BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice.

abstract：:Here we describe the presence of IgG antibodies, in the sera of patients presenting with insulin-dependent diabetes mellitus (IDDM), that react in Western blots with a 60-kD protein (Mr 60K) from rat hepatic microsomal extracts. Sera from 60 IDDM patients were screened and 31.6% were positive for the Mr 60K band. This...

journal_title：Clinical and experimental immunology

authors： Pehuet-Figoni M,Alvarez F,Bach JF,Chatenoud L

更新日期：2000-11-01 00:00:00

abstract：:CVID is a primary immune disorder in which hypogammaglobulinaemia may be associated with a number of T cell defects including lymphopenia, anergy, impaired lymphocyte proliferation and deficient cytokine secretion. In this study we show that T cells of CVID subjects, in comparison with control T cells, undergo spontan...

journal_title：Clinical and experimental immunology

authors： Di Renzo M,Zhou Z,George I,Becker K,Cunningham-Rundles C

更新日期：2000-06-01 00:00:00

abstract：:Human peripheral blood lymphocytes injected intradermally into X-ray immunosuppressed mice were tested for angiogenesis-inducing capacity. Both T and B lymphocytes evoked angiogenesis of the same intensity. The total T cell population was fractionated into three subpopulations on the basis of their different affinitie...

journal_title：Clinical and experimental immunology

authors： Kamiński MJ,Nowacyk M,Skopińska-Rozewska E,Kamińska G,Bem W

更新日期：1981-11-01 00:00:00

abstract：:It is unclear how breakdown in immune tolerance to the ubiquitous self-antigen pyruvate dehydrogenase complex (PDC), seen in the autoimmune liver disease PBC, gives rise to tissue damage with such a limited distribution (restricted to the liver and salivary and lachrymal glands). One property shared by these tissues i...

journal_title：Clinical and experimental immunology

authors： Palmer JM,Doshi M,Kirby JA,Yeaman SJ,Bassendine MF,Jones DE

更新日期：2000-12-01 00:00:00

abstract：:Acute RSV infection in infancy may produce some asthma-like symptoms and may be followed by a recurrent wheeze later in childhood. It has been proposed that RSV infection stimulates type-2 cytokine responses, resembling those found in atopy and asthma. Peripheral blood cells were obtained from RSV-infected infants (n ...

journal_title：Clinical and experimental immunology

authors： Bendelja K,Gagro A,Bace A,Lokar-Kolbas R,Krsulovic-Hresic V,Drazenovic V,Mlinaric-Galinovic G,Rabatic S

更新日期：2000-08-01 00:00:00

abstract：:Human thymic stromal lymphopoietin (TSLP) promotes CD4(+) T-cell proliferation both directly and indirectly through dendritic cell (DC) activation. Although human TSLP-activated DCs induce CD8(+) T-cell proliferation, it is not clear whether TSLP acts directly on CD8(+) T cells. In this study, we show that human CD8(+...

journal_title：Clinical and experimental immunology

authors： Akamatsu T,Watanabe N,Kido M,Saga K,Tanaka J,Kuzushima K,Nishio A,Chiba T

更新日期：2008-10-01 00:00:00

abstract：:Immune repopulation, despite virological failure, often occurs in children under highly active anti-retroviral therapy (HAART). The aim of this study was to analyse the characteristics of immune repopulation and activation in children with and without virological response to HAART. Fourteen human immunodeficiency viru...

journal_title：Clinical and experimental immunology

authors： Anselmi A,Vendrame D,Rampon O,Giaquinto C,Zanchetta M,De Rossi A

更新日期：2007-12-01 00:00:00

abstract：:PHA activated human peripheral blood mononuclear cells (MNC) were incubated with human interleukin 2 (IL-2) in the absence or in the presence of 10(-6)-10(-9) M hydrocortisone (HC). HC suppressed the proliferative response of the activated MNC to highly purified human leucocyte IL-2 in a dose dependent manner. This su...

journal_title：Clinical and experimental immunology

authors： Horst HJ,Flad HD

更新日期：1987-04-01 00:00:00

abstract：:Factor H and the FHL-1/reconectin protein are two human plasma proteins that act as important regulators of the alternative complement pathway. Each protein is encoded by a unique transcript, but both mRNAs are derived from the factor H gene by means of alternative processing. In order to address potential functional ...

journal_title：Clinical and experimental immunology

authors： Friese MA,Hellwage J,Jokiranta TS,Meri S,Müller-Quernheim HJ,Peter HH,Eibel H,Zipfel PF

更新日期：2000-08-01 00:00:00

abstract：:It has been suggested that the immune system may be responsible for the destruction of insulin secreting cells in some types of diabetes. In order to test this hypothesis, we studied the consequences of immune-mediated reactions on the function of pancreatic islet cells in vitro. A model was set up in vitro where mous...

