Proceedings of a Consensus Conference: pathogen inactivation-making decisions about new technologies.


:Significant progress has been made in reducing the risk of pathogen transmission to transfusion recipients. Nonetheless, there remains a continuing risk of transmission of viruses, bacteria, protozoa, and prions to recipients. These include many of the viruses for which specific screening tests exist as well as pathogens for which testing is currently not being done, including various species of bacteria, babesiosis, variant Creutzfeld-Jacob disease, hepatitis A virus, human herpes virus 8, chikungunya virus, Chagas disease, and malaria. Pathogen inactivation (PI) technologies potentially provide an additional way to protect the blood supply from emerging agents and also provide additional protection against both known and as-yet-unidentified agents. However, the impact of PI on product quality and recipient safety remains to be determined. The purpose of this consensus conference was to bring together international experts in an effort to consider the following issues with respect to PI: implementation criteria; licensing requirements; blood service and clinical issues; risk management issues; cost-benefit impact; and research requirements. These proceedings are provided to make available to the transfusion medicine community the considerable amount of important information presented at this consensus conference.


Transfus Med Rev


Webert KE,Cserti CM,Hannon J,Lin Y,Pavenski K,Pendergrast JM,Blajchman MA




Has Abstract


2008-01-01 00:00:00














  • The Role of Complement in Hereditary Angioedema.

    abstract::Low levels of C1 inhibitor, the main inhibitor of the classic complement system, result in paroxysmal angioedema attacks that can be incapacitating or even life-threatening in affected individuals. Molecular defects in the gene for C1 inhibitor cause hereditary angioedema. In recent years, new insights in the pathways...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Levi M,Cohn DM

    更新日期:2019-10-01 00:00:00

  • Meeting the clinical challenge of care for Jehovah's Witnesses.

    abstract::Quality patient care entails more than simply biomedical interventions. Respect for the wishes, values, and preferences of patients are important elements of quality care. Unique aspects of the beliefs of Jehovah's Witnesses may present physicians with ethical and clinical conflicts. Witnesses believe that allogeneic ...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Bodnaruk ZM,Wong CJ,Thomas MJ

    更新日期:2004-04-01 00:00:00

  • Hemostatic and signaling functions of transfused platelets.

    abstract::Metabolic studies have revealed a gradual impairment in platelet integrity during storage, a process termed the platelet storage lesion. Recent evidence shows that stored platelets also lose signaling responses to physiological agonists with impaired integrin activation, secretion, and aggregation of the cells. On the...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Cauwenberghs S,van Pampus E,Curvers J,Akkerman JW,Heemskerk JW

    更新日期:2007-10-01 00:00:00

  • The regulation of complement on cell surfaces.

    abstract::The regulation of complement at the surface of cells is mediated by both plasma and membrane proteins. These molecules act in concert to prevent the accelerated catabolism of complement proteins and the concomitant lysis of homologous blood cells. The deficiency of either a plasma or membrane protein predisposes to th...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Devine DV

    更新日期:1991-04-01 00:00:00

  • Appropriateness of allogeneic red blood cell transfusion: the international consensus conference on transfusion outcomes.

    abstract::An international multidisciplinary panel of 15 experts reviewed 494 published articles and used the RAND/UCLA Appropriateness Method to determine the appropriateness of allogeneic red blood cell (RBC) transfusion based on its expected impact on outcomes of stable nonbleeding patients in 450 typical inpatient medical, ...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,多中心研究,评审


    authors: Shander A,Fink A,Javidroozi M,Erhard J,Farmer SL,Corwin H,Goodnough LT,Hofmann A,Isbister J,Ozawa S,Spahn DR,International Consensus Conference on Transfusion Outcomes Group.

