A high level of serum neopterin is associated with rapidly progressive interstitial lung disease and reduced survival in dermatomyositis.

abstract：:Factor H is an abundant plasma glycoprotein that plays a critical role in the regulation of the complement system in plasma and in the protection of host cells and tissues from damage by complement activation. Several recent studies have described the association of genetic variations of the complement factor H gene (...

journal_title：Clinical and experimental immunology

authors： de Córdoba SR,de Jorge EG

更新日期：2008-01-01 00:00:00

abstract：:Haemophagocytic lymphohistiocytosis (HLH) constitutes a spectrum of immunological disorders characterized by uncontrolled immune activation and key symptoms such as fever, splenomegaly, pancytopenia, haemophagocytosis, hyperferritinaemia and hepatitis. In genetic or primary HLH, hyperactivated CD8+ T cells are the mai...

journal_title：Clinical and experimental immunology

authors： Brisse E,Imbrechts M,Mitera T,Vandenhaute J,Berghmans N,Boon L,Wouters C,Snoeck R,Andrei G,Matthys P

更新日期：2018-04-01 00:00:00

abstract：:The potential value of interleukin 1 (IL-1) containing supernatants as a radioprotective agent was evaluated. It was found that the response of irradiated thymocytes to mitogens was partially restored if IL-1 containing supernatants was included in the culture medium immediately after irradiation. A delay of 24 h in t...

journal_title：Clinical and experimental immunology

authors： Manori I,Kushilevsky A,Weinstein Y

更新日期：1986-03-01 00:00:00

abstract：:Studies in humans and murine disease models have clearly shown dietary fish oil to possess anti-inflammatory properties, apparently mediated by the n-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). To determine the mechanisms by which dietary EPA and DHA modulate mouse T-cell...

journal_title：Clinical and experimental immunology

authors： Arrington JL,Chapkin RS,Switzer KC,Morris JS,McMurray DN

更新日期：2001-09-01 00:00:00

abstract：:The effects of various cytokines on synthesis and microheterogeneity of carbohydrate structure of alpha 1-proteinase inhibitor (PI) and alpha-fetoprotein (AFP) in the human hepatoma cell lines Hep 3B and Hep G2 were studied. In both lines, crude cytokine preparations from LPS-activated human monocytes (CM) and several...

journal_title：Clinical and experimental immunology

authors： Mackiewicz A,Schultz D,Mathison J,Ganapathi M,Kushner I

更新日期：1989-01-01 00:00:00

abstract：:Immunoglobulin M (IgM) levels and their relationship to isohaemagglutinins, febrile agglutinins, sheep cell agglutinins, and rheumatoid factor were measured in patients with acute hepatitis A, acute hepatitis B, chronic hepatitis B antigenaemia, and normal control populations. Significant IgM elevations were observed ...

journal_title：Clinical and experimental immunology

authors： Dietz WH Jr,Porcell O,Moon TE,Peters CJ,Purcell RH

更新日期：1976-01-01 00:00:00

abstract：:Estimation of the concentration of C9, C-reactive protein (CRP) and alpha1-antitrypsin in forty sera from patients with Behcet's syndrome and recurrent oral ulcers showed significantly increased amounts of C9 and CRP in Behcet's syndrome. The concentration of C9 was also significantly raised in recurrent oral ulcerati...

journal_title：Clinical and experimental immunology

authors： Adinolfi M,Lehner T

更新日期：1976-07-01 00:00:00

abstract：:C3b-coated immune complexes adhere to the complement receptor 1 (CR1, CD35) on human erythrocytes. This multi-valent binding might be favoured by the known clustering of CR1 and by the multiple C3b-binding sites on each CR1. The size of the CR1 clusters correlates directly with the number of CR1/erythrocytes, and the ...

journal_title：Clinical and experimental immunology

authors： Madi N,Paccaud JP,Steiger G,Schifferli JA

更新日期：1991-04-01 00:00:00

abstract：:There is increasing interest in the role of T cell exhaustion and it is well known that the natural history of chronic hepatitis C virus infection (HCV) is modulated by CD8(+) T cell immunobiology. There are many pathways that alter the presence of exhaustive T cells and, in particular, they are functionally impaired ...

journal_title：Clinical and experimental immunology

authors： Sumida K,Shimoda S,Iwasaka S,Hisamoto S,Kawanaka H,Akahoshi T,Ikegami T,Shirabe K,Shimono N,Maehara Y,Selmi C,Gershwin ME,Akashi K

更新日期：2013-10-01 00:00:00

abstract：:The possibility that shared idiotypes may be present on antibodies of different specificities was explored using sera from 13 patients with systemic lupus erythematosus. Eleven sera had anti-DNA and seven carried the 16/6 idiotype (ID). Two of the sera with 16/6 ID also had lymphocytotoxic antibodies, the activity of ...

