abstract：:The available biomonitoring studies on workers producing/handling nanomaterials (NMs) focused on potential effects on respiratory, immune and cardio-vascular system. Aim of this study was to identify a panel of sensitive biomarkers and suitable biological matrices to evaluate particularly genotoxic and oxidative effec...

journal_title：Nanotoxicology

authors： Ursini CL,Fresegna AM,Ciervo A,Maiello R,Del Frate V,Folesani G,Galetti M,Poli D,Buresti G,Di Cristo L,Sabella S,Iavicoli S,Cavallo D

更新日期：2020-12-29 00:00:00

abstract：:Nanodiamonds have been suggested as biocompatible materials and are suitable for various biomedical applications, but little is known about how to synthesize safer nanodiamonds. Herein, seven different detonation-synthesized nanodiamonds (DNDs) with sequential sp3/sp2 carbon ratios were assembled by controlling the ch...

journal_title：Nanotoxicology

authors： Lee DK,Ha S,Jeon S,Jeong J,Kim DJ,Lee SW,Cho WS

更新日期：2020-11-01 00:00:00

abstract：:Dose-response by in vitro testing is only valid if the fraction of the particle dose that deposits onto adherent cells is known. Modeling tools such as the 'distorted grid' (DG) code are common practices to predict that fraction. As another challenge, workflow efficiency depends on parallelized sample preparation, for...

journal_title：Nanotoxicology

authors： Keller JG,Quevedo DF,Faccani L,Costa AL,Landsiedel R,Werle K,Wohlleben W

更新日期：2020-10-26 00:00:00

abstract：:Multi-walled carbon nanotubes (MWCNTs) are one of the most widely used types of novel nano-fiber materials. The aim of this study was to establish an experimental system based on actual exposure dosage and environments and explore the roles and mechanisms of inflammation in the malignant transformation of pleural meso...

journal_title：Nanotoxicology

authors： Huang X,Tian Y,Shi W,Chen J,Yan L,Ren L,Zhang X,Zhu J

更新日期：2020-09-01 00:00:00

abstract：:Nanoscale titanium dioxide (TiO2) is manufactured in wide scale, with a range of applications in consumer products. Significant toxicity of TiO2 nanoparticles has, however, been recognized, suggesting considerable risk to human health. To evaluate fully their toxicity, assessment of the epigenetic action of these nano...

journal_title：Nanotoxicology

authors： Pogribna M,Koonce NA,Mathew A,Word B,Patri AK,Lyn-Cook B,Hammons G

更新日期：2020-05-01 00:00:00

abstract：:No detailed information on in vivo biokinetics of CeO2 nanoparticles (NPs) following chronic low-dose inhalation is available. The CeO2 burden for lung, lung-associated lymph nodes, and major non-pulmonary organs, blood, and feces, was determined in a chronic whole-body inhalation study in female Wistar rats undertake...

journal_title：Nanotoxicology

authors： Tentschert J,Laux P,Jungnickel H,Brunner J,Estrela-Lopis I,Merker C,Meijer J,Ernst H,Ma-Hock L,Keller J,Landsiedel R,Luch A

更新日期：2020-05-01 00:00:00

abstract：:We systematically investigated how the combinations of size, shape and the natural organic matter (NOM)-ecocorona of gold (Au) engineered nanoparticles (ENPs) influence the attachment of the particles to algae and physical toxicity to the cells. Spherical (10, 60 and 100 nm), urchin-shaped (60 nm), rod-shaped (10 × 45...

journal_title：Nanotoxicology

authors： Abdolahpur Monikh F,Arenas-Lago D,Porcal P,Grillo R,Zhang P,Guo Z,Vijver MG,J G M Peijnenburg W

更新日期：2020-04-01 00:00:00

abstract：:Iron nanoparticles (NPs) have been proposed as a tool in very different fields such as environmental remediation and biomedical applications, including food fortification against iron deficiency, even if there is still concern about their safety. Here, we propose Xenopus laevis embryos as a suitable model to investiga...

