听力与言语-语言病理学

行为科学

医学伦理学

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  • Factors associated with progression to inflammatory arthritis in first-degree relatives of individuals with RA following autoantibody positive screening in a non-clinical setting.

    abstract:OBJECTIVES:Little is known about the likelihood of developing inflammatory arthritis (IA) in individuals who screen autoantibody positive (aAb+) in a non-clinical research setting. METHODS:We screened for serum cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor isotype aAbs in subjects who were at ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2020-217066

    authors: Bemis EA,Demoruelle MK,Seifert JA,Polinski KJ,Weisman MH,Buckner JH,Gregersen PK,Mikuls TR,ODell JR,Keating RM,Deane KD,Holers VM,Norris JM

    更新日期:2021-02-01 00:00:00

  • Machine learning integration of scleroderma histology and gene expression identifies fibroblast polarisation as a hallmark of clinical severity and improvement.

    abstract:OBJECTIVE:We sought to determine histologic and gene expression features of clinical improvement in early diffuse cutaneous systemic sclerosis (dcSSc; scleroderma). METHODS:Fifty-eight forearm biopsies were evaluated from 26 individuals with dcSSc in two clinical trials. Histologic/immunophenotypic assessments of glob...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2020-217840

    authors: Showalter K,Spiera R,Magro C,Agius P,Martyanov V,Franks JM,Sharma R,Geiger H,Wood TA,Zhang Y,Hale CR,Finik J,Whitfield ML,Orange DE,Gordon JK

    更新日期:2021-02-01 00:00:00

  • Natural killer cells and type II interferon in Ro/SSA and La/SSB autoantibody-exposed newborns at risk of congenital heart block.

    abstract:OBJECTIVE:Congenital heart block (CHB) with immune cell infiltration develops in the fetus after exposure to maternal Ro/La autoantibodies. CHB-related serology has been extensively studied, but reports on immune-cell profiles of anti-Ro/La-exposed neonates are lacking. In the current study, we characterised circulatin...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-216786

    authors: Ivanchenko M,Thorlacius GE,Hedlund M,Ottosson V,Meneghel L,Björkander S,Ossoinak A,Tingström J,Bremme K,Sverremark-Ekström E,Gemzell-Danielsson K,Sonesson SE,Chemin K,Wahren-Herlenius M

    更新日期:2021-02-01 00:00:00

  • 2019 EULAR points to consider for the assessment of competences in rheumatology specialty training.

    abstract:BACKGROUND AND AIM:Striving for harmonisation of specialty training and excellence of care in rheumatology, the European League Against Rheumatism (EULAR) established a task force to develop points to consider (PtCs) for the assessment of competences during rheumatology specialty training. METHODS:A systematic literat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2020-218015

    authors: Sivera F,Alunno A,Najm A,Avcin T,Baraliakos X,Bijlsma JW,Badreh S,Burmester G,Cikes N,Da Silva JA,Damjanov N,Dougados M,Dudler J,Edwards CJ,Iagnocco A,Lioté F,Nikiphorou E,van Onna M,Stones SR,Vassilopoulos D,Hain

    更新日期:2021-01-01 00:00:00

  • EULAR recommendations for a core data set for pregnancy registries in rheumatology.

    abstract:BACKGROUND AND OBJECTIVE:There is an urgent need for robust data on the trajectories and outcomes of pregnancies in women with inflammatory rheumatic diseases (IRD). In particular when rare outcomes or rare diseases are to be investigated, collaborative approaches are required. However, joint data analyses are often li...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2020-218356

    authors: Meissner Y,Fischer-Betz R,Andreoli L,Costedoat-Chalumeau N,De Cock D,Dolhain RJEM,Forger F,Goll D,Molto A,Nelson-Piercy C,Özdemir R,Raio L,Rodríguez-García SC,Sciascia S,Wallenius M,Zbinden A,Zink A,Strangfeld A

    更新日期:2021-01-01 00:00:00

  • Upadacitinib for psoriatic arthritis refractory to biologics: SELECT-PsA 2.