journal_title：Clinical and experimental immunology

authors： Boitard C,Saï P,Debray-Sachs M,Assan R,Hamburger J

更新日期：1984-03-01 00:00:00

abstract：:Evidence is emerging that exposure to mercury (Hg) may elicit many pathological manifestations, including immunomodulation. We tested whether changing cellular activation pathways may affect the immunomodulation by Hg. Human cell cultures were set up where isolated peripheral blood mononuclear cells, activated by mono...

journal_title：Clinical and experimental immunology

authors： Hemdan NY,Lehmann I,Wichmann G,Lehmann J,Emmrich F,Sack U

更新日期：2007-05-01 00:00:00

abstract：:The failure of B cells from CVI patients to secrete normal amounts of antibodies has been attributed either to an intrinsic B cell defect or to a lack of cooperation from T cells. In an attempt to improve the definition of the origin of this defect in one of the main cellular compartments, we studied the ability of he...

journal_title：Clinical and experimental immunology

authors： Ferrer JM,Iglesias J,Hernández M,Matamoros N

更新日期：1995-11-01 00:00:00

abstract：:The expression of guinea-pig major histocompatibility antigens (class I and II) has been investigated on guinea-pig epididymal spermatozoa. Specific alloantisera (anti-B1, anti-B3, anti-Ia2,4 and anti-Ia1,3,7) were obtained by cross-immunization of strains 2, 13 and BIO-AD animals with relevant spleen cell membranes. ...

journal_title：Clinical and experimental immunology

authors： Thyphronitis G,De Almeida M,Neveu T,Voisin GA

更新日期：1984-09-01 00:00:00

abstract：:Merozoite surface protein 2 (MSP2) expressed by Plasmodium falciparum asexual blood stages has been identified as a promising vaccine candidate. In order to explore allelic family-specific humoral responses which may be responsible for parasite neutralization during natural infections, isolates from individuals with e...

journal_title：Clinical and experimental immunology

authors： Ekala MT,Jouin H,Lekoulou F,Mercereau-Puijalon O,Ntoumi F

更新日期：2002-08-01 00:00:00

abstract：:Dogs can develop systemic lupus erythematosus syndromes that are clinically similar to those seen in humans. In contrast, previous observations suggest differences in their autoantibody reactivity patterns against histones and DNA which are components of the nucleosome in chromatin. The objective of this study was to ...

journal_title：Clinical and experimental immunology

authors： Monestier M,Novick KE,Karam ET,Chabanne L,Monier JC,Rigal D

更新日期：1995-01-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is the name given to a clinically heterogeneous group of hypogammaglobulinaemic immunodeficiency states. Bronchiectasis is a feature of this disease and is believed to be the result of recurrent bacterial infection affecting the respiratory tract. Bronchiectasis is also a featur...

journal_title：Clinical and experimental immunology

authors： Sansom ME,Ferry BL,Sherrell ZP,Chapel HM

更新日期：2002-12-01 00:00:00

abstract：:Previous studies using isolated complement proteins have shown that more C4A than C4B binds to certain types of immune complexes. However, the in vivo binding of the C4 isoforms to an immune complex has not been investigated in detail and may differ from events when measured with the isolated proteins. We report here ...

journal_title：Clinical and experimental immunology

authors： Reilly BD

更新日期：1999-07-01 00:00:00

abstract：:Patients with common variable immunodeficiency disorders are monitored for liver function test abnormalities. A proportion of patients develop deranged liver function and some also develop hepatomegaly. We investigated the prevalence of abnormalities and types of liver disease, aiming to identify those at risk and det...

journal_title：Clinical and experimental immunology

authors： Ward C,Lucas M,Piris J,Collier J,Chapel H

更新日期：2008-09-01 00:00:00

abstract：:Human mononuclear leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor-alpha (TNF-alpha) (by ELISA) in culture when stimulated with killed Staphylococcus aureus. The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF-alpha at a concen...

journal_title：Clinical and experimental immunology

authors： Ferrante A,Seow WK,Rowan-Kelly B,Thong YH

更新日期：1990-05-01 00:00:00

abstract：:The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Thyroglobulin antibody (TgAb) is a diagnostic hallmark of HT. The aim of our study was to evaluate the avidity of TgAb in sera from HT patients with different thyroid functional status. Sera from 50 patients with newly diagnosed HT ...

journal_title：Clinical and experimental immunology

authors： Zhang Y,Gao Y,Li M,Xie L,Huang Y,Gao Y,Guo X

更新日期：2010-07-01 00:00:00

abstract：:Increased serum cytokine levels have been reported in patients with autoimmune thyroid disease, but less is known about their levels in patients with Graves' ophthalmopathy (GO). It is not known whether GO is a cell-mediated or humoral autoimmune disease. We investigated whether serum cytokines are elevated in GO pati...

