abstract：OBJECTIVES:Little is known about the likelihood of developing inflammatory arthritis (IA) in individuals who screen autoantibody positive (aAb+) in a non-clinical research setting. METHODS:We screened for serum cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor isotype aAbs in subjects who were at ...

journal_title：Annals of the rheumatic diseases

authors： Bemis EA,Demoruelle MK,Seifert JA,Polinski KJ,Weisman MH,Buckner JH,Gregersen PK,Mikuls TR,ODell JR,Keating RM,Deane KD,Holers VM,Norris JM

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:We sought to determine histologic and gene expression features of clinical improvement in early diffuse cutaneous systemic sclerosis (dcSSc; scleroderma). METHODS:Fifty-eight forearm biopsies were evaluated from 26 individuals with dcSSc in two clinical trials. Histologic/immunophenotypic assessments of glob...

journal_title：Annals of the rheumatic diseases

authors： Showalter K,Spiera R,Magro C,Agius P,Martyanov V,Franks JM,Sharma R,Geiger H,Wood TA,Zhang Y,Hale CR,Finik J,Whitfield ML,Orange DE,Gordon JK

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:Congenital heart block (CHB) with immune cell infiltration develops in the fetus after exposure to maternal Ro/La autoantibodies. CHB-related serology has been extensively studied, but reports on immune-cell profiles of anti-Ro/La-exposed neonates are lacking. In the current study, we characterised circulatin...

journal_title：Annals of the rheumatic diseases

authors： Ivanchenko M,Thorlacius GE,Hedlund M,Ottosson V,Meneghel L,Björkander S,Ossoinak A,Tingström J,Bremme K,Sverremark-Ekström E,Gemzell-Danielsson K,Sonesson SE,Chemin K,Wahren-Herlenius M

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND AND AIM:Striving for harmonisation of specialty training and excellence of care in rheumatology, the European League Against Rheumatism (EULAR) established a task force to develop points to consider (PtCs) for the assessment of competences during rheumatology specialty training. METHODS:A systematic literat...

journal_title：Annals of the rheumatic diseases

authors： Sivera F,Alunno A,Najm A,Avcin T,Baraliakos X,Bijlsma JW,Badreh S,Burmester G,Cikes N,Da Silva JA,Damjanov N,Dougados M,Dudler J,Edwards CJ,Iagnocco A,Lioté F,Nikiphorou E,van Onna M,Stones SR,Vassilopoulos D,Hain

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There is an urgent need for robust data on the trajectories and outcomes of pregnancies in women with inflammatory rheumatic diseases (IRD). In particular when rare outcomes or rare diseases are to be investigated, collaborative approaches are required. However, joint data analyses are often li...

journal_title：Annals of the rheumatic diseases

authors： Meissner Y,Fischer-Betz R,Andreoli L,Costedoat-Chalumeau N,De Cock D,Dolhain RJEM,Forger F,Goll D,Molto A,Nelson-Piercy C,Özdemir R,Raio L,Rodríguez-García SC,Sciascia S,Wallenius M,Zbinden A,Zink A,Strangfeld A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Upadacitinib is a Janus kinase inhibitor under evaluation for the treatment of psoriatic arthritis (PsA). We evaluated upadacitinib in patients with PsA and prior inadequate response or intolerance to at least one biologic disease-modifying antirheumatic drug (DMARD). METHODS:In this 24-week randomised, pla...

journal_title：Annals of the rheumatic diseases

authors： Mease PJ,Lertratanakul A,Anderson JK,Papp K,Van den Bosch F,Tsuji S,Dokoupilova E,Keiserman M,Wang X,Zhong S,McCaskill RM,Zueger P,Pangan AL,Tillett W

更新日期：2020-12-03 00:00:00

abstract：OBJECTIVES:Eosinophils possess pro-inflammatory functions in asthma. However, our recent studies have suggested that innate lymphoid cells type 2 (ILC2s) and eosinophils have proresolving properties in rheumatoid arthritis (RA). Nothing is known yet about the mechanisms determining the double-edged role of eosinophils....

journal_title：Annals of the rheumatic diseases

authors： Andreev D,Liu M,Kachler K,Llerins Perez M,Kirchner P,Kölle J,Gießl A,Rauber S,Song R,Aust O,Grüneboom A,Kleyer A,Cañete JD,Ekici A,Ramming A,Finotto S,Schett G,Bozec A

