Copper nanoparticles induce early fibrotic changes in the liver via TGF-β/Smad signaling and cause immunosuppressive effects in rats.

abstract：:Silver nanoparticles (Ag-NPs) are used in a wide variety of products, prompting concerns regarding their potential environmental impacts. To accurately determine the toxicity of Ag-NPs it is necessary to differentiate between the toxicity of the nanoparticles themselves and the toxicity of ionic silver (Ag) released f...

journal_title：Nanotoxicology

authors： Sekine R,Khurana K,Vasilev K,Lombi E,Donner E

更新日期：2015-01-01 00:00:00

abstract：:A thorough understanding of nanoparticle bio-distribution at the feto-maternal interface will be a prerequisite for their diagnostic or therapeutic application in women of childbearing age and for teratologic risk assessment. Therefore, the tissue interaction of biocompatible dendritic polyglycerol nanoparticles (dPG-...

journal_title：Nanotoxicology

authors： Juch H,Nikitina L,Reimann S,Gauster M,Dohr G,Obermayer-Pietsch B,Hoch D,Kornmueller K,Haag R

更新日期：2018-03-01 00:00:00

abstract：:The objective of this study was to evaluate the distribution of silver nanoparticles (NPs) in pregnant mice and their developing embryos. Silver NPs (average diameter 50 nm) were intravenously injected into pregnant CD-1 mice on gestation days (GDs) 7, 8, and 9 at dose levels of 0, 35, or 66 μg Ag/mouse. Mice were eut...

journal_title：Nanotoxicology

authors： Austin CA,Umbreit TH,Brown KM,Barber DS,Dair BJ,Francke-Carroll S,Feswick A,Saint-Louis MA,Hikawa H,Siebein KN,Goering PL

更新日期：2012-12-01 00:00:00

abstract：:The widespread increase in the production and use of nanomaterials has increased the potential for nanoparticle exposure; however, the biological effects of nanoparticle inhalation are poorly understood. Rats were exposed to nanosized titanium dioxide aerosols (10 μg lung burden); at 24 h post-exposure, the spinotrape...

journal_title：Nanotoxicology

authors： Knuckles TL,Yi J,Frazer DG,Leonard HD,Chen BT,Castranova V,Nurkiewicz TR

更新日期：2012-11-01 00:00:00

abstract：:The addition of a transmitted electron detector to a scanning electron microscope (SEM) allows the recording of bright and dark field scanning transmission electron microscope (STEM) images and the corresponding in-lens secondary electron images from the same region of a thin sample. These combined imaging techniques ...

journal_title：Nanotoxicology

authors： Hondow N,Harrington J,Brydson R,Doak SH,Singh N,Manshian B,Brown A

更新日期：2011-06-01 00:00:00

abstract：:The printer is one of the most common office equipment. Recently, it was reported that toner formulations for printing equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during printing. To date, insufficient research has been performed to understand the ...

journal_title：Nanotoxicology

authors： Sisler JD,Pirela SV,Friend S,Farcas M,Schwegler-Berry D,Shvedova A,Castranova V,Demokritou P,Qian Y

更新日期：2015-01-01 00:00:00

abstract：:Cadmium (Cd) is a component in quantum dot 705 (QD705). Whether QD705 behaves similar to Cd in vivo is of great concern. We compared the distributional kinetics of cadmium chloride (CdCl(2)) and QD705 in mice after intravenous injection. QD705 showed a longer plasma and body retention than CdCl(2) and could be detecte...

journal_title：Nanotoxicology

authors： Yeh TK,Wu JP,Chang LW,Tsai MH,Chang WH,Tsai HT,Yang CS,Lin P

更新日期：2011-03-01 00:00:00

abstract：:With the increased production and widespread commercial use of silver nanoparticles (AgNPs), human and environmental exposures to silver nanoparticles are inevitably increasing. In particular, persons manufacturing and handling silver nanoparticles and silver nanoparticle containing products are at risk of exposure, p...

