Amplification of extrachromosomal small circular DNAs in a murine model of accelerated senescence. A brief note.

Abstract:

:Extrachromosomal circular DNA complexes from peripheral blood lymphocytes from inbred mice of accelerated senescence, were detected by mica-press-adsorption method. In senescence-resistant series (SAM-R), polydisperse circular DNAs were observed at 7 weeks of age and a restricted size class of small circular forms of 0.4-0.8 microns in contour length was amplified several-fold at 26 months of age. In senescence-prone series (SAM-P), a similar amplification of small circular DNAs was observed at young age of 10 weeks and more progressive at 17 months of age.

journal_name

Mech Ageing Dev

authors

Yamagishi H,Kunisada T,Takeda T

doi

10.1016/0047-6374(85)90051-x

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

101-3

issue

1

eissn

0047-6374

issn

1872-6216

pii

0047-6374(85)90051-X

journal_volume

29

pub_type

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