    abstract:BACKGROUND:Upadacitinib is a Janus kinase inhibitor under evaluation for the treatment of psoriatic arthritis (PsA). We evaluated upadacitinib in patients with PsA and prior inadequate response or intolerance to at least one biologic disease-modifying antirheumatic drug (DMARD). METHODS:In this 24-week randomised, pla...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2020-218870

    authors: Mease PJ,Lertratanakul A,Anderson JK,Papp K,Van den Bosch F,Tsuji S,Dokoupilova E,Keiserman M,Wang X,Zhong S,McCaskill RM,Zueger P,Pangan AL,Tillett W

    更新日期:2020-12-03 00:00:00

  • Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis.

    abstract:OBJECTIVES:Eosinophils possess pro-inflammatory functions in asthma. However, our recent studies have suggested that innate lymphoid cells type 2 (ILC2s) and eosinophils have proresolving properties in rheumatoid arthritis (RA). Nothing is known yet about the mechanisms determining the double-edged role of eosinophils....

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2020-218902

    authors: Andreev D,Liu M,Kachler K,Llerins Perez M,Kirchner P,Kölle J,Gießl A,Rauber S,Song R,Aust O,Grüneboom A,Kleyer A,Cañete JD,Ekici A,Ramming A,Finotto S,Schett G,Bozec A

    更新日期:2020-11-04 00:00:00

  • Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases.

    abstract:OBJECTIVES:To describe patients with autoimmune inflammatory rheumatic diseases (AIRD) who had COVID-19 disease; to compare patients who required hospital admission with those who did not and assess risk factors for hospital admission related to COVID-19. METHODS:An observational longitudinal study was conducted durin...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2020-217984

    authors: Freites Nuñez DD,Leon L,Mucientes A,Rodriguez-Rodriguez L,Font Urgelles J,Madrid García A,Colomer JI,Jover JA,Fernandez-Gutierrez B,Abasolo L

    更新日期:2020-11-01 00:00:00

  • Safety profile of upadacitinib in rheumatoid arthritis: integrated analysis from the SELECT phase III clinical programme.

    abstract:OBJECTIVES:This integrated analysis presents the safety profile of upadacitinib, a Janus kinase inhibitor, at 15 mg and 30 mg once daily in patients with moderately to severely active rheumatoid arthritis (RA). METHODS:Treatment-emergent adverse events (TEAEs) and laboratory data from five randomised, placebo- or acti...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2020-218510

    authors: Cohen SB,van Vollenhoven RF,Winthrop KL,Zerbini CAF,Tanaka Y,Bessette L,Zhang Y,Khan N,Hendrickson B,Enejosa JV,Burmester GR

    更新日期:2020-10-28 00:00:00

  • Prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases: a systematic review and meta-analysis.

    abstract:OBJECTIVES:The prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases who are frequently treated with disease modifying therapies remains poorly understood. This meta-analysis aims to assess the prevalence and clinical outcomes of COVID-19 in autoimmune diseases. METHODS:Electronic databases...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2020-218946

    authors: Akiyama S,Hamdeh S,Micic D,Sakuraba A

    更新日期:2020-10-13 00:00:00

  • Long-term efficacy and safety of canakinumab in patients with colchicine-resistant familial Mediterranean fever: results from the randomised phase III CLUSTER trial.

    abstract:OBJECTIVES:To evaluate the long-term efficacy and safety of canakinumab to treat patients with colchicine-resistant familial Mediterranean fever (crFMF) during Epoch 4 (weeks 41 to 113) of the CLUSTER study. METHODS:Patients received open-label canakinumab 150 or 300 mg, every 4 or 8 weeks during a 72-week period. We ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/annrheumdis-2020-217419

    authors: Ozen S,Ben-Cherit E,Foeldvari I,Amarilyo G,Ozdogan H,Vanderschueren S,Marzan K,Kahlenberg JM,Dekker E,De Benedetti F,Koné-Paut I