journal_title：Nanotoxicology

authors： Bonfanti P,Colombo A,Saibene M,Fiandra L,Armenia I,Gamberoni F,Gornati R,Bernardini G,Mantecca P

更新日期：2020-03-01 00:00:00

abstract：:Although the production of engineered nanoparticles increases our knowledge of toxicity and mechanisms of bioactivity during relevant exposures is lacking. In the present study mice were exposed to PbO nanoparticles (PbONP; 192.5 µg/m3; 1.93 × 106 particles/cm3) for 2, 5 and 13 weeks through continuous inhalation. The...

journal_title：Nanotoxicology

authors： Bláhová L,Nováková Z,Večeřa Z,Vrlíková L,Dočekal B,Dumková J,Křůmal K,Mikuška P,Buchtová M,Hampl A,Hilscherová K,Bláha L

更新日期：2020-03-01 00:00:00

abstract：:Lung deposition and retention measurements are now required by the newly revised OECD inhalation toxicity testing guidelines 412 and 413 when evaluating the clearance and biopersistence of poorly soluble nanomaterials, such as multi-walled carbon nanotubes (MWCNTs). However, evaluating the lung deposition concentratio...

journal_title：Nanotoxicology

authors： Kim JK,Jo MS,Kim Y,Kim TG,Shin JH,Kim BW,Kim HP,Lee HK,Kim HS,Ahn K,Oh SM,Cho WS,Yu IJ

更新日期：2020-03-01 00:00:00

abstract：:Suspensions of the UV filter, zinc oxide nanoparticles (ZnO NP), are widely used in sunscreen products. This paper compared the relative disposition and local cytotoxicity of ZnO NP, and zinc ions formed on its dissolution, against keratinocyte cultures and in the human epidermis (ex vivo) after application of suspens...

journal_title：Nanotoxicology

authors： Holmes AM,Mackenzie L,Roberts MS

更新日期：2020-03-01 00:00:00

abstract：:Copper oxide nanoparticles (CuO NPs) have severe nano-toxic effects on organisms. Limited data is available on influence of CuO NPs on plant cells. Here, the molecular mechanisms involved in the toxicity of CuO NPs are studied. Exposure to CuO NPs significantly increased copper content in roots (0.062-0.325 mg/g FW), ...

journal_title：Nanotoxicology

authors： Jia H,Chen S,Wang X,Shi C,Liu K,Zhang S,Li J

更新日期：2020-02-01 00:00:00

abstract：:Foodborne nanoparticles (NPs) refer to the nanostructures generated during food processing, rather than the man-made nano-structural additives that are added to improve the property of food. In this research, discovery of fluorescent NPs in roasted pork was reported at different temperature of 180, 230, and 280 °C. Th...

journal_title：Nanotoxicology

authors： Zhao X,Shan S,Li J,Cao L,Lv J,Tan M

更新日期：2019-12-01 00:00:00

abstract：:The spread of antibiotic resistance genes (ARGs) has become a global environmental issue; it has been found that nanoparticles (NPs) can promote the transfer of ARGs between bacteria. However, it remains unclear whether NPs can affect this kind of conjugation in Streptomyces, which mainly conjugate with other bacteria...

journal_title：Nanotoxicology

authors： Liu X,Tang J,Song B,Zhen M,Wang L,Giesy JP

更新日期：2019-12-01 00:00:00

abstract：:Uptake of polydispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs) in resting and LPS-activated B cells was studied using fluorescence-tagged AF-SWCNTs (FAF-SWCNTs). Activated B cells internalized substantially higher amounts of FAF-SWCNTs [76.5% AF-SWCNT+ B cells, mean fluorescence intensity (MFI)...

journal_title：Nanotoxicology

authors： Dutt TS,Mia MB,Saxena RK

更新日期：2019-08-01 00:00:00

abstract：:The fiber-like shape of multi-walled carbon nanotubes (MWCNTs) is reminiscent of asbestos, suggesting they pose similar health hazards when inhaled, including pulmonary fibrosis and mesothelioma. Mice deficient in the tumor suppressor p53 are susceptible to carcinogenesis. However, the chronic pathologic effect of MWC...

