Abstract:
BACKGROUND:The goal of the present study was to investigate the osteogenic potential of ligament fibroblasts from patients with ankylosing spondylitis (AS). MATERIALS AND METHODS:Ligament fibroblasts were isolated from tissues harvested from AS patients and patients with aseptic necrosis of the femoral head (ANFH) who had undergone total hip arthroplasty (THA). Cells were cultured in osteogenic induction medium (OIM) with or without bone morphogenetic protein 2 (BMP-2) for 30 days. During this time, the levels of alkaline phosphatase (ALP) and osteocalcin (OC) were determined as markers of osteogenesis. RESULTS:Ligament fibroblasts isolated from patients with AS exhibited significantly greater potential for differentiation than those isolated from patients with osteoarthritis (ANFH). CONCLUSION:These findings illuminate osteogenesis as a new pathway for studying the mechanism underlying ankylosis in AS patients. Factors which cause localized stromal remodeling at the enthesis significantly influence formation of new bone and further research is required to determine the mechanisms responsible for the osteogenic potential of enthesis cells and ligament fibroblasts in AS patients.
journal_name
Z Rheumatoljournal_title
Zeitschrift fur Rheumatologieauthors
Yang M,Yuan H,Miao M,Xu Wdoi
10.1007/s00393-014-1394-zsubject
Has Abstractpub_date
2015-05-01 00:00:00pages
340-5issue
4eissn
0340-1855issn
1435-1250journal_volume
74pub_type
杂志文章abstract::In the last years some important therapies were introduced in the treatment of rheumatoid arthritis (RA), which represent a significant clinical advance. This concerns the introduction of TNF blockade with etanercept and inflixmab, the combination of DMARDs, leflunomide and the COX-2-specific inhibitors. In the year 2...
journal_title:Zeitschrift fur Rheumatologie
pub_type: 杂志文章
doi:10.1007/s003930170011
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journal_title:Zeitschrift fur Rheumatologie
pub_type: 临床试验,杂志文章,随机对照试验
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abstract:: ...
journal_title:Zeitschrift fur Rheumatologie
pub_type: 新闻
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journal_title:Zeitschrift fur Rheumatologie
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journal_title:Zeitschrift fur Rheumatologie
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journal_title:Zeitschrift fur Rheumatologie
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journal_title:Zeitschrift fur Rheumatologie
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journal_title:Zeitschrift fur Rheumatologie
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journal_title:Zeitschrift fur Rheumatologie
pub_type: 杂志文章
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journal_title:Zeitschrift fur Rheumatologie
pub_type: 杂志文章,评审
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更新日期:2020-12-02 00:00:00
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journal_title:Zeitschrift fur Rheumatologie
pub_type: 杂志文章,评审
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更新日期:2010-05-01 00:00:00
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journal_title:Zeitschrift fur Rheumatologie
pub_type: 杂志文章,meta分析
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journal_title:Zeitschrift fur Rheumatologie
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journal_title:Zeitschrift fur Rheumatologie
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journal_title:Zeitschrift fur Rheumatologie
pub_type: 杂志文章,评审
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journal_title:Zeitschrift fur Rheumatologie
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