Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short-term exposure to two-dimensional and three-dimensional spheroid cell cultures.

abstract：:The brain is a well-organized, yet highly complex, organ in the mammalian system. Most investigators use the whole brain, instead of a selected brain region(s), for biochemical analytes as toxicological endpoints. As a result, the obtained data is often of limited value, since their significance is compromised due to ...

journal_title：Toxicology mechanisms and methods

authors： Gupta RC

更新日期：2004-01-01 00:00:00

abstract：:Benzo(a)pyrene (BaP) was a well-known environmental pollutant, numerous studies had implicated BaP as a causative agent in human cancer, particularly lung cancer. The lemongrass essential oil (LEO) possessed various pharmacological activities, especially the anti-oxidative stress and cancer prevention. In the current ...

journal_title：Toxicology mechanisms and methods

authors： Jiang J,Xu H,Wang H,Zhang Y,Ya P,Yang C,Li F

更新日期：2017-02-01 00:00:00

abstract：:Allergic rhinitis (also known as hay fever) is the most commonly occurring immunological disorder, and it affects 40 million men, women, and children in the United States. Symptomatically, it is an inflammation and irritation of the mucous membranes that line the nose. Allergy is defined as a state of hypersensitivity...

journal_title：Toxicology mechanisms and methods

authors： Amit A,Saxena VS,Pratibha N,Bagchi M,Bagchi D,Stohs SJ

更新日期：2003-01-01 00:00:00

abstract：:A suboptimal in utero environment can have detrimental effects on the pregnancy and long-term adverse "programing" effects on the offspring. Aflatoxin B1 is one of the potent reproductive toxicants and currently detected in both milk and tissues. This article focuses on the effects of prenatal exposure to graded doses...

journal_title：Toxicology mechanisms and methods

authors： Supriya Ch,Akhila B,Pratap Reddy K,Girish BP,Sreenivasula Reddy P

更新日期：2016-01-01 00:00:00

abstract：:During the last years, much attention was focused on the measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a marker of oxidative DNA damage. Among various analytical techniques, the (32)P-postlabeling assay has been applied in determination of 8-oxo-dG. However, artefactual DNA oxidation could take plac...

journal_title：Toxicology mechanisms and methods

authors： Maatouk I,Bouaïcha N,Plessis MJ,Périn F

更新日期：2006-01-01 00:00:00

abstract：CONTEXT:The critical role of CaMKIIδ isoforms in cardiac hypertrophy is well documented. OBJECTIVE:This study was aimed to investigate the possible inhibitory effects of aliskiren (ALS) and/or carvedilol (CAV) on CaMKIIδ isoforms expression in experimental cardiac hypertrophy. MATERIALS AND METHODS:Male Wistar albino...

journal_title：Toxicology mechanisms and methods

authors： Bin-Dayel AF,Abdel Baky NA,Fadda LM,Mohammad RA,Al-Mohanna F

更新日期：2016-02-01 00:00:00

abstract：:A potency of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) to reactivate cyclosarin-inhibited acetylcholinesterase and to reduce cyclosarin-induced acute toxic effects was evaluated in this study. In vivo determined percentage of reactivation of cyclosarin-inhibited blood and tissue ac...

journal_title：Toxicology mechanisms and methods

authors： Kassa J,Karasova JZ,Musilek K,Kuca K

更新日期：2009-06-01 00:00:00

abstract：:This article described an improved brine shrimp larvae lethality microwell test method. A simply designed connecting vessel with alternative photoperiod was used to culture and collect high yield of active Artemia parthenogenetica nauplii for brine shrimp larvae lethality microwell test. Using this method, pure A. par...

journal_title：Toxicology mechanisms and methods

authors： Zhang Y,Mu J,Han J,Gu X

更新日期：2012-01-01 00:00:00

abstract：:Chlorpyrifos (CPF) is one of the organophosphorus pesticides widely used around the world, especially in China. Acetylcholinesterase inhibition is the main effect of organophosphorus insecticides exposure. Studies showed that CPF may also interfere with the metabolism of monoamine transmitters. To investigate the effe...

journal_title：Toxicology mechanisms and methods

authors： Xu F,Chang X,Lou D,Wu Q,Zhou Z

更新日期：2012-05-01 00:00:00

abstract：CONTEXT:Over expression of renin-angiotensin system (RAS) and nuclear factor-kappaB (NF-κB) has a major role in many cancers. It has been suggested that some angiotensin receptor blockers (ARBs) could reduce the proliferation of cancer cells. The role of NF-κB pathway has been documented in cell proliferation. OBJECTI...

journal_title：Toxicology mechanisms and methods

authors： Bakhtiari E,Hosseini A,Boroushaki MT,Mousavi SH

更新日期：2015-01-01 00:00:00

abstract：:ABSTRACT Although copper is an essential metal and cadmium is an environmental pollutant, both are toxic when present in excess. Metallothionein and glutathione are two of the key components that participate in detoxification of copper and cadmium. In the present study the role of glutathione in resistance to copper a...

