Amplification of arsenic genotoxicity by TiO2 nanoparticles in mammalian cells: new insights from physicochemical interactions and mitochondria.

abstract：:Although the production of engineered nanoparticles increases our knowledge of toxicity and mechanisms of bioactivity during relevant exposures is lacking. In the present study mice were exposed to PbO nanoparticles (PbONP; 192.5 µg/m3; 1.93 × 106 particles/cm3) for 2, 5 and 13 weeks through continuous inhalation. The...

journal_title：Nanotoxicology

authors： Bláhová L,Nováková Z,Večeřa Z,Vrlíková L,Dočekal B,Dumková J,Křůmal K,Mikuška P,Buchtová M,Hampl A,Hilscherová K,Bláha L

更新日期：2020-03-01 00:00:00

abstract：:The use of imaging tools to probe nanoparticle-cell interactions will be crucial to elucidating the mechanisms of nanoparticle-induced toxicity. Of particular interest are mechanisms associated with cell penetration, translocation and subsequent accumulation inside the cell, or in cellular compartments. The objective ...

journal_title：Nanotoxicology

authors： Tantra R,Knight A

更新日期：2011-09-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials. Following oral exposure, AgNPs can accumulate in various organs including kidneys where they show gender specific accumulation. There is limited information on their effect on renal system following long-term animal exposure especially at the ...

journal_title：Nanotoxicology

authors： Tiwari R,Singh RD,Khan H,Gangopadhyay S,Mittal S,Singh V,Arjaria N,Shankar J,Roy SK,Singh D,Srivastava V

更新日期：2017-06-01 00:00:00

abstract：:Passion fruit-like nano-architectures (NAs) are all-in-one platforms of increasing interest for the translation of metal nanoparticles into clinics. NAs are nature-inspired disassembling inorganic theranostics, which jointly combine most of the appealing behaviors of noble metal nanoparticles with their potential orga...

journal_title：Nanotoxicology

authors： d'Amora M,Cassano D,Pocoví-Martínez S,Giordani S,Voliani V

更新日期：2018-10-01 00:00:00

abstract：:The spread of antibiotic resistance genes (ARGs) has become a global environmental issue; it has been found that nanoparticles (NPs) can promote the transfer of ARGs between bacteria. However, it remains unclear whether NPs can affect this kind of conjugation in Streptomyces, which mainly conjugate with other bacteria...

journal_title：Nanotoxicology

authors： Liu X,Tang J,Song B,Zhen M,Wang L,Giesy JP

更新日期：2019-12-01 00:00:00

abstract：:The available biomonitoring studies on workers producing/handling nanomaterials (NMs) focused on potential effects on respiratory, immune and cardio-vascular system. Aim of this study was to identify a panel of sensitive biomarkers and suitable biological matrices to evaluate particularly genotoxic and oxidative effec...

journal_title：Nanotoxicology

authors： Ursini CL,Fresegna AM,Ciervo A,Maiello R,Del Frate V,Folesani G,Galetti M,Poli D,Buresti G,Di Cristo L,Sabella S,Iavicoli S,Cavallo D

更新日期：2020-12-29 00:00:00

abstract：:Here, we evaluate the extent of sorption of silver nanoparticles (AgNPs) with different primary sizes (30 and 70 nm) and surface properties (branched polyethylene imine, "bPEI" and citrate coating) to laboratory plastic during (eco)toxicological testing. Under conditions of algal growth inhibition assay, up to 97% of ...

journal_title：Nanotoxicology

authors： Malysheva A,Ivask A,Hager C,Brunetti G,Marzouk ER,Lombi E,Voelcker NH

更新日期：2016-01-01 00:00:00

abstract：:If engineered nanomaterials are released into the environment, some are likely to end up associated with the food of animals due to aggregation and sorption processes. However, few studies have considered dietary exposure of nanomaterials. Here we show that zinc (Zn) from isotopically modified (67)ZnO particles is eff...

