Abstract:
OBJECTIVES:The aim of this study was to investigate the role of the extended Abbé flap in the reconstruction of complex midfacial defects (upper lip, nasal base and medial cheek). We describe our personal experience with this method and present some interesting aspects from the relevant literature. MATERIALS AND METHODS:Between 2003 and 2017 we retrospectively evaluated the records of all patients with defects of the upper lip and nasal base after the resection of malignant tumors or traumata and reconstruction by means of the extended Abbé flap. We looked for information on the origin of the defect, the functional result, the aesthetic outcome and postoperative complications. The functional result of the reconstruction of the oral commissure was assessed with regard to postoperative subjective speech integrity, preservation of competence of the oral sphincter and lip sensation. The aesthetic outcome was evaluated with regard to limitations in facial expression and scar formation. RESULTS:The study included 8 patients. Follow-up in the oncological cases was 85 months (range: 20-150 months). No tumor recurrences were detected. All patients achieved normal oral competence and mouth opening. No cases of blunting or microstomia were detected. CONCLUSION:Reconstruction of the upper lip and nasal base with the extended Abbé flap is associated with an outstanding functional outcome that is cosmetically very acceptable.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Mantsopoulos K,Iro H,Constantinidis Jdoi
10.1016/j.oraloncology.2019.104470subject
Has Abstractpub_date
2020-01-01 00:00:00pages
104470eissn
1368-8375issn
1879-0593pii
S1368-8375(19)30381-1journal_volume
100pub_type
信件,多中心研究相关文献
ORAL ONCOLOGY文献大全abstract:BACKGROUND:Given the propensity for HPV-positive head and neck squamous cell carcinoma (HPV-HNSCC) to metastasize to cervical lymph nodes, fine needle aspiration (FNA) plays an important diagnostic role in their initial detection. Indeed, there is now an unwavering commitment to HPV testing of FNAs even in the absence ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2019.02.006
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:A standardized assay to determine the HPV status of head and neck squamous cell carcinoma (HNSCC) specimens has not yet been established, particularly for cytologic samples. The goal of this study was to determine whether the hybrid capture-2 (HC-2) assay, already widely used for the detection of high risk HP...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2014.02.011
更新日期:2014-06-01 00:00:00
abstract::The detection of distant metastases and second primary tumours at the time of initial evaluation changes the prognosis and influences the selection of treatment modality in patients with HNSCC. Until recently chest CT was the single most effective test to screen for distant metastases in HNSCC patients. In this observ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2005.07.009
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:ICIs have expanded treatment options for HNSCC. A minority of the patients respond to these expensive treatments. PATIENTS AND METHODS:This is a single institutional retrospective review on 121 unresectable or metastatic HNSCC patients treated with ICIs. We predicted that inflammatory markers available thro...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.104900
更新日期:2020-11-01 00:00:00
abstract::Bisphosphonates (BP) have been associated with the occurrence of osteonecrosis of the jaw (ONJ), possibly by causing an excessive bone turnover inhibition. However, little in vivo evidence exists to support this theory. The (99m)Tc-medronate scintigrams of patients with skeletal metastases and BP use (n=40) were indiv...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2010.01.001
更新日期:2010-03-01 00:00:00
abstract::Recently, we reported the preliminary results of a prospective study on the possible premalignant character of oral lichen planus (OLP) and oral lichenoid lesions (OLL). Based on these data it was concluded that there was some but no convincing support for the hypothesis that patients with OLL have an increased risk o...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2006.09.006
更新日期:2007-09-01 00:00:00
abstract::The semaphorins belong to a family of proteins originally shown to be important in axon migration and proper central nervous system development. Recent evidence has demonstrated that semaphorins and their receptors are expressed in tissues outside of the nervous system and represent a widespread signaling system that ...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2007.10.005
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:Research has identified significant challenges that patients experience following treatment for head and neck cancer (HNC). These include the physical and emotional impacts of the diagnosis and treatment, which compound weight loss and negatively impact eating ability. There is limited research about the lived ...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2015.04.014
更新日期:2015-07-01 00:00:00
abstract:UNLABELLED:DNA microarray technology has been used for genome-wide gene expression studies that incorporate molecular genetics and computer science skills on massive levels. The technology permits the simultaneous analysis of tens of thousands of genes for the purposes of gene discovery, disease diagnosis. improved dru...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/s1368-8375(02)00013-1
更新日期:2002-10-01 00:00:00
abstract::Preoperative elevation of serum C-reactive protein (CRP) has been demonstrated as a prognostic indicator in oesophageal, gastric and colorectal cancer. This study was designed to establish if elevated preoperative levels of serum CRP could predict the prognosis of patients treated with primary surgery for oral squamou...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2009.03.015
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Adenoid cystic carcinomas (ACC) are characterized by high rate of local recurrence and late distant metastasis. Chromosomal changes in the evolution from primary tumors to metastatic disease of ACC have not been appointed. Here we investigated the chromosomal alterations of 53 primary tumors from...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.104615
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:The need to improve chemotherapeutic efficacy against head and neck squamous cell carcinomas (HNSCC) is well recognized. In this study, we investigated the potential of targeting the established tumor vasculature in combination with chemotherapy in head and neck cancer. METHODS:Experimental studies were carrie...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2013.06.011
更新日期:2013-09-01 00:00:00
abstract::Adenocarcinoma of the minor salivary gland (MSG) is a rare neoplasm. It represents about 2% of all MSG malignant tumours. It is more common in the palate and in females. This tumour occurs in a mean age of sixty and its mean size at presentation is 1.5cm. Microscopically, the neoplasms classified as adenocarcinoma not...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2006.12.015
更新日期:2008-03-01 00:00:00
abstract::Salivary gland carcinomas are a rare and clinically diverse group of neoplasms among which mucoepidermoid carcinomas (MEC) are reported to be the most frequently encountered. During the years 1994-2004 18 patients with MEC were treated in our Department. All patients underwent surgery with a curative intent, and in 11...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2006.03.001
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVES:The prognostic value of metabolic tumor volume (MTV) in locally advanced laryngeal or hypopharyngeal cancer is established in the setting of chemoradiotherapy, while it remains unknown in the setting of upfront total laryngectomy. MATERIALS AND METHODS:We retrospectively analyzed 88 patients receiving total...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2019.04.011
更新日期:2019-06-01 00:00:00
abstract::Mel-CAM (CD146) is a cell-cell adhesion protein found in normal and tumoral tissues. The aim of this study was to analyse Mel-CAM expression in mucoepidermoid carcinoma (MEC), and assess its importance in prognosis and its utility in differentiating high-grade MEC from squamous cell carcinoma (SCC). Immunohistochemica...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(02)00115-x
更新日期:2003-04-01 00:00:00
abstract::Cytokeratin (CK) expression was studied in buccal mucosa (BM) from 20 leucoplakia and 7 submucous fibrosis patients using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting and two-dimensional gel electrophoresis with iso-electric focussing (IEF) as the first dimension. Normal BM exp...
