Role of inflammation in the malignant transformation of pleural mesothelial cells induced by multi-walled carbon nanotubes.

abstract：:Here, we present evidence on complete transformation of ZnO and CuO nanoparticles, which are among the most heavily studied metal oxide particles, during 24 h in vitro toxicological testing with human T-lymphocytes. Synchrotron radiation-based X-ray absorption near edge structure (XANES) spectroscopy results revealed ...

journal_title：Nanotoxicology

authors： Ivask A,Scheckel KG,Kapruwan P,Stone V,Yin H,Voelcker NH,Lombi E

更新日期：2017-03-01 00:00:00

abstract：:Upon inhalation, multi-walled carbon nanotubes (MWCNTs) may reach the subpleura and pleural spaces, and induce pleural inflammation and/or mesothelioma in humans. However, the mechanisms of MWCNT-induced pathology after direct intrapleural injections are still only partly elucidated. In particular, a role of the proin...

journal_title：Nanotoxicology

authors： Arnoldussen YJ,Skaug V,Aleksandersen M,Ropstad E,Anmarkrud KH,Einarsdottir E,Chin-Lin F,Granum Bjørklund C,Kasem M,Eilertsen E,Apte RN,Zienolddiny S

更新日期：2018-08-01 00:00:00

abstract：:Silver nanoparticles (Ag-NPs) are used in a wide variety of products, prompting concerns regarding their potential environmental impacts. To accurately determine the toxicity of Ag-NPs it is necessary to differentiate between the toxicity of the nanoparticles themselves and the toxicity of ionic silver (Ag) released f...

journal_title：Nanotoxicology

authors： Sekine R,Khurana K,Vasilev K,Lombi E,Donner E

更新日期：2015-01-01 00:00:00

abstract：:Titanium dioxide nanoparticles (TiO2 NPs) have shown great adsorption capacity for arsenic (As); however, the potential impact of TiO2 NPs on the behavior and toxic responses of As remains largely unexplored. In the present study, we focused on the physicochemical interaction between TiO2 NPs and As(III) to clarify th...

journal_title：Nanotoxicology

authors： Wang X,Liu Y,Wang J,Nie Y,Chen S,Hei TK,Deng Z,Wu L,Zhao G,Xu A

更新日期：2017-10-01 00:00:00

abstract：:Growing experimental evidences suggest the existence of direct relationships between the surface chemistry of nanomaterials and their biological effects. Herein, we have employed computational approaches to design a set of biologically active carbon nanotubes (CNTs) with controlled protein binding and cytotoxicity. Qu...

journal_title：Nanotoxicology

authors： Fourches D,Pu D,Li L,Zhou H,Mu Q,Su G,Yan B,Tropsha A

更新日期：2016-01-01 00:00:00

abstract：:Since nanomaterials are a heterogeneous group of substances used in various applications, risk assessment needs to be done on a case-by-case basis. Here the authors assess the risk (hazard and exposure) of a glass cleaner with synthetic amorphous silicon dioxide (SAS) nanoparticles during production and consumer use (...

journal_title：Nanotoxicology

authors： Michel K,Scheel J,Karsten S,Stelter N,Wind T

更新日期：2013-08-01 00:00:00

abstract：:Six TiO₂ and two CeO₂ nanomaterials with dry sizes ranging from 6-410 nm were tested for their ability to cause DNA centered free radicals in vitro in the concentration range of 10-3,000 ug/ml. All eight of the nanomaterials significantly increased the adduction of the spin trap agent 5,5-dimethyl-1-pyroline N-oxide (...

journal_title：Nanotoxicology

authors： Kitchin KT,Prasad RY,Wallace K

更新日期：2011-12-01 00:00:00

abstract：:Accumulating evidence indicates that carbon nanotubes (CNTs) are biopersistent and can cause lung damage. With similar fibrous morphology and mode of exposure to asbestos, a known human carcinogen, growing concern has arisen for elevated risk of CNT-induced lung carcinogenesis; however, relatively little is known abou...

journal_title：Nanotoxicology

authors： Wang L,Stueckle TA,Mishra A,Derk R,Meighan T,Castranova V,Rojanasakul Y

更新日期：2014-08-01 00:00:00

abstract：:ZnO nanoparticles (NPs) elicit significant adverse effects in various cell types, organisms and in the environment. The toxicity of nanoscale ZnO has often been ascribed to the release of zinc ions from the NPs but it is not yet understood to which extent these ions contribute to ZnO NP toxicity and what are the under...

journal_title：Nanotoxicology

authors： Buerki-Thurnherr T,Xiao L,Diener L,Arslan O,Hirsch C,Maeder-Althaus X,Grieder K,Wampfler B,Mathur S,Wick P,Krug HF

更新日期：2013-06-01 00:00:00

abstract：:Nanoscale titanium dioxide (TiO2) is manufactured in wide scale, with a range of applications in consumer products. Significant toxicity of TiO2 nanoparticles has, however, been recognized, suggesting considerable risk to human health. To evaluate fully their toxicity, assessment of the epigenetic action of these nano...