更新日期：2020-11-04 00:00:00

abstract：OBJECTIVES:To describe patients with autoimmune inflammatory rheumatic diseases (AIRD) who had COVID-19 disease; to compare patients who required hospital admission with those who did not and assess risk factors for hospital admission related to COVID-19. METHODS:An observational longitudinal study was conducted durin...

journal_title：Annals of the rheumatic diseases

authors： Freites Nuñez DD,Leon L,Mucientes A,Rodriguez-Rodriguez L,Font Urgelles J,Madrid García A,Colomer JI,Jover JA,Fernandez-Gutierrez B,Abasolo L

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:This integrated analysis presents the safety profile of upadacitinib, a Janus kinase inhibitor, at 15 mg and 30 mg once daily in patients with moderately to severely active rheumatoid arthritis (RA). METHODS:Treatment-emergent adverse events (TEAEs) and laboratory data from five randomised, placebo- or acti...

journal_title：Annals of the rheumatic diseases

authors： Cohen SB,van Vollenhoven RF,Winthrop KL,Zerbini CAF,Tanaka Y,Bessette L,Zhang Y,Khan N,Hendrickson B,Enejosa JV,Burmester GR

更新日期：2020-10-28 00:00:00

abstract：OBJECTIVES:The prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases who are frequently treated with disease modifying therapies remains poorly understood. This meta-analysis aims to assess the prevalence and clinical outcomes of COVID-19 in autoimmune diseases. METHODS:Electronic databases...

journal_title：Annals of the rheumatic diseases

authors： Akiyama S,Hamdeh S,Micic D,Sakuraba A

更新日期：2020-10-13 00:00:00

abstract：OBJECTIVES:To evaluate the long-term efficacy and safety of canakinumab to treat patients with colchicine-resistant familial Mediterranean fever (crFMF) during Epoch 4 (weeks 41 to 113) of the CLUSTER study. METHODS:Patients received open-label canakinumab 150 or 300 mg, every 4 or 8 weeks during a 72-week period. We ...

journal_title：Annals of the rheumatic diseases

authors： Ozen S,Ben-Cherit E,Foeldvari I,Amarilyo G,Ozdogan H,Vanderschueren S,Marzan K,Kahlenberg JM,Dekker E,De Benedetti F,Koné-Paut I

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To compare effectiveness of treatment with secukinumab (SEC) with that of alternative tumour necrosis factor inhibitors (TNFis) in patients with axial spondyloarthritis (axSpA) after withdrawal from one or more TNFis. METHODS:Patients diagnosed as having axSpA in the Swiss Clinical Quality Management cohort ...

journal_title：Annals of the rheumatic diseases

authors： Micheroli R,Tellenbach C,Scherer A,Bürki K,Niederman K,Nissen MJ,Zufferey P,Exer P,Möller B,Kyburz D,Ciurea A

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease (AID) worldwide. The disease is caused by mutations in the MEFV gene encoding the inflammasome sensor Pyrin. Clinical diagnosis of FMF is complicated by overlap in symptoms with other diseases, and interpre...

journal_title：Annals of the rheumatic diseases

authors： Van Gorp H,Huang L,Saavedra P,Vuylsteke M,Asaoka T,Prencipe G,Insalaco A,Ogunjimi B,Jeyaratnam J,Cataldo I,Jacques P,Vermaelen K,Dullaers M,Joos R,Sabato V,Stella A,Frenkel J,De Benedetti F,Dehoorne J,Haerynck F,C

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:Target trial emulation is an intuitive design framework that encourages investigators to formulate their comparative effectiveness research (CER) question as a hypothetical randomised controlled trial (RCT). Our aim was to systematically review CER studies in rheumatoid arthritis (RA) to provide examples of ...

journal_title：Annals of the rheumatic diseases

authors： Zhao SS,Lyu H,Solomon DH,Yoshida K

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:The impact of immunosuppression on postoperative outcomes has primarily been studied in patients undergoing joint replacement surgery. We aimed to evaluate the impact of biologics and glucocorticoids on outcomes after other major surgeries. METHODS:This retrospective cohort study used Medicare data 2006-201...

journal_title：Annals of the rheumatic diseases

authors： George MD,Baker JF,Winthrop KL,Goldstein SD,Alemao E,Chen L,Wu Q,Xie F,Curtis JR