journal_title：Nanotoxicology

authors： Croteau MN,Dybowska AD,Luoma SN,Valsami-Jones E

更新日期：2011-03-01 00:00:00

abstract：:ZnO nanoparticles (NPs) elicit significant adverse effects in various cell types, organisms and in the environment. The toxicity of nanoscale ZnO has often been ascribed to the release of zinc ions from the NPs but it is not yet understood to which extent these ions contribute to ZnO NP toxicity and what are the under...

journal_title：Nanotoxicology

authors： Buerki-Thurnherr T,Xiao L,Diener L,Arslan O,Hirsch C,Maeder-Althaus X,Grieder K,Wampfler B,Mathur S,Wick P,Krug HF

更新日期：2013-06-01 00:00:00

abstract：:The effect of non-functionalized and amino-functionalized multiwall carbon nanotube (CNT) exposure, as well as the impact of CNT presence on coexistent pesticide accumulation, was investigated in lettuce (Lactuca sativa L.). Lettuce seeds were sown directly into CNT-amended vermiculite (1000 mg L(-1)) to monitor phyto...

journal_title：Nanotoxicology

authors： Hamdi H,De La Torre-Roche R,Hawthorne J,White JC

更新日期：2015-03-01 00:00:00

abstract：:Accumulating evidence indicates that carbon nanotubes (CNTs) are biopersistent and can cause lung damage. With similar fibrous morphology and mode of exposure to asbestos, a known human carcinogen, growing concern has arisen for elevated risk of CNT-induced lung carcinogenesis; however, relatively little is known abou...

journal_title：Nanotoxicology

authors： Wang L,Stueckle TA,Mishra A,Derk R,Meighan T,Castranova V,Rojanasakul Y

更新日期：2014-08-01 00:00:00

abstract：:The fiber-like shape of multi-walled carbon nanotubes (MWCNTs) is reminiscent of asbestos, suggesting they pose similar health hazards when inhaled, including pulmonary fibrosis and mesothelioma. Mice deficient in the tumor suppressor p53 are susceptible to carcinogenesis. However, the chronic pathologic effect of MWC...

journal_title：Nanotoxicology

authors： Duke KS,Thompson EA,Ihrie MD,Taylor-Just AJ,Ash EA,Shipkowski KA,Hall JR,Tokarz DA,Cesta MF,Hubbs AF,Porter DW,Sargent LM,Bonner JC

更新日期：2018-11-01 00:00:00

abstract：:To address the impact of cadmium sulphide nanoparticles (CdSNPs) of two different sizes (8 and 50 nm), Danio rerio zebrafish were dietary exposed to very low doses: 100 or 40 ng CdSNPs/day/g body weight for 36 or 60 days, respectively. The results obtained using RAPD-PCR genotoxicity test showed genomic alteration sin...

journal_title：Nanotoxicology

authors： Ladhar C,Geffroy B,Cambier S,Treguer-Delapierre M,Durand E,Brèthes D,Bourdineaud JP

更新日期：2014-09-01 00:00:00

abstract：:We systematically investigated how the combinations of size, shape and the natural organic matter (NOM)-ecocorona of gold (Au) engineered nanoparticles (ENPs) influence the attachment of the particles to algae and physical toxicity to the cells. Spherical (10, 60 and 100 nm), urchin-shaped (60 nm), rod-shaped (10 × 45...

journal_title：Nanotoxicology

authors： Abdolahpur Monikh F,Arenas-Lago D,Porcal P,Grillo R,Zhang P,Guo Z,Vijver MG,J G M Peijnenburg W

更新日期：2020-04-01 00:00:00

abstract：:There is a paucity of data regarding the safety of administering solid gold nanoparticles (AuNPs) in large animal tumor models. We assessed the acute toxicity and biodistribution of 5 nm and 25 nm solid AuNPs in New Zealand White rabbits (n = 6 in each) with implanted liver Vx2 tumors 24 h after intravenous injection....