journal_title：Nanotoxicology

authors： Duke KS,Thompson EA,Ihrie MD,Taylor-Just AJ,Ash EA,Shipkowski KA,Hall JR,Tokarz DA,Cesta MF,Hubbs AF,Porter DW,Sargent LM,Bonner JC

更新日期：2018-11-01 00:00:00

abstract：:Boron and boron nitride nanotubes (BNNTs) are increasingly used in different industrial fields and, potentially, in some biomedical areas. As occurs with other nanomaterials (NMs), to increase our knowledge on their potential health hazards is a priority. Although in vitro approaches are a routine in getting biologica...

journal_title：Nanotoxicology

authors： Demir E,Marcos R

更新日期：2018-10-01 00:00:00

abstract：:The biological fate of nanoparticles (NPs) taken up by organisms from their environment is a crucial issue for assessing ecological hazard. Despite its importance, it has scarcely been addressed due to the technical difficulties of doing so in whole organism in vivo studies. Here, by using transmission electron micros...

journal_title：Nanotoxicology

authors： Noventa S,Hacker C,Correia A,Drago C,Galloway T

更新日期：2018-10-01 00:00:00

abstract：:Passion fruit-like nano-architectures (NAs) are all-in-one platforms of increasing interest for the translation of metal nanoparticles into clinics. NAs are nature-inspired disassembling inorganic theranostics, which jointly combine most of the appealing behaviors of noble metal nanoparticles with their potential orga...

journal_title：Nanotoxicology

authors： d'Amora M,Cassano D,Pocoví-Martínez S,Giordani S,Voliani V

更新日期：2018-10-01 00:00:00

abstract：:Glycodendrimers (Glyco-DDMs) represent a rapidly growing class of nanoparticles with promising properties for biomedical applications but concerns regarding the impact on human health and environment are still justified. Here we report, for the first time, the comparative study of in vivo developmental toxicity of car...

journal_title：Nanotoxicology

authors： Liegertová M,Wrobel D,Herma R,Müllerová M,Šťastná LČ,Cuřínová P,Strašák T,Malý M,Čermák J,Smejkal J,Štofik M,Maly J

更新日期：2018-10-01 00:00:00

abstract：:Understanding the relationship between adverse exposure events and specific material properties will facilitate predictive classification of carbon nanotubes (CNTs) according to their mechanisms of action, and a safe-by-design approach for the next generation of CNTs. Mass-spectrometry-based proteomics is a reliable t...

journal_title：Nanotoxicology

authors： Ndika JDT,Sund J,Alenius H,Puustinen A

更新日期：2018-08-01 00:00:00

abstract：:Upon inhalation, multi-walled carbon nanotubes (MWCNTs) may reach the subpleura and pleural spaces, and induce pleural inflammation and/or mesothelioma in humans. However, the mechanisms of MWCNT-induced pathology after direct intrapleural injections are still only partly elucidated. In particular, a role of the proin...

journal_title：Nanotoxicology

authors： Arnoldussen YJ,Skaug V,Aleksandersen M,Ropstad E,Anmarkrud KH,Einarsdottir E,Chin-Lin F,Granum Bjørklund C,Kasem M,Eilertsen E,Apte RN,Zienolddiny S

更新日期：2018-08-01 00:00:00

abstract：:Copper nanoparticles (Cu NPs) have various uses, including as additives in polymers/plastics, lubricants for metallic coating, and biomedical applications. We investigated the role of transforming growth factor (TGF)-β1 signaling in hepatic damage caused by Cu NPs and explored the effects of a 28-day repeated oral adm...

journal_title：Nanotoxicology

authors： Lee IC,Ko JW,Park SH,Shin NR,Shin IS,Moon C,Kim SH,Yun WK,Kim HC,Kim JC

更新日期：2018-08-01 00:00:00

abstract：:A thorough understanding of nanoparticle bio-distribution at the feto-maternal interface will be a prerequisite for their diagnostic or therapeutic application in women of childbearing age and for teratologic risk assessment. Therefore, the tissue interaction of biocompatible dendritic polyglycerol nanoparticles (dPG-...