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:The differential diagnosis of seronegative rheumatoid arthritis (negRA) and psoriasis arthritis (PsA) is often difficult due to the similarity of symptoms and the unavailability of reliable clinical markers. Since chronic inflammation induces major changes in the serum metabolome and lipidome, we tested whet...

journal_title：Annals of the rheumatic diseases

authors： Souto-Carneiro M,Tóth L,Behnisch R,Urbach K,Klika KD,Carvalho RA,Lorenz HM

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterised by aberrant B cell hyperactivation, whose mechanism is partially understood. METHODS:We performed whole transcriptome sequencing of B cells from three pSS patients and three matched healthy controls (HC). Differentially expressi...

journal_title：Annals of the rheumatic diseases

authors： Sun JL,Zhang HZ,Liu SY,Lian CF,Chen ZL,Shao TH,Zhang S,Zhao LL,He CM,Wang M,Zhang W,Chen H,Zhang FC

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Hospitalisation is a risk factor for flares in people with gout. However, the predictors of inpatient gout flare are not well understood. The aim of this study was to develop a prediction model for inpatient gout flare among people with comorbid gout. METHODS:We used data from a retrospective cohort of hosp...

journal_title：Annals of the rheumatic diseases

authors： Jatuworapruk K,Grainger R,Dalbeth N,Taylor WJ

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of the immunotherapeutic vaccine interferon-α kinoid (IFN-K) in a 36-week (W) phase IIb, randomised, double-blind, placebo (PBO)-controlled trial in adults with active systemic lupus erythematosus (SLE) despite standard of care. METHODS:Patients with SLE (185) with moderat...

journal_title：Annals of the rheumatic diseases

authors： Houssiau FA,Thanou A,Mazur M,Ramiterre E,Gomez Mora DA,Misterska-Skora M,Perich-Campos RA,Smakotina SA,Cerpa Cruz S,Louzir B,Croughs T,Tee ML

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:Although shared decision making (SDM) is advocated in rheumatoid arthritis (RA) treatment, it is largely unclear when, how and to what extent SDM is applied in routine clinical care of patients with RA. This study aimed to investigate the level of SDM in RA treatment from an observer perspective and to asses...

journal_title：Annals of the rheumatic diseases

authors： Mathijssen EGE,Vriezekolk JE,Popa CD,van den Bemt BJF

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:To evaluate the rate of tuberculosis (TB) in biologic users for rheumatic diseases in South Africa, the effectiveness of our latent TB infection (LTBI) programme, risk factors and outcome. METHODS:TB cases were collected from the South African Biologics Registry (SABIO), rheumatologists and pharmaceutical c...

journal_title：Annals of the rheumatic diseases

authors： Pettipher C,Benitha R

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:Classification criteria are biased towards classifying long-standing disease. We compared the European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR)-2019, Systemic Lupus International Collaborating Clinics (SLICC)-2012 and ACR-1997 criteria in an early (median 48 months) systemic l...

journal_title：Annals of the rheumatic diseases

authors： Adamichou C,Nikolopoulos D,Genitsaridi I,Bortoluzzi A,Fanouriakis A,Papastefanakis E,Kalogiannaki E,Gergianaki I,Sidiropoulos P,Boumpas DT,Bertsias GK

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Since the publication of the European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis (LVV) in 2009, several relevant randomised clinical trials and cohort analyses have been published, which have the potential to change clinical care and therefore supporting t...

journal_title：Annals of the rheumatic diseases

authors： Hellmich B,Agueda A,Monti S,Buttgereit F,de Boysson H,Brouwer E,Cassie R,Cid MC,Dasgupta B,Dejaco C,Hatemi G,Hollinger N,Mahr A,Mollan SP,Mukhtyar C,Ponte C,Salvarani C,Sivakumar R,Tian X,Tomasson G,Turesson C,S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:To maintain and optimise the quality of care provided by health professionals in rheumatology (HPRs), adequate educational offerings are needed. This task force (TF) aimed to develop evidence-based recommendations for the generic core competences of HPRs, with specific reference to nurses, physica...

journal_title：Annals of the rheumatic diseases

authors： Edelaar L,Nikiphorou E,Fragoulis GE,Iagnocco A,Haines C,Bakkers M,Barbosa L,Cikes N,Ndosi M,Primdahl J,Prior Y,Pchelnikova P,Ritschl V,Schäfer VS,Smucrova H,Storrønning I,Testa M,Wiek D,Vliet Vlieland TPM