    更新日期:2020-10-01 00:00:00

  • Effectiveness of secukinumab versus an alternative TNF inhibitor in patients with axial spondyloarthritis previously exposed to TNF inhibitors in the Swiss Clinical Quality Management cohort.

    abstract:OBJECTIVE:To compare effectiveness of treatment with secukinumab (SEC) with that of alternative tumour necrosis factor inhibitors (TNFis) in patients with axial spondyloarthritis (axSpA) after withdrawal from one or more TNFis. METHODS:Patients diagnosed as having axSpA in the Swiss Clinical Quality Management cohort ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-215934

    authors: Micheroli R,Tellenbach C,Scherer A,Bürki K,Niederman K,Nissen MJ,Zufferey P,Exer P,Möller B,Kyburz D,Ciurea A

    更新日期:2020-09-01 00:00:00

  • Blood-based test for diagnosis and functional subtyping of familial Mediterranean fever.

    abstract:BACKGROUND AND OBJECTIVE:Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease (AID) worldwide. The disease is caused by mutations in the MEFV gene encoding the inflammasome sensor Pyrin. Clinical diagnosis of FMF is complicated by overlap in symptoms with other diseases, and interpre...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-216701

    authors: Van Gorp H,Huang L,Saavedra P,Vuylsteke M,Asaoka T,Prencipe G,Insalaco A,Ogunjimi B,Jeyaratnam J,Cataldo I,Jacques P,Vermaelen K,Dullaers M,Joos R,Sabato V,Stella A,Frenkel J,De Benedetti F,Dehoorne J,Haerynck F,C

    更新日期:2020-07-01 00:00:00

  • Improving rheumatoid arthritis comparative effectiveness research through causal inference principles: systematic review using a target trial emulation framework.

    abstract:OBJECTIVES:Target trial emulation is an intuitive design framework that encourages investigators to formulate their comparative effectiveness research (CER) question as a hypothetical randomised controlled trial (RCT). Our aim was to systematically review CER studies in rheumatoid arthritis (RA) to provide examples of ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2020-217200

    authors: Zhao SS,Lyu H,Solomon DH,Yoshida K

    更新日期:2020-07-01 00:00:00

  • Immunosuppression and the risk of readmission and mortality in patients with rheumatoid arthritis undergoing hip fracture, abdominopelvic and cardiac surgery.

    abstract:OBJECTIVES:The impact of immunosuppression on postoperative outcomes has primarily been studied in patients undergoing joint replacement surgery. We aimed to evaluate the impact of biologics and glucocorticoids on outcomes after other major surgeries. METHODS:This retrospective cohort study used Medicare data 2006-201...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-216802

    authors: George MD,Baker JF,Winthrop KL,Goldstein SD,Alemao E,Chen L,Wu Q,Xie F,Curtis JR

    更新日期:2020-05-01 00:00:00

  • Differences in the serum metabolome and lipidome identify potential biomarkers for seronegative rheumatoid arthritis versus psoriatic arthritis.

    abstract:OBJECTIVES:The differential diagnosis of seronegative rheumatoid arthritis (negRA) and psoriasis arthritis (PsA) is often difficult due to the similarity of symptoms and the unavailability of reliable clinical markers. Since chronic inflammation induces major changes in the serum metabolome and lipidome, we tested whet...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-216374

    authors: Souto-Carneiro M,Tóth L,Behnisch R,Urbach K,Klika KD,Carvalho RA,Lorenz HM

    更新日期:2020-04-01 00:00:00

  • Elevated EPSTI1 promote B cell hyperactivation through NF-κB signalling in patients with primary Sjögren's syndrome.

    abstract:BACKGROUND:Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterised by aberrant B cell hyperactivation, whose mechanism is partially understood. METHODS:We performed whole transcriptome sequencing of B cells from three pSS patients and three matched healthy controls (HC). Differentially expressi...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-216428

    authors: Sun JL,Zhang HZ,Liu SY,Lian CF,Chen ZL,Shao TH,Zhang S,Zhao LL,He CM,Wang M,Zhang W,Chen H,Zhang FC

