[Bone morphogenetic proteins in the skeletal system].

abstract：:Systemic lupus erythematosus (SLE) is a classic systemic autoimmune disease. Standard treatment consists of chronic therapy with antimalarials, glucocorticoids and immunosuppressive/cytotoxic drugs, which is associated with considerable side effects. In contrast, immunoablation of autoreactive immunologic memory follo...

journal_title：Zeitschrift fur Rheumatologie

authors： Alexander T,Arnold R,Hiepe F

更新日期：2009-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease, which is mainly characterized by synovial hyperplasia, pathological immune phenomena and progressive destruction of the affected joints. Various cell types are involved in the pathogenesis of RA including T cells, antigen presenting cells, and endothelial ce...

journal_title：Zeitschrift fur Rheumatologie

authors： Seemayer CA,Distler O,Kuchen S,Müller-Ladner U,Michel BA,Neidhart M,Gay RE,Gay S

更新日期：2001-10-01 00:00:00

abstract：:A female patient developed systemic rash, lung edema, electrocardiogram (ECG) abnormalities and fulminant hepatitis with partial liver failure 4 weeks after the start of sulfasalazine treatment. Peripheral T-cell activation, a positive PCR test for human herpesvirus (HHV) 6 as well as eosinophilia in bronchial lavage ...

journal_title：Zeitschrift fur Rheumatologie

authors： Pirklbauer M,Gruber J

更新日期：2014-03-01 00:00:00

abstract：:Various rheumatic symptoms can occur in association with malignancies and are termed the so-called paraneoplastic arthropathy. The clinical picture is often similar to primary inflammatory rheumatic diseases. At present there exist no epidemiological data on this disease entity. The case of a patient with tibial pain ...

journal_title：Zeitschrift fur Rheumatologie

authors： Lange U,Bachmann G,Müller-Ladner U

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Up to now indirect immunofluorescence (IIF) followed by an antigen-specific assay specific for proteinase 3 (PR3) or myeloperoxidase (MPO) has been the standard method for the detection of antineutrophil cytoplasmic antibodies (ANCA). The development of more sensitive and highly specific PR3-ANCA and MPO-ANC...

journal_title：Zeitschrift fur Rheumatologie

authors： Csernok E,Kempiners N,Hellmich B

更新日期：2017-03-01 00:00:00

abstract：:Biochemical studies of rats with mycoplasma arthritis revealed new findings in pathogenesis and pathophysiology. Preliminary examinations showed that mycoplasmas release specific endonucleases and exonucleases. In evaluating the isoenzymes of the lactate dehydrogenases, malate dehydrogenases as well as of the esterase...

journal_title：Zeitschrift fur Rheumatologie

authors： Klein G

更新日期：1975-05-01 00:00:00

abstract：BACKGROUND:Patients with rheumatoid arthritis (RA) tend to be less physically active. Physical activity has been shown to have a positive impact on disease activity and quality of life and is recommended by the European League Against Rheumatism (EULAR) as an integral component of standard treatment. OBJECTIVE:A cross...

journal_title：Zeitschrift fur Rheumatologie

authors： Beider S,Flohr S,Gehlert S,Witte T,Ernst D

更新日期：2020-06-25 00:00:00

abstract：:Inflammatory rheumatic diseases often affect females of childbearing age and pregnancy remains a challenge for this group of patients and their physicians. However, the majority of patients can now have successful pregnancies and deliver healthy babies as a result of our improved knowledge of the risks encountered dur...

journal_title：Zeitschrift fur Rheumatologie

authors： Fischer-Betz R,Gromnica-Ihle E

更新日期：2010-09-01 00:00:00

abstract：:Due to their anti-inflammatory effects and their capacity to affect the synthesis of most cytokines and the Th1/Th2 balance, endogenous glucocorticoids contribute to control the basal operation of immune cells. Immune processes result in the production of cytokines, such as IL-1, IL-2, IL-6, IL-11, IL-12, TNF-alpha, a...

journal_title：Zeitschrift fur Rheumatologie

authors： Besedovsky HO,del Rey A

更新日期：2000-01-01 00:00:00

abstract：:From the about 400 virus species known to cause illness in man, only a small but growing list of representatives are able to induce arthritis. Although virus-associated arthritides are mostly of acute and short-living type, some patients develop long-lasting or even chronic joint inflammation. The viral or host factor...

