Orthopädische Rheumatologie.

abstract：:Serum protein binding of naproxen is considerably reduced in patients with renal insufficiency. The hypothetical plasma concentration at time zero and the half life are not significantly altered in uremic patients in comparison with healthy subjects when the drug is given orally. This suggests an increased pharmacodyn...

journal_title：Zeitschrift fur Rheumatologie

authors： Held H

更新日期：1979-03-01 00:00:00

abstract：:Cartilage destruction in arthritis and osteoarthritis is linked to aberrant cytokine and growth factor expression in the affected tissues. It becomes clear that the balance of protective and destructive cytokines is more important for the net destruction than the absolute levels of destructive mediators. IL-1 is a key...

journal_title：Zeitschrift fur Rheumatologie

authors： van den Berg WB

更新日期：1999-06-01 00:00:00

abstract：:Transmitting a substantial amount of basic knowledge in Rheumatology to all medical students is essential for the future medical care of patients with rheumatic diseases for two reasons: on the one hand, future general practitioners will need to master the patterns of rheumatic diseases to recognize them fast enough i...

journal_title：Zeitschrift fur Rheumatologie

authors： Aringer M,Baerwald C,Bergner R,Feuchtenberger M,Gebhardt C,Hagen M,Keyßer G,Lorenz HM,Witte T

更新日期：2020-12-02 00:00:00

abstract：:Due to their anti-inflammatory effects and their capacity to affect the synthesis of most cytokines and the Th1/Th2 balance, endogenous glucocorticoids contribute to control the basal operation of immune cells. Immune processes result in the production of cytokines, such as IL-1, IL-2, IL-6, IL-11, IL-12, TNF-alpha, a...

journal_title：Zeitschrift fur Rheumatologie

authors： Besedovsky HO,del Rey A

更新日期：2000-01-01 00:00:00

abstract：:Autoinflammatory syndromes are characterized by periodic febrile attacks in combination with increased inflammatory markers. The dysregulation of different cellular signaling pathways leads to an excessive immune response, which can in turn promote multisystemic inflammatory processes. Due to overlapping symptoms, var...

journal_title：Zeitschrift fur Rheumatologie

authors： Schnappauf O

更新日期：2020-09-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease, which is mainly characterized by synovial hyperplasia, pathological immune phenomena and progressive destruction of the affected joints. Various cell types are involved in the pathogenesis of RA including T cells, antigen presenting cells, and endothelial ce...

journal_title：Zeitschrift fur Rheumatologie

authors： Seemayer CA,Distler O,Kuchen S,Müller-Ladner U,Michel BA,Neidhart M,Gay RE,Gay S

更新日期：2001-10-01 00:00:00

abstract：:The knee joint is often involved in rheumatoid arthritis. Despite ever-improving medical antirheumatic therapies, surgical treatment continues to play an important role in optimal multidisciplinary care. The aim of the present work is to process current orthopedic surgical therapy procedures on the knee joint accordin...

journal_title：Zeitschrift fur Rheumatologie

authors： Maderbacher G,Greimel F,Schaumburger J,Grifka J,Baier C

更新日期：2018-12-01 00:00:00

abstract：:The development of synovitis was studied in 64 rabbits with experimentally produced allergic arthritis and in 30 rabbits with experimentally produced non-allergic arthritis. The results are compared with the morphological changes of the synovial membrane in rheumatoid arthritis, especially in early stages, known from ...

journal_title：Zeitschrift fur Rheumatologie

authors： Püschel W

更新日期：1982-01-01 00:00:00

abstract：AIM:To explore the circadian rhythm of serum interleukin (IL)-6 in collagen-induced arthritis (CIA) rats and compare the safety and effectiveness of methotrexate (MTX) administered traditionally and via chronotherapy. METHODS:CIA rat models were immunized with bovine type II collagen. Serum IL-6 levels in normal and C...

journal_title：Zeitschrift fur Rheumatologie

authors： Wang X,Yan X,Wang F,Ge F,Li Z

更新日期：2018-04-01 00:00:00

abstract：:Tendomyopathies (TM) comprise two subgroups. Both are caused by the irritation of nociceptors (IN). Type I results from IN within muscles and tendons with the consequence of local pain, whereas type II refers to TM occurring at a site distant from IN anywhere in the body. Such TM-type II are understood to serve for th...

