Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system.

abstract：:Prostaglandin (PG) synthesis by human embryo lung fibroblasts in culture was determined with increasing population doubling. These cultures synthesized PGE2, PGF2 alpha, PGI2 (prostacyclin) and TXA2 (thromboxane A2) in response to fetal bovine serum or ascorbic acid. Changes in prostaglandin synthesis by these cells d...

journal_title：Mechanisms of ageing and development

authors： Polgar P,Taylor L

更新日期：1980-04-01 00:00:00

abstract：:Amyloidosis refers to a group of protein folding diseases. Various innocuous and soluble proteins in physiological conditions polymerize to insoluble amyloid fibrils in several serious diseases, including Alzheimer's disease (AD) and prion diseases. In addition, senile amyloidosis is a form of amyloidosis in which the...

journal_title：Mechanisms of ageing and development

authors： Xing Y,Higuchi K

更新日期：2002-11-01 00:00:00

abstract：:Hypertension is a common age-related disease, along with vascular and neurodegenerative diseases. Vascular ageing increases during hypertension, but hypertension itself accelerates vascular ageing, thus creating a vicious circle. Vascular stiffening, endothelial dysfunction, impaired contractility and vasorelaxation a...

journal_title：Mechanisms of ageing and development

authors： Forte M,Stanzione R,Cotugno M,Bianchi F,Marchitti S,Rubattu S

更新日期：2020-07-01 00:00:00

abstract：:We studied the pattern of lectins binding by liver lysosomal proteins from rats between 18 days of gestation and 72 weeks of age. An analysis of the carbohydrate structure was carried out after an electrophoresis and blotting, followed by a very sensitive detection system with highly specific digoxigenin-labelled lect...

journal_title：Mechanisms of ageing and development

authors： Lityńska A,Przybyło M

更新日期：1998-05-01 00:00:00

abstract：:Mortality trends in industrialized countries are characterized by declines in vascular disease (ischemic heart disease and stroke) and rises in cancers and degenerative diseases. These trends are typically analyzed by examining each disorder in isolation using the perspective of genetic and environmental influences. H...

journal_title：Mechanisms of ageing and development

authors： Riggs JE,Millecchia RJ

更新日期：1992-09-01 00:00:00

abstract：:Morphometric comparison of freeze-fractured mitochondria in flight muscles of adult (37-day-old) and old (68-day-old) houseflies revealed a 28% decrease of cristae in the old flies. The major membrane change with age was an increase in the 90-120-A particles in the inner membrane external face concomitant with a loss ...

journal_title：Mechanisms of ageing and development

authors： Turturro A,Shafiq SA

更新日期：1981-06-01 00:00:00

abstract：:The purpose of the present study was to investigate the effect of aging on silica-induced lung toxicity. In young animals silica induced a significant increase in bronchoalveolar lavage tumor necrosis factor-alpha (TNF), lactate dehydrogenase as well as in cell numbers, which correlate with increased collagen depositi...

journal_title：Mechanisms of ageing and development

authors： Corsini E,Giani A,Peano S,Marinovich M,Galli CL

更新日期：2004-02-01 00:00:00

abstract：:The growing proportion of older people, especially the very old, is often thought of in negative terms such as the need for more health care. But the implications are wider and affect the future of family care as well as issues of intergenerational relations, employment, living arrangements and attitudes. This paper l...

journal_title：Mechanisms of ageing and development

authors： Tinker A

更新日期：2002-04-01 00:00:00

abstract：:Food intake, body weight and serum LH, FSH, progesterone and oestradiol-17 beta were monitored from weaning to puberty in fully fed females housed in groups of four or individually and in females individually housed and dietary restricted. Restriction of food intake from weaning delayed the onset of puberty (34-39 day...

journal_title：Mechanisms of ageing and development

authors： Holehan AM,Merry BJ

更新日期：1985-11-01 00:00:00

abstract：:This paper is the second one in a series of two papers hypothesizing and testing systemic grounds of reproductive life history in the female fruit fly. In the first paper, we analyzed mechanisms of individual fecundity scheduling and have drawn the following conclusions. Individual fecundity in female flies is endowed...

journal_title：Mechanisms of ageing and development

authors： Novoseltsev VN,Carey RJ,Novoseltseva JA,Papadopoulos NT,Blay S,Yashin AI

