Abstract:
PURPOSE OF REVIEW:Despite decades of advances in prehospital and in-hospital medical care, patients with out-of-hospital cardiac arrest continue to have poor neurologic and cardiac function following otherwise successful resuscitation. This review examines the mechanisms and therapeutic strategies currently under development to activate the post-conditioning pathways and thereby improve survival and function. RECENT FINDINGS:Post-conditioning utilizes the reperfusion injury salvage kinase (RISK) and survivor activating factor enhancement (SAFE) pathways as common avenues to promote cell survival and function. Ischemic post-conditioning and multiple medications activate these pathways resulting in improved cardiac and neurological function in animal models of cardiac arrest. SUMMARY:Detailed knowledge of the RISK and SAFE pathways can be used for further drug development. Human studies are now underway to test some of these strategies, but further clinical trials are necessary to translate these therapies to clinical practice.
journal_name
Curr Opin Crit Carejournal_title
Current opinion in critical careauthors
Bartos JA,Debaty G,Matsuura T,Yannopoulos Ddoi
10.1097/MCC.0000000000000087subject
Has Abstractpub_date
2014-06-01 00:00:00pages
242-9issue
3eissn
1070-5295issn
1531-7072journal_volume
20pub_type
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journal_title:Current opinion in critical care
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journal_title:Current opinion in critical care
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journal_title:Current opinion in critical care
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journal_title:Current opinion in critical care
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journal_title:Current opinion in critical care
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journal_title:Current opinion in critical care
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
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journal_title:Current opinion in critical care
pub_type: 杂志文章,评审
doi:10.1097/MCC.0000000000000061
更新日期:2014-02-01 00:00:00
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journal_title:Current opinion in critical care
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doi:10.1097/MCC.0b013e328348bef5
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更新日期:2018-10-01 00:00:00
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journal_title:Current opinion in critical care
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doi:10.1097/MCC.0000000000000561
更新日期:2018-12-01 00:00:00
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journal_title:Current opinion in critical care
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doi:10.1097/01.ccx.0000216571.80944.65
更新日期:2006-04-01 00:00:00
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journal_title:Current opinion in critical care
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doi:10.1097/MCC.0b013e32835ebb52
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更新日期:2013-06-01 00:00:00
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journal_title:Current opinion in critical care
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journal_title:Current opinion in critical care
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