Complex midfacial defects: Is the extended Abbé flap the ideal solution to a tough problem?

Abstract:

OBJECTIVES:The aim of this study was to investigate the role of the extended Abbé flap in the reconstruction of complex midfacial defects (upper lip, nasal base and medial cheek). We describe our personal experience with this method and present some interesting aspects from the relevant literature. MATERIALS AND METHODS:Between 2003 and 2017 we retrospectively evaluated the records of all patients with defects of the upper lip and nasal base after the resection of malignant tumors or traumata and reconstruction by means of the extended Abbé flap. We looked for information on the origin of the defect, the functional result, the aesthetic outcome and postoperative complications. The functional result of the reconstruction of the oral commissure was assessed with regard to postoperative subjective speech integrity, preservation of competence of the oral sphincter and lip sensation. The aesthetic outcome was evaluated with regard to limitations in facial expression and scar formation. RESULTS:The study included 8 patients. Follow-up in the oncological cases was 85 months (range: 20-150 months). No tumor recurrences were detected. All patients achieved normal oral competence and mouth opening. No cases of blunting or microstomia were detected. CONCLUSION:Reconstruction of the upper lip and nasal base with the extended Abbé flap is associated with an outstanding functional outcome that is cosmetically very acceptable.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

Mantsopoulos K,Iro H,Constantinidis J

doi

10.1016/j.oraloncology.2019.104470

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

104470

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(19)30381-1

journal_volume

100

pub_type

信件,多中心研究
  • Real-time PCR HPV genotyping in fine needle aspirations of metastatic head and neck squamous cell carcinoma: Exposing the limitations of conventional p16 immunostaining.

    abstract:BACKGROUND:Given the propensity for HPV-positive head and neck squamous cell carcinoma (HPV-HNSCC) to metastasize to cervical lymph nodes, fine needle aspiration (FNA) plays an important diagnostic role in their initial detection. Indeed, there is now an unwavering commitment to HPV testing of FNAs even in the absence ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2019.02.006

    authors: El-Salem F,Mansour M,Gitman M,Miles BA,Posner MR,Bakst RL,Genden EM,Westra WH

    更新日期:2019-03-01 00:00:00

  • Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay.

    abstract:OBJECTIVE:A standardized assay to determine the HPV status of head and neck squamous cell carcinoma (HNSCC) specimens has not yet been established, particularly for cytologic samples. The goal of this study was to determine whether the hybrid capture-2 (HC-2) assay, already widely used for the detection of high risk HP...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2014.02.011

    authors: Smith DF,Maleki Z,Coughlan D,Gooi Z,Akpeng B,Ogawa T,Bishop JA,Frick KD,Agrawal N,Gourin CG,Ha PK,Koch WM,Richmon JD,Westra WH,Pai SI

    更新日期:2014-06-01 00:00:00

  • Screening for distant metastases in patients with head and neck cancer: is there a role for (18)FDG-PET?

    abstract::The detection of distant metastases and second primary tumours at the time of initial evaluation changes the prognosis and influences the selection of treatment modality in patients with HNSCC. Until recently chest CT was the single most effective test to screen for distant metastases in HNSCC patients. In this observ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2005.07.009

    authors: Brouwer J,Senft A,de Bree R,Comans EF,Golding RP,Castelijns JA,Hoekstra OS,Leemans CR

    更新日期:2006-03-01 00:00:00

  • A predictive survival model for patients with head and neck squamous cell carcinoma treated with immune check point inhibitors.

    abstract:BACKGROUND:ICIs have expanded treatment options for HNSCC. A minority of the patients respond to these expensive treatments. PATIENTS AND METHODS:This is a single institutional retrospective review on 121 unresectable or metastatic HNSCC patients treated with ICIs. We predicted that inflammatory markers available thro...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2020.104900

    authors: Bonomi M,Bhateja P,Issa M,Klamer B,Pan X,Blakaj A,Karivedu V,Mousa L,Mitchell D,Gamez M,Kang S,Seim NB,Old M,Carrau R,Rocco J,Blakaj D

    更新日期:2020-11-01 00:00:00

  • Scintigraphic evaluation of mandibular bone turnover in patients with solid tumors receiving zoledronic acid.

    abstract::Bisphosphonates (BP) have been associated with the occurrence of osteonecrosis of the jaw (ONJ), possibly by causing an excessive bone turnover inhibition. However, little in vivo evidence exists to support this theory. The (99m)Tc-medronate scintigrams of patients with skeletal metastases and BP use (n=40) were indiv...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2010.01.001

    authors: Van den Wyngaert T,Huizing MT,Fossion E,Vermorken JB

    更新日期:2010-03-01 00:00:00

  • The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 patients.