更新日期：2004-01-01 00:00:00

abstract：:Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiest...

journal_title：Mechanisms of ageing and development

authors： Cesarini V,Guida E,Campolo F,Crescioli C,Di Baldassarre A,Pisano C,Balistreri CR,Ruvolo G,Jannini EA,Dolci S

更新日期：2020-09-01 00:00:00

abstract：:The occurrence of inactive enzyme molecules in a variety of tissues and animal species has been shown to be of a general nature. The levels of inactive enzyme molecules found in old animals were produced by amino acid analogs in young animals. These levels have been shown to be initially detrimental but subsequently t...

journal_title：Mechanisms of ageing and development

authors： Gershon D

更新日期：1979-02-01 00:00:00

abstract：:It strikes me that among our relatively small community of gerontologists concerned with genetic approaches to our science, there is somewhat of a dichotomization. On the one hand, there are those of us, like myself, who tend to be dour 'complificationists'. Journalists talk to us, but are usually disappointed by the ...

journal_title：Mechanisms of ageing and development

authors： Martin GM

更新日期：2002-01-01 00:00:00

abstract：:Neurons that degenerate in the brains of persons with Alzheimer's disease accumulate mitochondrial amyloid precursor protein (APP), which is thought to negatively affect mitochondrial function and cellular homeostasis. Because proteins that enter mitochondria require assistance from chaperone proteins, we hypothesized...

journal_title：Mechanisms of ageing and development

authors： Yang TT,Hsu CT,Kuo YM

更新日期：2009-09-01 00:00:00

abstract：:Gut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence. Here, we compared the gut micro...

journal_title：Mechanisms of ageing and development

authors： Tuikhar N,Keisam S,Labala RK,Imrat,Ramakrishnan P,Arunkumar MC,Ahmed G,Biagi E,Jeyaram K

更新日期：2019-04-01 00:00:00

abstract：:Hepatic growth and protein synthesis in vivo was studied with age in ad libitum-fed and dietary restricted rats in which the mean and maximum lifespan was significantly extended. Livers from underfed rats showed significantly lower DNA, RNA and protein contents, and total protein synthesis. The fractional rate of synt...

journal_title：Mechanisms of ageing and development

authors： Merry BJ,Holehan AM,Lewis SE,Goldspink DF

更新日期：1987-07-01 00:00:00

abstract：:Scavenger receptor B1 (SR-B1) is a trans-membrane protein, involved in tissue reverse cholesterol transport. Several studies have demonstrated that SR-B1 is also implicated in other physiological processes, such as bacteria and apoptotic cells recognition and regulation of intracellular tocopherol and carotenoids leve...

journal_title：Mechanisms of ageing and development

authors： Muresan XM,Sticozzi C,Belmonte G,Savelli V,Evelson P,Valacchi G

更新日期：2018-06-01 00:00:00

abstract：:We compared cardiovascular responses to various adrenergic agonists in conscious 3-month and 12-month old rats that had been treated with propranolol daily for 7 days, to determine whether changes in beta-adrenergic hypersensitivity induced by abrupt propranolol withdrawal would differ with age. Depressor and tachycar...

journal_title：Mechanisms of ageing and development

authors： Teräväinen TL,Buñag RD

更新日期：1992-03-15 00:00:00

abstract：:The localization of the beta/A4 amyloid precursor protein (APP) was studied in the human lumbar paravertebral sympathetic ganglia of subjects of different ages, free of neurologic disease, using combined immunohistochemistry and image analysis techniques (optic microdensitometry). To ascertain which cells displayed AP...

journal_title：Mechanisms of ageing and development

authors： Calzada B,Cabal A,Naves FJ,del Valle ME,Represa JJ,Vega JA

更新日期：1994-10-20 00:00:00

abstract：:Lipofuscin-specific autofluorescence of living, cultured rat neonatal myocardial myocytes was studied with respect to intensity and spectral characteristics. The autofluorescence emission spectrum changed over time indicating continuously ongoing intramolecular reorganisation of the pigment. Moreover, as compared with...

journal_title：Mechanisms of ageing and development

authors： Gao G,Johansson U,Rundquist I,Ollinger K

更新日期：1994-01-01 00:00:00

abstract：:We determined the number of fibroblastoid progenitors (fibroblastoid colony-forming units, CFU-F) in femurs and spleens derived from (CBA X C57BL)F1 mice of different ages. The femoral CFU-F population size increased from 350 at 1 week of age and plateaued at approximately 1900 CFU-F at 8 weeks of age. The mean incide...