journal_title:Oral oncology
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract::Costimulatory molecules have complementary effects on T-cell activation and their balance may control the development of oral cancer. The aim of this study was to determine the relevance of cytotoxic T-lymphocyte antigen 4 (CTLA-4), CD28 and inducible costimulator (ICOS) polymorphisms in oral squamous cell carcinoma (...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2010.03.025
更新日期:2010-07-01 00:00:00
abstract::Oral cancer is a potentially preventable disease due to its association with well-known risk factors and easy detectability. There is a significant deficiency in the awareness of oral cancer and its risk factors among the public. Raising public awareness could effectively contribute to achieving a significant reductio...
journal_title:Oral oncology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.oraloncology.2011.05.001
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES:We investigated the effect of prophylactic oral nutrition supplements (ONS) in locally advanced nasopharyngeal carcinoma patients receiving neoadjuvant chemotherapy and concurrent chemoradiotherapy (CCRT). METHODS:Eligible patients were randomly assigned to an intervention or control group. Patients in the ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.105025
更新日期:2020-12-01 00:00:00
abstract::Maté is a beverage regularly consumed by Latin American populations. Upper aerodigestive tract (UADT) cancers are frequent in this region and are suspected to be associated with maté consumption. The aim of this systematic review and meta-analysis was to answer a focused question: "Is there an association between maté...
journal_title:Oral oncology
pub_type: 杂志文章,meta分析
doi:10.1016/j.oraloncology.2018.04.023
更新日期:2018-07-01 00:00:00
abstract::Oral cavity and oropharyngeal carcinomas (oral cancer) represents a significant cause of morbidity and mortality. Despite efforts in improving early diagnosis and treatment, the 5-year survival rate of advanced stage of the disease is less than 63%. The field of nanomedicine has offered promising diagnostic and therap...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2017.11.014
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To evaluate a single-institutional experience with the use of re-irradiation for recurrent and new primary cancers of the head and neck. METHODS:The medical charts of 80 consecutive patients who underwent re-irradiation for local-regionally recurrent or second primary head and neck cancer between November 1998...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2017.01.007
更新日期:2017-04-01 00:00:00
abstract::Apicidin acts as a potent histone deacetylases (HDAC) inhibitor and the precise mechanism for its anti-tumor activity in human oral squamous cell carcinoma (OSCC) cells has not been examined. The aim of this study was to evaluate the anti-tumor efficacy of apicidin through apoptosis and autophagy in OSCC cells. Cells ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2011.07.027
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:The chemokine receptor CCR7 is expressed on lymphocytes and dendritic cells and is responsible for trafficking of these cells in and out of secondary lymphoid organs. It has recently been shown that CCR7 expression is elevated in a number of cancers, including head and neck cancers, and that its expression c...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2018.03.014
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Head and neck radiotherapy can cause several toxicities, and its management has important treatment implications. Proper information about treatment is crucial to assist patients by preparing them and enhancing their ability to manage their illness. Thus, this study aimed to verify the impact of an education...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.104712
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:To characterize the representation of women in clinical trials directing the National Comprehensive Cancer Network (NCCN) guidelines for chemotherapy use in head and neck squamous cell carcinoma (HNSCC), as well as the relationship between gender and chemotherapy administration in the definitive treatment of...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2019.05.009
更新日期:2019-07-01 00:00:00
abstract::Despite easy access to clinical examination majority of oral cancer patients ironically present with locally advanced disease, which is a heterogeneous group that includes all stage III/IV tumours in absence of distant metastasis. The AJCC TNM classification has included all tumours with depth of invasion >1 cm into l...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.104662
更新日期:2020-06-01 00:00:00
abstract::The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinici...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2009.08.006
更新日期:2009-12-01 00:00:00
abstract::Oral cancer (OC), which is the most common form of head and neck cancers, has one of the lowest (~50%) overall 5-year survival rates. The main reasons for this high mortality rate are diagnosis of OC in advanced stages in most patients and spread to distant organs via lymph node metastasis. Many studies have shown tha...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2020.104950
更新日期:2020-08-19 00:00:00