journal_title：Nanotoxicology

authors： Pogribna M,Koonce NA,Mathew A,Word B,Patri AK,Lyn-Cook B,Hammons G

更新日期：2020-05-01 00:00:00

abstract：:Copper oxide nanoparticles (CuO NPs) have severe nano-toxic effects on organisms. Limited data is available on influence of CuO NPs on plant cells. Here, the molecular mechanisms involved in the toxicity of CuO NPs are studied. Exposure to CuO NPs significantly increased copper content in roots (0.062-0.325 mg/g FW), ...

journal_title：Nanotoxicology

authors： Jia H,Chen S,Wang X,Shi C,Liu K,Zhang S,Li J

更新日期：2020-02-01 00:00:00

abstract：:Cellular adaptation is the dynamic response of a cell to adverse changes in its intra/extra cellular environment. The aims of this study were to investigate the role of: (i) the glutathione antioxidant system, and (ii) the transcription factor EB (TFEB), a newly revealed master regulator of lysosome biogenesis, in cel...

journal_title：Nanotoxicology

authors： Neibert KD,Maysinger D

更新日期：2012-05-01 00:00:00

abstract：:Dose-response by in vitro testing is only valid if the fraction of the particle dose that deposits onto adherent cells is known. Modeling tools such as the 'distorted grid' (DG) code are common practices to predict that fraction. As another challenge, workflow efficiency depends on parallelized sample preparation, for...

journal_title：Nanotoxicology

authors： Keller JG,Quevedo DF,Faccani L,Costa AL,Landsiedel R,Werle K,Wohlleben W

更新日期：2020-10-26 00:00:00

abstract：:The rapid proliferation of silver nanoparticles (AgNP) in industry and the environment requires realistic toxicity assessments based on approaches that consider the biological complexity of ecosystems. Here we assessed the acute toxicity of carbonate-coated AgNP and, for comparison, AgNO3 (Ag(+)) by using a model syst...

journal_title：Nanotoxicology

authors： Tlili A,Cornut J,Behra R,Gil-Allué C,Gessner MO

更新日期：2016-08-01 00:00:00

abstract：:The use of imaging tools to probe nanoparticle-cell interactions will be crucial to elucidating the mechanisms of nanoparticle-induced toxicity. Of particular interest are mechanisms associated with cell penetration, translocation and subsequent accumulation inside the cell, or in cellular compartments. The objective ...

journal_title：Nanotoxicology

authors： Tantra R,Knight A

更新日期：2011-09-01 00:00:00

abstract：:Nanoparticle (NP) uptake across the gut is poorly understood. In vitro gut sac preparations and isolated perfused intestines were used to investigate the absorption mechanism(s). Exposure of whole gut sacs to 1 mg/l TiO₂ NPs for 4 h caused total Ti metal concentrations to increase in the intestine, with 80% or more of...

journal_title：Nanotoxicology

authors： Al-Jubory AR,Handy RD

更新日期：2013-12-01 00:00:00

abstract：:Titanium-dioxide nanoparticles (TiO2-NPs) are increasingly released in agricultural soils through, e.g. biosolids, irrigation or nanoagrochemicals. Soils are submitted to a wide range of concentrations of TiO2-NPs depending on the type of exposure. However, most studies have assessed the effects of unrealistically hig...

journal_title：Nanotoxicology

authors： Simonin M,Martins JM,Le Roux X,Uzu G,Calas A,Richaume A

更新日期：2017-03-01 00:00:00

abstract：:The objective of this study was to evaluate the distribution of silver nanoparticles (NPs) in pregnant mice and their developing embryos. Silver NPs (average diameter 50 nm) were intravenously injected into pregnant CD-1 mice on gestation days (GDs) 7, 8, and 9 at dose levels of 0, 35, or 66 μg Ag/mouse. Mice were eut...

journal_title：Nanotoxicology

authors： Austin CA,Umbreit TH,Brown KM,Barber DS,Dair BJ,Francke-Carroll S,Feswick A,Saint-Louis MA,Hikawa H,Siebein KN,Goering PL

更新日期：2012-12-01 00:00:00

abstract：:Foodborne nanoparticles (NPs) have drawn great attention due to human health concerns. This study reports the detection of the presence of fluorescent NPs, about 5 nm, in two of the most popular beverages, Coca-Cola (Coke) and Pepsi-Cola (Pepsi). The NPs contain H, C and O, three elements with a tunable emission and w...

journal_title：Nanotoxicology

authors： Li S,Jiang C,Wang H,Cong S,Tan M

更新日期：2018-02-01 00:00:00

abstract：:Abstract Nickel, zinc, and copper oxide nanoparticles (NiONP, ZnONP, and CuONP) and their aqueous extracts (AEs) were applied to A549 lung epithelial cells to determine the cytotoxicity, IL-8 production, and activation of transcription factors. Nanoparticles (NPs) and their AEs were also instilled into rat lungs to ...

