Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

abstract：:Lipid peroxidation, one of the most common expressions of oxidative stress, may be altered during normal physiological states including development. We have examined the changes in lipid peroxidation in rat brain, a tissue highly susceptible to oxidative damage, during this physiological state. In vivo lipid peroxidat...

journal_title：Mechanisms of ageing and development

authors： Pushpendran CK,Subramanian M,Devasagayam TP

更新日期：1994-03-01 00:00:00

abstract：:Extrachromosomal circular DNA complexes from peripheral blood lymphocytes from inbred mice of accelerated senescence, were detected by mica-press-adsorption method. In senescence-resistant series (SAM-R), polydisperse circular DNAs were observed at 7 weeks of age and a restricted size class of small circular forms of ...

journal_title：Mechanisms of ageing and development

authors： Yamagishi H,Kunisada T,Takeda T

更新日期：1985-01-01 00:00:00

abstract：:A morphometric investigation has been carried out on the synaptic junctions in the cerebellar glomeruli of young-adult rats chronically deprived of vitamin E for 10 months and control animals of the same age. The following parameters were evaluated: the average length of the synapses (L), the numerical (NV) as well as...

journal_title：Mechanisms of ageing and development

authors： Bertoni-Freddari C,Giuli C,Pieri C

更新日期：1984-02-01 00:00:00

abstract：:Whether lymphoid cells or their environment are responsible for the decreased tolerogen sensitivity of aged mice was examined using an adoptive transfer system. Bone marrow cells from old (24 months), middle aged (12 months) and young adult mice (2 months) were equally sensitive to tolerance induction with deaggregate...

journal_title：Mechanisms of ageing and development

authors： Habicht GS

更新日期：1985-04-01 00:00:00

abstract：:The kinetics of accumulation and loss of zinc from the liver following subcutaneous administration of 10 mg of zinc per kg were examined in young adult (6 months old) and old (24 months old) male C57BL/6J mice. After zinc treatment, total liver zinc concentrations rose equally in both groups and returned to basal leve...

journal_title：Mechanisms of ageing and development

authors： Thomas DJ,Winchurch RA,Adler WH

更新日期：1989-03-01 00:00:00

abstract：:Understanding mechanisms underlying longevity, and endeavor towards the specific goals of alleviating frailty in old age, require a comprehensive approach that considers the various theoretical and experimental approaches, as well as compiling the data on humans. This logistic has underlined the program of the confere...

journal_title：Mechanisms of ageing and development

authors： Globerson A,Barzilai N

更新日期：2005-02-01 00:00:00

abstract：:T cell activation involves events at the plasma membrane; therefore, molecules such as long chain omega-3 fatty acids that alter the structure of the plasma membrane may affect the activation of aged T cells. In this project we investigated whether the incorporation of omega-3 fatty acids (from fish oil), in the prese...

journal_title：Mechanisms of ageing and development

authors： VanMeter AR,Ehringer WD,Stillwell W,Blumenthal EJ,Jenski LJ

更新日期：1994-08-01 00:00:00

abstract：:It has been previously well documented that partial pressure of oxygen (PO2) and weight-specific rate of O2 consumption in chick embryo (Gallus gallus domesticus) transiently increase midway through the 21-day in ovo incubation period. The present study found that these oxidative changes were paralleled by the concent...

journal_title：Mechanisms of ageing and development

authors： Wilson JX,Lui EM,Del Maestro RF

更新日期：1992-08-01 00:00:00

abstract：:Susceptibility for Friend leukemia virus (FLV)-induced leukemogenesis was examined in the C3H/He (C3H)-->C57BL/6 (B6) radiation bone marrow chimeras of various age groups, and the effect of aging of host mice on the susceptibility was determined. The bone marrow chimera system provided the various age of FLV-resistant...

journal_title：Mechanisms of ageing and development

authors： Yamaguchi S,Kitagawa M,Inoue M,Tejima Y,Kimura M,Aizawa S,Utsuyama M,Hirokawa K

更新日期：2001-02-01 00:00:00

abstract：:This paper is part of a series aimed to investigate the mechanism of the action of Folcysteine, a substance that has the capacity to release in the body active -SH groups and has been proved to be effective in the control of menopausal troubles. As an experimental model the ovariectomized rat, rather similar, from the...

