidence is emerging that suggests ribosomal proteins are also capable of performing tissue-restricted, regulatory functions that impact normal development and...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v35.i5.30

    authors: Fahl SP,Wang M,Zhang Y,Duc AC,Wiest DL

    更新日期:2015-01-01 00:00:00

  • Role of LAT1 in the promotion of amino acid incorporation in activated T cells.

    abstract::Intake of nutrients from the environment is fundamental to cellular activity. The requirement of nutrients depends on the situation in which cells are placed. Activation of T cells changes the structure and scale of cellular metabolism, which requires a large amount of nutrients. Hydrophilic nutrients such as glucose ...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.2014011872

    authors: Hayashi K,Anzai N

    更新日期:2014-01-01 00:00:00

  • T-cell immunity to influenza A viruses.

    abstract::Influenza infection remains a global threat to human health. Influenza viruses are normally controlled by antibodies specific for the surface glycoproteins hemagglutinin (HA) and neuraminidase (NA). Standard influenza vaccines are aimed at inducing these antibodies, but they must be administered annually and can be re...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.2013010019

    authors: Grant EJ,Chen L,Quiñones-Parra S,Pang K,Kedzierska K,Chen W

    更新日期:2014-01-01 00:00:00

  • Tumor plasticity interferes with anti-tumor immunity.

    abstract::Since tumor cell plasticity was first shown to be crucial in tumor promotion and immune surveillance evasion, it has become an issue of intense investigation. Several mechanisms are associated with the acquisition of tumor cell plasticity and immune evasion, including loss of epithelial phenotype through epithelial-to...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.2014010183

    authors: Chouaib S,Janji B,Tittarelli A,Eggermont A,Thiery JP

    更新日期:2014-01-01 00:00:00

  • The role of polyunsaturated ω-3 fatty acid eicosapentaenoic acid-derived resolvin E1 (RvE1) in bone preservation.

    abstract::Resolvin E1 (RvE1) is a recently discovered lipid-derived mediator that is endogenously synthesized from the polyunsaturated fatty acid eicosapentaenoic acid. RvE1 is locally generated in response to inflammation where it enhances the resolution phase of inflammation by diminishing neutrophil chemotaxis and by enhanci...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.2014009982

    authors: Gyurko R,Van Dyke TE

    更新日期:2014-01-01 00:00:00

  • CD40 signaling to the rescue: A CD8 exhaustion perspective in chronic infectious diseases.

    abstract::Chronic infectious diseases such as HIV, HBV, and HCV, among others, cause severe morbidity and mortality globally. Progressive decline in CD8 functionality, survival, and proliferative potential-a phenomenon referred to as CD8 exhaustion-is believed to be responsible for poor pathogen control in chronic infectious di...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章

    doi:10.1615/critrevimmunol.2013007444

    authors: Bhadra R,Cobb DA,Khan IA

    更新日期:2013-01-01 00:00:00

  • The immune system in the pathogenesis of ovarian cancer.

    abstract::Clinical outcomes in ovarian cancer are heterogeneous even when considering common features such as stage, response to therapy, and grade. This disparity in outcomes warrants further exploration into tumor and host characteristics. One compelling host characteristic is the immune response to ovarian cancer. While seve...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.2013006813

    authors: Charbonneau B,Goode EL,Kalli KR,Knutson KL,Derycke MS

    更新日期:2013-01-01 00:00:00

  • Antigen-specific tolerance in immunotherapy of Th2-associated allergic diseases.

    abstract::Allergic diseases are an increasing health concern, particularly in the developed world. The standard clinical approach to treatment of allergic disease focuses on allergen avoidance and symptom control but does little to address the underlying Th2 bias of disease. Specific immunotherapy (SIT) consisting of controlled...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.2013007046

    authors: Smarr CB,Bryce PJ,Miller SD

    更新日期:2013-01-01 00:00:00

  • Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens.

    abstract::Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolytic activity against tumor cells, and CD4 T cells mount a variety of re...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v32.i2.10

    authors: Caserta S,Borger JG,Zamoyska R

    更新日期:2012-01-01 00:00:00

  • Cross-reactivity of T cells and its role in the immune system.

