Abstract:
PURPOSE OF REVIEW:The gut has long been hypothesized to be the 'motor' of multiple organ dysfunction syndrome. This review serves as an update on new data elucidating the role of the gut as the propagator of organ failure in critical illness. RECENT FINDINGS:Under basal conditions, the gut absorbs nutrients and serves as a barrier that prevents approximately 40 trillion intraluminal microbes and their products from causing host injury. However, in critical illness, gut integrity is disrupted with hyperpermeability and increased epithelial apoptosis, allowing contamination of extraluminal sites that are ordinarily sterile. These alterations in gut integrity are further exacerbated in the setting of preexisting comorbidities. The normally commensal microflora is also altered in critical illness, with increases in microbial virulence and decreases in diversity, which leads to further pathologic responses within the host. SUMMARY:All components of the gut are adversely impacted by critical illness. Gut injury can not only propagate local damage, but can also cause distant injury and organ failure. Understanding how the multifaceted components of the gut interact and how these are perturbed in critical illness may play an important role in turning off the 'motor' of multiple organ dysfunction syndrome in the future.
journal_name
Curr Opin Crit Carejournal_title
Current opinion in critical careauthors
Meng M,Klingensmith NJ,Coopersmith CMdoi
10.1097/MCC.0000000000000386subject
Has Abstractpub_date
2017-04-01 00:00:00pages
143-148issue
2eissn
1070-5295issn
1531-7072journal_volume
23pub_type
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/MCC.0000000000000413
更新日期:2017-06-01 00:00:00
abstract:PURPOSE OF REVIEW:We sought to review the evidence supporting neurocritical care as a distinct specialty of medicine. RECENT FINDINGS:Over the past 20 years, neuro-intensive care units have evolved from neurosurgical units focused primarily on postoperative monitoring to units that provide comprehensive medical and sp...
journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/MCC.0b013e32808255c6
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/00075198-200110000-00004
更新日期:2001-10-01 00:00:00
abstract:PURPOSE OF REVIEW:In this review, we focus on the dual face of antibiotic therapy in the critically ill that must harmonize the need for early, appropriate and adequate antibiotic therapy in the individual-infected patient with the obligation to limit antibiotic selection pressure as much as possible to preserve its fu...
journal_title:Current opinion in critical care
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更新日期:2019-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes current understanding of the pathophysiology of cardiogenic pulmonary edema, its causes and treatment. RECENT FINDINGS:The pathobiology and classification of pulmonary edema is more complex than the hydrostatic vs. permeability dichotomy of the past. Mechanisms of alveolar flui...
journal_title:Current opinion in critical care
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更新日期:2019-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Although vitamin C is essentially a nontoxic vitamin; however, it is important to be aware regarding the safety of high doses before the wide clinical use. RECENT FINDINGS:Minor side effects of vitamin C have been reported, many being reported in earlier studies. High doses of vitamin C (up to 1.5 g/...
journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/MCC.0000000000000622
更新日期:2019-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Multiple factors influence the dependability of intensive care provision. The management of a group of unstable, critically ill patients requires focused attention from the clinical team. Medical simulation is an important tool to improve safety and team work within the ICU. RECENT FINDINGS:The criti...
journal_title:Current opinion in critical care
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doi:10.1097/MCC.0b013e3282f1bb32
更新日期:2007-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The comparison of morbidity, mortality, and length-of-stay outcomes in patients receiving critical care requires adjustment based on their presenting illness. These adjustments are made with severity-of-illness models. These models must be periodically updated to reflect current medical practices. Thi...
journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/MCC.0b013e3283101643
更新日期:2008-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The present article will review the current state of our understanding of nephrotoxic medication-associated acute kidney injury (AKI) and provide strategies to reduce its impact. RECENT FINDINGS:Nephrotoxic medications contribute to a substantial proportion of AKI in hospitalized patients. The previo...
journal_title:Current opinion in critical care
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更新日期:2016-12-01 00:00:00
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journal_title:Current opinion in critical care
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doi:10.1097/01.ccx.0000179806.15328.b9
更新日期:2005-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Acute liver failure (ALF) is associated with significant mortality. Although specific therapies may be available, the evidence base for these and for many aspects of supportive therapy has been slow to emerge. Liver transplantation continues to be a cornerstone of treatment, and the management of ALF,...
journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/MCC.0000000000000073
更新日期:2014-04-01 00:00:00
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/00075198-200102000-00007
更新日期:2001-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Glutamine (GLN) is a versatile amino acid, long believed to have important implications in ICU and surgical patients. An extensive body of data examining GLN supplementation of TPN demonstrated a consistent signal of improved outcomes. However, recently signals of risk have come from two large-scale m...
journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/MCC.0000000000000633
更新日期:2019-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Although conventional anticonvulsant agents can terminate status epilepticus in most cases, a substantial minority of patients develops medically refractory status and requires more aggressive care. This review explores the options available. RECENT FINDINGS:Increasing numbers of previously unexpecte...
journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/01.ccx.0000157079.72999.87
更新日期:2005-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Securing the airway to provide sufficient oxygenation and ventilation is of paramount importance in the management of all types of emergency patients. Particularly in severely injured patients, strategies should be adapted according to useful recent literature findings. RECENT FINDINGS:The role of ou...
journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/MCC.0000000000000160
更新日期:2014-12-01 00:00:00
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/MCC.0000000000000254
更新日期:2015-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Health-related quality of life (HRQoL) is an important patient-reported outcome measure following critical illness. 'Validated' and professionally endorsed generic measures are widely used to evaluate critical care intervention and guide practice, policy and research. Although recognizing that they ar...
journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/MCC.0b013e32834a4bd4
更新日期:2011-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the role of microcirculatory abnormalities in critically ill patients and the link between systemic hemodynamics and microvascular perfusion. RECENT FINDINGS:Microcirculatory alterations have been repeatedly observed in patients with severe sepsis, but recent findings show that these also ...
journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/MCC.0b013e3283383621
更新日期:2010-06-01 00:00:00
abstract:PURPOSE OF REVIEW:We reviewed the topic of quality of life and prognosis of out-of-hospital cardiac arrest survivors, focusing on more recent developments. RECENT FINDINGS:In 2003 to 2004, published experiences from Canada, the United States, and Europe indicate that the quality of life among out-of-hospital cardiac a...
journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/01.ccx.0000125494.84614.fb
更新日期:2004-06-01 00:00:00
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/00075198-200302000-00010
更新日期:2003-02-01 00:00:00
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更新日期:2020-04-01 00:00:00
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journal_title:Current opinion in critical care
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
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更新日期:2013-08-01 00:00:00
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
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更新日期:2020-10-01 00:00:00
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
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更新日期:2002-10-01 00:00:00
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
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更新日期:2001-12-01 00:00:00
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
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journal_title:Current opinion in critical care
pub_type: 杂志文章
doi:10.1097/00075198-200008000-00005
更新日期:2000-08-01 00:00:00