journal_title：Zeitschrift fur Rheumatologie

authors： Saal JG

更新日期：1995-11-01 00:00:00

abstract：:The data from a combined pathological and kinesiological investigation in autopsy specimens of the cervical spine were used to test whether adjacent motion segments compensate for loss of mobility at a given level. In the segments adjacent to a low-mobile one no evidence was found of compensatory hypermobility, of an ...

journal_title：Zeitschrift fur Rheumatologie

authors： Eulderink F,ten Have HA

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease with a prevalence of up to 1 % in the adult population. OBJECTIVE:This study describes the prevalence of RA diagnoses in outpatient health insurance claims data, based on different case definitions and stratified by age, sex and...

journal_title：Zeitschrift fur Rheumatologie

authors： Hense S,Luque Ramos A,Callhoff J,Albrecht K,Zink A,Hoffmann F

更新日期：2016-10-01 00:00:00

abstract：:In a sequential study the pathogenesis of chronic polyarthritis occurring spontaneously in MRL mice was analysed by light microscopy. A total of 128 MRL mice of both substrains (MRL/Mp-lpr/lpr and +/+) and different age groups was studied. In 50 lpr/lpr mice, tinctorial and histochemical methods were applied for the i...

journal_title：Zeitschrift fur Rheumatologie

authors： Hewicker M,Garcés LH,Kromschröder E,Trautwein G

更新日期：1988-07-01 00:00:00

abstract：:The sulfhydryl groups are chemically active parts of the protein molecule and participate in many important biochemical and metabolic processes. The present material comprised 132 patients with rheumatoid arthritis, 104 patients with other diseases and 44 controls. The patients with rheumatoid arthritis had decreased ...

journal_title：Zeitschrift fur Rheumatologie

authors： Haataja M,Kalliomäki JL

更新日期：1977-03-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common cause of functional disability in the elderly. Pain and loss of motion induce a vicious circle, leading to instability, frailty and ultimately invalidity. Currently, there is no treatment to reverse or slow the disease progression to a clinically meaningful extent. Thus, the prim...

journal_title：Zeitschrift fur Rheumatologie

authors： Brabant T,Stichtenoth D

更新日期：2005-10-01 00:00:00

abstract：:D-penicillamine treatment of 50 patients with rheumatoid arthritis with negative ANF tests, was followed by means of protein disk electrophoresis of the urine. In the beginning the urine proteins were analysed every 4 weeks, later at intervals of 3 to 6 months. A glomerular proteinuria, caused by an immune-complex nep...

journal_title：Zeitschrift fur Rheumatologie

authors： Rautenstrauch H

更新日期：1977-11-01 00:00:00

abstract：:A 74-year-old female patient with rheumatoid arthritis was diagnosed with Pneumocystis jiroveci pneumonia (PcP) following therapy with methotrexate and prednisone. Although bactrim treatment was initiated and PcP was not detected by a control bronchoalveolar lavage, the patient died. The precise cause of death remains...

journal_title：Zeitschrift fur Rheumatologie

authors： Bertisch B,Ruef C

更新日期：2006-02-01 00:00:00

abstract：:Heberden nodes affect mainly middle-aged women. Inheritance is autosomal dominant in female and autosomal recessive in male patients. We report the case of a young man who presented already with 12 years of age with pain in the distal finger joints. There were no other clinical or serological signs for other rheumatoi...

journal_title：Zeitschrift fur Rheumatologie

authors： Rascu A,Kraetsch HG,Grünke M,Kalden JR,Manger B

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Taking part in physical education is an important element of social participation for children with chronic diseases. Nevertheless, children suffering from rheumatism mostly receive recommendations to stop sport activities either completely or partially, without underlying scientific guidelines. OBJECTIVE:T...

journal_title：Zeitschrift fur Rheumatologie

authors： Hartmann M,Merker J,Schrödl S,König M,Georgi M,Hinze C,Schwirtz A,Haas JP

更新日期：2018-10-01 00:00:00

abstract：:Eighteen patients suffering from chronic rheumatoid arthritis were selected for the present study. Plasma levels of stress hormones like catecholamines and cortisol were found to be elevated. At the same time reduction in percentage of E-rosette forming lymphocytes and an elevation in levels of major serum immunoglobu...