journal_title：Nanotoxicology

authors： Weldon BA,M Faustman E,Oberdörster G,Workman T,Griffith WC,Kneuer C,Yu IJ

更新日期：2016-09-01 00:00:00

abstract：:Glycodendrimers (Glyco-DDMs) represent a rapidly growing class of nanoparticles with promising properties for biomedical applications but concerns regarding the impact on human health and environment are still justified. Here we report, for the first time, the comparative study of in vivo developmental toxicity of car...

journal_title：Nanotoxicology

authors： Liegertová M,Wrobel D,Herma R,Müllerová M,Šťastná LČ,Cuřínová P,Strašák T,Malý M,Čermák J,Smejkal J,Štofik M,Maly J

更新日期：2018-10-01 00:00:00

abstract：:There is a paucity of data regarding the safety of administering solid gold nanoparticles (AuNPs) in large animal tumor models. We assessed the acute toxicity and biodistribution of 5 nm and 25 nm solid AuNPs in New Zealand White rabbits (n = 6 in each) with implanted liver Vx2 tumors 24 h after intravenous injection....

journal_title：Nanotoxicology

authors： Glazer ES,Zhu C,Hamir AN,Borne A,Thompson CS,Curley SA

更新日期：2011-12-01 00:00:00

abstract：:Inhalation of zinc oxide nanoparticles (ZnONP) has potential health impact. Because zinc ion may involve in the toxicity of ZnONP, we compared adverse effects of inhaled aerosolized ZnONP and zinc nitrate in mice. Aerosolized ZnONP and zinc nitrate were well-dispersed in the inhalation chamber. Inhalation of 0.86 mg/m...

journal_title：Nanotoxicology

authors： Chen JK,Ho CC,Chang H,Lin JF,Yang CS,Tsai MH,Tsai HT,Lin P

更新日期：2015-02-01 00:00:00

abstract：:Enhanced in vitro human and ex vivo rat platelet aggregation from direct exposure to silver nanoparticles is previously reported. Given the increasing human use of engineered silver nanoscale products, platelet aggregation prompted by silver nanoparticles may contribute to human cardiovascular events. To understand ho...

journal_title：Nanotoxicology

authors： Smock KJ,Schmidt RL,Hadlock G,Stoddard G,Grainger DW,Munger MA

更新日期：2014-05-01 00:00:00

abstract：:Surface coatings of nanoparticles (NPs) are known to influence advantageous features of NPs as well as potential toxicity. Iron oxide (Fe3O4) NPs are applied for both medical diagnostics and targeted drug delivery. We investigated the potential cytotoxicity and genotoxicity of uncoated iron oxide (U-Fe3O4) NPs in comp...

journal_title：Nanotoxicology

authors： Magdolenova Z,Drlickova M,Henjum K,Rundén-Pran E,Tulinska J,Bilanicova D,Pojana G,Kazimirova A,Barancokova M,Kuricova M,Liskova A,Staruchova M,Ciampor F,Vavra I,Lorenzo Y,Collins A,Rinna A,Fjellsbø L,Volkovova K,Mar

更新日期：2015-05-01 00:00:00

abstract：:The whitening and opacifying properties of titanium dioxide (TiO2) are commonly exploited when it is used as a food additive (E171). However, the safety of this additive can be questioned as TiO2 nanoparticles (TiO2-NPs) have been classed at potentially toxic. This study aimed to shed some light on the mechanisms behi...

journal_title：Nanotoxicology

authors： Dorier M,Béal D,Marie-Desvergne C,Dubosson M,Barreau F,Houdeau E,Herlin-Boime N,Carriere M

更新日期：2017-08-01 00:00:00

abstract：:Understanding the relationship between adverse exposure events and specific material properties will facilitate predictive classification of carbon nanotubes (CNTs) according to their mechanisms of action, and a safe-by-design approach for the next generation of CNTs. Mass-spectrometry-based proteomics is a reliable t...