journal_title：Zeitschrift fur Rheumatologie

authors： Menninger H,Hiemeyer K

更新日期：1989-11-01 00:00:00

abstract：:Ocular manifestation of sarcoidosis occurs in up to 60% of patients with confirmed systemic sarcoidosis and represents one of the most common forms of noninfectious uveitis. In known pulmonary sarcoidosis, ocular involvement can occur in up to 80% of cases. Sarcoidosis can also present only in the eye, without a syste...

journal_title：Zeitschrift fur Rheumatologie

authors： Springer-Wanner C,Brauns T

更新日期：2017-06-01 00:00:00

abstract：:Clinical pathways for three rheumatological indications have been successfully developed in the rheumatological departments of two hospitals. These diseases were selected because of the number of inpatients seen and/or the costs for diagnostics and therapy. Three quota-concepts, the coordination of treatment processes...

journal_title：Zeitschrift fur Rheumatologie

authors： Lakomek HJ,Hülsemann JL,Küttner T,Buscham K,Roeder N

更新日期：2007-05-01 00:00:00

abstract：:Neuro-endocrine immune mechanisms play an important immunomodulatory role for rheumatic diseases as evidenced by long-recognized effects of glucocorticoids, gender, pregnancy, hemiparalysis, and stress on various clinical and epidemiological aspects. Recently, some regulatory pathways have been identified between the ...

journal_title：Zeitschrift fur Rheumatologie

authors： Straub RH,Schaible HG,Wahle M,Schedlowski M,Neeck G,Buttgereit F

更新日期：2002-04-01 00:00:00

abstract：:A dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis was found in animal models of chronic inflammatory diseases, and the defect was located in more central portions of the HPA axis. This defect of neuroendocrine regulatory mechanisms contributes to the onset of the model disease. Since these first observati...

journal_title：Zeitschrift fur Rheumatologie

authors： Straub RH,Schölmerich J,Zietz B

更新日期：2000-01-01 00:00:00

abstract：:Inflammation-mediated osteopenia is an animal model for bone mass reduction following chronic inflammation. We found a reduction of calcitriol serum concentrations during the inflammatory process, in addition cytokines are increased. Treatment of the animals with calcitriol is able to prevent bone mass reduction and t...

journal_title：Zeitschrift fur Rheumatologie

authors： Scharla SH,Lempert UG,Kamilli I

更新日期：2000-01-01 00:00:00

abstract：:In a twenty-nine year old female patient with progressive systemic sclerosis (scleroderma) (PSS) and an impressing involvement of the intestine (disturbance of the oesophageal motility, pseudo-obstruction, malabsorption) a spontaneous, asymptomatic pneumoperitoneum is observed. Perforation or pneumatosis cystoides int...

journal_title：Zeitschrift fur Rheumatologie

authors： Lang B,Meske S,Billmann P,Vaith P,Peter HH

更新日期：1986-03-01 00:00:00

abstract：:Tocilizumab, a monoclonal humanized antibody against IL-6, was licensed in January 2009 in combination with Methotrexate for the treatment of adult patients with moderately to severely active rheumatoid arthritis and inadequate response to one or more DMARDs or TNF antagonists. Tocilizumab is given once every 4 weeks ...

journal_title：Zeitschrift fur Rheumatologie

authors： Roll P,Rubbert-Roth A,Tony HP

更新日期：2010-09-01 00:00:00

abstract：:Sulfasalazine was used as second line agent in 15 children with different forms of rheumatoid arthritis. In 9 cases amelioration could be achieved with respect to clinical symptoms as well as laboratory parameters. Thus, sulfasalazine can be recommended as basic medication also in juvenile rheumatoid arthritis. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Suschke HJ

更新日期：1987-03-01 00:00:00

abstract：:Polyarteritis nodosa (PAN) is a necrotizing vasculitis of medium size arteries that may affect various organs. The clinical appearance is very variable. The most common manifestations are of the skin, the peripheral nervous system presenting as mononeuritis multiplex and the mesenteric and renal blood vessels due to t...

journal_title：Zeitschrift fur Rheumatologie

authors： Schirmer JH,Holl-Ulrich K,Moosig F

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Taking part in physical education is an important element of social participation for children with chronic diseases. Nevertheless, children suffering from rheumatism mostly receive recommendations to stop sport activities either completely or partially, without underlying scientific guidelines. OBJECTIVE:T...

journal_title：Zeitschrift fur Rheumatologie

authors： Hartmann M,Merker J,Schrödl S,König M,Georgi M,Hinze C,Schwirtz A,Haas JP