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:The recombinant zoster vaccine (RZV) containing a strong non-aluminium adjuvant is associated with increased risk of gout flares, presumably via NLRP3 inflammasome activation. We tested the possibility that other vaccines may also be associated with gout flares. METHODS:We conducted an online case-crossover...

journal_title：Annals of the rheumatic diseases

authors： Yokose C,McCormick N,Chen C,Neogi T,Chaisson C,Terkeltaub R,Hunter DJ,Zhang Y,Choi H

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:An increased proportion of circulating follicular helper T (Tfh) cells was reported in rheumatoid arthritis (RA), but it remains uncertain how Tfh cells affect antibody hyposialylation. We investigated the regulation of autoantibody hyposialylation by Tfh cells in RA using murine model. METHODS:Behaviours of...

journal_title：Annals of the rheumatic diseases

authors： Kurata I,Matsumoto I,Ohyama A,Osada A,Ebe H,Kawaguchi H,Kaneko S,Kondo Y,Tsuboi H,Tomioka A,Kaji H,Sumida T

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:To investigate the efficacy and safety of peficitinib, an oral Janus kinase inhibitor, in patients with rheumatoid arthritis (RA). METHODS:In this double-blind phase III study, patients with RA and an inadequate response to prior disease-modifying anti-rheumatic drugs (DMARDs) were randomised to peficitinib...

journal_title：Annals of the rheumatic diseases

authors： Tanaka Y,Takeuchi T,Tanaka S,Kawakami A,Iwasaki M,Song YW,Chen YH,Wei JC,Lee SH,Rokuda M,Izutsu H,Ushijima S,Kaneko Y,Akazawa R,Shiomi T,Yamada E

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with unknown aetiology. Epstein-Barr virus (EBV) is an environmental factor associated with SLE. EBV maintains latency in B cells with frequent reactivation measured by antibodies against viral capsid antigen (VCA) and early antigen (EA). In ...

journal_title：Annals of the rheumatic diseases

authors： Jog NR,Young KA,Munroe ME,Harmon MT,Guthridge JM,Kelly JA,Kamen DL,Gilkeson GS,Weisman MH,Karp DR,Gaffney PM,Harley JB,Wallace DJ,Norris JM,James JA

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early,...

journal_title：Annals of the rheumatic diseases

authors： Gohar F,McArdle A,Jones M,Callan N,Hernandez B,Kessel C,Miranda-Garcia M,Lavric M,Holzinger D,Pretzer C,Lainka E,Vastert SJ,de Roock S,FitzGerald O,Pennington SR,Foell D

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:There is a need to identify effective treatments for rheumatic diseases, and while genetic studies have been successful it is unclear which genes contribute to the disease. Using our existing Capture Hi-C data on three rheumatic diseases, we can identify potential causal genes which are targets for existing ...

journal_title：Annals of the rheumatic diseases

authors： Martin P,Ding J,Duffus K,Gaddi VP,McGovern A,Ray-Jones H,Yarwood A,Worthington J,Barton A,Orozco G

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:Although genome-wide association studies (GWAS) have identified approximately 100 loci for rheumatoid arthritis (RA), the disease mechanisms are not completely understood. We evaluated the pathogenesis of RA by focusing on rare coding variants. METHODS:The coding regions of 98 candidate genes identified by G...

journal_title：Annals of the rheumatic diseases

authors： Motegi T,Kochi Y,Matsuda K,Kubo M,Yamamoto K,Momozawa Y

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:To investigate the effect of Janus kinase inhibitors (Jakinibs) on cardiovascular risk in adult patients with rheumatoid arthritis (RA) via a meta-analysis of randomised controlled trials (RCTs). METHODS:PubMed, Embase and Cochrane library were thoroughly searched for RCTs reporting safety issues in patient...

journal_title：Annals of the rheumatic diseases

authors： Xie W,Huang Y,Xiao S,Sun X,Fan Y,Zhang Z

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:The aorta inhibits paravertebral ossification in diffuse idiopathic skeletal hyperostosis. We investigated if syndesmophytes in ankylosing spondylitis (AS) occurred less often at the vertebral rim near the aorta. METHODS:We performed thoracolumbar CT scans in 60 subjects in this cross-sectional study. The m...

