Abstract:
:Suspensions of the UV filter, zinc oxide nanoparticles (ZnO NP), are widely used in sunscreen products. This paper compared the relative disposition and local cytotoxicity of ZnO NP, and zinc ions formed on its dissolution, against keratinocyte cultures and in the human epidermis (ex vivo) after application of suspensions of ZnO NP. HaCaT keratinocyte cytotoxicities were found to be related to labile intra-cellular zinc but also total zinc and extra-cellular concentrations in cell culture media and to a degree ameliorated by the presence of a zinc chelating agent. Secondly, the zinc species were then dosed onto exposed ex vivo viable human epidermis and it was found that an increase in labile zinc level correlated with a shift in the metabolic state of the viable epidermis. This study highlights that excised viable skin acts as a more relevant model for determining cutaneous toxicity over keratinocyte monolayers in vitro.
journal_name
Nanotoxicologyjournal_title
Nanotoxicologyauthors
Holmes AM,Mackenzie L,Roberts MSdoi
10.1080/17435390.2019.1692382subject
Has Abstractpub_date
2020-03-01 00:00:00pages
263-274issue
2eissn
1743-5390issn
1743-5404journal_volume
14pub_type
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