GC-MS metabolomics analysis of mesenchymal stem cells treated with copper oxide nanoparticles.

abstract：:The current study evaluated in vitro and in vivo toxicity of carboxyl or amine polyethylene glycol (PEG) surface functionalization of single-walled carbon nanotubes (SWCNTs). Assessments of cytotoxicity, genotoxicity, immunotoxicity, and oxidative stress were performed in vitro and in vivo (in a 1-month follow-up stud...

journal_title：Toxicology mechanisms and methods

authors： Shaik AS,Shaik AP,Bammidi VK,Al Faraj A

更新日期：2019-05-01 00:00:00

abstract：:Benzene (C6H6) is one of the most commonly used industrial chemicals causing environmental pollution. This study aimed to examine the effect of benzene and its metabolite hydroquinone on glucose regulating organs, liver and pancreas, and to reveal the involved toxic mechanisms, in rats. In the in vivo part, benzene wa...

journal_title：Toxicology mechanisms and methods

authors： Bahadar H,Maqbool F,Mostafalou S,Baeeri M,Gholami M,Ghafour-Boroujerdi E,Abdollahi M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate genotoxicity and mutagenicity in peripheral blood and buccal mucosal cells in mucopolysaccharidosis (MPS) I, II or VI patients. METHODS:A total of 12 patients with MPS type I, II and VI attended at the Institute of Genetics and Inborn Errors of Metabolism...

journal_title：Toxicology mechanisms and methods

authors： Guilheiro JM,Chaves MD,Martins AM,Ribeiro DA,D'Almeida V

更新日期：2014-12-01 00:00:00

abstract：AIM:Nicotine exerts a number of physiological effects. The purpose of this study was to determine the effects of nicotine on thioacetamide (TAA)-induced liver fibrosis in mice. MATERIALS AND METHODS:For in vivo experiments, hepatic fibrosis was induced by TAA (0.25 g/kg, i.p.) three times a week for 6 weeks. Mice of T...

journal_title：Toxicology mechanisms and methods

authors： Zhou Z,Park S,Kim JW,Zhao J,Lee MY,Choi KC,Lim CW,Kim B

更新日期：2017-09-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) activity is used widely as a biomarker for tumor promotion in animal model systems. Several previous studies have reported increases in ODC activity in tissues of rats exposed to 60 Hz magnetic fields. The goals of this study were to confirm these findings and to determine whether ODC act...

journal_title：Toxicology mechanisms and methods

authors： McDonald LJ,Loberg LI,McCormick DL,Gauger JR,Savage RE Jr,Zhu H,Lotz WG,Mandeville R,Owen RD,Cress LW,Desta AB

更新日期：2003-01-01 00:00:00

abstract：:Owing to their structure and function, low-density lipoproteins (LDLs) are particularly susceptible to the oxidative modifications. To prevent against oxidative modification of LDL, L-carnitine, with endogenous small water-soluble quaternary amine possessing antioxidative properties, was used. The aim of this paper wa...

journal_title：Toxicology mechanisms and methods

authors： Augustyniak A,Stankiewicz A,Skrzydlewska E

更新日期：2008-07-01 00:00:00

abstract：:ABSTRACT This paper presents the results from an evaluation of the noncommercial, (quantitative) structure-activity relationship ([Q]SAR) models for the prediction of mutagenicity and carcinogenicity, carried out in a collaboration between the European Chemicals Bureau Group on Computational Toxicology and the Italian...

journal_title：Toxicology mechanisms and methods

authors： Benigni R,Bossa C

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of different doses of an adenosine A(1) selective agonist, phenylisopropyl adenosine (PIA), on metamidophos-induced cholinergic symptoms, mortality, diaphragm muscle necrosis, and brain oxidative stress. A LD(50) dose of metamidophos (20 mg/kg body weight, p.o.) was fo...

journal_title：Toxicology mechanisms and methods

authors： Kalkan S,Ozdemir D,Ergur BU,Hazardin NU,Akgun A,Topcu A,Kaplan YC,Hocaoglu N,Oransay K,Tuncok Y

更新日期：2009-02-01 00:00:00

abstract：:This study applied broccoli and cauliflower extracts (whole, floret, and stem) to zebrafish larvae in parallel to receive 100 mJ/cm(2) of UVB six times, and recorded their fin malformation phenotypes. Chemopreventive effects of each group, including UVB, whole-, floret-, and stem-extracts of broccoli and cauliflower o...

journal_title：Toxicology mechanisms and methods

authors： Chen YH,Wen CC,Lin CY,Chou CY,Yang ZS,Wang YH

更新日期：2011-01-01 00:00:00

abstract：:Crotonaldehyde is a hazardous pollutant present in cigarette smoke and automobile exhausts that is generated by lipid peroxidation, and harmful to reproductive organs. Although we are often exposed to low doses of crotonaldehyde daily, its adverse effects on the reproductive organs have not been fully elucidated. To e...