journal_title：Clinical and experimental immunology

authors： Wakelkamp IM,Gerding MN,Van Der Meer JW,Prummel MF,Wiersinga WM

更新日期：2000-09-01 00:00:00

abstract：:The spot-ELISA technique has been used to enumerate the frequency of cells secreting tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), isolated from biopsies of normal intestine and from biopsies of children with inflammatory bowel disease. TNF-alpha production was undetectable in six out of 12...

journal_title：Clinical and experimental immunology

authors： MacDonald TT,Hutchings P,Choy MY,Murch S,Cooke A

更新日期：1990-08-01 00:00:00

abstract：:Exposure to intratracheal immunization and aerosolization with soluble antigen plus murmayl-dipeptide (MDP) induces the development of plaque-forming cells in the pulmonary draining lymph nodes of two of three inbred mouse strains. Splenectomy before immunization led to a heightened plaque-forming cell response in the...

journal_title：Clinical and experimental immunology

authors： Allen EM,Abramoff P,Fink JN,Calvanico NJ

更新日期：1987-08-01 00:00:00

abstract：:We have shown previously that IgG2a anti-Thy-1 MoAb (ER4G) induces apoptosis of rat mesangial cells (GMC) in vitro. Since the classical complement pathway plays an essential role in Thy-1 nephritis, we analysed whether C1q, a subunit of the first component of complement, enhances the ER4G-mediated apoptosis of rat GMC...

journal_title：Clinical and experimental immunology

authors： Sato T,van Dixhoorn MG,Heemskerk E,van Es LA,Daha MR

更新日期：1997-09-01 00:00:00

abstract：:We have developed CD4+, tetanus antigen-specific T cell clones that proliferate in the presence of tetanus antigen and autologous irradiated peripheral blood leucocytes (PBL) as antigen-presenting cells (APC). There have been several reports that T cells can present antigen themselves. We have used tetanus antigen-spe...

journal_title：Clinical and experimental immunology

authors： Chirmule N,Kalyanaraman VS,Slade H,Oyaizu N,Pahwa S

更新日期：1990-05-01 00:00:00

abstract：:Interleukin 15 (IL-15) is critical for the development of human and murine natural killer (NK) cells and hepatic-derived NK T cells (NKT) in mice, and for the homeostatic maintenance of NK/NKT and CD8(+) memory T cells. The lymphocyte repertoire of an adult human liver includes significant populations of NK and NKT-li...

journal_title：Clinical and experimental immunology

authors： Golden-Mason L,Kelly AM,Doherty DG,Traynor O,McEntee G,Kelly J,Hegarty JE,O'Farrelly C

更新日期：2004-10-01 00:00:00

abstract：:Excessive T helper type 1 (Th1) cell activity has been reported in Behçet's disease (BD). Recently, association of Th17 cells with certain autoimmune diseases was reported, and we thus investigated circulating Th17 cells in BD. CD4(+) CD45RO(-) (naive) T cells were cultured with Th0-, Th1-, Th2- and Th17-related cyto...

journal_title：Clinical and experimental immunology

authors： Shimizu J,Takai K,Fujiwara N,Arimitsu N,Ueda Y,Wakisaka S,Yoshikawa H,Kaneko F,Suzuki T,Suzuki N

更新日期：2012-04-01 00:00:00

abstract：:Traumatic injury and sepsis reduce HLA-DR expression on monocytes. This study assessed the effect of interferon-gamma (IFN-gamma) on the expression of HLA-DR on monocytes taken from severely injured patients. The mononuclear layer of each blood sample was incubated with either 500 units IFN-gamma or control media. The...

journal_title：Clinical and experimental immunology

authors： Hershman MJ,Appel SH,Wellhausen SR,Sonnenfeld G,Polk HC Jr

更新日期：1989-07-01 00:00:00

abstract：:Monocytes (MO) migrating into normal, non-inflamed intestinal mucosa undergo a specific differentiation resulting in a non-reactive, tolerogenic intestinal macrophage (IMAC). Recently we demonstrated the differentiation of MO into an intestinal-like macrophage (MAC) phenotype in vitro in a three-dimensional cell cultu...

journal_title：Clinical and experimental immunology

authors： Spoettl T,Hausmann M,Herlyn M,Gunckel M,Dirmeier A,Falk W,Herfarth H,Schoelmerich J,Rogler G

更新日期：2006-07-01 00:00:00

abstract：:Increased levels of 3% PEG precipitable circulating immune complexes (CIC) were found in healthy homosexual men, in homosexual patients with the acquired immune deficiency syndrome (AIDS), and in the AIDS related lymphadenopathy syndrome (LAS). The degree of CIC elevation increases from healthy homosexual men to LAS a...

journal_title：Clinical and experimental immunology

authors： Euler HH,Kern P,Löffler H,Dietrich M

更新日期：1985-02-01 00:00:00