journal_title：Nanotoxicology

authors： Glazer ES,Zhu C,Hamir AN,Borne A,Thompson CS,Curley SA

更新日期：2011-12-01 00:00:00

abstract：:Copper nanoparticles (Cu NPs) have various uses, including as additives in polymers/plastics, lubricants for metallic coating, and biomedical applications. We investigated the role of transforming growth factor (TGF)-β1 signaling in hepatic damage caused by Cu NPs and explored the effects of a 28-day repeated oral adm...

journal_title：Nanotoxicology

authors： Lee IC,Ko JW,Park SH,Shin NR,Shin IS,Moon C,Kim SH,Yun WK,Kim HC,Kim JC

更新日期：2018-08-01 00:00:00

abstract：:Surface coatings of nanoparticles (NPs) are known to influence advantageous features of NPs as well as potential toxicity. Iron oxide (Fe3O4) NPs are applied for both medical diagnostics and targeted drug delivery. We investigated the potential cytotoxicity and genotoxicity of uncoated iron oxide (U-Fe3O4) NPs in comp...

journal_title：Nanotoxicology

authors： Magdolenova Z,Drlickova M,Henjum K,Rundén-Pran E,Tulinska J,Bilanicova D,Pojana G,Kazimirova A,Barancokova M,Kuricova M,Liskova A,Staruchova M,Ciampor F,Vavra I,Lorenzo Y,Collins A,Rinna A,Fjellsbø L,Volkovova K,Mar

更新日期：2015-05-01 00:00:00

abstract：:Cellular adaptation is the dynamic response of a cell to adverse changes in its intra/extra cellular environment. The aims of this study were to investigate the role of: (i) the glutathione antioxidant system, and (ii) the transcription factor EB (TFEB), a newly revealed master regulator of lysosome biogenesis, in cel...

journal_title：Nanotoxicology

authors： Neibert KD,Maysinger D

更新日期：2012-05-01 00:00:00

abstract：:Engineered nanoparticles are increasingly discharged into the environment. After discharge, these nanoparticles can interact with co-existing organic contaminants, resulting in a phenomena referred to as 'joint toxicity'. This study evaluated joint toxicities of TiO2 nanoparticles (TiO2NPs) with four different (atrazi...

journal_title：Nanotoxicology

authors： Zhang S,Deng R,Lin D,Wu F

更新日期：2017-01-01 00:00:00

abstract：:Here, we present evidence on complete transformation of ZnO and CuO nanoparticles, which are among the most heavily studied metal oxide particles, during 24 h in vitro toxicological testing with human T-lymphocytes. Synchrotron radiation-based X-ray absorption near edge structure (XANES) spectroscopy results revealed ...

journal_title：Nanotoxicology

authors： Ivask A,Scheckel KG,Kapruwan P,Stone V,Yin H,Voelcker NH,Lombi E

更新日期：2017-03-01 00:00:00

abstract：:In our previous studies of nanocalcium carbonate, in which we performed physicochemical analysis, genotoxicity, acute single-dose and repeated-dose 14-day oral toxicity testings in Sprague-Dawley (SD) rats, nanocalcium carbonate did not show a difference in toxicity compared to vehicle control. Here, we provide the fi...

journal_title：Nanotoxicology

authors： Sung JH,Park SJ,Jeong MS,Song KS,Ahn KS,Ryu HR,Lee H,Song MR,Cho MH,Kim JS

更新日期：2015-01-01 00:00:00

abstract：:No detailed information on in vivo biokinetics of CeO2 nanoparticles (NPs) following chronic low-dose inhalation is available. The CeO2 burden for lung, lung-associated lymph nodes, and major non-pulmonary organs, blood, and feces, was determined in a chronic whole-body inhalation study in female Wistar rats undertake...

journal_title：Nanotoxicology

authors： Tentschert J,Laux P,Jungnickel H,Brunner J,Estrela-Lopis I,Merker C,Meijer J,Ernst H,Ma-Hock L,Keller J,Landsiedel R,Luch A