journal_title：Nanotoxicology

authors： Juch H,Nikitina L,Reimann S,Gauster M,Dohr G,Obermayer-Pietsch B,Hoch D,Kornmueller K,Haag R

更新日期：2018-03-01 00:00:00

abstract：:Nanotechnology offers innovation in products from cosmetics to drug delivery, leading to increased engineered nanomaterial (ENM) exposure. Unfortunately, health impacts of ENM are not fully realized. Titanium dioxide (TiO2) is among the most widely produced ENM due to its use in numerous applications. Extrapulmonary e...

journal_title：Nanotoxicology

authors： Nichols CE,Shepherd DL,Hathaway QA,Durr AJ,Thapa D,Abukabda A,Yi J,Nurkiewicz TR,Hollander JM

更新日期：2018-02-01 00:00:00

abstract：:Foodborne nanoparticles (NPs) have drawn great attention due to human health concerns. This study reports the detection of the presence of fluorescent NPs, about 5 nm, in two of the most popular beverages, Coca-Cola (Coke) and Pepsi-Cola (Pepsi). The NPs contain H, C and O, three elements with a tunable emission and w...

journal_title：Nanotoxicology

authors： Li S,Jiang C,Wang H,Cong S,Tan M

更新日期：2018-02-01 00:00:00

abstract：:Titanium dioxide nanoparticles (TiO2 NPs) have shown great adsorption capacity for arsenic (As); however, the potential impact of TiO2 NPs on the behavior and toxic responses of As remains largely unexplored. In the present study, we focused on the physicochemical interaction between TiO2 NPs and As(III) to clarify th...

journal_title：Nanotoxicology

authors： Wang X,Liu Y,Wang J,Nie Y,Chen S,Hei TK,Deng Z,Wu L,Zhao G,Xu A

更新日期：2017-10-01 00:00:00

abstract：:The whitening and opacifying properties of titanium dioxide (TiO2) are commonly exploited when it is used as a food additive (E171). However, the safety of this additive can be questioned as TiO2 nanoparticles (TiO2-NPs) have been classed at potentially toxic. This study aimed to shed some light on the mechanisms behi...

journal_title：Nanotoxicology

authors： Dorier M,Béal D,Marie-Desvergne C,Dubosson M,Barreau F,Houdeau E,Herlin-Boime N,Carriere M

更新日期：2017-08-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials. Following oral exposure, AgNPs can accumulate in various organs including kidneys where they show gender specific accumulation. There is limited information on their effect on renal system following long-term animal exposure especially at the ...

journal_title：Nanotoxicology

authors： Tiwari R,Singh RD,Khan H,Gangopadhyay S,Mittal S,Singh V,Arjaria N,Shankar J,Roy SK,Singh D,Srivastava V

更新日期：2017-06-01 00:00:00

abstract：:Titanium-dioxide nanoparticles (TiO2-NPs) are increasingly released in agricultural soils through, e.g. biosolids, irrigation or nanoagrochemicals. Soils are submitted to a wide range of concentrations of TiO2-NPs depending on the type of exposure. However, most studies have assessed the effects of unrealistically hig...

journal_title：Nanotoxicology

authors： Simonin M,Martins JM,Le Roux X,Uzu G,Calas A,Richaume A

更新日期：2017-03-01 00:00:00

abstract：:Here, we present evidence on complete transformation of ZnO and CuO nanoparticles, which are among the most heavily studied metal oxide particles, during 24 h in vitro toxicological testing with human T-lymphocytes. Synchrotron radiation-based X-ray absorption near edge structure (XANES) spectroscopy results revealed ...

journal_title：Nanotoxicology

authors： Ivask A,Scheckel KG,Kapruwan P,Stone V,Yin H,Voelcker NH,Lombi E

更新日期：2017-03-01 00:00:00

abstract：:Engineered nanoparticles are increasingly discharged into the environment. After discharge, these nanoparticles can interact with co-existing organic contaminants, resulting in a phenomena referred to as 'joint toxicity'. This study evaluated joint toxicities of TiO2 nanoparticles (TiO2NPs) with four different (atrazi...

