Abstract:
:"What I cannot create, I do not understand." Richard Feynman may have championed reasoning from first principles in his famous blackboard missive, but he could just as well have been referring to the plight of a molecular virologist. What cannot be grown in a controlled laboratory setting, we cannot fully understand. The story of the laboratory domestication of hepatitis C virus (HCV) is now a classic example of virologists applying all manner of inventive skill to create cell-based models of infection in order to clarify prospective drug targets. In this review, we highlight key successes and failures that were instructive in achieving cell-based models for HCV studies and drug development. We also emphasize the lessons learned from the ∼40 year saga that may be applicable to viruses yet unknown and uncultured.
journal_name
Curr Opin Viroljournal_title
Current opinion in virologyauthors
Luna JM,Saeed M,Rice CMdoi
10.1016/j.coviro.2019.02.008subject
Has Abstractpub_date
2019-04-01 00:00:00pages
27-34eissn
1879-6257issn
1879-6265pii
S1879-6257(18)30133-0journal_volume
35pub_type
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journal_title:Current opinion in virology
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
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journal_title:Current opinion in virology
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
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journal_title:Current opinion in virology
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2016.06.007
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journal_title:Current opinion in virology
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journal_title:Current opinion in virology
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journal_title:Current opinion in virology
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journal_title:Current opinion in virology
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
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journal_title:Current opinion in virology
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
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journal_title:Current opinion in virology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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