journal_title：Clinical and experimental immunology

authors： Lydyard PM,Isenberg D,de Sousa B,Mackenzie L,Cooke A

更新日期：1987-03-01 00:00:00

abstract：:Complement convertases are enzymatic complexes that play a central role in sustaining and amplification of the complement cascade. Impairment of complement function leads directly or indirectly to pathological conditions, including higher infection rate, kidney diseases, autoimmune- or neurodegenerative diseases and i...

journal_title：Clinical and experimental immunology

authors： Blom AM,Volokhina EB,Fransson V,Strömberg P,Berghard L,Viktorelius M,Mollnes TE,López-Trascasa M,van den Heuvel LP,Goodship TH,Marchbank KJ,Okroj M

更新日期：2014-10-01 00:00:00

abstract：:Growth of a methylcholanthrene-induced fibrosarcoma in BALB/c mice was accompanied by an increase in the activation state of tumour-associated macrophages (TAM), as measured by their FcIgG receptor expression, phagocytic index and beta-glucuronidase levels. All of these parameters were markedly higher in TAM than in p...

journal_title：Clinical and experimental immunology

authors： Valdéz JC,Perdigón G

更新日期：1991-11-01 00:00:00

abstract：:Successful T cell activation via the T cell receptor (TCR)/CD3 complex requires at least one contact-dependent second signal delivered by costimulatory molecules, including the B7/BB1 molecule, that are present on antigen-presenting cells (APC). SLE is characterized by multiple complex lymphocyte abnormalities of unde...

journal_title：Clinical and experimental immunology

authors： Sfikakis PP,Oglesby R,Sfikakis P,Tsokos GC

更新日期：1994-04-01 00:00:00

abstract：:The high concentration of ascorbate in leucocytes and its rapid expenditure during infection and phagocytosis suggests a role for the vitamin in the immune process. Evidence published to date shows an involvement in the migration and phagocytosis by macrophages and leucocytes, as well as the induction and expression o...

journal_title：Clinical and experimental immunology

authors： Thomas WR,Holt PG

更新日期：1978-05-01 00:00:00

abstract：:Both the complement system and tissue factor (TF), a key initiating component of coagulation, are activated in sepsis, and cross-talk occurs between the complement and coagulation systems. C1-inhibitor (C1-INH) can act as a regulator in both systems. Our aim in this study was to examine this cross-talk by investigatin...

journal_title：Clinical and experimental immunology

authors： Landsem A,Nielsen EW,Fure H,Christiansen D,Ludviksen JK,Lambris JD,Østerud B,Mollnes TE,Brekke OL

更新日期：2013-08-01 00:00:00

abstract：:Studies in experimental animals suggest that antibody responses to certain polysaccharide antigens may be restricted in IgG subclass distribution. To determine if human antibodies to pneumococcal polysaccharides are similarly restricted we measured the IgG subclass specific response to immunization with purified polyv...

journal_title：Clinical and experimental immunology

authors： Barrett DJ,Ayoub EM

更新日期：1986-01-01 00:00:00

abstract：:In vitro IgG synthesis by peripheral blood mononuclear cells (PBM) from patients with chronic liver disease (CLD) was studied. In addition, the effect of pokeweed mitogen (PWM), polyadenylic-polyuridylic acid complexes (poly A:U) and thymosin fraction 5 on IgG synthesis was determined. Unstimulated cultures of PBM fro...

journal_title：Clinical and experimental immunology

authors： Mutchnick MG,Lederman HM,Missirian A,Johnson AG

更新日期：1981-02-01 00:00:00

abstract：:Cell-mediated cytotoxicity (CTX) of meningioma patients was assessed postoperatively by a [3H]proline microcytotoxicity test. Autologous and allogeneic tumour cells were used for prelabelling with isotope and peripheral blood lymphocytes added in a ratio of 200:1. After 60 hg the plates were washed and residual CMP co...

journal_title：Clinical and experimental immunology

authors： Pees HW,Seidel B

更新日期：1976-05-01 00:00:00

abstract：:The kinetics of efflux of calcium mobilized from intracellular stores following activation of human neutrophils with the synthetic chemotactic tripeptide, fMLP (1 microM), as well as that of the subsequent store-operated influx of this cation, has been measured by radiometric procedures using 45Ca. These procedures en...

journal_title：Clinical and experimental immunology

authors： Anderson R,Goolam Mahomed A

更新日期：1997-10-01 00:00:00

abstract：:Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4 (Y4 CP) induces bone resorption in a mouse organ culture system and osteoclast formation in mouse bone marrow cultures, as reported in previous studies. We also found that Y4 CP inhibits the release of interleukin (IL)-6 and IL-8 from human gingival ...

journal_title：Clinical and experimental immunology

authors： Iwata T,Mitani A,Ishihara Y,Tanaka S,Yamamoto G,Kikuchi T,Naganawa T,Matsumura Y,Suga T,Koide M,Sobue T,Suzuki T,Noguchi T