journal_title：Mechanisms of ageing and development

authors： Brockbank KG,Ploemacher RE,van Peer CM

更新日期：1983-05-01 00:00:00

abstract：:The effect of the oral administration of 0.150 mg/m2 clonidine on the plasma level of human growth hormone (hGH) was studied in 53 adults (25 males and 28 females) aged from 28 to 68 years, of which 15 were healthy volunteers and 38 were hypertensive. Both the normal and hypertensive subjects of both sexes showed an a...

journal_title：Mechanisms of ageing and development

authors： Gil-Ad I,Gurewitz R,Marcovici O,Rosenfeld J,Laron Z

更新日期：1984-09-01 00:00:00

abstract：:A morphometric investigation has been carried out on the synaptic junctions in the cerebellar glomeruli of young-adult rats chronically deprived of vitamin E for 10 months and control animals of the same age. The following parameters were evaluated: the average length of the synapses (L), the numerical (NV) as well as...

journal_title：Mechanisms of ageing and development

authors： Bertoni-Freddari C,Giuli C,Pieri C

更新日期：1984-02-01 00:00:00

abstract：:The results of this study show that an isogeneic barrier to the successful adoptive immunotherapy of Mycobacterium tuberculosis infected mice is progressively lost as these animals age. This was shown in this study by the demonstration that increasing levels of transferred acquired specific resistance could be conferr...

journal_title：Mechanisms of ageing and development

authors： Orme IM

更新日期：1988-12-01 00:00:00

abstract：:We have developed a cell model for loss of differentiated gene expression in cellular aging. Over long periods in culture, bovine adrenocortical cells lose expression of a specialized gene, steroid 17 alpha-hydroxylase. The decline in expression of 17 alpha-hydroxylase in mass cultures and clones of bovine adrenocorti...

journal_title：Mechanisms of ageing and development

authors： Hornsby PJ,Yang LQ

更新日期：1991-04-01 00:00:00

abstract：:The serotonin content of platelets, serum and plasma from rats of various ages was examined. In male rats, platelet serotonin content, which was about 0.65 nmol/10(8) platelets at young age (6-7 months), increased slightly at middle age (12-14 months) but decreased markedly at old age (25-26 months). Significant diffe...

journal_title：Mechanisms of ageing and development

authors： Yonezawa Y,Kondo H,Nomaguchi TA

更新日期：1989-01-01 00:00:00

abstract：:Oxidative stress may contribute to the cellular alterations, which occur as the result of aging, and the nervous system is particularly vulnerable to aging associated oxidative injury. The multicatalytic proteasome (MCP) is responsible for the majority of protein degradation and is sensitive to oxidative stress. To de...

journal_title：Mechanisms of ageing and development

authors： Keller JN,Hanni KB,Markesbery WR

更新日期：2000-01-24 00:00:00

abstract：:The development and aging of the nucleolus and nucleus in layer V pyramidal cells in the hamster cerebrum were studied by light and electron microscopy. The nucleoli appeared in the newborn as occasional fibrillar masses adjacent to peripherally placed bodies of chromatin. By maturity, a single, generally central, nuc...

journal_title：Mechanisms of ageing and development

authors： Buschmann MB,LaVelle A

更新日期：1981-04-01 00:00:00

abstract：:Loss of telomere length homeostasis has been linked to age-related disease especially cancer. In this review, we discuss two major causes of telomere dysfunction that potentially lead to tumorigenesis: replicative aging and environmental assaults. Aging has long been recognized as a source for telomere dysfunction thr...

journal_title：Mechanisms of ageing and development

authors： Gilley D,Herbert BS,Huda N,Tanaka H,Reed T

更新日期：2008-01-01 00:00:00

abstract：:Alteration of T cell surface marker expression with a decrease of CD3 positive cells relative to the number of CD4 and CD8 positive cells, diminished in vitro proliferative response to mitogenic stimuli like PHA and antibodies to the CD3/Ti complex, and increase in serum IL-2 receptor levels, are among the changes in ...

journal_title：Mechanisms of ageing and development

authors： Hallgren HM,Bergh N,Rodysill KJ,O'Leary JJ

更新日期：1988-05-01 00:00:00