    abstract::T-cell receptors recognize peptides presented by the major histocompatibility complex (MHC) on the surface of antigen-presenting cells (APC). The ability of the T-cell receptor (TCR) to recognize more than one peptide-MHC structure defines cross-reactivity. Cross-reactivity is a documented phenomenon of the immune sys...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v32.i4.50

    authors: Petrova G,Ferrante A,Gorski J

    更新日期:2012-01-01 00:00:00

  • Regulatory T cells for tolerance therapy: revisiting the concept.

    abstract::The discovery of regulatory T cells (Tregs) as a crucial component of peripheral down-regulation of immunity to self and allogeneic antigens has raised legitimate hope for the development of Treg-based clinical protocols for tolerance to allografts. The present review addresses the question of whether therapeutic Treg...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v31.i3.20

    authors: Leguern C

    更新日期:2011-01-01 00:00:00

  • Expression and immune function of tenascin-C.

    abstract::Our immune system is designed to protect us from danger. Upon pathogen invasion and tissue injury, activation of both innate and adaptive immunity enables us to combat infection and to repair tissue damage. Tenascin-C is a large, extracellular matrix glycoprotein that has a very tightly controlled pattern of expressio...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v31.i2.30

    authors: Udalova IA,Ruhmann M,Thomson SJ,Midwood KS

    更新日期:2011-01-01 00:00:00

  • Regulation of NK cell repertoire and function in the liver.

    abstract::NK cells represent a large proportion of the lymphocyte population in the liver and are involved in early innate immunity to pathogen infection. As a result of liver endothelial cell fenestrations, parenchymal cells are not separated by a basal membrane, and thereby pathogen-infected hepatocytes are extensively capabl...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v31.i1.40

    authors: Krueger PD,Lassen MG,Qiao H,Hahn YS

    更新日期:2011-01-01 00:00:00

  • Induction of cytokines and chemokines by Toll-like receptor signaling: strategies for control of inflammation.

    abstract::Recognition of the pathogen-associated molecular pattern (PAMP) by host Toll-like receptors (TLR) is an important component of the innate immune response for countering against invading viruses, bacteria, and fungi. Upon PAMP recognition, the TLR induces intracellular signaling cascades that involve adapter, signaloso...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v30.i1.40

    authors: Zeytun A,Chaudhary A,Pardington P,Cary R,Gupta G

    更新日期:2010-01-01 00:00:00

  • Biomarkers for serum diagnosis of infectious diseases and their potential application in novel sensor platforms.

    abstract::Nanotechnological tools and biomarkers for diagnosis and prognosis, as well as strategies for disease control and monitoring populations at higher risk, are continuous worldwide challenges for infectious diseases. Phage display and monoclonal antibody combinatorial libraries are important sources for biomarker discove...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v30.i2.70

    authors: Goulart LR,Vieira CU,Freschi AP,Capparelli FE,Fujimura PT,Almeida JF,Ferreira LF,Goulart IM,Brito-Madurro AG,Madurro JM

    更新日期:2010-01-01 00:00:00

  • Function of neurotrophic factors beyond the nervous system: inflammation and autoimmune demyelination.

    abstract::In the nervous system, neurotrophic factors play a role during development, especially for the differentiation of neuronal and glial cells. Moreover, they promote cell survival of neurons, axons, and oligodendrocytes, as well as their precursors, in vitro and in lesional paradigms. In recent years, several functions o...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v29.i1.20

    authors: Linker R,Gold R,Luhder F

    更新日期:2009-01-01 00:00:00

  • Regulation of airway innate and adaptive immune responses: the IL-17 paradigm.

    abstract::IL-17 is a proinflammatory cytokine produced by immune cells. Its significance in host defense and disease development has been demonstrated in various infection and autoimmune models. Recently, additional studies have shown that IL-17 is also important in modulating airway immune response in several aspects. Along wi...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v28.i4.10

    authors: Hung LY,Velichko S,Huang F,Thai P,Wu R

    更新日期:2008-01-01 00:00:00

  • Novel functions of B cells.

    abstract::T cells clearly help B cells to produce antibodies and acquire memory. Recently, B cells were found to support some T-cell responses through antigen presentation, and perhaps more importantly, through the generation of diverse T cells and lymphoid organogenesis. These new findings show that the development and functio...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v27.i2.20

    authors: Cascalho M,Platt JL

    更新日期:2007-01-01 00:00:00

  • Fungal capsular polysaccharide and T-cell suppression: the hidden nature of poor immunogenicity.

