Epigenetic alterations on C1-inhibitor expression may influence hereditary angioedema attack frequency and C4 levels: Comment on: Karagianni P, Goules AV, Tzioufas AG. Epigenetic alterations in Sjogren's syndrome patient saliva.

Abstract:

:Epigenetic studies reveal how our genes (nature) are influenced by environment (nurture) leading to wide variability in clinical presentations, especially in autoimmune diseases. Patients with C1-inhibitor deficiency, even within the same family, have diverse clinical presentations that may reflect epigenetic control of gene expression by hormones or inflammatory signals.

journal_name

Clin Exp Immunol

authors

Khan S,Longhurst H

doi

10.1111/cei.13516

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

144-145

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

202

pub_type

评论,杂志文章
  • In vivo effects of a single infusion of theophylline on human peripheral blood lymphocytes.

    abstract::It has recently been proposed that theophylline activates T suppressor systems in vivo and this evidence is further supported by the ability of the drug to attenuate the allograft rejection in humans and in experimental animals. In this study the acute effects of aminophylline on human peripheral blood lymphocyte (PBL...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Pardi R,Zocchi MR,Ferrero E,Ciboddo GF,Inverardi L,Rugarli C

    更新日期:1984-09-01 00:00:00

  • Vitamin C and immunity: an assessment of the evidence.

    abstract::The high concentration of ascorbate in leucocytes and its rapid expenditure during infection and phagocytosis suggests a role for the vitamin in the immune process. Evidence published to date shows an involvement in the migration and phagocytosis by macrophages and leucocytes, as well as the induction and expression o...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Thomas WR,Holt PG

    更新日期:1978-05-01 00:00:00

  • T cell participation in autoreactivity to NC16a epitopes in bullous pemphigoid.

    abstract::Bullous pemphigoid is a blistering skin disease characterized by autoantibodies against the NC16a domain of bullous pemphigoid 180. This study was performed to characterize and map the fine specificity of T cell responses to NC16a. Peripheral blood mononuclear cells (PBMC) from a total of 28 bullous pemphigoid patient...

    journal_title:Clinical and experimental immunology

    pub_type: 临床试验,杂志文章

    doi:10.1111/cei.12566

    authors: Pickford WJ,Gudi V,Haggart AM,Lewis BJ,Herriot R,Barker RN,Ormerod AD

    更新日期:2015-05-01 00:00:00

  • Epitope mapping of an HLA-B27 monoclonal antibody that also reacts with a 35-kD bacterial outer-membrane protein.

    abstract::Ye-3 is an HLA-B27-specific murine monoclonal antibody recognizing the heat-modifiable protein of Enterobacteriaceae. Here we used recombinant hybrid molecules between the HLA-B7 and HLA-B27 antigens to delineate the epitope recognized by Ye-3. Results of these experiments indicated that the segment of HLA-B*2705 span...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1990.tb05397.x

    authors: Toubert A,Hamachi M,Raffoux C,Park MS,Yu DT

    更新日期:1990-10-01 00:00:00

  • Efficacy, safety, tolerability and pharmacokinetics of a novel human immune globulin subcutaneous, 20%: a Phase 2/3 study in Europe in patients with primary immunodeficiencies.

    abstract::A highly concentrated (20%) immunoglobulin (Ig)G preparation for subcutaneous administration (IGSC 20%), would offer a new option for antibody replacement therapy in patients with primary immunodeficiency diseases (PIDD). The efficacy, safety, tolerability and pharmacokinetics of IGSC 20% were evaluated in a prospecti...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/cei.12866

    authors: Borte M,Kriván G,Derfalvi B,Maródi L,Harrer T,Jolles S,Bourgeois C,Engl W,Leibl H,McCoy B,Gelmont D,Yel L

    更新日期:2017-01-01 00:00:00

  • Reduced circulating CD4+CD25+ cell populations in haemorrhagic fever with renal syndrome.

    abstract::Immunopathological mechanisms are speculated to underlie haemorrhagic fever with renal syndrome (HFRS) caused by Hantaviruses. CD4+CD25+ T regulatory cells (T(regs)), a subset of CD4+ T cells, expressed high levels of CD25 and the forkhead box transcription factor P3 (FoxP3), plays an important role in the down-regula...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2008.03858.x

    authors: Zhu LY,Chi LJ,Wang X,Zhou H

    更新日期:2009-04-01 00:00:00

  • Electrophoresis of lymphoid cells. Differences in the cell membrane structure of murine thymocytes, T and B cells revealed by enzyme and formalin treatment.