    更新日期:2011-07-01 00:00:00

  • The challenge of platelet alloimmunization: management and prevention.

    abstract::The limiting factor in platelet transfusion therapy is the development of alloimmunization. Although using HLA matched platelets may be effective in reducing the problem of alloimmune platelet transfusion refractoriness, relying solely upon HLA matching has its shortcomings. The selection of compatible platelet transf...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Kickler TS

    更新日期:1990-10-01 00:00:00

  • In vitro assessment of platelet function.

    abstract::With the realization that the skin bleeding time is often an unreliable measure of platelet function, efforts have been made to identify ways to assess qualitative platelet dysfunction. Currently available techniques measure platelet adhesion, platelet aggregation, the ability of platelets to retard or stop flow throu...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Carr ME Jr

    更新日期:1997-04-01 00:00:00

  • The use of immunoglobulin therapy for patients undergoing solid organ transplantation: an evidence-based practice guideline.

    abstract::This guideline for the use of immunoglobulin (IG) for sensitized patients undergoing solid organ transplantation (SOT) is an initiative of the Canadian Blood Services and the National Advisory Committee on Blood and Blood Products of Canada to (1) provide guidance for Canadian practitioners involved in the care of pat...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Shehata N,Palda VA,Meyer RM,Blydt-Hansen TD,Campbell P,Cardella C,Martin S,Nickerson P,Peltekian K,Ross H,Waddell TK,West L,Anderson D,Freedman J,Hume H

    更新日期:2010-01-01 00:00:00

  • Clinical trial opportunities in Transfusion Medicine: proceedings of a National Heart, Lung, and Blood Institute State-of-the-Science Symposium.

    abstract::The use of blood products to support patients undergoing the large variety of medical and surgical interventions requiring such support has continued to escalate very significantly over time. Relevantly, significant practice variation in the use of blood products exists among practitioners and institutions, largely be...

    journal_title:Transfusion medicine reviews



    authors: Blajchman MA,Glynn SA,Josephson CD,Kleinman SH,State-of-the Science Symposium Transfusion Medicine Committee.

    更新日期:2010-10-01 00:00:00

  • Chromosome location of genes encoding human blood groups.

    abstract::The chromosomal locations of genes controlling the expression of some 200 antigens constituting the 23 established human blood group systems have been reviewed. Twenty-one of the these genes are located on 12 autosomes, and two are located on the X chromosome. Refined chromosomal positions, to a single cytogenetically...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Reid ME,McManus K,Zelinski T

    更新日期:1998-07-01 00:00:00

  • Cold agglutination.

    abstract::Autoantibodies against red cells optimally reacting at 0 degree C, ie, CA, are normally found with low titers in the serum of human adults. High-titer CA may be induced by certain infectious agents, including M pneumoniae, EBV, CMV, and rubella virus, or may develop on the basis of chronic (malignant) B cell lymphopro...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Roelcke D

    更新日期:1989-04-01 00:00:00

  • Red Blood Cell Alloimmunization in Transfused Patients With Sickle Cell Disease in Sub-Saharan Africa; a Systematic Review and Meta-Analysis.

    abstract::Sickle cell disease (SCD) is the most common monogenic disorder in sub-Saharan Africa (SSA). Blood transfusion to increase the oxygen carrying capacity of blood is vital in the management of many patients with SCD. However, red blood cell (RBC) alloimmunization is a major challenge to transfusions in these patients. C...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,meta分析


    authors: Boateng LA,Ngoma AM,Bates I,Schonewille H

    更新日期:2019-07-01 00:00:00

  • Neonatal Platelet Transfusions and Future Areas of Research.

    abstract::Thrombocytopenia affects approximately one fourth of neonates admitted to neonatal intensive care units, and prophylactic platelet transfusions are commonly administered to reduce bleeding risk. However, there are few evidence-based guidelines to inform clinicians' decision-making process. Developmental differences in...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Sola-Visner M,Bercovitz RS

    更新日期:2016-10-01 00:00:00

  • Drivers of transfusion decision making and quality of the evidence in orthopedic surgery: a systematic review of the literature.