journal_title：Toxicology mechanisms and methods

authors： Bi WX,Kong F,Hu XY,Cui X

更新日期：2007-01-01 00:00:00

abstract：:ABSTRACT Dermal exposure to JP-8 petroleum jet fuel leads to toxicological responses in humans and rodents. Serum profiling is a molecular analysis of changes in the levels of serum proteins and other molecules in response to changes in physiology. This present study utilizes serum profiling approaches to examine biom...

journal_title：Toxicology mechanisms and methods

authors： Larabee JL,Hocker JR,Cheung JY,Gallucci RM,Hanas JS

更新日期：2008-01-01 00:00:00

abstract：:Methylthiophanate is one of the widely used fungicides to control important fungal diseases of crops. The aim of this study was to elucidate the short-term hematoxicity and genotoxicity effects of methylthiophanate administered by intraperitoneal way at three doses (300, 500 and 700 mg/kg of body weight) after 24, 48 ...

journal_title：Toxicology mechanisms and methods

authors： Ben Amara I,Ben Saad H,Cherif B,Elwej A,Lassoued S,Kallel C,Zeghal N

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Gentamicin (GM) is used against bacterial infections. The aim of our investigation was to evaluate the role of inflammation and also oxidative damage in nephrotoxic potential of GM and protective effects of Nasturtium officinale (watercress) against GM-induced nephrotoxicity in Wistar rats. MATE...

journal_title：Toxicology mechanisms and methods

authors： Shahani S,Behzadfar F,Jahani D,Ghasemi M,Shaki F

更新日期：2017-02-01 00:00:00

abstract：:ABSTRACT Body packers are people who illegally carry drugs, mostly cocaine as well as opium and/or heroin, concealed within their bodies. The packets are inserted in the mouth, rectum, or vagina in order to get across borders without being detected. In this presentation we report a case of an opium body packer and rev...

journal_title：Toxicology mechanisms and methods

authors： Shadnia S,Faiaz-Noori MR,Pajoumand A,Talaie H,Khoshkar A,Vosough-Ghanbari S,Abdollahi M

更新日期：2007-01-01 00:00:00

abstract：:Methylglyoxal (MG) is a reactive dicarbonyl metabolite originated mainly from glucose degradation pathway that plays an important role in the pathogenesis of diabetes mellitus (DM). Reactions of MG with biological macromolecules (proteins, DNA and lipids) can induce cytotoxicity and apoptosis. Here, human erythrocytes...

journal_title：Toxicology mechanisms and methods

authors： Prestes AS,Dos Santos MM,Ecker A,Zanini D,Schetinger MR,Rosemberg DB,da Rocha JB,Barbosa NV

更新日期：2017-05-01 00:00:00

abstract：:This study applied broccoli and cauliflower extracts (whole, floret, and stem) to zebrafish larvae in parallel to receive 100 mJ/cm(2) of UVB six times, and recorded their fin malformation phenotypes. Chemopreventive effects of each group, including UVB, whole-, floret-, and stem-extracts of broccoli and cauliflower o...

journal_title：Toxicology mechanisms and methods

authors： Chen YH,Wen CC,Lin CY,Chou CY,Yang ZS,Wang YH

更新日期：2011-01-01 00:00:00

abstract：:Plethysmograph measurement of respiratory phenotypes provides a highly sensitive means to study nicotine response in experimental model animals. We measured average respiratory frequency, tidal volume, minute volume and inspiratory time in C3H/HeJ and C57BL/6J mice subcutaneously administered 0.35 and 0.70 mg/kg nicot...

journal_title：Toxicology mechanisms and methods

authors： Bloom AJ

更新日期：2019-09-01 00:00:00

abstract：:The present study was designed to investigate the effects of aqueous Azadirchta Indica leaf extract (AAILE) on serum glycoprotein contents and tumor incidence rate in colon of rats subjected to Dimethylhydrazine (DMH) treatment. Forty rats were divided equally and randomly into four groups viz., Group I (normal contro...

journal_title：Toxicology mechanisms and methods

authors： Ramzanighara A,Ezzatighadi F,Rai DV,Dhawan DK

更新日期：2009-05-01 00:00:00

abstract：:Crotonaldehyde is a hazardous pollutant present in cigarette smoke and automobile exhausts that is generated by lipid peroxidation, and harmful to reproductive organs. Although we are often exposed to low doses of crotonaldehyde daily, its adverse effects on the reproductive organs have not been fully elucidated. To e...