更新日期：2005-08-01 00:00:00

abstract：:Organ transplantation is the treatment of choice for patients with end-stage organ failure, but chronic immunosuppression is taking its toll in terms of morbidity and poor efficacy in preventing late graft loss. Therefore, a drug-free state would be desirable where the recipient permanently accepts a donor organ while...

journal_title：Clinical and experimental immunology

authors： Mahr B,Wekerle T

更新日期：2017-08-01 00:00:00

abstract：:Bone marrow (BM) lymphocytes were obtained by sucrose density gradient centrifugation of the nucleated cells from adult human BM. BM was obtained from rib sections removed routinely during thoracotomy from thirteen patients with a localized lung tumour and from two other patients without tumour (mean age 47 years). Th...

journal_title：Clinical and experimental immunology

authors： De Gast GC,Platts-Mills TA

更新日期：1979-10-01 00:00:00

abstract：:In addition to its activity as a metabolic hormone and a regulator of somatic growth, insulin-like growth factor-I (IGF-I) has cytokine-like activities on lymphoid cells. A 14-day infusion of recombinant human (rh)IGF-I increased lymphocyte numbers in all the peripheral lymphoid organs examined. This increase was appa...

journal_title：Clinical and experimental immunology

authors： Robbins K,McCabe S,Scheiner T,Strasser J,Clark R,Jardieu P

更新日期：1994-02-01 00:00:00

abstract：:We have recently demonstrated that peripheral blood monocytes from patients with multiple sclerosis (MS) have a defect in stimulating autologous and allogeneic T lymphocytes. This defect was found to correlate with disease activity. In this report we demonstrate that prothymosin alpha (ProT alpha), a rat thymus fracti...

journal_title：Clinical and experimental immunology

authors： Reclos GJ,Baxevanis CN,Sfagos C,Papageorgiou C,Tsokos GC,Papamichail M

更新日期：1987-11-01 00:00:00

abstract：:Young rats were not able to expel adult N. brasiliensis infections even when the worms were damaged by antibodies and the young rats were given all the cellular components (sensitized lymphocytes and bone marrow cells) shown to be necessary for the expulsion of antibody-damaged worms from adult rats. In contrast, most...

journal_title：Clinical and experimental immunology

authors： Love RJ,Ogilvie BM

更新日期：1975-07-01 00:00:00

abstract：:A previously unrecognized autoantibody, detected by immunofluorescence, reacted with all human organs but gave negative results on tissues from rat, mouse, rabbit, guinea-pig, calf and chicken. From its predilection for mitochondria-rich cells (oncocytes) and its selective absorption with human but not animal mitochon...

journal_title：Clinical and experimental immunology

authors： Swana GT,Swana MR,Bottazzo GF,Doniach D

更新日期：1977-06-01 00:00:00

abstract：:In the present study we have investigated the clearance kinetics and tissue distribution of monomeric (m) IgG and soluble aggregates of IgG (AIgG) and immune complexes (IC) in normal and Kupffer cell (KC) depleted rats. In normal rats, clearance of mIgG occurred in a biphasic manner with a first half-life (T1/2) (T1) ...

journal_title：Clinical and experimental immunology

authors： Bogers WM,Stad RK,Janssen DJ,van Rooijen N,van Es LA,Daha MR

更新日期：1991-11-01 00:00:00

abstract：:Dendritic cells (DCs) are powerful antigen-presenting cells capable of maintaining peripheral tolerance. The possibility to generate tolerogenic DCs opens new therapeutic approaches in the prevention or remission of autoimmunity. There is currently no treatment inducing long-term tolerance and remission in type 1 diab...

journal_title：Clinical and experimental immunology

authors： Marin-Gallen S,Clemente-Casares X,Planas R,Pujol-Autonell I,Carrascal J,Carrillo J,Ampudia R,Verdaguer J,Pujol-Borrell R,Borràs FE,Vives-Pi M

更新日期：2010-05-01 00:00:00

abstract：:Macrophage activation syndrome (MAS) is hyperinflammatory life-threatening syndrome, associated typically with high levels of serum ferritin. This is an iron storage protein including heavy (H) and light (L) subunits, categorized on their molecular weight. The H-/L subunits ratio may be different in tissues, depending...

journal_title：Clinical and experimental immunology

authors： Ruscitti P,Cipriani P,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Ciccia F,Guggino G,Triolo G,Giacomelli R

更新日期：2018-02-01 00:00:00

abstract：:Hypersensitivity to Chironomidae (non-biting midges) has been a problem in Northern Sudan since about 1927 and is probably due to the working of dams which have produced lake-like conditions on parts of the Blue and main Niles where breeding has evidently increased. Studies were undertaken to determine whether this hy...

journal_title：Clinical and experimental immunology

authors： Kay AB,Gad El Rab MO,Stewart J,Erwa HH

更新日期：1978-10-01 00:00:00