    abstract::Reasons for variation in transfusion practice in orthopedic surgery are not well understood. This systematic review identified and appraised the quality of the literature in this area to assess the impact of factors associated with the use of allogeneic red blood cell (RBC) transfusion in orthopedic procedures. MEDLIN...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Barr PJ,Donnelly M,Cardwell C,Alam SS,Morris K,Parker M,Bailie KE

    更新日期:2011-10-01 00:00:00

  • Platelets are not just for clots.

    abstract::Although the role of platelets as central mediators of hemostasis and thrombosis has been the primary focus of research into platelet biology for more than a century, over the last decade, nonhemostatic functions of platelets have been increasingly defined. As such, a large body of experimental evidence now exists, wh...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: McFadyen JD,Kaplan ZS

    更新日期:2015-04-01 00:00:00

  • Allogeneic blood transfusion as a risk factor for the subsequent development of non-Hodgkin's lymphoma.

    abstract::In summary, it is impossible to reconcile the contradictory results of the studies of the association between previous blood transfusion and subsequent development of NHL (Figs 1 and 2). Most of the studies were of high quality, and the authors discussed the possible sources of bias that might have generated a spuriou...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Vamvakas EC

    更新日期:2000-07-01 00:00:00

  • Complement and Coagulation: Cross Talk Through Time.

    abstract::Two complex protein defense systems-complement and coagulation-are based on amplifying enzyme cascades triggered by specific local stimuli. Excess systemic activation of either system is pathologic and is normally prevented by a family of regulatory proteins. The 2 systems are ancient biological processes which share ...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Dzik S

    更新日期:2019-10-01 00:00:00

  • Evidence-Based Red Blood Cell Transfusion Practices in Cardiac Surgery.

    abstract::Cardiac surgical patients are among the highest consumers of allogeneic red blood cells (RBCs) due to the prevalence of anemia and bleeding. Up until recently, there was a paucity of high-quality evidence informing transfusion decisions in this patient group which led to wide variability in transfusion decision making...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Patel NN,Murphy GJ

    更新日期:2017-10-01 00:00:00

  • Centralized transfusion service: a novel approach to the delivery of transfusion services.

    abstract::The development and expansion of the CTS in Pittsburgh shows the feasibility of this transfusion medicine delivery system. Few of the changes driven by health care reform both improve patient care and reduce costs. When properly implemented, a CTS achieves these objectives, benefits the community as a whole, and enhan...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Triulzi DJ,Portman WH,Mango PD,Lopez-Plaza I,Hahn LF

    更新日期:1995-04-01 00:00:00

  • Metabolomics of ADSOL (AS-1) red blood cell storage.

    abstract::Population-based investigations suggest that red blood cells (RBCs) are therapeutically effective when collected, processed, and stored for up to 42 days under validated conditions before transfusion. However, some retrospective clinical studies have shown worse patient outcomes when transfused RBCs have been stored f...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章


    authors: Roback JD,Josephson CD,Waller EK,Newman JL,Karatela S,Uppal K,Jones DP,Zimring JC,Dumont LJ

    更新日期:2014-04-01 00:00:00

  • Platelet Immunology in China: Research and Clinical Applications.

    abstract::Immunization against human platelet alloantigens (HPAs) is associated with a number of clinical complications. The detection and identification of clinically relevant platelet antibodies are important for the diagnosis and management of patients affected with immune-mediated thrombocytopenias. Human platelet alloantig...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Wu G,Zhou Y,Li L,Zhong Z,Li H,Li H,Yu M,Shen W,Ni H

    更新日期:2017-04-01 00:00:00

  • Platelet derivatives in regenerative medicine: an update.

    abstract::Prior preclinical and clinical studies support the use of platelet-derived products for the treatment of soft and hard tissue lesions. These regenerative effects are controlled by autocrine and paracrine biomolecules including growth factors and cytokines contained in platelet alpha granules. Each growth factor is inv...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: De Pascale MR,Sommese L,Casamassimi A,Napoli C

    更新日期:2015-01-01 00:00:00

  • The Canadian blood donor health assessment questionnaire: lessons from history, application of cognitive science principles, and recommendations for change.