journal_title：Annals of the rheumatic diseases

authors： Tan S,Dasgupta A,Flynn JA,Ward MM

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety, efficacy and therapeutic mechanism of BI 655064, an antagonistic anti-CD40 monoclonal antibody, in patients with rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX-IR). METHODS:In total, 67 patients were randomised to receive weekly subcutaneous doses of 120 mg ...

journal_title：Annals of the rheumatic diseases

authors： Visvanathan S,Daniluk S,Ptaszyński R,Müller-Ladner U,Ramanujam M,Rosenstock B,Eleftheraki AG,Vinisko R,Petříková A,Kellner H,Dokoupilova E,Kwiatkowska B,Alten R,Schwabe C,Baum P,Joseph D,Fine JS,Padula SJ,Steffgen J

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:With the tools available currently, confirming the diagnosis of inclusion body myositis (IBM) can be difficult. Many patients are initially misdiagnosed with polymyositis (PM). In this observational study at a UK adult neuromuscular centre, we investigated whether amyloid positron emission tomography could d...

journal_title：Annals of the rheumatic diseases

authors： Lilleker JB,Hodgson R,Roberts M,Herholz K,Howard J,Hinz R,Chinoy H

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:To see if a group course delivered by rheumatology teams using cognitive-behavioural approaches, plus usual care, reduced RA fatigue impact more than usual care alone. METHODS:Multicentre, 2-year randomised controlled trial in RA adults (fatigue severity>6/10, no recent major medication changes). RAFT (Redu...

journal_title：Annals of the rheumatic diseases

authors： Hewlett S,Almeida C,Ambler N,Blair PS,Choy EH,Dures E,Hammond A,Hollingworth W,Kadir B,Kirwan JR,Plummer Z,Rooke C,Thorn J,Turner N,Pollock J,RAFT Study Group.

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:Wnt16 is implicated in bone fracture and bone mass accrual both in animals and humans. However, its functional roles and molecular mechanism in chondrocyte differentiation and osteoarthritis (OA) pathophysiology remain largely undefined. In this study, we analysed its mechanistic association and functional r...

journal_title：Annals of the rheumatic diseases

authors： Tong W,Zeng Y,Chow DHK,Yeung W,Xu J,Deng Y,Chen S,Zhao H,Zhang X,Ho KK,Qin L,Mak KK

更新日期：2019-04-01 00:00:00

abstract：:The current management of autoimmunity involves the administration of immunosuppressive drugs coupled to symptomatic and functional interventions such as anti-inflammatory therapies and hormone replacement. Given the chronic nature of autoimmunity, however, the ideal therapeutic strategy would be to reinduce self-tole...

journal_title：Annals of the rheumatic diseases

authors： Mosanya CH,Isaacs JD

更新日期：2019-03-01 00:00:00

abstract：QUESTION:Which is the best strategy to achieve (drug-free) inactive disease in juvenile idiopathic arthritis (JIA)? METHODS:In a randomised, single-blinded, study in disease-modifying anti-rheumatic drug (DMARD)-naive patients with JIA, three treatment-strategies were compared: (1) sequential DMARD-monotherapy (sulfas...

journal_title：Annals of the rheumatic diseases

authors： Hissink Muller P,Brinkman DMC,Schonenberg-Meinema D,van den Bosch WB,Koopman-Keemink Y,Brederije ICJ,Bekkering PW,Kuijpers TW,Van Rossum M,van Suijlekom-Smit LWA,van den Berg JM,Boehringer S,Allaart CF,Ten Cate R

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To assess survival and identify predictors of survival in patients with systemic sclerosis-interstitial lung disease (SSc-ILD) who participated in the Scleroderma Lung Studies (SLS) I and II. METHODS:SLS I randomised 158 patients with SSc-ILD to 1  year of oral cyclophosphamide (CYC) vs placebo. SLS II rando...

journal_title：Annals of the rheumatic diseases

authors： Volkmann ER,Tashkin DP,Sim M,Li N,Goldmuntz E,Keyes-Elstein L,Pinckney A,Furst DE,Clements PJ,Khanna D,Steen V,Schraufnagel DE,Arami S,Hsu V,Roth MD,Elashoff RM,Sullivan KM,SLS I and SLS II study groups.

更新日期：2019-01-01 00:00:00