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Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study.

Abstract：

:Changes in the surface morphology of the orbitofrontal cortex (OFC), such as a fewer orbital sulci and altered sulcogyral pattern of the 'H-shaped' orbital sulcus, have been reported in schizophrenia, possibly reflecting abnormal neurodevelopment during gestation. However, whether high-risk subjects for developing psychosis also exhibit these gross morphologic anomalies is not well documented. This multicenter MRI study from four scanning sites in Japan investigated the distribution of the number of intermediate and posterior orbital sulci, as well as the OFC sulcogyral pattern, in 125 individuals with an at-risk mental state (ARMS) [of whom 22 later developed psychosis (ARMS-P) and 89 did not (ARMS-NP)] and 110 healthy controls. The ARMS group as a whole had a significantly lower number of intermediate and posterior orbital sulci compared with the controls, which was associated with prodromal symptomatology. However, there was no group difference in OFC pattern distribution. The ARMS-P and -NP groups did not differ in OFC surface morphology. These results suggest that gross morphology of the OFC in high-risk subjects may at least partly reflect neurodevelopmental pathology related to vulnerability to psychosis.

journal_name

Eur Arch Psychiatry Clin Neurosci

journal_title

European archives of psychiatry and clinical neuroscience

authors

Nakamura M,Takahashi T,Takayanagi Y,Sasabayashi D,Katagiri N,Sakuma A,Obara C,Koike S,Yamasue H,Furuichi A,Kido M,Nishikawa Y,Noguchi K,Matsumoto K,Mizuno M,Kasai K,Suzuki M

doi

10.1007/s00406-018-0890-6

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

397-406

issue

4

eissn

0940-1334

issn

1433-8491

pii

10.1007/s00406-018-0890-6

journal_volume

269

pub_type

杂志文章,多中心研究

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