journal_title：Toxicology mechanisms and methods

authors： Zhang B,Wei P,Men J,Zhang S,Shao H,Zhang Z

更新日期：2020-01-01 00:00:00

abstract：:Reported myocardial pathology resulting from increased levels of catecholamines in vivo has led us to investigate the effect of adrenalin on the gap junction proteins connexin 40 (Cx40) and Cx43 and the possible relationship to vascular toxicity. Adrenalin and its known metabolites, adrenochrome and adrenolutin, were ...

journal_title：Toxicology mechanisms and methods

authors： Moreau V,Novak MJ,Moore LK

更新日期：2006-01-01 00:00:00

abstract：:Abstract The effects of 4-hydroxytamoxifen (OHTAM) on the mitochondrial permeability transition (MPT) induced by Ca(2+) plus peroxynitrite (ONOO(-)) or phenylarsine oxide (PhAsO) were studied to clarify its mechanisms of MPT inhibition. Ca(2+) plus ONOO(-) induced mitochondrial swelling, membrane potential (Delta Psi)...

journal_title：Toxicology mechanisms and methods

authors： Cardoso CM,Almeida LM,Custódio JB

更新日期：2005-01-01 00:00:00

abstract：:Ethanol metabolism induces generation of excessive amount of reactive oxygen species (ROS) which results in immune dysfunction. We examined the efficacy of silymarin on ethanol-induced oxidative stress, immunomodulatory activity, and vascular function in mice blood. Effectiveness of silymarin was compared with potent ...

journal_title：Toxicology mechanisms and methods

authors： Das SK,Mukherjee S

更新日期：2012-06-01 00:00:00

abstract：:Multi-walled carbon nanotubes (MWCNTs) have industrial applications in the nanotechnology field. The physico-chemical properties of MWCNTs vary greatly depending on MWCNT manufacture and application. It has been pointed out that their needle shape and high durability are important factors that determine the biopersist...

journal_title：Toxicology mechanisms and methods

authors： Fujita K,Obara S,Maru J,Endoh S

更新日期：2020-09-01 00:00:00

abstract：:Preeclampsia is a multisystem disorder with profound implications on both mother and fetus. Analysis of umbilical cord blood red blood cell (RBC) changes shall depict the fetal response to pregnancy-specific complications like preeclampsia. This study aims to analyze the regulation relationship between HSP90α and heme...

journal_title：Toxicology mechanisms and methods

authors： Ekambaram P,Jayachandran T,Dhakshinamoorthy L

更新日期：2013-02-01 00:00:00

abstract：:The metabolism of aromatic hydrocarbons by the organism forms products that cause cell death depending on the type of exposure. Benzene exposure has been linked to oxidative stress, hepatic damage, aplastic anemia, and hematopoietic cancer as lymphoid and myeloid leukemia. However, there are not fast methods to evalua...

journal_title：Toxicology mechanisms and methods

authors： Martínez-Rodríguez JL,Gutiérrez-Hernández R,Reyes-Estrada CA,Granados-López AJ,Arcos-Ortega T,López JA

更新日期：2018-07-01 00:00:00

abstract：:Limited information is available regarding systemic changes in mammals associated with exposures to petroleum/hydrocarbon fuels. In this study, systemic toxicity of JP-8 jet fuel was observed in a rat inhalation model at different JP-8 fuel vapor concentrations (250, 500, or 1000 mg/m(3), for 91 days). Gel electrophor...

journal_title：Toxicology mechanisms and methods

authors： Hanas JS,Bruce Briggs G,Lerner MR,Lightfoot SA,Larabee JL,Karsies TJ,Epstein RB,Hanas RJ,Brackett DJ,Hocker JR

更新日期：2010-05-01 00:00:00

abstract：:Xysmalobium undulatum (Uzara) is one of the most widely used indigenous traditional herbal remedies in Southern Africa. Commercially available Uzara plant material was used to prepare a crude aqueous extract, of which the toxicity potential was investigated in the hepatic HepG2/C3A cell line in both traditional two-di...

journal_title：Toxicology mechanisms and methods

authors： Calitz C,Hamman JH,Viljoen AM,Fey SJ,Wrzesinski K,Gouws C

更新日期：2018-11-01 00:00:00

abstract：:A potency of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) to reactivate cyclosarin-inhibited acetylcholinesterase and to reduce cyclosarin-induced acute toxic effects was evaluated in this study. In vivo determined percentage of reactivation of cyclosarin-inhibited blood and tissue ac...

journal_title：Toxicology mechanisms and methods

authors： Kassa J,Karasova JZ,Musilek K,Kuca K

更新日期：2009-06-01 00:00:00

abstract：:This study was to evaluate the protective effects of Danshensu on liver injury induced by omethoate in Sprague Dawley rats. The acute omethoate poisoning model was established by administrating subcutaneously with omethoate at a single dose of 60 mg/kg. Danshensu treatment markedly inhibited the increases of aspartate...