    abstract::Recently, we reported the preliminary results of a prospective study on the possible premalignant character of oral lichen planus (OLP) and oral lichenoid lesions (OLL). Based on these data it was concluded that there was some but no convincing support for the hypothesis that patients with OLL have an increased risk o...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2006.09.006

    authors: van der Meij EH,Mast H,van der Waal I

    更新日期:2007-09-01 00:00:00

  • Semaphorins in vascular development and head and neck squamous cell carcinoma-induced angiogenesis.

    abstract::The semaphorins belong to a family of proteins originally shown to be important in axon migration and proper central nervous system development. Recent evidence has demonstrated that semaphorins and their receptors are expressed in tissues outside of the nervous system and represent a widespread signaling system that ...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2007.10.005

    authors: Sun Q,Nawabi-Ghasimi F,Basile JR

    更新日期:2008-06-01 00:00:00

  • The eating experience after treatment for head and neck cancer: A review of the literature.

    abstract:PURPOSE:Research has identified significant challenges that patients experience following treatment for head and neck cancer (HNC). These include the physical and emotional impacts of the diagnosis and treatment, which compound weight loss and negatively impact eating ability. There is limited research about the lived ...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2015.04.014

    authors: Ganzer H,Touger-Decker R,Byham-Gray L,Murphy BA,Epstein JB

    更新日期:2015-07-01 00:00:00

  • Gene expression profiling by DNA microarrays and its application to dental research.

    abstract:UNLABELLED:DNA microarray technology has been used for genome-wide gene expression studies that incorporate molecular genetics and computer science skills on massive levels. The technology permits the simultaneous analysis of tens of thousands of genes for the purposes of gene discovery, disease diagnosis. improved dru...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/s1368-8375(02)00013-1

    authors: Kuo WP,Whipple ME,Sonis ST,Ohno-Machado L,Jenssen TK

    更新日期:2002-10-01 00:00:00

  • Serum C-reactive protein as a prognostic indicator in patients with oral squamous cell carcinoma.

    abstract::Preoperative elevation of serum C-reactive protein (CRP) has been demonstrated as a prognostic indicator in oesophageal, gastric and colorectal cancer. This study was designed to establish if elevated preoperative levels of serum CRP could predict the prognosis of patients treated with primary surgery for oral squamou...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2009.03.015

    authors: Khandavilli SD,Ceallaigh PO,Lloyd CJ,Whitaker R

    更新日期:2009-10-01 00:00:00

  • Shallow whole genome sequencing of adenoid cystic carcinomas of the salivary glands identifies specific chromosomal aberrations related to tumor progression.

    abstract:BACKGROUND AND PURPOSE:Adenoid cystic carcinomas (ACC) are characterized by high rate of local recurrence and late distant metastasis. Chromosomal changes in the evolution from primary tumors to metastatic disease of ACC have not been appointed. Here we investigated the chromosomal alterations of 53 primary tumors from...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2020.104615

    authors: Cordesmeyer R,Laskawi R,Schliephake H,Kauffmann P,Beck J,Bornemann-Kolatzki K,Schütz E,Ströbel P,Kueffer S,Fichtner A,Bremmer F

    更新日期:2020-04-01 00:00:00

  • Vascular priming enhances chemotherapeutic efficacy against head and neck cancer.

    abstract:PURPOSE:The need to improve chemotherapeutic efficacy against head and neck squamous cell carcinomas (HNSCC) is well recognized. In this study, we investigated the potential of targeting the established tumor vasculature in combination with chemotherapy in head and neck cancer. METHODS:Experimental studies were carrie...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2013.06.011

    authors: Folaron M,Kalmuk J,Lockwood J,Frangou C,Vokes J,Turowski SG,Merzianu M,Rigual NR,Sullivan-Nasca M,Kuriakose MA,Hicks WL Jr,Singh AK,Seshadri M

    更新日期:2013-09-01 00:00:00

  • Sentinel lymph node biopsy in adenocarcinoma of minor salivary gland.

    abstract::Adenocarcinoma of the minor salivary gland (MSG) is a rare neoplasm. It represents about 2% of all MSG malignant tumours. It is more common in the palate and in females. This tumour occurs in a mean age of sixty and its mean size at presentation is 1.5cm. Microscopically, the neoplasms classified as adenocarcinoma not...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2006.12.015

    authors: Moreno M,Moreno A,Tomé C

    更新日期:2008-03-01 00:00:00

  • Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients.

