Abstract:
:COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the pathogenesis of severe infections and ARDS and evidence is emerging that the IL-1/IL-6 pathway is highly upregulated in patients with severe disease. These findings open new avenues for host-directed therapies in patients with symptomatic SARS-CoV-2 infection and might in addition to antiviral treatment be enough to curb the currently unacceptably high morbidity and mortality associated with COVID-19.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
van de Veerdonk FL,Netea MGdoi
10.1186/s13054-020-03166-0subject
Has Abstractpub_date
2020-07-18 00:00:00pages
445issue
1eissn
1364-8535issn
1466-609Xpii
10.1186/s13054-020-03166-0journal_volume
24pub_type
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