    abstract::Many capsular polysaccharide antigens are generally considered to be classic T-cell independent antigens that stimulate humoral response. This response is poor and short lived due to the absence of T-cell involvement. Recent emerging evidence suggests that fungal capsular polysaccharides may negatively affect T-cell r...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v27.i6.50

    authors: Vecchiarelli A

    更新日期:2007-01-01 00:00:00

  • Alpha-cobratoxin as a possible therapy for multiple sclerosis: a review of the literature leading to its development for this application.

    abstract::The use of snake venom in the treatment of multiple sclerosis has been, at best, controversial. The anecdotal reports for snake venom's beneficial effects in this condition may be supportable now by recent scientific evidence. Cobratoxin, a neurotoxin obtained from the venom of the Thailand cobra, has demonstrated sev...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v27.i4.10

    authors: Reid PF

    更新日期:2007-01-01 00:00:00

  • Peptide mimotopes as prototypic templates of broad-spectrum surrogates of carbohydrate antigens for cancer vaccination.

    abstract::Mechanisms of broad cross-protection, as seen in viral infection and also applied to vaccines, emphasize preexisting antibodies, CD8+ memory T cells, and accelerated B-cell responses reactive with conserved regions in antigens. Another practical application to induce broad-spectrum responses is making use of multispec...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v27.i3.50

    authors: Pashov A,Monzavi-Karbassi B,Raghava G,Kieber-Emmons T

    更新日期:2007-01-01 00:00:00

  • Caspase function and the immune system.

    abstract::Caspases are key effector components of apoptosis, the process of programmed cell death. However, a large body of recent work has shown that caspase activity is necessary for several nonapoptotic cellular functions, such as proliferation, differentiation, survival, and the regulation of cytokine expression. In this re...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v26.i2.30

    authors: Sehra S,Dent AL

    更新日期:2006-01-01 00:00:00

  • The proteasome and its inhibitors in immune regulation and immune disorders.

    abstract::The ubiquitin-proteasome pathway is a well-characterized mechanism deputed to the degradation of intracellular proteins. Proteasomal degradation intervenes in the regulation of numerous cellular functions including signal transduction, apoptosis, cell cycle, and antigen presentation. In vitro and in vivo studies have ...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v26.i6.20

    authors: Nencioni A,Grunebach F,Patrone F,Ballestrero A,Brossart P

    更新日期:2006-01-01 00:00:00

  • Mechanisms regulating lymphocytic infiltration of the thyroid in murine models of thyroiditis.

    abstract::The autoimmune diseases of the thyroid are the most prevalent autoimmune diseases in man. In these diseases, the thyroid is invariably infiltrated by lymphocytes, which play a major role in pathogenesis. In this review, we discuss the mechanisms associated with lymphocytic infiltration of the thyroid, examining differ...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v25.i4.10

    authors: Lira SA,Martin AP,Marinkovic T,Furtado GC

    更新日期:2005-01-01 00:00:00

  • Dendritic epidermal T-cell activation.

    abstract::Although gammadelta T cells compose a small proportion of lymphocytes in lymphoid compartments and peripheral blood, they are the major T-cell population present in epithelial tissues. However, the role played by gammadelta TCR expressing intraepithelial lymphocytes (IEL) has been enigmatic. The location of tissue-res...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v25.i1.10

    authors: Sharp LL,Jameson JM,Witherden DA,Komori HK,Havran WL

    更新日期:2005-01-01 00:00:00

  • Mechanisms of transcriptional regulation of the human IL-3/GM-CSF locus by inducible tissue-specific promoters and enhancers.

    abstract::The IL-3 and GM-CSF genes are closely linked in the genome and reside within a cluster of cytokine genes. IL-3 and GM-CSF are expressed in a highly inducible and tissue-specific pattern, and this review attempts to provide a comprehensive description of the key regulatory elements in this locus that control their expr...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v24.i6.10

    authors: Cockerill PN

    更新日期:2004-01-01 00:00:00

  • Acquisition of MHC-specific receptors on murine natural killer cells.

    abstract::NK cells in adult mice express two families of MHC class I-specific receptors, namely, Ly49 and CD94/NKG2. Co-expression of these receptors in various combinations generates diverse receptor repertoires. The expression of individual receptors is mostly stochastic and independent of each other. NK cells acquire the rec...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审

    doi:10.1615/critrevimmunol.v23.i4.10

    authors: Veinotte LL,Wilhelm BT,Mager DL,Takei F

    更新日期:2003-01-01 00:00:00

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