    更新日期:2020-04-01 00:00:00

  • Development of a prediction model for inpatient gout flares in people with comorbid gout.

    abstract:OBJECTIVES:Hospitalisation is a risk factor for flares in people with gout. However, the predictors of inpatient gout flare are not well understood. The aim of this study was to develop a prediction model for inpatient gout flare among people with comorbid gout. METHODS:We used data from a retrospective cohort of hosp...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-216277

    authors: Jatuworapruk K,Grainger R,Dalbeth N,Taylor WJ

    更新日期:2020-03-01 00:00:00

  • IFN-α kinoid in systemic lupus erythematosus: results from a phase IIb, randomised, placebo-controlled study.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of the immunotherapeutic vaccine interferon-α kinoid (IFN-K) in a 36-week (W) phase IIb, randomised, double-blind, placebo (PBO)-controlled trial in adults with active systemic lupus erythematosus (SLE) despite standard of care. METHODS:Patients with SLE (185) with moderat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/annrheumdis-2019-216379

    authors: Houssiau FA,Thanou A,Mazur M,Ramiterre E,Gomez Mora DA,Misterska-Skora M,Perich-Campos RA,Smakotina SA,Cerpa Cruz S,Louzir B,Croughs T,Tee ML

    更新日期:2020-03-01 00:00:00

  • Shared decision making in routine clinical care of patients with rheumatoid arthritis: an assessment of audio-recorded consultations.

    abstract:OBJECTIVES:Although shared decision making (SDM) is advocated in rheumatoid arthritis (RA) treatment, it is largely unclear when, how and to what extent SDM is applied in routine clinical care of patients with RA. This study aimed to investigate the level of SDM in RA treatment from an observer perspective and to asses...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-216137

    authors: Mathijssen EGE,Vriezekolk JE,Popa CD,van den Bemt BJF

    更新日期:2020-02-01 00:00:00

  • Tuberculosis in biologic users for rheumatic diseases: results from the South African Biologics Registry (SABIO).

    abstract:OBJECTIVES:To evaluate the rate of tuberculosis (TB) in biologic users for rheumatic diseases in South Africa, the effectiveness of our latent TB infection (LTBI) programme, risk factors and outcome. METHODS:TB cases were collected from the South African Biologics Registry (SABIO), rheumatologists and pharmaceutical c...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-216128

    authors: Pettipher C,Benitha R

    更新日期:2020-02-01 00:00:00

  • In an early SLE cohort the ACR-1997, SLICC-2012 and EULAR/ACR-2019 criteria classify non-overlapping groups of patients: use of all three criteria ensures optimal capture for clinical studies while their modification earlier classification and treatment.

    abstract:OBJECTIVES:Classification criteria are biased towards classifying long-standing disease. We compared the European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR)-2019, Systemic Lupus International Collaborating Clinics (SLICC)-2012 and ACR-1997 criteria in an early (median 48 months) systemic l...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-216155

    authors: Adamichou C,Nikolopoulos D,Genitsaridi I,Bortoluzzi A,Fanouriakis A,Papastefanakis E,Kalogiannaki E,Gergianaki I,Sidiropoulos P,Boumpas DT,Bertsias GK

    更新日期:2020-02-01 00:00:00

  • 2018 Update of the EULAR recommendations for the management of large vessel vasculitis.

    abstract:BACKGROUND:Since the publication of the European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis (LVV) in 2009, several relevant randomised clinical trials and cohort analyses have been published, which have the potential to change clinical care and therefore supporting t...

    journal_title:Annals of the rheumatic diseases

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1136/annrheumdis-2019-215672

    authors: Hellmich B,Agueda A,Monti S,Buttgereit F,de Boysson H,Brouwer E,Cassie R,Cid MC,Dasgupta B,Dejaco C,Hatemi G,Hollinger N,Mahr A,Mollan SP,Mukhtyar C,Ponte C,Salvarani C,Sivakumar R,Tian X,Tomasson G,Turesson C,S