journal_title：Nanotoxicology

authors： Ndika JDT,Sund J,Alenius H,Puustinen A

更新日期：2018-08-01 00:00:00

abstract：:Although the production of engineered nanoparticles increases our knowledge of toxicity and mechanisms of bioactivity during relevant exposures is lacking. In the present study mice were exposed to PbO nanoparticles (PbONP; 192.5 µg/m3; 1.93 × 106 particles/cm3) for 2, 5 and 13 weeks through continuous inhalation. The...

journal_title：Nanotoxicology

authors： Bláhová L,Nováková Z,Večeřa Z,Vrlíková L,Dočekal B,Dumková J,Křůmal K,Mikuška P,Buchtová M,Hampl A,Hilscherová K,Bláha L

更新日期：2020-03-01 00:00:00

abstract：:This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nano-silver based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not...

journal_title：Nanotoxicology

authors： Christensen FM,Johnston HJ,Stone V,Aitken RJ,Hankin S,Peters S,Aschberger K

更新日期：2010-09-01 00:00:00

abstract：:Deciphering the molecular basis of toxicology mechanism induced by nanoparticles (NPs) remains an essential challenge. Ion Beam Analysis (IBA) was applied in combination with Transmission Electron Microscopy and Confocal Microscopy to analyze human keratinocytes exposed to TiO(2)-NPs. Investigating chemical elemental ...

journal_title：Nanotoxicology

authors： Simon M,Barberet P,Delville MH,Moretto P,Seznec H

更新日期：2011-06-01 00:00:00

abstract：:The increasing presence of ZnO nanoparticles (NPs) in consumer products may be having a dramatic impact in aquatic environments. The evaluation of ZnO NP toxicity represents a great challenge. This study aimed at evaluating the cytotoxic effect of micro- and nanosized ZnO in a fish and a mammalian hepatoma cell line. ...

journal_title：Nanotoxicology

authors： Fernández-Cruz ML,Lammel T,Connolly M,Conde E,Barrado AI,Derick S,Perez Y,Fernandez M,Furger C,Navas JM

更新日期：2013-08-01 00:00:00

abstract：:Single-walled carbon nanotubes (SWCNTs) are widely used in industrial and medical sectors, and the increasing exposure of SWCNTs necessitates the studies of their potential environmental and health effects. Considerable efforts have been made to improve the dispersion of SWCNTs by chemical modifications. However, the ...

journal_title：Nanotoxicology

authors： Dong PX,Wan B,Guo LH

更新日期：2012-05-01 00:00:00

abstract：:Titanium-dioxide nanoparticles (TiO2-NPs) are increasingly released in agricultural soils through, e.g. biosolids, irrigation or nanoagrochemicals. Soils are submitted to a wide range of concentrations of TiO2-NPs depending on the type of exposure. However, most studies have assessed the effects of unrealistically hig...

journal_title：Nanotoxicology

authors： Simonin M,Martins JM,Le Roux X,Uzu G,Calas A,Richaume A

更新日期：2017-03-01 00:00:00

abstract：:Nanosized zeolite particles are important materials for many applications in the field of nanotechnology. The possible adverse effects of these nanomaterials on human health have been scarcely investigated and remain largely unknown. This study reports the synthesis of nanozeolites Y and A with particle sizes of 25-10...

journal_title：Nanotoxicology

authors： Thomassen LC,Napierska D,Dinsdale D,Lievens N,Jammaer J,Lison D,Kirschhock CE,Hoet PH,Martens JA

更新日期：2012-08-01 00:00:00

abstract：:Nanotechnology offers innovation in products from cosmetics to drug delivery, leading to increased engineered nanomaterial (ENM) exposure. Unfortunately, health impacts of ENM are not fully realized. Titanium dioxide (TiO2) is among the most widely produced ENM due to its use in numerous applications. Extrapulmonary e...