journal_title：Mechanisms of ageing and development

authors： Moldoveanu E,Klein R,Bartoc R,Bruhis S,Oeriu I

更新日期：1975-09-01 00:00:00

abstract：:Telomeres are supposed to play a role in cellular aging and might contribute to the genetic background of human aging and longevity. During the past few years telomere length has been measured in various human tissues. However, very little is known about the individual telomere loss in different tissues from the same ...

journal_title：Mechanisms of ageing and development

authors： Friedrich U,Griese E,Schwab M,Fritz P,Thon K,Klotz U

更新日期：2000-11-15 00:00:00

abstract：:Cellular and organismal decline is, in part, believed to be a consequence of oxygen and nitrogen-based reactants which persistently damage macromolecules throughout a lifetime. The resulting accumulation of damaged molecules eventually seriously compromises essential functions of cells leading to their death. Excessiv...

journal_title：Mechanisms of ageing and development

authors： Reiter RJ,Tan DX,Burkhardt S

更新日期：2002-04-30 00:00:00

abstract：:Researchers and clinicians interested in human diseases of DNA repair deficiency and premature aging gathered at the National Conference Center in Lansdowne, Virginia on 5-8 September 2006 to attend a workshop co-organized by Vilhelm Bohr (National Institute of Aging) and Kenneth Kraemer (National Cancer Institute). A...

journal_title：Mechanisms of ageing and development

authors： Kraemer KH,Sander M,Bohr VA

更新日期：2007-02-01 00:00:00

abstract：:Chronic health conditions are commonplace in older populations. The process of aging impacts many of the world's top health concerns. With the average life expectancy continuing to climb, understanding patterns of morbidity in aging populations has become progressively more important. Cancer is an age-related disease,...

journal_title：Mechanisms of ageing and development

authors： Nolen SC,Evans MA,Fischer A,Corrada MM,Kawas CH,Bota DA

更新日期：2017-06-01 00:00:00

abstract：:Metabolite concentrations in gastrocnemius and soleus muscles were compared in young-adult (4 months), mature (12 months) and senescent (24 months) rats after continuous (72 consecutive hours) exposure to normobaric hypoxia or normoxia with the intraperitoneal administration of the vasodilator naftidrofuryl or saline ...

journal_title：Mechanisms of ageing and development

authors： Pastoris O,Dossena M,Allorio F,Vercesi L

更新日期：1990-06-01 00:00:00

abstract：:Cellular senescence is a phenomenon of irreversible growth arrest in mammalian somatic cells in culture. Various stresses induce cellular senescence and indeed, we have found that excess thymidine effectively induces cellular senescence in human cells. Further, many reports indicate the implication of chromatin protei...

journal_title：Mechanisms of ageing and development

authors： Arai R,En A,Takauji Y,Maki K,Miki K,Fujii M,Ayusawa D

更新日期：2019-03-01 00:00:00

abstract：:The circulating antibody titers to bovine serum albumin (BSA) were determined for two groups of aged Fischer 344 rats obtained form the National Institute on Aging. One group received a single immunization of BSA in complete Freund's adjuvant, and the second group was immunized three times at two-week intervals with t...

journal_title：Mechanisms of ageing and development

authors： Kaplan PJ,Caperna TJ,Garvey JS

更新日期：1981-05-01 00:00:00

abstract：:During experiments on the molecular basis of morphological and functional changes observed in rat liver mitochondria upon aging, we found that the buoyant density profile of mitochondrial DNA (mtDNA) shows a wide distribution pattern especially in the lighter region than that of young rat liver mtDNA. The heterogeneou...

journal_title：Mechanisms of ageing and development

authors： Asano K,Amagase S,Matsuura ET,Yamagishi H

更新日期：1991-11-01 00:00:00

abstract：:The B cell responsiveness mediated by T cells has been evaluated in 50 aged donors by using a Pokeweed mitogen (PWM)-driven differentiation system. Peripheral blood mononuclear cells (PBMC) from aged donors exhibited a lower plaque-forming cell (PFC) generation in comparison with young donors. Similar results were obt...

journal_title：Mechanisms of ageing and development

authors： Antonaci S,Jirillo E,Gallitelli M,Garofalo AR,Bonomo L

更新日期：1987-11-01 00:00:00

abstract：:A major cause of ageing is thought to be the accumulation of damage to macromolecules. Accumulation to DNA damage in cells therefore presupposes that aged cells are unable to repair this damage. We have used the in vitro model of cellular ageing to test the idea that senescent cells are deficient in some aspect of DNA...