    更新日期:2020-01-01 00:00:00

  • 2019 EULAR recommendations for the generic core competences of health professionals in rheumatology.

    abstract:BACKGROUND/OBJECTIVES:To maintain and optimise the quality of care provided by health professionals in rheumatology (HPRs), adequate educational offerings are needed. This task force (TF) aimed to develop evidence-based recommendations for the generic core competences of HPRs, with specific reference to nurses, physica...

    journal_title:Annals of the rheumatic diseases

    pub_type: 共识发展会议,指南,杂志文章

    doi:10.1136/annrheumdis-2019-215803

    authors: Edelaar L,Nikiphorou E,Fragoulis GE,Iagnocco A,Haines C,Bakkers M,Barbosa L,Cikes N,Ndosi M,Primdahl J,Prior Y,Pchelnikova P,Ritschl V,Schäfer VS,Smucrova H,Storrønning I,Testa M,Wiek D,Vliet Vlieland TPM

    更新日期:2020-01-01 00:00:00

  • Risk of gout flares after vaccination: a prospective case cross-over study.

    abstract:OBJECTIVES:The recombinant zoster vaccine (RZV) containing a strong non-aluminium adjuvant is associated with increased risk of gout flares, presumably via NLRP3 inflammasome activation. We tested the possibility that other vaccines may also be associated with gout flares. METHODS:We conducted an online case-crossover...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-215724

    authors: Yokose C,McCormick N,Chen C,Neogi T,Chaisson C,Terkeltaub R,Hunter DJ,Zhang Y,Choi H

    更新日期:2019-11-01 00:00:00

  • Potential involvement of OX40 in the regulation of autoantibody sialylation in arthritis.

    abstract:OBJECTIVE:An increased proportion of circulating follicular helper T (Tfh) cells was reported in rheumatoid arthritis (RA), but it remains uncertain how Tfh cells affect antibody hyposialylation. We investigated the regulation of autoantibody hyposialylation by Tfh cells in RA using murine model. METHODS:Behaviours of...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-215195

    authors: Kurata I,Matsumoto I,Ohyama A,Osada A,Ebe H,Kawaguchi H,Kaneko S,Kondo Y,Tsuboi H,Tomioka A,Kaji H,Sumida T

    更新日期:2019-11-01 00:00:00

  • Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to conventional DMARDs: a randomised, double-blind, placebo-controlled phase III trial (RAJ3).

    abstract:OBJECTIVES:To investigate the efficacy and safety of peficitinib, an oral Janus kinase inhibitor, in patients with rheumatoid arthritis (RA). METHODS:In this double-blind phase III study, patients with RA and an inadequate response to prior disease-modifying anti-rheumatic drugs (DMARDs) were randomised to peficitinib...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/annrheumdis-2019-215163

    authors: Tanaka Y,Takeuchi T,Tanaka S,Kawakami A,Iwasaki M,Song YW,Chen YH,Wei JC,Lee SH,Rokuda M,Izutsu H,Ushijima S,Kaneko Y,Akazawa R,Shiomi T,Yamada E

    更新日期:2019-10-01 00:00:00

  • Association of Epstein-Barr virus serological reactivation with transitioning to systemic lupus erythematosus in at-risk individuals.

    abstract:OBJECTIVE:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with unknown aetiology. Epstein-Barr virus (EBV) is an environmental factor associated with SLE. EBV maintains latency in B cells with frequent reactivation measured by antibodies against viral capsid antigen (VCA) and early antigen (EA). In ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-215361

    authors: Jog NR,Young KA,Munroe ME,Harmon MT,Guthridge JM,Kelly JA,Kamen DL,Gilkeson GS,Weisman MH,Karp DR,Gaffney PM,Harley JB,Wallace DJ,Norris JM,James JA

    更新日期:2019-09-01 00:00:00

  • Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis.