journal_title：Zeitschrift fur Rheumatologie

authors： Kumar R,Singh LM,Vaidya MP

更新日期：1981-05-01 00:00:00

abstract：:Within the group of inflammatory rheumatic diseases, spondyloarthropathy is the most common diagnosis after rheumatoid arthritis. Its prevalence was long underestimated. Ankylosing spondylitis (AS) and undifferentiated spondyloathropathy (uSpA) are the most common subgroups in western countries. There are still diffic...

journal_title：Zeitschrift fur Rheumatologie

authors： Haibel H,Rudwaleit M,Braun J,Sieper J

更新日期：2002-02-01 00:00:00

abstract：:Autoimmune rheumatic diseases (ARD) affect young females during childbearing age. Over the last decades, improvements in survival as well as quality of life in patients affected with ARD have led to an increased number of pregnancies observed during the course of such diseases. Systemic lupus erythematosus (SLE) is th...

journal_title：Zeitschrift fur Rheumatologie

authors： Doria A,Iaccarino L,Ghirardello A,Arienti S,Zampieri S,Rampudda ME,Tincani A,Todesco S

更新日期：2006-05-01 00:00:00

abstract：UNLABELLED:Influence of anti-rheumatic drugs on human lymphocytes, especially T and B cell membranes, was studies with D-penicillamine, aurothiomalate, dexamethasone, cyclophosphamide, mitomycin C and aspirin. METHOD:Peripheral blood obtained from five healthy individuals and lymphocytes were separated by centrifugati...

journal_title：Zeitschrift fur Rheumatologie

authors： Yoshino S,Ishiyama I

更新日期：1977-01-01 00:00:00

abstract：:The classical septic bacterial arthritis is a rare event, but can be distinguished by unequivocal signs such as fibrin exudation and neutrophilic masses (pus). For a long time we have been observing an abortive form of bacterial arthritis in biopsies which subsides spontaneously without antibiotic intervention. Only v...

journal_title：Zeitschrift fur Rheumatologie

authors： Meyer-Scholten C,Valeva A,Zorn K,Meurer A,Fassbender HG

更新日期：2008-02-01 00:00:00

abstract：:The development of synovitis was studied in 64 rabbits with experimentally produced allergic arthritis and in 30 rabbits with experimentally produced non-allergic arthritis. The results are compared with the morphological changes of the synovial membrane in rheumatoid arthritis, especially in early stages, known from ...

journal_title：Zeitschrift fur Rheumatologie

authors： Püschel W

更新日期：1982-01-01 00:00:00

abstract：:Osteoarthritis is the most common joint disease. In addition to known risk factors e.g. genetics, age and hormonal status it has been suggested that chronic-repetitive micro- and substantial (macro-) injury may play an important pathogenetic role. In a longitudinal case-study we examined Judo-players for clinical and ...

journal_title：Zeitschrift fur Rheumatologie

authors： Strasser P,Hauser M,Häuselmann HJ,Michel BA,Frei A,Stucki G

更新日期：1997-12-01 00:00:00

abstract：:Drug treatment in the polymorbid elderly should focus on the more important symptoms. Pharmacokinetic differences should be considered, e.g. a reduced volume of distribution and decreased liver and renal function. Special alterations in the pharmacodynamics with respect to the central nervous system and other organs a...

journal_title：Zeitschrift fur Rheumatologie

authors： Breithaupt H

更新日期：1992-11-01 00:00:00

abstract：:Serum protein binding of naproxen is considerably reduced in patients with renal insufficiency. The hypothetical plasma concentration at time zero and the half life are not significantly altered in uremic patients in comparison with healthy subjects when the drug is given orally. This suggests an increased pharmacodyn...

journal_title：Zeitschrift fur Rheumatologie

authors： Held H

更新日期：1979-03-01 00:00:00

abstract：:Sulfasalazine was used as second line agent in 15 children with different forms of rheumatoid arthritis. In 9 cases amelioration could be achieved with respect to clinical symptoms as well as laboratory parameters. Thus, sulfasalazine can be recommended as basic medication also in juvenile rheumatoid arthritis. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Suschke HJ

更新日期：1987-03-01 00:00:00

abstract：:The Lequesne algofunctional indices for the knee and the hip require a physician interview. We adapted the Lequesne indices for the German language and tested the metric properties, test-retest reliability and validity of a self-report questionnaire-format in 51 patients with hip or knee OA. The symptom and function c...

journal_title：Zeitschrift fur Rheumatologie

authors： Stucki G,Meier D,Stucki S,Michel BA,Tyndall AG,Elke R,Theiler R

更新日期：1996-01-01 00:00:00