journal_title：Mechanisms of ageing and development

authors： Al-Baker EA,Oshin M,Hutchison CJ,Kill IR

更新日期：2005-06-01 00:00:00

abstract：:The current increase in life expectancy observed in industrialized societies underscores the need to achieve a better understanding of the aging process that could help the development of effective strategies to achieve healthy aging. This will require not only identifying genes involved in the aging process, but also...

journal_title：Mechanisms of ageing and development

authors： Lai CQ,Parnell LD,Lyman RF,Ordovas JM,Mackay TF

更新日期：2007-03-01 00:00:00

abstract：:The effect of various immunosuppressive treatments on mean life-span and disease incidence have been studied. Significant life shortening was seen only in mice which recieved X-irradiation early in life and can be ascribed primarily to an increased incidence of certain malignancies. Marginal life shortening was seen i...

journal_title：Mechanisms of ageing and development

authors： Peter CP,Perkins EH,Peterson WJ,Walburg HE,Makinodan T

更新日期：1975-05-01 00:00:00

abstract：:We determined the number of fibroblastoid progenitors (fibroblastoid colony-forming units, CFU-F) in femurs and spleens derived from (CBA X C57BL)F1 mice of different ages. The femoral CFU-F population size increased from 350 at 1 week of age and plateaued at approximately 1900 CFU-F at 8 weeks of age. The mean incide...

journal_title：Mechanisms of ageing and development

authors： Brockbank KG,Ploemacher RE,van Peer CM

更新日期：1983-05-01 00:00:00

abstract：:Expression of dystrophin and the dystrophin-related protein utrophin has been studied in the human fetal brain both in vivo and in vitro. Results showed that both these proteins were developmentally regulated, even if their expression followed a different pattern. Utrophin was found since very early stages of developm...

journal_title：Mechanisms of ageing and development

authors： Sogos V,Curto M,Reali C,Gremo F

更新日期：2002-03-15 00:00:00

abstract：:We have examined the effects of aging on guinea pig biliary motility both in vitro and in vivo. The first experiment compared contractile tension of gallbladder strips from young adult (6-12 months old) and 3-year-old guinea pigs in vitro. Contraction of gallbladder strips from the young guinea pigs was twice as force...

journal_title：Mechanisms of ageing and development

authors： Poston GJ,Singh P,Maclellan DG,Yao CZ,Uchida T,Townsend CM Jr,Thompson JC

更新日期：1988-12-01 00:00:00

abstract：:Influenza is a public health concern, especially for the elderly. While influenza vaccination is efficacious in the young, it offers only limited protection in the elderly. Thus, it becomes imperative to understand age-related changes in the primary response to influenza infection. This study identified potential age-...

journal_title：Mechanisms of ageing and development

authors： Beli E,Clinthorne JF,Duriancik DM,Hwang I,Kim S,Gardner EM

更新日期：2011-10-01 00:00:00

abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of Marie-Ange Teste, Isabelle Léger-Silvestre, Jean M François and Jean-Luc Parrou. Marjorie Petitjean could not b...

journal_title：Mechanisms of ageing and development

authors： Petitjean M,Teste MA,Léger-Silvestre I,François JM,Parrou JL

更新日期：2017-01-01 00:00:00

abstract：:Age-specific mortality rates from stomach cancer (SC) in Japan from 1950 through 1993 were subjected to longitudinal Gompertzian analysis. Age-specific SC mortality rate distributions between ages 45 and 75 years were highly Gompertzian for each- and every year for both men and women. Between 1950 and 1993, age-adjust...

journal_title：Mechanisms of ageing and development

authors： Imaizumi Y

更新日期：1995-11-24 00:00:00

abstract：:The increased lifespan caused by food limitation has been observed in a wide range of animals including the nematode Caenorhabditis elegans. We show here that the lifespans of eat-2 and eat-5 feeding-defective mutants and a mutant of dbl-1 encoding a TGFβ ligand significantly change between the cultures fed on Escheri...

journal_title：Mechanisms of ageing and development

authors： So S,Tokumaru T,Miyahara K,Ohshima Y

更新日期：2011-04-01 00:00:00

abstract：:It has been approximately 25 years since Dr. Rosenberg first brought attention to sarcopenia. To date, this aging-associated condition is recognized as a chronic loss of muscle mass and is usually accompanied by dynapenia. Despite its poly-etiological factors, sarcopenia has a strong neurogenic component underlying th...

journal_title：Mechanisms of ageing and development

authors： Kwan P

更新日期：2013-09-01 00:00:00