    abstract:OBJECTIVES:The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early,...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-215051

    authors: Gohar F,McArdle A,Jones M,Callan N,Hernandez B,Kessel C,Miranda-Garcia M,Lavric M,Holzinger D,Pretzer C,Lainka E,Vastert SJ,de Roock S,FitzGerald O,Pennington SR,Foell D

    更新日期:2019-08-01 00:00:00

  • Chromatin interactions reveal novel gene targets for drug repositioning in rheumatic diseases.

    abstract:OBJECTIVES:There is a need to identify effective treatments for rheumatic diseases, and while genetic studies have been successful it is unclear which genes contribute to the disease. Using our existing Capture Hi-C data on three rheumatic diseases, we can identify potential causal genes which are targets for existing ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2018-214649

    authors: Martin P,Ding J,Duffus K,Gaddi VP,McGovern A,Ray-Jones H,Yarwood A,Worthington J,Barton A,Orozco G

    更新日期:2019-08-01 00:00:00

  • Identification of rare coding variants in TYK2 protective for rheumatoid arthritis in the Japanese population and their effects on cytokine signalling.

    abstract:OBJECTIVE:Although genome-wide association studies (GWAS) have identified approximately 100 loci for rheumatoid arthritis (RA), the disease mechanisms are not completely understood. We evaluated the pathogenesis of RA by focusing on rare coding variants. METHODS:The coding regions of 98 candidate genes identified by G...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-215062

    authors: Motegi T,Kochi Y,Matsuda K,Kubo M,Yamamoto K,Momozawa Y

    更新日期:2019-08-01 00:00:00

  • Impact of Janus kinase inhibitors on risk of cardiovascular events in patients with rheumatoid arthritis: systematic review and meta-analysis of randomised controlled trials.

    abstract:OBJECTIVES:To investigate the effect of Janus kinase inhibitors (Jakinibs) on cardiovascular risk in adult patients with rheumatoid arthritis (RA) via a meta-analysis of randomised controlled trials (RCTs). METHODS:PubMed, Embase and Cochrane library were thoroughly searched for RCTs reporting safety issues in patient...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,meta分析

    doi:10.1136/annrheumdis-2018-214846

    authors: Xie W,Huang Y,Xiao S,Sun X,Fan Y,Zhang Z

    更新日期:2019-08-01 00:00:00

  • Aortic-vertebral interaction in ankylosing spondylitis: syndesmophyte development at the juxta-aortic vertebral rim.

    abstract:OBJECTIVES:The aorta inhibits paravertebral ossification in diffuse idiopathic skeletal hyperostosis. We investigated if syndesmophytes in ankylosing spondylitis (AS) occurred less often at the vertebral rim near the aorta. METHODS:We performed thoracolumbar CT scans in 60 subjects in this cross-sectional study. The m...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2018-214675

    authors: Tan S,Dasgupta A,Flynn JA,Ward MM

    更新日期:2019-07-01 00:00:00

  • Effects of BI 655064, an antagonistic anti-CD40 antibody, on clinical and biomarker variables in patients with active rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase IIa study.

    abstract:OBJECTIVE:To evaluate the safety, efficacy and therapeutic mechanism of BI 655064, an antagonistic anti-CD40 monoclonal antibody, in patients with rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX-IR). METHODS:In total, 67 patients were randomised to receive weekly subcutaneous doses of 120 mg ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/annrheumdis-2018-214729

    authors: Visvanathan S,Daniluk S,Ptaszyński R,Müller-Ladner U,Ramanujam M,Rosenstock B,Eleftheraki AG,Vinisko R,Petříková A,Kellner H,Dokoupilova E,Kwiatkowska B,Alten R,Schwabe C,Baum P,Joseph D,Fine JS,Padula SJ,Steffgen J

    更新日期:2019-06-01 00:00:00

  • [18F]Florbetapir positron emission tomography: identification of muscle amyloid in inclusion body myositis and differentiation from polymyositis.

