abstract：PURPOSE OF REVIEW:Ventilator weaning forms an integral part in critical care medicine and strategies to shorten duration are rapidly evolving alongside our knowledge of the relevant physiological processes. The purpose of the current review is to discuss new physiological and clinical insights in ventilator weaning tha...

journal_title：Current opinion in critical care

authors： Haaksma ME,Tuinman PR,Heunks L

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Progress has been made in our understanding of gut dysfunction in critical illness. This review will outline new findings and give perspectives based on previous knowledge and concurrent advances in nutrition. RECENT FINDINGS:The relationship between gut dysfunction and poor outcomes in critical illn...

journal_title：Current opinion in critical care

authors： Chapple LS,Plummer MP,Chapman MJ

更新日期：2021-01-21 00:00:00

abstract：PURPOSE OF REVIEW:Point-of-care ultrasound (POCUS) is commonly used during cardiac arrest to screen for potential causes and to inform termination of resuscitation. However, unique biases and limitations in diagnostic and prognostic test accuracy studies lead to potential for misinterpretation. The present review highl...

journal_title：Current opinion in critical care

authors： Reynolds JC,Del Rios M

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiac arrest is one of the most challenging disease processes to study with clinical trials due to the emergent and unpredictable nature of these events and complexity of the patient population. In recent years, there has been a major push to complete more large, multicentre trials. In many cases, h...

journal_title：Current opinion in critical care

authors： Berg KM

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe current antimicrobial resistance in ESKAPE Gram-negative microorganisms and their situation in the ICUs, the implication of the so-called high-risk clones (HiRCs) involved in the spread of antimicrobial resistance as well as relevance of the COVID-19 pandemic in the potential increase of r...

journal_title：Current opinion in critical care

authors： Cantón R,Gijón D,Ruiz-Garbajosa P

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:There is growing evidence that bone health is impacted during and after critical illness in multiple ways. In this review, we provide a practical update on postcritical care bone loss with an insight on identification of persons at risk, prevention and treatment strategies. RECENT FINDINGS:Critical i...

journal_title：Current opinion in critical care

authors： Rousseau AF,Kerschan-Schindl K,Scherkl M,Amrein K

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Survivorship or addressing impaired quality of life (QoL) in ICU survivors has been named 'the defining challenge of critical care' for this century to address this challenge; in addition to optimal nutrition, we must learn to employ targeted metabolic/muscle assessment techniques and utilize structur...

journal_title：Current opinion in critical care

authors： Molinger J,Pastva AM,Whittle J,Wischmeyer PE

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Multimodal monitoring has emerged as a novel paradigm of care in acute brain injury, and in this context the value of noninvasive devices is increasingly under scrutiny. This narrative review summarizes recent clinical investigation focused on the role of automated infrared pupillometry (AIP) and opti...

journal_title：Current opinion in critical care

authors： Romagnosi F,Bongiovanni F,Oddo M

更新日期：2020-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Status epilepticus is a neurological emergency associated with high morbidity and mortality. There is a lack of robust data to guide the management of this neurological emergency beyond the initial treatment. This review examines recent literature on treatment considerations including the choice of co...

journal_title：Current opinion in critical care

authors： Der-Nigoghossian C,Rubinos C,Alkhachroum A,Claassen J

更新日期：2019-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe recent data about Acinetobacter baumannii pneumonia epidemiology and the therapeutic options including adjunctive nebulized therapy. RECENT FINDINGS:A. baumannii is a major cause of nosocomial pneumonia in certain geographic areas affecting mainly debilitated patients, with prolonged hosp...

journal_title：Current opinion in critical care

authors： Amaya-Villar R,Garnacho-Montero J

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we focus on the dual face of antibiotic therapy in the critically ill that must harmonize the need for early, appropriate and adequate antibiotic therapy in the individual-infected patient with the obligation to limit antibiotic selection pressure as much as possible to preserve its fu...

journal_title：Current opinion in critical care

authors： Depuydt P,De Waele JJ

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Although vitamin C is essentially a nontoxic vitamin; however, it is important to be aware regarding the safety of high doses before the wide clinical use. RECENT FINDINGS:Minor side effects of vitamin C have been reported, many being reported in earlier studies. High doses of vitamin C (up to 1.5 g/...

journal_title：Current opinion in critical care

authors： Khoshnam-Rad N,Khalili H

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes current understanding of the pathophysiology of cardiogenic pulmonary edema, its causes and treatment. RECENT FINDINGS:The pathobiology and classification of pulmonary edema is more complex than the hydrostatic vs. permeability dichotomy of the past. Mechanisms of alveolar flui...

