Abstract:
Background:Bacterial and fungal infections (BFIs) are frequent in patients with cirrhosis and often trigger acute-on-chronic liver failure (ACLF). This prospective observational study aims to describe the interactions between BFI and ACLF in terms of mortality and related risk factors. Methods:We performed a 2-center prospective observational study enrolling hospitalized patients with cirrhosis admitted for acute decompensation. Data were recorded at admission and during hospitalization. Survival was recorded up to 1 year. Results:Among the 516 patients enrolled, 108 (21%) were infected at admission, while an additional 61 patients (12%) developed an infection during hospital stay. In the absence of ACLF, the 1-year mortality rate of patients with BFI did not differ from that of patients without BFI (33% vs 31%; P = .553). In contrast, those with ACLF triggered or complicated by BFI had a significantly higher mortality rate than those who remained free from BFI (75% vs 54%; P = .011). Competing risk analysis showed that the negative impact of ACLF-related BFI on long-term prognosis was independent from Model for End-stage Liver Disease (MELD) incorporating serum sodium concentration score, comorbidity, and basal C-reactive protein level. Finally, multivariable logistic regression showed that higher MELD score (P < .001), QuickSOFA score ≥2 points (P = .007), and secondary bloodstream (P = .022) and multidrug-resistant pathogen isolation (P = .030) were independently associated with ACLF in patients with BFI. Conclusions:This large prospective study indicated that the adverse impact of BFI on long-term survival in decompensated cirrhosis is not universal but is limited to those patients who also develop ACLF. Both disease severity and microbiological factors predispose infected decompensated patients to ACLF.
journal_name
Open Forum Infect Disjournal_title
Open forum infectious diseasesauthors
Bartoletti M,Baldassarre M,Domenicali M,Lewis RE,Giannella M,Antognoli A,Rinaldi M,Zaccherini G,Verucchi G,Marconi L,Tamè M,Berardi S,Napoli L,Siniscalchi A,Fabbri A,Biselli M,Tufoni M,Pavarin RM,Trevisani F,Viale Pdoi
10.1093/ofid/ofaa453subject
Has Abstractpub_date
2020-11-04 00:00:00pages
ofaa453issue
11issn
2328-8957pii
ofaa453journal_volume
7pub_type
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