    abstract::Over the last 20 years, the Canadian Blood Services' (CBS) Donor Health Assessment Questionnaire (DHAQ), used to screen prospective blood donors to determine their eligibility, has grown in complexity and length. Its growth is inextricably linked to the evolution of the environment within which CBS operates from unreg...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: O'Brien SF,Ram SS,Vamvakas EC,Goldman M

    更新日期:2007-07-01 00:00:00

  • James Blundell, Obstetrical Hemorrhage, and the Origins of Transfusion Medicine.

    abstract::Although James Blundell is rightly acknowledged as the father of modern transfusion therapy, a review of the events surrounding the initial human-to-human transfusions in the first decades of the 19th century reveals substantial contributions by Blundell's collaborators. Bundell's uncle John Haighton provided substant...

    journal_title:Transfusion medicine reviews

    pub_type: 传,历史文章,杂志文章,评审


    authors: Dzik S

    更新日期:2018-10-01 00:00:00

  • Effects of cardiac surgery on hemostasis.

    abstract::Cardiac surgery affects both coagulation and platelet function. Revision of surgery due to bleeding has to be performed in 2% to 6% of patients undergoing cardiac surgery and is generally associated with a marked deterioration in prognosis. Factors contributing to acquired hemostatic abnormalities in cardiac surgery i...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Hartmann M,Sucker C,Boehm O,Koch A,Loer S,Zacharowski K

    更新日期:2006-07-01 00:00:00

  • Possible Utility of the Basophil Activation Test for the Analysis of Mechanisms Involved in Allergic Transfusion Reactions.

    abstract::Allergic transfusion reactions (ATRs) are the most common adverse reactions occurring during transfusion of blood components. Although most reactions are mild and involve cutaneous manifestations, severe ATRs including life-threatening anaphylaxis may also occur. The mechanisms of ATRs are largely unknown because they...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Hirayama F,Yasui K,Matsuyama N,Okamura-Shiki I

    更新日期:2018-01-01 00:00:00

  • Prenatal typing of Rh and Kell blood group system antigens: the edge of a watershed.

    abstract::Knowledge of the molecular basis of the blood group systems has enabled the development of assays for blood group genotyping. At this time, polymerase chain reaction (PCR)-based assays validated on fetal material obtained by invasive means (chorionic villus sampling or amniocentesis) are available for all clinically r...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: van der Schoot CE,Tax GH,Rijnders RJ,de Haas M,Christiaens GC

    更新日期:2003-01-01 00:00:00

  • Evolution and Utility of Antiplatelet Autoantibody Testing in Patients with Immune Thrombocytopenia.

    abstract::To this day, immune thrombocytopenia (ITP) remains a clinical diagnosis made by exclusion of other causes for thrombocytopenia. Reliable detection of platelet autoantibodies would support the clinical diagnosis, but the lack of specificity and sensitivity of the available methods for platelet autoantibody testing limi...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Porcelijn L,Schmidt DE,Oldert G,Hofstede-van Egmond S,Kapur R,Zwaginga JJ,de Haas M

    更新日期:2020-10-01 00:00:00

  • Does hybridoma technology still have a place in transfusion medicine?

    abstract::Hybridoma technology has contributed to virtually all areas of biology and medicine and set the scene for important advances in cell biology and immunodiagnostics. Blood transfusion and transfusion medicine have benefited significantly from development in hybridoma technology, and this has resulted in the generation o...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Yuan FF,Watt JM,Geczy AF

    更新日期:2002-07-01 00:00:00

  • Cost-effectiveness analysis: what it really means for transfusion medicine decision making.

    abstract::Some have suggested that "blood is different," and the role for cost-effectiveness is thus circumscribed. In this article, the authors start by reviewing key concepts in health economics and economic analysis methods. Examples are drawn from published blood safety studies. After explaining the underlying reasoning beh...

    journal_title:Transfusion medicine reviews

    pub_type: 杂志文章,评审


    authors: Custer B,Hoch JS

    更新日期:2009-01-01 00:00:00