更新日期：2020-05-01 00:00:00

abstract：:The current study tests the hypothesis that multi-walled carbon nanotubes (MWCNT) with different surface chemistries exhibit different bioactivity profiles in vivo. In addition, the study examined the potential contribution of the NLRP3 inflammasome in MWCNT-induced lung pathology. Unmodified (BMWCNT) and MWCNT that w...

journal_title：Nanotoxicology

authors： Sager TM,Wolfarth MW,Andrew M,Hubbs A,Friend S,Chen TH,Porter DW,Wu N,Yang F,Hamilton RF,Holian A

更新日期：2014-05-01 00:00:00

abstract：:Foodborne nanoparticles (NPs) refer to the nanostructures generated during food processing, rather than the man-made nano-structural additives that are added to improve the property of food. In this research, discovery of fluorescent NPs in roasted pork was reported at different temperature of 180, 230, and 280 °C. Th...

journal_title：Nanotoxicology

authors： Zhao X,Shan S,Li J,Cao L,Lv J,Tan M

更新日期：2019-12-01 00:00:00

abstract：:Nanosized zeolite particles are important materials for many applications in the field of nanotechnology. The possible adverse effects of these nanomaterials on human health have been scarcely investigated and remain largely unknown. This study reports the synthesis of nanozeolites Y and A with particle sizes of 25-10...

journal_title：Nanotoxicology

authors： Thomassen LC,Napierska D,Dinsdale D,Lievens N,Jammaer J,Lison D,Kirschhock CE,Hoet PH,Martens JA

更新日期：2012-08-01 00:00:00

abstract：:Nanoparticle (NP) uptake across the gut is poorly understood. In vitro gut sac preparations and isolated perfused intestines were used to investigate the absorption mechanism(s). Exposure of whole gut sacs to 1 mg/l TiO₂ NPs for 4 h caused total Ti metal concentrations to increase in the intestine, with 80% or more of...

journal_title：Nanotoxicology

authors： Al-Jubory AR,Handy RD

更新日期：2013-12-01 00:00:00

abstract：:Iron nanoparticles (NPs) have been proposed as a tool in very different fields such as environmental remediation and biomedical applications, including food fortification against iron deficiency, even if there is still concern about their safety. Here, we propose Xenopus laevis embryos as a suitable model to investiga...

journal_title：Nanotoxicology

authors： Bonfanti P,Colombo A,Saibene M,Fiandra L,Armenia I,Gamberoni F,Gornati R,Bernardini G,Mantecca P

更新日期：2020-03-01 00:00:00

abstract：:Cadmium (Cd) is a component in quantum dot 705 (QD705). Whether QD705 behaves similar to Cd in vivo is of great concern. We compared the distributional kinetics of cadmium chloride (CdCl(2)) and QD705 in mice after intravenous injection. QD705 showed a longer plasma and body retention than CdCl(2) and could be detecte...

journal_title：Nanotoxicology

authors： Yeh TK,Wu JP,Chang LW,Tsai MH,Chang WH,Tsai HT,Yang CS,Lin P

更新日期：2011-03-01 00:00:00

abstract：:Six TiO₂ and two CeO₂ nanomaterials with dry sizes ranging from 6-410 nm were tested for their ability to cause DNA centered free radicals in vitro in the concentration range of 10-3,000 ug/ml. All eight of the nanomaterials significantly increased the adduction of the spin trap agent 5,5-dimethyl-1-pyroline N-oxide (...

journal_title：Nanotoxicology

authors： Kitchin KT,Prasad RY,Wallace K

更新日期：2011-12-01 00:00:00

abstract：:Sunscreens containing metal oxide nanoparticles appear transparent on the skin and provide excellent protection against sunburn caused by UV radiation. While it is likely that nanoparticles remain on the surface of the skin of healthy adult humans, and thus are considered safe for use in sunscreens, there has been no ...

journal_title：Nanotoxicology

authors： Osmond MJ,McCall MJ

更新日期：2010-03-01 00:00:00