    abstract::Salivary gland carcinomas are a rare and clinically diverse group of neoplasms among which mucoepidermoid carcinomas (MEC) are reported to be the most frequently encountered. During the years 1994-2004 18 patients with MEC were treated in our Department. All patients underwent surgery with a curative intent, and in 11...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2006.03.001

    authors: Rapidis AD,Givalos N,Gakiopoulou H,Stavrianos SD,Faratzis G,Lagogiannis GA,Katsilieris I,Patsouris E

    更新日期:2007-02-01 00:00:00

  • Metabolic tumor volume of metastatic lymph nodes and survival after total laryngectomy in laryngeal and hypopharyngeal cancer.

    abstract:OBJECTIVES:The prognostic value of metabolic tumor volume (MTV) in locally advanced laryngeal or hypopharyngeal cancer is established in the setting of chemoradiotherapy, while it remains unknown in the setting of upfront total laryngectomy. MATERIALS AND METHODS:We retrospectively analyzed 88 patients receiving total...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2019.04.011

    authors: Fujii T,Miyabe J,Yoshii T,Suzuki M,Otozai S,Komukai S,Kishikawa T,Takemoto N,Fukusumi T,Tatsumi M,Hatazawa J,Inohara H

    更新日期:2019-06-01 00:00:00

  • Mel-CAM (CD146) expression in parotid mucoepidermoid carcinoma.

    abstract::Mel-CAM (CD146) is a cell-cell adhesion protein found in normal and tumoral tissues. The aim of this study was to analyse Mel-CAM expression in mucoepidermoid carcinoma (MEC), and assess its importance in prognosis and its utility in differentiating high-grade MEC from squamous cell carcinoma (SCC). Immunohistochemica...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(02)00115-x

    authors: Pires FR,Shih IeM,da Cruz Perez DE,de Almeida OP,Kowalski LP

    更新日期:2003-04-01 00:00:00

  • Cytokeratin expression in precancerous lesions of the human oral cavity.

    abstract::Cytokeratin (CK) expression was studied in buccal mucosa (BM) from 20 leucoplakia and 7 submucous fibrosis patients using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting and two-dimensional gel electrophoresis with iso-electric focussing (IEF) as the first dimension. Normal BM exp...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:

    authors: Vaidya MM,Sawant SS,Borges AM,Ogale SB,Bhisey AN

    更新日期:1998-07-01 00:00:00

  • Association of T-cell regulatory gene polymorphisms with oral squamous cell carcinoma.

    abstract::Costimulatory molecules have complementary effects on T-cell activation and their balance may control the development of oral cancer. The aim of this study was to determine the relevance of cytotoxic T-lymphocyte antigen 4 (CTLA-4), CD28 and inducible costimulator (ICOS) polymorphisms in oral squamous cell carcinoma (...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2010.03.025

    authors: Kämmerer PW,Toyoshima T,Schöder F,Kämmerer P,Kuhr K,Brieger J,Al-Nawas B

    更新日期:2010-07-01 00:00:00

  • Mouth self-examination to improve oral cancer awareness and early detection in a high-risk population.

    abstract::Oral cancer is a potentially preventable disease due to its association with well-known risk factors and easy detectability. There is a significant deficiency in the awareness of oral cancer and its risk factors among the public. Raising public awareness could effectively contribute to achieving a significant reductio...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.oraloncology.2011.05.001

    authors: Elango KJ,Anandkrishnan N,Suresh A,Iyer SK,Ramaiyer SK,Kuriakose MA

    更新日期:2011-07-01 00:00:00

  • A prospective randomized controlled trial on the value of prophylactic oral nutritional supplementation in locally advanced nasopharyngeal carcinoma patients receiving chemo-radiotherapy.

    abstract:OBJECTIVES:We investigated the effect of prophylactic oral nutrition supplements (ONS) in locally advanced nasopharyngeal carcinoma patients receiving neoadjuvant chemotherapy and concurrent chemoradiotherapy (CCRT). METHODS:Eligible patients were randomly assigned to an intervention or control group. Patients in the ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2020.105025

    authors: Huang S,Piao Y,Cao C,Chen J,Sheng W,Shu Z,Hua Y,Jiang F,Hu Q,Chen X,Chen Y

    更新日期:2020-12-01 00:00:00

  • Maté consumption association with upper aerodigestive tract cancers: A systematic review and meta-analysis.

    abstract::Maté is a beverage regularly consumed by Latin American populations. Upper aerodigestive tract (UADT) cancers are frequent in this region and are suspected to be associated with maté consumption. The aim of this systematic review and meta-analysis was to answer a focused question: "Is there an association between maté...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.oraloncology.2018.04.023

    authors: Mello FW,Scotti FM,Melo G,Warnakulasuriya S,Guerra ENS,Rivero ERC

    更新日期:2018-07-01 00:00:00

  • Nanomedicine, an emerging therapeutic strategy for oral cancer therapy.

