Validation of the 'Test of the Adherence to Inhalers' (TAI) for Asthma and COPD Patients.

abstract：BACKGROUND:The effectiveness of metered-dose inhalers (MDIs) in delivering medication to the lungs highly depends on its correct usage technique. Current guidelines state optimal technique for high lung deposition should include a slow inhalation (>5 seconds) at an inspiratory flow rate of 30 L/min and inhaler actuatio...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Biswas R,Hanania NA,Sabharwal A

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:High flow nasal cannula oxygen therapy (HFT) is increasingly used in intensive and emergency care departments. Patients suffering from respiratory failure, who are likely to benefit from HFT, may require aerosolized bronchodilators; therefore, combining nebulization with HFT may be relevant. This study aimed...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Réminiac F,Vecellio L,Heuzé-Vourc'h N,Petitcollin A,Respaud R,Cabrera M,Pennec DL,Diot P,Ehrmann S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Secondary lung infections are the primary cause of morbidity associated with cystic fibrosis lung disease. Aerosolized antibiotic inhalation is potentially advantageous but has limited effectiveness due to altered airway aerodynamics and deposition patterns that limit drug access to infected regions. One pot...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Iasella SV,Stetten AZ,Corcoran TE,Garoff S,Przybycien TM,Tilton RD

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Model predictions of regional deposition in the respiratory tract are useful in assessing factors that influence the effectiveness of aerosol delivery. Regional deposition models have previously been coupled with models of mucous production and clearance to estimate initial concentrations of drug deposited i...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Martin AR,Finlay WH

更新日期：2018-02-01 00:00:00

abstract：:Significant advances have been made in the last 50 years in developing safe and efficacious aerosol formulations for pulmonary delivery. The key to future innovation may lie at the interface between biology and particle engineering. Improved understanding of biological processes including particle clearance, cellular ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Weers JG,Bell J,Chan HK,Cipolla D,Dunbar C,Hickey AJ,Smith IJ

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The site of deposition in the respiratory tract for aerosolized, inhaled therapeutic drugs depends on both the particles' aerodynamic size and the patient's breathing pattern. METHODS:In 21 healthy subjects with normal lung function, we evaluated an extremely slow inhalation of a large 9.5-μm MMAD particle ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Zeman KL,Wu J,Bennett WD

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The Abbreviated Impactor Measurement (AIM) concept simplifies determination of aerodynamic size metrics for inhaler quality control testing. A similar approach is needed to compare in vitro particle size distribution metrics with human respiratory tract (HRT) deposition. METHODS:An abbreviated impactor base...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Mitchell J,Copley M,Sizer Y,Russell T,Solomon D

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Mechanically ventilated patients commonly suffer from ventilator-associated pneumonia, hypoxemia, and other lower respiratory tract infection as a result of pathogen colonization and poor sputum clearance. Consequently, there is a high rate of morbidity and mortality in these patients. Dry powder mannitol in...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Feng B,Tang P,Leung SS,Dhanani J,Chan HK

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Use of a valved holding chamber (VHC) in conjunction with a pressurized metered dose inhaler (pMDI) can reduce issues relating to poor actuation-inhalation coordination and potentially improve the lung deposition of aerosol, compared with use of a pMDI alone. However, the performance of a VHC is influenced b...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Hatley RH,von Hollen D,Sandell D,Slator L

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Particle size and velocity are two of the most significant factors that impact the deposition of pressurized metered-dose inhaler (pMDI) sprays in the mouth cavity. pMDIs are prominently used around the world in the treatment of patients suffering from a variety of lung diseases such as asthma and chronic ob...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Alatrash A,Matida E

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Remote inhaler monitoring is an emerging technology that enables the healthcare team to monitor the time and location of a patient's inhaler use. We assessed the feasibility of remote inhaler monitoring for chronic obstructive pulmonary disease (COPD) patients and the pattern of albuterol inhaler use associa...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Sumino K,Locke ER,Magzamen S,Gylys-Colwell I,Humblet O,Nguyen HQ,Thomas RM,Fan VS

更新日期：2018-06-01 00:00:00

abstract：: Background: Many countries have introduced a compulsory use of community masks for certain public areas during the SARS-CoV-2 pandemic. Different manufacturers offer reusable community masks in large quantities. The efficacy of these masks, however, is unknown. ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Maurer L,Peris D,Kerl J,Guenther F,Koehler D,Dellweg D

更新日期：2020-09-23 00:00:00

abstract：BACKGROUND:Preclinical evaluation of new chemical entities (NCEs) designed to be administered by inhalation route requires lung administration to rodents, especially in the discovery phase. Different administration methods have been used until now, but more efforts are required to obtain controlled and reproducible lun...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Fioni A,Selg E,Cenacchi V,Acevedo F,Brogin G,Gerde P,Puccini P

更新日期：2018-02-01 00:00:00

abstract：: Background: Salvia miltiorrhiza polyphenolic acid (SMPA) is effective in the treatment of cardiovascular diseases and currently it is administered orally or intravenously. However, SMPA is poorly absorbed orally and quickly eliminated in vivo. A long-term frequent intraveno...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Lu P,Xing Y,Peng H,Liu Z,Zhou QT,Xue Z,Ma Z,Kebebe D,Zhang B,Liu H

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Programmed cell death 4 (PDCD4), a protein that binds to eukaryotic initiation factor 4A (eIF4A), inhibits the initiation of translation. Although a number of tumor suppressors target transcription, Pdcd4 is the first suppressor targeting protein translation, and has also been suggested to function as a tumo...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Hwang SK,Minai-Tehrani A,Lim HT,Shin JY,An GH,Lee KH,Park KR,Kim YS,Beck GR Jr,Yang HS,Cho MH