    abstract::Low concentrations of protease and trypsin reduced the electrophoretic mobility (EPM) of thymocytes; with higher concentrations it was normal or above. Differences in membrane structure of thymocytes, T and B cells was found as B cells showed no reduction while T cells gave intermediate values. Further the reduction w...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Wiig JN

    更新日期:1975-10-01 00:00:00

  • Blastogenic responses to Pneumocystis carinii among patients with human immunodeficiency (HIV) infection.

    abstract::Proliferative responses by human peripheral blood mononuclear cells and rat spleen cells were measured to Pneumocystis carinii in a blastogenic assay using organisms obtained from rat lungs and propagated in tissue culture as the antigen. Responses occurred only in subjects with known prior exposure to P. carinii and ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Hagler DN,Deepe GS,Pogue CL,Walzer PD

    更新日期:1988-10-01 00:00:00

  • Autoantibodies to box A of high mobility group box 1 in systemic lupus erythematosus.

    abstract::Autoantibodies to nuclear structures are a hallmark of systemic lupus erythematosus (SLE), including autoantibodies to nuclear protein high mobility group box 1 (HMGB1). HMGB1 consists of three separate domains: box A, box B and an acidic tail. Recombinant box A acts as a competitive antagonist for HMGB1 and might be ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12951

    authors: Schaper F,de Leeuw K,Horst G,Maas F,Bootsma H,Heeringa P,Limburg PC,Westra J

    更新日期:2017-06-01 00:00:00

  • Suppressor activity of splenic macrophages in murine plasmacytoma (PC) is inhibited by PC specific ligands.

    abstract::Spleens of BALB/c mice with plasmacytoma contain macrophages (M phi) which were found to suppress the in vitro immune function of normal splenic cells through a diffusible factor. The suppressor activity of these macrophages was reversibly inhibited by ligands specific for the corresponding PC globulin, but not by ant...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Chen YH,Heller P

    更新日期:1982-11-01 00:00:00

  • Rosette formation of human null lymphocytes with Rhesus monkey erythrocytes.

    abstract::Human null lymphocytes which lack B- and T-lymphocyte markers were found to form spontaneous rosettes with uncoated Rhesus monkey erythrocytes. Rosette-forming null lymphocytes were determined in null lymphocyte-enriched preparations of healthy persons and of patients with lymphoproliferative diseases. Quantitative de...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Chiao JW,Dowling M,Good RA

    更新日期:1978-06-01 00:00:00

  • Linomide suppresses experimental autoimmune neuritis in Lewis rats by inhibiting myelin antigen-reactive T and B cell responses.

    abstract::Linomide (quinoline-3-carboxamide) is a synthetic immunomodulator that suppresses several experimental autoimmune diseases. Here we report the effects of Linomide on experimental autoimmune neuritis (EAN), a CD4+ T cell-mediated animal model of acute Guillain-Barré syndrome (GBS) in humans. EAN induced in Lewis rats b...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1999.00768.x

    authors: Zhu J,Bai XF,Hedlund G,Björk J,Bakhiet M,Van Der Meide PH,Link H

    更新日期:1999-01-01 00:00:00

  • Interleukin-1 beta enhances and interferon-gamma suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts.

    abstract::Activin A is a multi-functional cytokine with a potent stimulation on erythroid cell differentiation in the bone marrow. The actions of activin A are determined by a balance of the levels of activin A and its inhibitor, follistatin (FS). However, the regulation of its actions in the bone marrow has been unclear. Here ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2001.01644.x

    authors: Abe M,Shintani Y,Eto Y,Harada K,Fujinaka Y,Kosaka M,Matsumoto T

    更新日期:2001-10-01 00:00:00

  • H-ferritin and CD68(+) /H-ferritin(+) monocytes/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease.

    abstract::Adult-onset Still's disease (AOSD) patients may show an evanescent salmon-pink erythema appearing during febrile attacks and reducing without fever. Some patients may experience this eruption for many weeks. During AOSD, exceptionally high serum levels of ferritin may be observed; it is an iron storage protein compose...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12826

    authors: Ruscitti P,Cipriani P,Ciccia F,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Guggino G,Di Bartolomeo S,Triolo G,Giacomelli R

