Abstract：
:Three days after cholecystectomy, seven patients received a single dose of auranofin (5 tablets Ridaura = 4.35 mg gold). At defined time points thereafter the gold content in samples of blood, plasma, urine, bile, and feces was determined by instrumental neutron activation analysis (INAA). Maxima of the mean gold concentrations in blood (140 +/- 42 ng/ml) and plasma (173 +/- 54 ng/ml) are found 2 h after oral administration of the antirheumatic agent, after 16 h in urine (43 +/- 28 ng/ml) and bile (65 +/- 50 ng/ml), and after 24 h in erythrocytes (greater than 200 ng/ml). The mean terminal half-lives are 7.6 days (blood), 15 days (plasma), 5 days (erythrocytes), and 6.5 days (bile). The cumulative biliary gold excretion within 8 days after the administration of auranofin was 1.6%, compared with 4% and 40% for renal and fecal elimination, respectively. The gold concentration in plasma is always higher than that in bile. There is a close correlation between the areas under the concentration curves (AUC) in bile and plasma (r = 0.864).
journal_name
Z Rheumatoljournal_title
Zeitschrift fur Rheumatologieauthors
Benn HP,Schnier C,Bauer E,Seiler KU,Elhöft H,Löffler Hsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
32-8issue
1eissn
0340-1855issn
1435-1250journal_volume
50pub_type
杂志文章abstract：:The duration and severity of rheumatic diseases of the shoulder correlate with symptom frequency, structural changes and associated functional limitations. The multifactorial character of the underlying rheumatic disease requires a multimodal therapeutic concept including interaction of surgical and non-surgical disci...
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journal_title：Zeitschrift fur Rheumatologie
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journal_title：Zeitschrift fur Rheumatologie
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journal_title：Zeitschrift fur Rheumatologie
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journal_title：Zeitschrift fur Rheumatologie
pub_type： 新闻
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journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
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journal_title：Zeitschrift fur Rheumatologie
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journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
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journal_title：Zeitschrift fur Rheumatologie
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journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
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journal_title：Zeitschrift fur Rheumatologie
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journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
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journal_title：Zeitschrift fur Rheumatologie
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journal_title：Zeitschrift fur Rheumatologie
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更新日期：2010-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-06-25 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2003-10-01 00:00:00
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journal_title：Zeitschrift fur Rheumatologie
pub_type： 临床试验,杂志文章
doi：
更新日期：1987-03-01 00:00:00
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journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
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journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
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journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
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journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-010-0734-x
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