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:This experimental study was conducted to determine the effects of training on inhaler technique and quality of life in patients with chronic obstructive pulmonary disease (COPD). METHODS:Among the patients who applied at the outpatient clinic of chest diseases between March 2009 and May 2010, a total of 69 ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Göriş S,Taşci S,Elmali F

更新日期：2013-12-01 00:00:00

abstract：: Background: The photo reflection method (PRM) is used to measure light reflected from particles released from dry powder inhalers (DPIs). This simple method depicts time trajectories of released drugs; however, it underestimates the number of particles at high peak inhalat...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Kondo T,Hibino M,Tanigaki T,Tajiri S,Horiuchi S

更新日期：2020-11-04 00:00:00

abstract：:The available toxicity data of benzalkonium chloride (BKC) clearly shows that it is toxic; however, the weight of evidence favors the view that at doses encountered in nasally and orally inhaled pharmaceutical preparations it is well tolerated. The adverse toxicological data predominantly come from in vitro and animal...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Johnson NF

更新日期：2018-02-01 00:00:00

abstract：: Background: Inhalation of medications is the cornerstone in the treatment of patients with lung diseases. A variety of inhalation devices exists and each device has specific requirements to achieve optimum inhalation of the drug. The goal of this study was to establish a c...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Pohlmann G,Hohlfeld JM,Haidl P,Pankalla J,Cloes RM

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Very little is known about the role of nasal morphology due to ethnic variation on particle deposition pattern in the sinonasal cavity. This preliminary study utilizes computational fluid dynamics (CFD) modeling to investigate sinonasal airway morphology and deposition patterns of intranasal sprayed particle...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Keeler JA,Patki A,Woodard CR,Frank-Ito DO

更新日期：2016-04-01 00:00:00

abstract：:Exhaled breath condensate (EBC) consists mainly of water, but also contains semivolatile and nonvolatile compounds. The aim of this study was to develop a system in which two condensers are simultaneously used in series to clarify the mechanisms of EBC condensation. Two aliquots of EBC (EBC1 and EBC2) were collected f...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Corradi M,Goldoni M,Caglieri A,Folesani G,Poli D,Corti M,Mutti A

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Dyspnea significantly impacts quality of life and is one of the most common symptoms in advanced illness. Systemically-administered opioids and benzodiazepines have been the most studied and utilized pharmacologic treatments for refractory dyspnea. Less attention has been given to the use of these medication...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Boyden JY,Connor SR,Otolorin L,Nathan SD,Fine PG,Davis MS,Muir JC

更新日期：2015-02-01 00:00:00

abstract：:The success of inhalation therapy is not only dependent upon the pharmacology of the drugs being inhaled but also upon the site and extent of deposition in the respiratory tract. Similarly, the toxicity of environmental and industrial particulate matter is affected not only by the nature of the dust but also by the am...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Darquenne C

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Currently bronchial provocation testing (BPT) using mannitol powder cannot be performed in children under 6 years. A primary reason is it is challenging for children at this age to generate a consistent inspiratory effort to inhale mannitol efficiently from a dry powder inhaler. A prototype system, which doe...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Tang P,Leung SS,Hor E,Ruzycki CA,Carrigy NB,Finlay WH,Brannan JD,Devadason S,Anderson SD,Sly PD,Samnick K,Chan HK

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Inhaled alpha1-antitrypsin (AAT) is being developed for treatment of cystic fibrosis to protect the lungs from excessive free elastase. High drug costs mandate a very efficient aerosol system to deliver a high payload to the airways. The I-neb Adaptive Aerosol Delivery (AAD) System is a portable, electronic,...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Geller DE,Kesser KC

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:The objective of this study was to determine optimal aerosol delivery conditions for a full-term (3.6 kg) infant receiving invasive mechanical ventilation by evaluating the effects of aerosol particle size, a new wye connector, and timing of aerosol delivery. METHODS:In vitro experiments used a vibrating mesh ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Longest PW,Azimi M,Hindle M

更新日期：2014-10-01 00:00:00

abstract：: Background: Many substances used in inhalation research are water soluble and can be administered as nebulized solutions. Typical examples are therapeutic, small-molecular agents, or macromolecules. Another category is a number of water-soluble agents used for airway diagn...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Gerde P,Nowenwik M,Sjöberg CO,Selg E

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:To our knowledge, quantification of intranasal deposition of aerosol generated by Accuspray(™) (AS) in children has never been published. We hypothesized that deposition would vary significantly with age and with placement of the device within, or outside, of the nostril. METHODS:We tested these hypotheses ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Laube BL,Sharpless G,Vikani AR,Harrand V,Zinreich SJ,Sedberry K,Knaus D,Barry J,Papania M

更新日期：2015-10-01 00:00:00

abstract：:Since the early 1960s, there has been a continuous evolution in scientific understanding regarding bioequivalence (BE) of oral dosage forms, intermittently punctuated by some breakthrough research findings and conceptual advances. The accumulated knowledge from this body of research has been translated into a sophisti...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Horhota ST

更新日期：2014-12-01 00:00:00

abstract：:The use of gamma camera imaging following the inhalation of a radiolabel has been widely used by researchers to investigate the fate of inhaled aerosols. The application of two-dimensional (2D) planar gamma scintigraphy and single-photon emission computed tomography (SPECT) to the study of inhaled aerosols is discusse...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Conway J,Fleming J,Bennett M,Havelock T

更新日期：2013-06-01 00:00:00