    更新日期:2016-10-01 00:00:00

  • Effects of therapy with soluble tumour necrosis factor receptor fusion protein on pulmonary cytokine expression and lung injury following haemorrhage and resuscitation.

    abstract::Acute lung injury frequently develops following haemorrhage, and is characterized by increased proinflammatory cytokine levels and massive neutrophil accumulation in the lung. Blood loss produces rapid increases in tumour necrosis factor-alpha (TNF-alpha) mRNA expression among pulmonary cell populations which precede ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1994.tb06602.x

    authors: Abraham E,Coulson WF,Schwartz MD,Allbee J

    更新日期:1994-10-01 00:00:00

  • T lymphocyte lines isolated from atheromatous plaque contain cells capable of responding to Chlamydia antigens.

    abstract::Chlamydia pneumoniae infection is associated with atherosclerosis and the organism has been identified in arterial lesions. To determine whether T lymphocyte-mediated immune responses to Chlamydia antigens within plaque could contribute to pathogenesis, we have derived T cell lines from atherosclerotic plaques of 32 p...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2000.01294.x

    authors: Curry AJ,Portig I,Goodall JC,Kirkpatrick PJ,Gaston JS

    更新日期:2000-08-01 00:00:00

  • Studies on J chain and binding site for secretory component in circulating human B cells.

    abstract::Lymphocyte-enriched mononuclear cell fractions were obtained from the peripheral blood of four healthy young adults. Living B cells with membrane immunoglobulin (Ig) were studied by immunofluorescence to reveal exposed J-chain determinants or surface affinity for the secretory component (SC). Alcohol-fixed cell smears...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Brandtzaeg P

    更新日期:1976-07-01 00:00:00

  • Haemorrhage-induced alterations in function and cytokine production of T cells and T cell subpopulations.

    abstract::Haemorrhage produces alterations in macrophage, T and B cell function. In order to better define the mechanism for the effects of blood loss on immune response, we examined function of and cytokine production by purified T cells, CD4+ and CD8+ subpopulations after blood loss. Whereas T and CD4+ cells from control, unh...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1992.tb05873.x

    authors: Abraham E,Chang YH

    更新日期:1992-12-01 00:00:00

  • Antibody dependent cellular cytotoxicity (ADCC) in acute hepatitis B and in chronic active hepatitis.

    abstract::Antibody-dependent cellular cytotoxicity (ADCC) of peripheral blood lymphocytes against chicken red blood cells (ChRBC) in the presence of specific antiserum has been studied in normal subjects and in patients with acute hepatitis B and with chronic active hepatitis (CAH). ADCC was significantly reduced in patients wi...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Bortolotti F,Realdi G,Diodati G,Fattovich G

    更新日期:1978-08-01 00:00:00

  • Ethyl pyruvate significantly inhibits tumour necrosis factor-α, interleukin-1β and high mobility group box 1 releasing and attenuates sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury.

    abstract::In this study, we examined the effect of ethyl pyruvate (EP) on pulmonary inflammation in rats with severe pancreatitis-associated acute lung injury (ALI). Severe acute pancreatitis (SAP) was induced in rats by the retrograde injection of 5% sodium taurocholate into the pancreatic duct. Rats were randomly divided into...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12062

    authors: Luan ZG,Zhang J,Yin XH,Ma XC,Guo RX

    更新日期:2013-06-01 00:00:00

  • Translational mini-review series on type 1 diabetes: Immune-based therapeutic approaches for type 1 diabetes.

    abstract::Type 1 diabetes (T1D) is often considered the prototype organ-specific autoimmune disease in clinical immunology circles. The key disease features - precise destruction of a single endocrine cell type occurring on a distinct genetic and autoimmune background - have been unravelled in recent years to such an extent tha...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2249.2007.03328.x

    authors: Staeva-Vieira T,Peakman M,von Herrath M

    更新日期:2007-04-01 00:00:00

  • Effect of simple sugars on natural killing: evidence against the involvement of a lectin like mechanism in target recognition.

    abstract::The spontaneous lysis of target cells sensitive to natural killer (NK) activity is accomplished in two distinct phases: (i) binding between target and effector cells and (ii) post-binding events leading to target cell destruction. To test the hypothesis that cell surface carbohydrate(s) might be involved in recognitiv...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Vose BM,Harding M,White W,Moore M,Gallagher J