journal_title：Nanotoxicology

authors： Cho WS,Duffin R,Poland CA,Duschl A,Oostingh GJ,Macnee W,Bradley M,Megson IL,Donaldson K

更新日期：2012-02-01 00:00:00

abstract：:Uptake of polydispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs) in resting and LPS-activated B cells was studied using fluorescence-tagged AF-SWCNTs (FAF-SWCNTs). Activated B cells internalized substantially higher amounts of FAF-SWCNTs [76.5% AF-SWCNT+ B cells, mean fluorescence intensity (MFI)...

journal_title：Nanotoxicology

authors： Dutt TS,Mia MB,Saxena RK

更新日期：2019-08-01 00:00:00

abstract：:Foodborne nanoparticles (NPs) refer to the nanostructures generated during food processing, rather than the man-made nano-structural additives that are added to improve the property of food. In this research, discovery of fluorescent NPs in roasted pork was reported at different temperature of 180, 230, and 280 °C. Th...

journal_title：Nanotoxicology

authors： Zhao X,Shan S,Li J,Cao L,Lv J,Tan M

更新日期：2019-12-01 00:00:00

abstract：:Single-walled carbon nanotubes (SWCNTs) are widely used in industrial and medical sectors, and the increasing exposure of SWCNTs necessitates the studies of their potential environmental and health effects. Considerable efforts have been made to improve the dispersion of SWCNTs by chemical modifications. However, the ...

journal_title：Nanotoxicology

authors： Dong PX,Wan B,Guo LH

更新日期：2012-05-01 00:00:00

abstract：:Nanowires (NWs) have unique electrical and optical properties of value for many applications including lighting, sensing, and energy harnessing. Consumer products containing NWs increase the risk of NWs being released in the environment, especially into aquatic ecosystems through sewage systems. Daphnia magna is a com...

journal_title：Nanotoxicology

authors： Mattsson K,Adolfsson K,Ekvall MT,Borgström MT,Linse S,Hansson LA,Cedervall T,Prinz CN

更新日期：2016-10-01 00:00:00

abstract：:The biological fate of nanoparticles (NPs) taken up by organisms from their environment is a crucial issue for assessing ecological hazard. Despite its importance, it has scarcely been addressed due to the technical difficulties of doing so in whole organism in vivo studies. Here, by using transmission electron micros...

journal_title：Nanotoxicology

authors： Noventa S,Hacker C,Correia A,Drago C,Galloway T

更新日期：2018-10-01 00:00:00

abstract：:The widespread increase in the production and use of nanomaterials has increased the potential for nanoparticle exposure; however, the biological effects of nanoparticle inhalation are poorly understood. Rats were exposed to nanosized titanium dioxide aerosols (10 μg lung burden); at 24 h post-exposure, the spinotrape...

journal_title：Nanotoxicology

authors： Knuckles TL,Yi J,Frazer DG,Leonard HD,Chen BT,Castranova V,Nurkiewicz TR

更新日期：2012-11-01 00:00:00

abstract：:Certain types of carbon nanotubes (CNT) can evoke inflammation, fibrosis and mesothelioma in vivo, raising concerns about their potential health effects. It has been recently postulated that NLRP3 inflammasome activation is important in the CNT-induced toxicity. However, more comprehensive studies of the protein secre...

journal_title：Nanotoxicology

authors： Palomäki J,Sund J,Vippola M,Kinaret P,Greco D,Savolainen K,Puustinen A,Alenius H

更新日期：2015-01-01 00:00:00

abstract：:Abstract To examine gold nanoparticle reprotoxicity, bovine spermatozoa were challenged with ligand-free or oligonucleotide-conjugated gold nanoparticles synthesized purely without any surfactants by laser ablation. Sperm motility declined at nanoparticle mass dose of 10 µg/ml (corresponding to ∼14 000 nanoparticles p...

journal_title：Nanotoxicology

authors： Taylor U,Barchanski A,Petersen S,Kues WA,Baulain U,Gamrad L,Sajti L,Barcikowski S,Rath D

更新日期：2014-08-01 00:00:00

abstract：:Nanodiamonds have been suggested as biocompatible materials and are suitable for various biomedical applications, but little is known about how to synthesize safer nanodiamonds. Herein, seven different detonation-synthesized nanodiamonds (DNDs) with sequential sp3/sp2 carbon ratios were assembled by controlling the ch...

journal_title：Nanotoxicology

authors： Lee DK,Ha S,Jeon S,Jeong J,Kim DJ,Lee SW,Cho WS

更新日期：2020-11-01 00:00:00

abstract：:Nano-titanium dioxide (nano-TiO2) is one of the most universal engineered nano-materials while perfluorooctanesulfonate (PFOS) is a typical new persistent organic pollutant. They are widely used and present in aquatic environment. In this study, a novel semi-static multilayer microcosm was setup to investigate the imp...

journal_title：Nanotoxicology

authors： Qiang L,Pan X,Zhu L,Fang S,Tian S

更新日期：2016-01-01 00:00:00