Biological Aspects of Cancer Health Disparities.

Abstract:

:Racial and ethnic disparities span the continuum of cancer care and are driven by a complex interplay among social, psychosocial, lifestyle, environmental, health system, and biological determinants of health. Research is needed to identify these determinants of cancer health disparities and to develop interventions to achieve cancer health equity. Herein, we focus on the overall burden of ancestry-related molecular alterations, the functional significance of the alterations in hallmarks of cancer, and the implications of the alterations for precision oncology and immuno-oncology. In conclusion, we reflect on the importance of estimating ancestry, improving diverse racial and ethnic participation in cancer clinical trials, and examining the intersection among determinants of cancer health disparities.

journal_name

Annu Rev Med

authors

Freedman JA,Al Abo M,Allen TA,Piwarski SA,Wegermann K,Patierno SR

doi

10.1146/annurev-med-070119-120305

subject

Has Abstract

pub_date

2021-01-27 00:00:00

pages

229-241

eissn

0066-4219

issn

1545-326X

journal_volume

72

pub_type

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