更新日期：2018-10-01 00:00:00

abstract：:Osteoarthritis is the most common joint disease. In addition to known risk factors e.g. genetics, age and hormonal status it has been suggested that chronic-repetitive micro- and substantial (macro-) injury may play an important pathogenetic role. In a longitudinal case-study we examined Judo-players for clinical and ...

journal_title：Zeitschrift fur Rheumatologie

authors： Strasser P,Hauser M,Häuselmann HJ,Michel BA,Frei A,Stucki G

更新日期：1997-12-01 00:00:00

abstract：:Seronegative rheumatoid arthritis (RA) patients have increased proportions of OKT-4+ (helper) T cells and diminished proportions of OKT-8+ (suppressor/cytotoxic) T cells in the peripheral blood. This phenomenon corresponds to diminished inhibition of B cell activation by peripheral blood lymphocytes (PBL). Seropositiv...

journal_title：Zeitschrift fur Rheumatologie

authors： Lemm G,Warnatz H

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:Clinical observation suggests a frequent coincidence of back pain (BP) and fibromyalgia (FMA). Based on data from a population survey on back pain we studied the hypothesis of FMA being a frequent underlying condition of BP. We additionally studied the association of the severity of back pain and both chroni...

journal_title：Zeitschrift fur Rheumatologie

authors： Hüppe A,Brockow T,Raspe H

更新日期：2004-02-01 00:00:00

abstract：:Three days after cholecystectomy, seven patients received a single dose of auranofin (5 tablets Ridaura = 4.35 mg gold). At defined time points thereafter the gold content in samples of blood, plasma, urine, bile, and feces was determined by instrumental neutron activation analysis (INAA). Maxima of the mean gold conc...

journal_title：Zeitschrift fur Rheumatologie

authors： Benn HP,Schnier C,Bauer E,Seiler KU,Elhöft H,Löffler H

更新日期：1991-01-01 00:00:00

abstract：:The modified significance of radiological criterion in the new ACR/EULAR classification criteria for rheumatoid arthritis is based on the fact that the bone erosion seen using conventional radiology is the result of an already longstanding inflammatory process.In contrast, new imaging modalities such as magnetic reson...

journal_title：Zeitschrift fur Rheumatologie

authors： Strunk J

更新日期：2011-04-01 00:00:00

abstract：:After approval of TNF and interleukin-1 inhibiting agents for treatment of refractory rheumathoid arthritis, new agents inhibiting interleukin-6 and costimulatory pathways are entering clinical phase I and II trials. Blockade of costimulation by using a CTLA4 immunoglobulin fusion protein (CTLA4Ig), which inhibits the...

journal_title：Zeitschrift fur Rheumatologie

authors： Perniok A,Rubbert-Roth A

更新日期：2003-10-01 00:00:00

abstract：:The improved options for effective treatment of osteoporosis and the shift to treatment strategies based on each patient's absolute fracture risk raise new questions in daily clinical care. Which patient should have what osteoprotective therapy and when and for how long? What techniques can be used to assess the indiv...

journal_title：Zeitschrift fur Rheumatologie

authors： Demary W

更新日期：2006-09-01 00:00:00

abstract：:The assessment of off-label medications is one of the most common reasons for assessment of drugs for individual patients in the German medical services. Tension is not uncommon because of great expectations of patients and doctors on the one hand and the requirements of the law on the other. They often do not match. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Grell L,Rieger M

更新日期：2012-02-01 00:00:00

abstract：:Eight patients with SLE were found on clinical and roentgenological grounds or by respiratory function tests to have evidence of lung involvement. Great discrepancies were noted between clinical findings and the results of the respiratory function tests on the one hand and lacking or discrete radiological changes on t...

journal_title：Zeitschrift fur Rheumatologie

authors： Görlitz N,Berzon R,Rössner B,Wessel G,Jäckel R

更新日期：1976-03-01 00:00:00

abstract：:The difference between mofebutazone and phenylbutazone is shown by means of toxicological, pharmacological and pharmacokinetic studies as well as by the protein binding. In spite of a certain chemical similarity both substances differ distinctly. Mofebutazone is approx. 5-6 times less toxic than phenylbutazone but its...

journal_title：Zeitschrift fur Rheumatologie

authors： Loew D,Schuster O,Knoell HE,Graul EH

更新日期：1985-07-01 00:00:00