Abstract：
:Various rheumatic symptoms can occur in association with malignancies and are termed the so-called paraneoplastic arthropathy. The clinical picture is often similar to primary inflammatory rheumatic diseases. At present there exist no epidemiological data on this disease entity. The case of a patient with tibial pain and unilateral knee arthritis as precursors of a paraneoplastic syndrome is presented. The patient presented with the clinical manifestation of small cell lung cancer 2 years after the first presentation in the rheumatology clinic.
journal_name
Z Rheumatoljournal_title
Zeitschrift fur Rheumatologieauthors
Lange U,Bachmann G,Müller-Ladner Udoi
10.1007/s00393-010-0734-xsubject
Has Abstractpub_date
2011-06-01 00:00:00pages
332-5issue
4eissn
0340-1855issn
1435-1250journal_volume
70pub_type
杂志文章abstract：:Insufficiency fractures are fractures in bones with nontumorous disease (e.g., osteoporosis, rheumatoid arthritis or following radiation) at normal load. Two cases of insufficiency fracture of the ilium and sacrum are presented. Predisposing factors, clinical picture, imaging procedure and therapy are outlined. ...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s003930070057
更新日期：2000-10-01 00:00:00
abstract：:A dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis was found in animal models of chronic inflammatory diseases, and the defect was located in more central portions of the HPA axis. This defect of neuroendocrine regulatory mechanisms contributes to the onset of the model disease. Since these first observati...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：:Monocytes from patients with definite or classical rheumatoid arthritis show a significantly higher release of O2-radicals in the chemiluminescence assay (2925 X 10(3) cpm) than those of healthy volunteers (267 X 10(3) cpm) (p = 0.01). This difference does not appear in a similar test with granulocytes, which in both ...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Due to the wide range of positive effects and the clear evidence of effectiveness, physical activity is one of the most important treatments for inflammatory rheumatic diseases. Because of the frequent overlap of disease and age-related aspects in older patients, the implementation of the German national physical acti...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-019-0592-0
更新日期：2019-03-01 00:00:00
abstract：:The difference between mofebutazone and phenylbutazone is shown by means of toxicological, pharmacological and pharmacokinetic studies as well as by the protein binding. In spite of a certain chemical similarity both substances differ distinctly. Mofebutazone is approx. 5-6 times less toxic than phenylbutazone but its...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:The enzyme poly-(ADP-ribose) polymerase (PARP) is localized within the cell nucleus and catalyzes DNA-repair. During programmed cell death (apoptosis), PARP is enzymatically cleaved. Detection of the cleavage products is characteristic for apoptosis. In patients with systemic lupus erythematosus (SLE), the highly orde...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-006-0045-4
更新日期：2006-10-01 00:00:00
abstract：:The modified significance of radiological criterion in the new ACR/EULAR classification criteria for rheumatoid arthritis is based on the fact that the bone erosion seen using conventional radiology is the result of an already longstanding inflammatory process.In contrast, new imaging modalities such as magnetic reson...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-011-0772-z
更新日期：2011-04-01 00:00:00
abstract：:Many rheumatological diseases are either caused by specific known proteins, such as antibodies or mediated by a plethora of cytokines. Both the unspecific immunosuppressive therapy and the specific action of biologics usually require time to be effective; therefore, extracorporeal forms of treatment are increasingly b...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-016-0219-7
更新日期：2016-12-01 00:00:00
abstract：:The biochemical defect leading to alcaptonuria is well known. However, the pathogenesis of ochronotic arthropathy is poorly understood. The present ultrastructural study elucidated the localization of ochronotic pigment in the articular cartilage and evidence was found that suggests a pathway for cartilage destruction...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:Due to their anti-inflammatory effects and their capacity to affect the synthesis of most cytokines and the Th1/Th2 balance, endogenous glucocorticoids contribute to control the basal operation of immune cells. Immune processes result in the production of cytokines, such as IL-1, IL-2, IL-6, IL-11, IL-12, TNF-alpha, a...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s003930070014
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Taking part in physical education is an important element of social participation for children with chronic diseases. Nevertheless, children suffering from rheumatism mostly receive recommendations to stop sport activities either completely or partially, without underlying scientific guidelines. OBJECTIVE:T...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-018-0518-2
更新日期：2018-10-01 00:00:00
abstract：:Biomarkers form the basis for patient stratification and the development of individualized treatment strategies. As the understanding of the pathophysiological processes underlying rheumatic diseases increases, novel biomarkers will become available and established markers can be used more efficiently. Autoantibodies ...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-011-0884-5
更新日期：2013-02-01 00:00:00
abstract：:ECG from 200 patients with radiologically and clinically definite rheumatoid arthritis were compared with those from a healthy group with the same age and sex distribution. The frequency of pathological changes of the ECG was found to be the same in both groups. Therefore doubt remains whether the pathological changes...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1979-07-01 00:00:00
abstract：BACKGROUND:Familial Mediterranean fever (FMF) in Germany is a rare, genetically linked disease of childhood and adolescence, which is characterized by recurrent febrile episodes and clinical signs of peritonitis, pleuritis and arthritis. Treatment with colchicine is effective and well-tolerated in the majority of patie...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-018-0588-1
