CCR5 antagonism in HIV infection: current concepts and future opportunities.

Abstract:

:CCR5 antagonists inhibit HIV-1 entry by blocking the interaction of HIV-1 with the CCR5 cellular receptor. In patients with established HIV-1 infection, some viral strains use an alternative coreceptor for HIV-1 entry, CXCR4; CCR5 antagonists are not effective in patients harboring these viral strains. Coreceptor tropism testing of viral strains in an individual patient is necessary prior to treating with a CCR5 antagonist. There is one CCR5 antagonist, maraviroc, that is FDA-approved for treatment of HIV-1 infection. This drug is used most commonly for the treatment of HIV-1 infection in patients who have failed other antiretroviral regimens. In addition to virologic effects, CCR5 antagonists are under investigation for immune-modulating effects and for HIV-1 prevention. Ongoing research will further elucidate the role of CCR5 antagonists in combating HIV disease.

journal_name

Annu Rev Med

authors

Wilkin TJ,Gulick RM

doi

10.1146/annurev-med-052010-145454

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

81-93

eissn

0066-4219

issn

1545-326X

journal_volume

63

pub_type

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