Case series of carbapenemase-producing Enterobacteriaceae osteomyelitis: Feel it in your bones.

Abstract:

OBJECTIVES:Limited data have been reported regarding osteomyelitis due to carbapenemase-producing Enterobacteriaceae (CPE), including co-infections with extended-spectrum β-lactamase (ESBL)-producing micro-organisms. METHODS:We conducted a retrospective study in a reference centre for bone and joint infections from 2011 to 2019 among patients infected with CPE. RESULTS:Nine patients (mean age 46.8 ± 16.6 years), including three with infected implants, were identified. Infections were mostly polymicrobial (n = 8/9), including Staphylococcus aureus (n = 6/9). CPE were mainly OXA-48-type, associated with ESBL-producing Enterobacteriaceae (n = 8/9), of which 5/9 isolates were Klebsiella pneumoniae. Control of the infection was achieved in seven cases. CONCLUSIONS:CPE osteomyelitides are essentially polymicrobial and fluoroquinolone-resistant infections, highlighting the need for efficient surgery with implant removal.

authors

Davido B,Noussair L,Saleh-Mghir A,Salomon E,Bouchand F,Matt M,Lawrence C,Bauer T,Herrmann JL,Perronne C,Gaillard JL,Rottman M,Dinh A

doi

10.1016/j.jgar.2020.08.007

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

74-78

eissn

2213-7165

issn

2213-7173

pii

S2213-7165(20)30212-5

journal_volume

23

pub_type

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