更新日期：2019-02-01 00:00:00
abstract：:Since 1978 a 63-year-old woman with rheumatoid arthritis received D-penicillamine (D-PA) in a daily dose of 250-500 mg (mean 300 mg/d). In 1982 the patient complained of diplopia for several days, the ophthalmological and neurological examinations three days later were normal. In July 1983 she developed a myasthenic s...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
abstract：BACKGROUND:The goal of the present study was to investigate the osteogenic potential of ligament fibroblasts from patients with ankylosing spondylitis (AS). MATERIALS AND METHODS:Ligament fibroblasts were isolated from tissues harvested from AS patients and patients with aseptic necrosis of the femoral head (ANFH) who...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-014-1394-z
更新日期：2015-05-01 00:00:00
abstract：:Binding of gold to serum proteins of patients treated with Na-aurothiomalate (AM), gold keratinate (GK) and triethylphosphine gold (PG) was compared. In addition the pattern of distribution of gold in serum of healthy donors after in vitro incubation with these compounds and with tetrachlorogoldacid (GC) was studied. ...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
abstract：:The effect of recombinant interleukin-2 (IL-2) on proliferative and cytotoxic response of peripheral blood mononuclear cells (PBMC) was investigated in a group of 21 patients with systemic lupus erythematosus (SLE). There was a significant decrease in thymidine uptake of peripheral blood mononuclear cells when compare...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Serum protein binding of naproxen is considerably reduced in patients with renal insufficiency. The hypothetical plasma concentration at time zero and the half life are not significantly altered in uremic patients in comparison with healthy subjects when the drug is given orally. This suggests an increased pharmacodyn...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：:Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by, among other things, spinal and extraspinal manifestations. Two studies on the prevalence and clinical significance of hyperostotic spurs and ectopic ossifications in the pelvic area are presented. Spinal DISH seems to be a risk factor for the develop...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:Chondral or osteochondral lesions are typical injuries in orthopaedics and traumatology. Since there is no regeneration of damaged articular cartilage, these lesions can lead to premature osteoarthritis. Therefore, an adequate therapy for these injuries is an important goal. Nowadays, common methods in cartilage thera...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-007-0213-1
更新日期：2007-10-01 00:00:00
abstract：:Alopecia universalis is an advanced form of alopecia areata, characterized by complete loss of hair on all hair-bearing areas. It is currently believed to be an autoimmune disorder. The development of alopecia during treatment with tumor necrosis factor alpha (TNF-α) inhibitors is a rarely observed adverse event. This...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-018-0464-z
更新日期：2018-06-01 00:00:00
abstract：:D-penicillamine treatment of 50 patients with rheumatoid arthritis with negative ANF tests, was followed by means of protein disk electrophoresis of the urine. In the beginning the urine proteins were analysed every 4 weeks, later at intervals of 3 to 6 months. A glomerular proteinuria, caused by an immune-complex nep...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1977-11-01 00:00:00
abstract：:The correlation of the determination of antinuclear antibodies, as shown by consumption tests and immunofluorescence was investigated in a collective of 100 sera of patients suspected for SLE, collagenosis and rheumatoid arthritis, sent for routine screening investigation. The results of both methods correlated in 78%...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1976-05-01 00:00:00
abstract：:OM 8930, a bacterial product with immunostimulatory capacities, was studied for its efficacy in the long-term treatment of rheumatoid arthritis (RA). Ten (10) patients with active seropositive rheumatoid arthritis were treated intermittently for six months with the agent and were evaluated according to clinical, labor...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1981-09-01 00:00:00
abstract：BACKGROUND:The treatment strategies for osteoarthritis (OA) are well known from numerous studies. One of the challenges is long-term patient compliance to the recommended therapies without supervision. OBJECTIVE:To examine the ability of salutogenic concepts to improve rehabilitative management of OA. MATERIALS AND M...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-014-1557-y
更新日期：2015-09-01 00:00:00
abstract：:Activated monocytes/macrophages secrete monokines, regulatory proteins which are capable of initiating and maintaining immune processes as well as having an effect on other non immunocompetent cells. In rheumatoid arthritis the monokine Interleukin-1 (IL-1) was detected in the synovial fluid. IL-1 activates immunocomp...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
abstract：:From the about 400 virus species known to cause illness in man, only a small but growing list of representatives are able to induce arthritis. Although virus-associated arthritides are mostly of acute and short-living type, some patients develop long-lasting or even chronic joint inflammation. The viral or host factor...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：
更新日期：1995-11-01 00:00:00
abstract：:Systemic sclerosis (SSc) is a polymorphic and heterogenic systemic disorder with inflammation, fibrosis and vascular damage. Early diagnosis and classification may be difficult if disease expression is oligosymptomatic (undifferentiated), presenting with only Raynaud's phenomenon or limited scleroderma. Scleroderma sp...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章,评审
doi：10.1007/s00393-006-0065-0
更新日期：2006-07-01 00:00:00
abstract：:Certolizumab pegol is a new anti-TNF-alpha inhibitor which has been approved for the treatment of rheumatoid arthritis since October 2009. Due to the modification of the antibody fragment by the adherence of polyethylene glycol (PEG) a sufficient distribution in inflammatory tissue was found in animal experiments. In ...
journal_title：Zeitschrift fur Rheumatologie
pub_type： 杂志文章
doi：10.1007/s00393-010-0629-x
更新日期：2010-09-01 00:00:00