    abstract:OBJECTIVES:With the tools available currently, confirming the diagnosis of inclusion body myositis (IBM) can be difficult. Many patients are initially misdiagnosed with polymyositis (PM). In this observational study at a UK adult neuromuscular centre, we investigated whether amyloid positron emission tomography could d...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2018-214644

    authors: Lilleker JB,Hodgson R,Roberts M,Herholz K,Howard J,Hinz R,Chinoy H

    更新日期:2019-05-01 00:00:00

  • Reducing arthritis fatigue impact: two-year randomised controlled trial of cognitive behavioural approaches by rheumatology teams (RAFT).

    abstract:OBJECTIVES:To see if a group course delivered by rheumatology teams using cognitive-behavioural approaches, plus usual care, reduced RA fatigue impact more than usual care alone. METHODS:Multicentre, 2-year randomised controlled trial in RA adults (fatigue severity>6/10, no recent major medication changes). RAFT (Redu...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/annrheumdis-2018-214469

    authors: Hewlett S,Almeida C,Ambler N,Blair PS,Choy EH,Dures E,Hammond A,Hollingworth W,Kadir B,Kirwan JR,Plummer Z,Rooke C,Thorn J,Turner N,Pollock J,RAFT Study Group.

    更新日期:2019-04-01 00:00:00

  • Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade.

    abstract:OBJECTIVES:Wnt16 is implicated in bone fracture and bone mass accrual both in animals and humans. However, its functional roles and molecular mechanism in chondrocyte differentiation and osteoarthritis (OA) pathophysiology remain largely undefined. In this study, we analysed its mechanistic association and functional r...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2018-214200

    authors: Tong W,Zeng Y,Chow DHK,Yeung W,Xu J,Deng Y,Chen S,Zhao H,Zhang X,Ho KK,Qin L,Mak KK

    更新日期:2019-04-01 00:00:00

  • Tolerising cellular therapies: what is their promise for autoimmune disease?

    abstract::The current management of autoimmunity involves the administration of immunosuppressive drugs coupled to symptomatic and functional interventions such as anti-inflammatory therapies and hormone replacement. Given the chronic nature of autoimmunity, however, the ideal therapeutic strategy would be to reinduce self-tole...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1136/annrheumdis-2018-214024

    authors: Mosanya CH,Isaacs JD

    更新日期:2019-03-01 00:00:00

  • Treat to target (drug-free) inactive disease in DMARD-naive juvenile idiopathic arthritis: 24-month clinical outcomes of a three-armed randomised trial.

    abstract:QUESTION:Which is the best strategy to achieve (drug-free) inactive disease in juvenile idiopathic arthritis (JIA)? METHODS:In a randomised, single-blinded, study in disease-modifying anti-rheumatic drug (DMARD)-naive patients with JIA, three treatment-strategies were compared: (1) sequential DMARD-monotherapy (sulfas...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/annrheumdis-2018-213902

    authors: Hissink Muller P,Brinkman DMC,Schonenberg-Meinema D,van den Bosch WB,Koopman-Keemink Y,Brederije ICJ,Bekkering PW,Kuijpers TW,Van Rossum M,van Suijlekom-Smit LWA,van den Berg JM,Boehringer S,Allaart CF,Ten Cate R

    更新日期:2019-01-01 00:00:00

  • Short-term progression of interstitial lung disease in systemic sclerosis predicts long-term survival in two independent clinical trial cohorts.

    abstract:OBJECTIVE:To assess survival and identify predictors of survival in patients with systemic sclerosis-interstitial lung disease (SSc-ILD) who participated in the Scleroderma Lung Studies (SLS) I and II. METHODS:SLS I randomised 158 patients with SSc-ILD to 1  year of oral cyclophosphamide (CYC) vs placebo. SLS II rando...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/annrheumdis-2018-213708

    authors: Volkmann ER,Tashkin DP,Sim M,Li N,Goldmuntz E,Keyes-Elstein L,Pinckney A,Furst DE,Clements PJ,Khanna D,Steen V,Schraufnagel DE,Arami S,Hsu V,Roth MD,Elashoff RM,Sullivan KM,SLS I and SLS II study groups.

    更新日期:2019-01-01 00:00:00

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