journal_title：Toxicology mechanisms and methods

authors： Ren R,Wang T,Jiang N,Liu T,Du Y,Li C,Zhang L,Fu F

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Oxytocin (OT) injections have been indiscriminately used to milk cattle in dairy industries. There is no study available regarding surveillance of OT in market milk samples. MATERIAL AND METHODS:OT from milk samples was extracted by precipitation with trichloroacetic acid and passed through the solid phase ...

journal_title：Toxicology mechanisms and methods

authors： Mishra M,Ali S,Das M

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Gentamicin (GM) is used against bacterial infections. The aim of our investigation was to evaluate the role of inflammation and also oxidative damage in nephrotoxic potential of GM and protective effects of Nasturtium officinale (watercress) against GM-induced nephrotoxicity in Wistar rats. MATE...

journal_title：Toxicology mechanisms and methods

authors： Shahani S,Behzadfar F,Jahani D,Ghasemi M,Shaki F

更新日期：2017-02-01 00:00:00

abstract：:Crotonaldehyde is a ubiquitous hazardous pollutant, present in cigarette smoke and automobile exhaust and is endogenously generated by lipid peroxidation. Most of the current studies focus on its lung toxicity. However, there have been few investigations on the cardiac and renal toxicity caused by crotonaldehyde expos...

journal_title：Toxicology mechanisms and methods

authors： Zhang B,Li S,Men J,Peng C,Shao H,Zhang Z

更新日期：2019-05-01 00:00:00

abstract：:The aim of this work was to characterize inner mitochondrial membrane channels permeable to calcium cations (Ca(++)). Mitochondrial membranes isolated from rat heart were incorporated into the bilayer lipid membrane, and single Ca(++) channel currents were measured. The observed channels were selective for Ca(++) and ...

journal_title：Toxicology mechanisms and methods

authors： Komínková V,Novotová M,Ondrias K,Ravingerová T,Szewczyk A

更新日期：2004-01-01 00:00:00

abstract：:Prochloraz is a broad-spectrum contact imidazol fungicide used against several diseases in wheat, barley and oleaginous plants but also for treatment of flower production. Although prochloraz has endocrine disrupting and hepatocarcinogenic effects, there is lack of data on toxic effects of prochloraz. Therefore, we ai...

journal_title：Toxicology mechanisms and methods

authors： Alpertunga B,Kara M,Abudayyak M,Oztas E,Ozden S,Ozhan G

更新日期：2014-05-01 00:00:00

abstract：CONTEXT:Over expression of renin-angiotensin system (RAS) and nuclear factor-kappaB (NF-κB) has a major role in many cancers. It has been suggested that some angiotensin receptor blockers (ARBs) could reduce the proliferation of cancer cells. The role of NF-κB pathway has been documented in cell proliferation. OBJECTI...

journal_title：Toxicology mechanisms and methods

authors： Bakhtiari E,Hosseini A,Boroushaki MT,Mousavi SH

更新日期：2015-01-01 00:00:00

abstract：:Chronic hyperglycemia leads to the development of microvascular complications like diabetic nephropathy. The present study investigated the potential effects of the hydroalcoholic extract of Tribulus terrestris, a plant of Zygophyllaceae family, on the renal complications in streptozotocin (STZ)-induced diabetic rats....

journal_title：Toxicology mechanisms and methods

authors： Gandhi S,Srinivasan BP,Akarte AS

更新日期：2013-09-01 00:00:00

abstract：:ABSTRACT The present investigation was undertaken to examine the effects of chlorpyrifos (CP, an organophosphate) and deltamethrin (DM, a pyrethroid pesticide) treatments at low and high doses and their combination on lipid peroxidation and antioxidant enzyme activities such as SOD, GSH-Px, and CAT and also AChE activ...

journal_title：Toxicology mechanisms and methods

authors： Tüzmen MN,Candan N,Kaya E

更新日期：2007-01-01 00:00:00

abstract：:In the present investigation acetylcholinesterase (AChE) was estimated in erythrocytes from blood samples exposed to four commonly used organophosphorus pesticides in vitro. The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitor...

journal_title：Toxicology mechanisms and methods

authors： Das GP,Jamil K,Rahman MF

更新日期：2006-01-01 00:00:00

abstract：:The US military has placed major emphasis on developing therapeutics against nerve agents (NA). Current efforts are hindered by the lack of effective in vitro cellular models to aid in the preliminary screening of potential candidate drugs/antidotes. The development of an in vitro cellular model to aid in discovering ...

journal_title：Toxicology mechanisms and methods

authors： Kanjilal B,Keyser BM,Andres DK,Nealley E,Benton B,Melber AA,Andres JF,Letukas VA,Clark O,Ray R

更新日期：2014-10-01 00:00:00