    更新日期:1983-03-01 00:00:00

  • Demonstration of two disease specific antigens in circulating immune complexes.

    abstract::A method is described to assess antigenic cross-reactivity between soluble immune complexes precipitated from sera with polyethylene glycol. The precipitated complex from one serum was dissociated in acid and used to coat a plastic cup. Radioiodinated complexes from another serum were dissociated in the cup, neutraliz...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Dambuyant C,Burton-Kee J,Mowbray JF

    更新日期:1979-09-01 00:00:00

  • Mechanism of a lymphocyte abnormality associated with HLA-B8/DR3: role of interleukin-1.

    abstract::Lymphocytes from normal individuals with the histocompatibility antigens HLA-B8 and DR3 have impaired proliferative responses when stimulated with suboptimal concentrations of mitogens. We have previously shown that an important factor in the impaired response is a failure to produce normal quantities of interleukin-2...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1990.tb05183.x

    authors: Hashimoto S,Michalski JP,Berman MA,McCombs C

    更新日期:1990-02-01 00:00:00

  • The effect of levamisole on cellular immunity in multiple sclerosis.

    abstract::The lymphocyte stimulation test has been standardized in a normal human population using four virus cell-associated antigens (VCAA): human embryonic lung cells infected with the LEC and Norrby strains of measles virus, mumps virus, and vaccinia virus. Following 1 week of treatment with the immunopotentiating drug leva...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Dau PC,Johnson KP,Spitler LE

    更新日期:1976-11-01 00:00:00

  • Efficacy of HIV-specific and 'antibody-independent' mechanisms for complement activation by HIV-infected cells.

    abstract::Previous studies in this laboratory have shown that efficient activation of complement (C) on HIV isolates and HIV-infected cells requires the binding of specific anti-HIV antibodies, while other investigators have observed 'antibody-independent' C activation. In an attempt to clarify these disparate findings, we inve...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1995.tb05531.x

    authors: Saarloos MN,Lint TF,Spear GT

    更新日期:1995-02-01 00:00:00

  • Pharmacodynamics of recombinant human DNase I in serum.

    abstract::Recombinant human deoxyribonuclease I (rhDNase) may be an effective therapeutic for the treatment of systemic lupus erythematosus (SLE). The pharmacodynamics of rhDNase in serum was investigated using two activity assays: one based on hydrolysis of a radiolabelled phage DNA and the other based on hydrolysis of human c...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1998.00647.x

    authors: Prince WS,Baker DL,Dodge AH,Ahmed AE,Chestnut RW,Sinicropi DV

    更新日期:1998-08-01 00:00:00

  • A comparison of the effects of plasma exchange and immunoadsorption on anti-insulin antibody synthesis in rabbits.

    abstract::Plasma exchange (PE) and ex vivo immunoadsorption (IA) may be applicable to the removal of anti-insulin antibodies (AI-Ab) from diabetic patients. However, the removal of antibodies may prompt an increase in their rate of synthesis and an overshoot of antibody levels which may be deleterious to the patient. The effect...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Charlton B,Antony G,Cooper SG,Schindhelm K

    更新日期:1988-05-01 00:00:00

  • Translational mini-review series on immunology of vascular disease: accelerated atherosclerosis in vasculitis.

    abstract::Premature atherosclerosis has been observed during the course of different systemic inflammatory diseases such as rheumatoid arthritis and sytemic lupus erythematosus. Remarkably, relatively few studies have been published on the occurrence of accelerated atherosclerosis in patients with vasculitis. In giant cell arte...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2249.2009.03885.x

    authors: Tervaert JW

    更新日期:2009-06-01 00:00:00

  • Impaired interleukin (IL)-4-associated generation of CCR4-expressing T cells in neonates with hereditary allergy risk.

    abstract::Reduced microbial exposure in early life may contribute to the increase of atopic diseases in 'westernized' societies but the underlying mechanisms remain elusive. The objective of this study was to examine how exposure to bacterial lipopolysaccharide (LPS) during early antigen encounter might influence the maturation...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2005.02706.x

    authors: Haddeland U,Sletten GB,Brandtzaeg P,Nakstad B

    更新日期:2005-02-01 00:00:00