journal_title：Nanotoxicology

authors： Nichols CE,Shepherd DL,Hathaway QA,Durr AJ,Thapa D,Abukabda A,Yi J,Nurkiewicz TR,Hollander JM

更新日期：2018-02-01 00:00:00

abstract：:Here, we present evidence on complete transformation of ZnO and CuO nanoparticles, which are among the most heavily studied metal oxide particles, during 24 h in vitro toxicological testing with human T-lymphocytes. Synchrotron radiation-based X-ray absorption near edge structure (XANES) spectroscopy results revealed ...

journal_title：Nanotoxicology

authors： Ivask A,Scheckel KG,Kapruwan P,Stone V,Yin H,Voelcker NH,Lombi E

更新日期：2017-03-01 00:00:00

abstract：:No detailed information on in vivo biokinetics of CeO2 nanoparticles (NPs) following chronic low-dose inhalation is available. The CeO2 burden for lung, lung-associated lymph nodes, and major non-pulmonary organs, blood, and feces, was determined in a chronic whole-body inhalation study in female Wistar rats undertake...

journal_title：Nanotoxicology

authors： Tentschert J,Laux P,Jungnickel H,Brunner J,Estrela-Lopis I,Merker C,Meijer J,Ernst H,Ma-Hock L,Keller J,Landsiedel R,Luch A

更新日期：2020-05-01 00:00:00

abstract：:Certain types of carbon nanotubes (CNT) can evoke inflammation, fibrosis and mesothelioma in vivo, raising concerns about their potential health effects. It has been recently postulated that NLRP3 inflammasome activation is important in the CNT-induced toxicity. However, more comprehensive studies of the protein secre...

journal_title：Nanotoxicology

authors： Palomäki J,Sund J,Vippola M,Kinaret P,Greco D,Savolainen K,Puustinen A,Alenius H

更新日期：2015-01-01 00:00:00

abstract：:Abstract To examine gold nanoparticle reprotoxicity, bovine spermatozoa were challenged with ligand-free or oligonucleotide-conjugated gold nanoparticles synthesized purely without any surfactants by laser ablation. Sperm motility declined at nanoparticle mass dose of 10 µg/ml (corresponding to ∼14 000 nanoparticles p...

journal_title：Nanotoxicology

authors： Taylor U,Barchanski A,Petersen S,Kues WA,Baulain U,Gamrad L,Sajti L,Barcikowski S,Rath D

更新日期：2014-08-01 00:00:00

abstract：:Nanoscale titanium dioxide (TiO2) is manufactured in wide scale, with a range of applications in consumer products. Significant toxicity of TiO2 nanoparticles has, however, been recognized, suggesting considerable risk to human health. To evaluate fully their toxicity, assessment of the epigenetic action of these nano...

journal_title：Nanotoxicology

authors： Pogribna M,Koonce NA,Mathew A,Word B,Patri AK,Lyn-Cook B,Hammons G

更新日期：2020-05-01 00:00:00

abstract：:Multifunctional nanomaterials are rapidly emerging for ophthalmic delivery of therapeutics to facilitate safe and effective targeting with improved patient compliance. Because of their extremely high area to volume ratio, nanomaterials often have physicochemical properties that are different from those of their larger...

journal_title：Nanotoxicology

authors： Mehra NK,Cai D,Kuo L,Hein T,Palakurthi S

更新日期：2016-09-01 00:00:00

abstract：:Nanowires (NWs) have unique electrical and optical properties of value for many applications including lighting, sensing, and energy harnessing. Consumer products containing NWs increase the risk of NWs being released in the environment, especially into aquatic ecosystems through sewage systems. Daphnia magna is a com...

journal_title：Nanotoxicology

authors： Mattsson K,Adolfsson K,Ekvall MT,Borgström MT,Linse S,Hansson LA,Cedervall T,Prinz CN

更新日期：2016-10-01 00:00:00