journal_title：Nanotoxicology

authors： Zhang S,Deng R,Lin D,Wu F

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The enormous physicochemical and structural diversity of metal oxide nanoparticles (MeONPs) poses significant challenges to the testing of their biological uptake, biodistribution, and effects that can be used to develop understanding of key nano-bio modes of action. This has generated considerable uncertain...

journal_title：Nanotoxicology

authors： Mu Y,Wu F,Zhao Q,Ji R,Qie Y,Zhou Y,Hu Y,Pang C,Hristozov D,Giesy JP,Xing B

更新日期：2016-11-01 00:00:00

abstract：:Nanowires (NWs) have unique electrical and optical properties of value for many applications including lighting, sensing, and energy harnessing. Consumer products containing NWs increase the risk of NWs being released in the environment, especially into aquatic ecosystems through sewage systems. Daphnia magna is a com...

journal_title：Nanotoxicology

authors： Mattsson K,Adolfsson K,Ekvall MT,Borgström MT,Linse S,Hansson LA,Cedervall T,Prinz CN

更新日期：2016-10-01 00:00:00

abstract：:Graphene, a two-dimensional engineered nanomaterial, is now being used in many applications, such as electronics, biological engineering, filtration, lightweight and strong nanocomposite materials, and energy storage. However, there is a lack of information on the potential health effects of graphene in humans based o...

journal_title：Nanotoxicology

authors： Kim JK,Shin JH,Lee JS,Hwang JH,Lee JH,Baek JE,Kim TG,Kim BW,Kim JS,Lee GH,Ahn K,Han SG,Bello D,Yu IJ

更新日期：2016-09-01 00:00:00

abstract：:The number of engineered nanomaterials (ENMs) being exploited commercially is growing rapidly, due to the novel properties they exhibit. Clearly, it is important to understand and minimize any risks to health or the environment posed by the presence of ENMs. Data-driven models that decode the relationships between the...

journal_title：Nanotoxicology

authors： Oksel C,Winkler DA,Ma CY,Wilkins T,Wang XZ

更新日期：2016-09-01 00:00:00

abstract：:With the increased production and widespread commercial use of silver nanoparticles (AgNPs), human and environmental exposures to silver nanoparticles are inevitably increasing. In particular, persons manufacturing and handling silver nanoparticles and silver nanoparticle containing products are at risk of exposure, p...

journal_title：Nanotoxicology

authors： Weldon BA,M Faustman E,Oberdörster G,Workman T,Griffith WC,Kneuer C,Yu IJ

更新日期：2016-09-01 00:00:00

abstract：:Multifunctional nanomaterials are rapidly emerging for ophthalmic delivery of therapeutics to facilitate safe and effective targeting with improved patient compliance. Because of their extremely high area to volume ratio, nanomaterials often have physicochemical properties that are different from those of their larger...

journal_title：Nanotoxicology

authors： Mehra NK,Cai D,Kuo L,Hein T,Palakurthi S

更新日期：2016-09-01 00:00:00

abstract：:Metal oxide nanoparticles are highly reactive from the biological point of view and, for this reason, it exists important reservations in regard human health impact. We used Drosophila as a promising in vivo model to diagnose the biological effects of copper oxide nanoparticles (CuO-NPs). Due to the potential role of ...

journal_title：Nanotoxicology

authors： Alaraby M,Hernández A,Marcos R

更新日期：2016-08-01 00:00:00

abstract：:The rapid proliferation of silver nanoparticles (AgNP) in industry and the environment requires realistic toxicity assessments based on approaches that consider the biological complexity of ecosystems. Here we assessed the acute toxicity of carbonate-coated AgNP and, for comparison, AgNO3 (Ag(+)) by using a model syst...

journal_title：Nanotoxicology

authors： Tlili A,Cornut J,Behra R,Gil-Allué C,Gessner MO

更新日期：2016-08-01 00:00:00