journal_title：Current opinion in critical care

authors： Ingbar DH

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Glutamine (GLN) is a versatile amino acid, long believed to have important implications in ICU and surgical patients. An extensive body of data examining GLN supplementation of TPN demonstrated a consistent signal of improved outcomes. However, recently signals of risk have come from two large-scale m...

journal_title：Current opinion in critical care

authors： Wischmeyer PE

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes the current intensive care management of acute liver failure (ALF) and the latest evidence for emerging therapies. RECENT FINDINGS:Mortality from ALF continues to improve and in some cases, medical therapy can negate the need for liver transplantation because of protocolized man...

journal_title：Current opinion in critical care

authors： Trovato FM,Rabinowich L,McPhail MJW

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Energy dysfunction is increasingly recognized as a key factor in the pathogenesis of acute brain injury (ABI). This one characterized by a high metabolic rate and nitrogen loss is often associated with an undernutrition support. We review the metabolism evolution and nutritional status in brain injure...

journal_title：Current opinion in critical care

authors： Quintard H,Ichai C

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the improvements in its management, community-acquired pneumonia (CAP) still exhibits high global morbidity and mortality rates, especially in elderly patients. This review focuses on the most recent findings on the epidemiology, cause, diagnosis and management of CAP. RECENT FINDINGS:There i...

journal_title：Current opinion in critical care

authors： Cillóniz C,Dominedò C,Garcia-Vidal C,Torres A

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to provide an overview of the immune response to major surgery, and the ways in which it may be modulated to improve postoperative outcomes. RECENT FINDINGS:Data from patients who have undergone a variety of tissue injuries (surgery, burns, sepsis, trauma) have shown the...

journal_title：Current opinion in critical care

authors： Shankar Hari M,Summers C

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The present article reviews the recent literature on the main aspects of perioperative acute kidney injury (AKI). RECENT FINDINGS:AKI occurs in 1 in every 10 surgical patients, with cardiac, orthopedic, and major abdominal surgeries being the procedures associated with the highest risk. Overall, comp...

journal_title：Current opinion in critical care

authors： Canet E,Bellomo R

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the current knowledge about clinical and microbiological diagnosis of nonventilated hospital-acquired pneumonia (NV-HAP). RECENT FINDINGS:NV-HAP is emerging as a new challenge for clinicians, particularly because VAP incidence has been decreasing. The clinical diagnosis of NV-HAP uses the...

journal_title：Current opinion in critical care

authors： Ranzani OT,De Pascale G,Park M

更新日期：2018-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Temporary circulatory support (TCS) with short-term mechanical circulatory support (MCS) devices is increasingly used as a salvage therapy for patients with refractory cardiogenic shock. This article provides an overview of current devices, their indications and management, and discusses results of re...

journal_title：Current opinion in critical care

authors： Pineton de Chambrun M,Bréchot N,Combes A

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Esophageal manometry has shown its usefulness to estimate transpulmonary pressure, that is lung stress, and the intensity of spontaneous effort in patients with acute respiratory distress syndrome. However, clinical uptake of esophageal manometry in ICU is still low. Thus, the purpose of review is to ...

journal_title：Current opinion in critical care

authors： Yoshida T,Brochard L

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe and put into context recent conceptual advances regarding the relationship of energy load and power to ventilator-induced lung injury (VILI). RECENT FINDINGS:Investigative emphasis regarding VILI has almost exclusively centered on the static characteristics of the individual tidal cycle -...

journal_title：Current opinion in critical care

authors： Marini JJ

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Delayed awakening after targeted temperature management (TTM) and sedation is frequent among cardiac arrest patients. Differentiating between prolonged coma and irreversible cerebral damage can be challenging, therefore the utilization of a multimodal approach is recommended by international guideline...

journal_title：Current opinion in critical care

authors： Oddo M,Friberg H

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the clear rationale for evidence-based medicine (EvBM) in the challenging realms of resuscitation research, yet also provide case examples in which even the well designed, multicentered randomized clinical trial may have had unrecognized limitations, and thus misleading results. This is whe...

journal_title：Current opinion in critical care

authors： Pepe PE,Aufderheide TP

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The gut has long been hypothesized to be the 'motor' of multiple organ dysfunction syndrome. This review serves as an update on new data elucidating the role of the gut as the propagator of organ failure in critical illness. RECENT FINDINGS:Under basal conditions, the gut absorbs nutrients and serves...

journal_title：Current opinion in critical care

authors： Meng M,Klingensmith NJ,Coopersmith CM

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In light of emerging data from clinical trials, the place of high-frequency oscillatory ventilation (HFOV) in the management of acute respiratory distress syndrome (ARDS) is uncertain. This review provides an overview of these new clinical data and also explores new areas of investigation for HFOV in ...