    abstract::Oral cavity and oropharyngeal carcinomas (oral cancer) represents a significant cause of morbidity and mortality. Despite efforts in improving early diagnosis and treatment, the 5-year survival rate of advanced stage of the disease is less than 63%. The field of nanomedicine has offered promising diagnostic and therap...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2017.11.014

    authors: Marcazzan S,Varoni EM,Blanco E,Lodi G,Ferrari M

    更新日期:2018-01-01 00:00:00

  • Re-irradiation for recurrent and second primary cancers of the head and neck.

    abstract:PURPOSE:To evaluate a single-institutional experience with the use of re-irradiation for recurrent and new primary cancers of the head and neck. METHODS:The medical charts of 80 consecutive patients who underwent re-irradiation for local-regionally recurrent or second primary head and neck cancer between November 1998...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2017.01.007

    authors: Velez MA,Veruttipong D,Wang PC,Chin R,Beron P,Abemayor E,St John M,Chen AM

    更新日期:2017-04-01 00:00:00

  • Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells.

    abstract::Apicidin acts as a potent histone deacetylases (HDAC) inhibitor and the precise mechanism for its anti-tumor activity in human oral squamous cell carcinoma (OSCC) cells has not been examined. The aim of this study was to evaluate the anti-tumor efficacy of apicidin through apoptosis and autophagy in OSCC cells. Cells ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2011.07.027

    authors: Ahn MY,Ahn SG,Yoon JH

    更新日期:2011-11-01 00:00:00

  • Hypoxia modulates CCR7 expression in head and neck cancers.

    abstract:BACKGROUND:The chemokine receptor CCR7 is expressed on lymphocytes and dendritic cells and is responsible for trafficking of these cells in and out of secondary lymphoid organs. It has recently been shown that CCR7 expression is elevated in a number of cancers, including head and neck cancers, and that its expression c...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2018.03.014

    authors: Basheer HA,Pakanavicius E,Cooper PA,Shnyder SD,Martin L,Hunter KD,Vinader V,Afarinkia K

    更新日期:2018-05-01 00:00:00

  • The impact of an educational video about radiotherapy and its toxicities in head and neck cancer patients. Evaluation of patients' understanding, anxiety, depression, and quality of life.

    abstract:OBJECTIVES:Head and neck radiotherapy can cause several toxicities, and its management has important treatment implications. Proper information about treatment is crucial to assist patients by preparing them and enhancing their ability to manage their illness. Thus, this study aimed to verify the impact of an education...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2020.104712

    authors: Fernandes DT,Prado-Ribeiro AC,Markman RL,Morais K,Moutinho K,Tonaki JO,Brandão TB,Rivera C,Santos-Silva AR,Lopes MA

    更新日期:2020-07-01 00:00:00

  • Gender disparities in head and neck cancer chemotherapy clinical trials participation and treatment.

    abstract:OBJECTIVES:To characterize the representation of women in clinical trials directing the National Comprehensive Cancer Network (NCCN) guidelines for chemotherapy use in head and neck squamous cell carcinoma (HNSCC), as well as the relationship between gender and chemotherapy administration in the definitive treatment of...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2019.05.009

    authors: Benchetrit L,Torabi SJ,Tate JP,Mehra S,Osborn HA,Young MR,Burtness B,Judson BL

    更新日期:2019-07-01 00:00:00

  • Management of locally advanced oral cancers.

    abstract::Despite easy access to clinical examination majority of oral cancer patients ironically present with locally advanced disease, which is a heterogeneous group that includes all stage III/IV tumours in absence of distant metastasis. The AJCC TNM classification has included all tumours with depth of invasion >1 cm into l...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2020.104662

    authors: Dhar H,Vaish R,D'Cruz AK

    更新日期:2020-06-01 00:00:00

  • Mucositis: The impact, biology and therapeutic opportunities of oral mucositis.

    abstract::The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinici...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2009.08.006

    authors: Sonis ST

    更新日期:2009-12-01 00:00:00

  • The roles of microRNAs in the stemness of oral cancer cells.

    abstract::Oral cancer (OC), which is the most common form of head and neck cancers, has one of the lowest (~50%) overall 5-year survival rates. The main reasons for this high mortality rate are diagnosis of OC in advanced stages in most patients and spread to distant organs via lymph node metastasis. Many studies have shown tha...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2020.104950

    authors: Barlak N,Capik O,Sanli F,Karatas OF

    更新日期:2020-08-19 00:00:00