journal_title：Toxicology mechanisms and methods

authors： Zhang B,Wei P,Men J,Zhang S,Shao H,Zhang Z

更新日期：2020-01-01 00:00:00

abstract：:This study was to evaluate the protective effects of Danshensu on liver injury induced by omethoate in Sprague Dawley rats. The acute omethoate poisoning model was established by administrating subcutaneously with omethoate at a single dose of 60 mg/kg. Danshensu treatment markedly inhibited the increases of aspartate...

journal_title：Toxicology mechanisms and methods

authors： Ren R,Wang T,Jiang N,Liu T,Du Y,Li C,Zhang L,Fu F

更新日期：2010-10-01 00:00:00

abstract：:Monte Carlo based method by using either SMILES based or combination of SMILES and Graph-based descriptors is an important strategy to build the QSAR/QSTR model for prediction of different biological endpoints. In this study, Monte Carlo based QSTR approach was applied to the dataset of 90 nitroaromatic compounds rela...

journal_title：Toxicology mechanisms and methods

authors： Mondal D,Ghosh K,Baidya ATK,Gantait AM,Gayen S

更新日期：2020-05-01 00:00:00

abstract：:Renal disease is a common complication of diabetes mellitus. The pathogenesis of diabetic nephropathy is not well understood, but hyperglycemia seems to be a crucial factor. Recent evidence indicates that the overproduction of reactive oxygen species, observed in both clinical and experimental diabetes, and mitochondr...

journal_title：Toxicology mechanisms and methods

authors： Seiça R,Santos DL,Palmeira CM,Moreno AJ,Sena C,Cunha MF,Santos MS

更新日期：2005-01-01 00:00:00

abstract：:We investigated the prooxidant effects of bisphenol A (BPA) phenoxyl radicals in comparison with the phenoxyl radicals of 3-tert-butyl-4-hydroxyanisole (BHA), 2,6-di-tert-butyl-methylphenol (BHT) and 4-tert-butylphenol (TBP). The phenoxyl radicals, generated in situ by 1-electron oxidation of the corresponding phenol,...

journal_title：Toxicology mechanisms and methods

authors： Babu S,Uppu S,Claville MO,Uppu RM

更新日期：2013-05-01 00:00:00

abstract：:ABSTRACT When two toxicants overtly producing similar effects are given together, the effect of the combination may either be equal to the algebraic sum of their individual effects or may be more than or less than the algebraic sum of their individual effects. Therefore, to ascertain the nature of interaction precisel...

journal_title：Toxicology mechanisms and methods

authors： Bhat AS,Ahangar AA

更新日期：2007-01-01 00:00:00

abstract：:The present study was designed to determine whether the treatment with an ethanolic extract of pomegranate (EEP) (Punica granatum) can be useful for the treatment of the deleterious effect of lead acetate (LA) administration on sperm production in rats. The effects of EEP were compared with those of ascorbic acid (AA)...

journal_title：Toxicology mechanisms and methods

authors： Leiva KP,Rubio J,Peralta F,Gonzales GF

更新日期：2011-07-01 00:00:00

abstract：:To explore the toxic effect of T-2 toxin on mouse Leydig cells and its underlying molecular mechanisms, we isolated Leydig cells from mature mice, set-up Leydig cells culture, treated cells with T-2 toxin, evaluated cell proliferation, detected the caspase-3 activity, mitochondrial activity and apoptosis rate, and mea...

journal_title：Toxicology mechanisms and methods

authors： Zhang YF,Su PK,Wang LJ,Zheng HQ,Bai XF,Li P,Meng XP,Yang JY

更新日期：2018-01-01 00:00:00

abstract：:The objective of this study was to examine the toxicity of 1-(4-morpholinophenyl)-3-(4-fluorophenyl)-propenone (A) and 1-(4-morpholinophenyl)-3-(3-fluorophenyl)-propenone (B) on Spodoptera frugiperda (Sf9) cells and the mechanism of the toxicity. By cell-based thiazolyl blue tetrazolium bromide (MTT) assay, we found t...

journal_title：Toxicology mechanisms and methods

authors： Zhang X,Tao K,Hou T

更新日期：2012-05-01 00:00:00

abstract：:The specific properties of silver nanoparticles (AgNPs), such as antimicrobial activity and electrical conductivity, allow them to be used in many fields. However, their expanding application is also raising health, environmental and safety concerns. Previous in vivo AgNP toxicity studies have indicated a gender-diffe...

journal_title：Toxicology mechanisms and methods

authors： Dong MS,Choi JY,Sung JH,Kim JS,Song KS,Ryu HR,Lee JH,Bang IS,An K,Park HM,Song NW,Yu IJ

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Arsenic has been shown to cause various diseases (such as blackfoot disease, cardiovascular diseases, bladder cancer and skin cancer) in many areas of the world. However, the effects of arsenic on cardiac rhythm functions still lack investigation. METHODS:In this study, different concentrations of arsenic w...

journal_title：Toxicology mechanisms and methods

authors： Phan NN,Li KL,Lin YC

更新日期：2018-07-01 00:00:00