journal_title：Current opinion in critical care

authors： Ng J,Ferguson ND

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Status epilepticus has a high morbidity and mortality. There are little definitive data to guide management; however, new recent data continue to improve understanding of management options of status epilepticus. This review examines recent advancements regarding the critical care management of status...

journal_title：Current opinion in critical care

authors： Bauerschmidt A,Martin A,Claassen J

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Ventilator-induced lung injury (VILI) can occur despite use of tidal volume (VT) limited to 6 ml/kg of predicted body weight, especially in patients with a smaller aerated compartment (i.e. the baby lung) in which, indeed, tidal ventilation takes place. Because respiratory system static compliance (CR...

journal_title：Current opinion in critical care

authors： Grieco DL,Chen L,Dres M,Brochard L

更新日期：2017-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The present article will review the current state of our understanding of nephrotoxic medication-associated acute kidney injury (AKI) and provide strategies to reduce its impact. RECENT FINDINGS:Nephrotoxic medications contribute to a substantial proportion of AKI in hospitalized patients. The previo...

journal_title：Current opinion in critical care

authors： Goldstein SL

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a minimally invasive damage control procedure for life-threatening abdominal or pelvic haemorrhage. The purpose of this review is to summarize the current understanding and experience with REBOA, outline potential future applications...

journal_title：Current opinion in critical care

authors： Perkins ZB,Lendrum RA,Brohi K

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose is to review the current application of extracorporeal life support (ECLS) in trauma patients. In addition, programmatic development is described. RECENT FINDINGS:ECLS use is increasing among trauma patients. Several recent studies among trauma patients report survival rates of 65-79%. De...

journal_title：Current opinion in critical care

authors： Zonies D,Merkel M

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:From an elderly patient's perspective, acute and chronic cognitive disturbances are among the most harmful complications that can occur following surgery. For elderly patients, these complications often mean the end of an independent life. This article focuses on this serious aspect, which is increasi...

journal_title：Current opinion in critical care

authors： Müller A,Lachmann G,Wolf A,Mörgeli R,Weiss B,Spies C

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Nutritional status and nutrient delivery during critical illness impact clinical outcomes. We have reviewed recent studies that may guide best practices regarding nutrition therapy in critically ill children. RECENT FINDINGS:Malnutrition is prevalent in the pediatric ICU population, and is associated...

journal_title：Current opinion in critical care

authors： Martinez EE,Mehta NM

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Stress ulcer prophylaxis (SUP) is considered standard of care in the majority of critically ill patients in the ICU. In this review, we will present the current evidence for the use of SUP in ICU patients, including data on the prevalence of gastrointestinal bleeding and the balance between benefits a...

journal_title：Current opinion in critical care

authors： Krag M,Perner A,Møller MH

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of the review is to summarize and discuss recent research regarding the role of mechanical ventilation in producing weakness and atrophy of the diaphragm in critically ill patients, an entity termed ventilator-induced diaphragmatic dysfunction (VIDD). RECENT FINDINGS:Severe weakness of th...

journal_title：Current opinion in critical care

authors： Petrof BJ,Hussain SN

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Shock occurs because of a failure to deliver adequate oxygen to meet the metabolic demands of the body resulting in metabolic acidosis, inflammation, and coagulopathy. Resuscitation is the process of treating shock in an attempt to restore normal physiology. Various hemodynamic, metabolic, and regiona...

journal_title：Current opinion in critical care

authors： Connelly CR,Schreiber MA

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Efforts to improve outcomes from acute kidney injury (AKI) have focussed on timely diagnosis and effective delivery of basic patient care. Electronic alerts (e-alerts) for AKI have attracted interest as a tool to facilitate this. Initial feasibility has already been demonstrated; this review will disc...

journal_title：Current opinion in critical care

authors： Horne KL,Selby NM

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past decades, survival of critically ill hematological patients has dramatically improved, and these patients are more frequently referred to the ICU for intensive treatment, including a rising need for administering anticancer-therapy in this setting. RECENT FINDINGS:The scarce literature o...

journal_title：Current opinion in critical care

authors： Moors I,Pène F,Lengline É,Benoit D

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Antimicrobials are very commonly used drugs in the intensive care setting. Extensive research has been conducted in recent years to describe their pharmacokinetics/pharmacodynamics in order to maximize the pharmacological benefit and patient outcome. Translating these new findings into clinical practi...

journal_title：Current opinion in critical care

authors： Tsai D,Lipman J,Roberts JA

更新日期：2015-10-01 00:00:00