Effect of chronic vitamin E deficiency on the synapses of cerebellar glomeruli in young rats.

Abstract:

:A morphometric investigation has been carried out on the synaptic junctions in the cerebellar glomeruli of young-adult rats chronically deprived of vitamin E for 10 months and control animals of the same age. The following parameters were evaluated: the average length of the synapses (L), the numerical (NV) as well as the surface (SV) density of the synaptic contact zones. The results from these experimental groups were compared with data from young, adult and old rats. The results obtained show a significant decrease of the surface density of the synaptic contact zones in old and alpha-tocopherol deprived young-adult (11-month-old) rats as compared to younger and normally fed animals. This reduction of the synaptic contact area seems to be due to the marked decline in the number of synapses found in both cases. The average size (L) of the synaptic junctions, on the other hand, was increased in alpha-tocopherol deficient rats as compared to normally fed littermates. The significant reduction of the synaptic contact area in old and vitamin E deprived young rats supports the hypothesis that a common denominator may be responsible to explain this alteration. Because of the recognized protective role of alpha-tocopherol against free radical attacks on plasma membranes, the present findings support an involvement of membrane structural alterations in aging as well as in vitamin E deficiency.

journal_name

Mech Ageing Dev

authors

Bertoni-Freddari C,Giuli C,Pieri C

doi

10.1016/0047-6374(84)90073-3

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

225-32

issue

2

eissn

0047-6374

issn

1872-6216

pii

0047-6374(84)90073-3

journal_volume

24

pub_type

杂志文章
  • The age-associated decline in immune function of healthy individuals is not related to changes in plasma concentrations of beta-carotene, retinol, alpha-tocopherol or zinc.

    abstract::The decline in the lymphoproliferative response to mitogenic stimuli shows marked heterogeneity in elderly individuals. Adequate nutriture is required for optimal immune function, yet nutritional status may be compromised in the elderly. To address whether this variation in the proliferative response of elderly indivi...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/s0047-6374(96)01838-6

    authors: Gardner EM,Bernstein ED,Dorfman M,Abrutyn E,Murasko DM

    更新日期:1997-03-01 00:00:00

  • Alzheimer's disease pathogenesis: Is there a role for folate?

    abstract::Epigenetic modifications, including changes in DNA methylation, have been implicated in a wide range of diseases including neurological diseases such as Alzheimer's. The role of dietary folate in providing methyl groups required for maintenance and modulation of DNA methylation makes it a nutrient of interest in Alzhe...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审

    doi:10.1016/j.mad.2017.10.001

    authors: Robinson N,Grabowski P,Rehman I

    更新日期:2018-09-01 00:00:00

  • Myofibrillar myosin ATPase activity in hindlimb muscles from young and aged rats.

    abstract::We tested the hypothesis that Ca(2+)-activated myosin ATPase activity is lower in muscles of aged rats relative to muscles of young rats, independent of changes in myosin isoform expression. Myofibrils were prepared from permeabilized fibers of soleus, plantaris, and semimembranosus muscles of young (8-12 months) and ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2004.07.002

    authors: Lowe DA,Husom AD,Ferrington DA,Thompson LV

    更新日期:2004-09-01 00:00:00

  • What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?

    abstract::Classical evolutionary theory predicts the existence of genes with antagonistic effects on longevity and various components of early-life fitness. Quantitative genetic studies have provided convincing evidence that such genes exist. However, antagonistic pleiotropic effects have rarely been attributed to individual lo...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审

    doi:10.1016/j.mad.2004.07.012

    authors: Leroi AM,Bartke A,De Benedictis G,Franceschi C,Gartner A,Gonos ES,Fedei ME,Kivisild T,Lee S,Kartaf-Ozer N,Schumacher M,Sikora E,Slagboom E,Tatar M,Yashin AI,Vijg J,Zwaan B

    更新日期:2005-03-01 00:00:00

  • Comparison of telomere length between population-specific mitochondrial haplogroups among different age groups in a Latvian population.

    abstract::Population studies have demonstrated that telomere length (TL) displays great diversity among different populations. Previously described controversial findings associated longevity with specific mitochondrial DNA haplogroups (hgs) (e.g., J and U). These observations may be influenced by population diversity, geograph...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2015.01.002

    authors: Zole E,Elferts D,Kimsis J,Krumina A,Narels K,Pole I,Ranka R,Pliss L

    更新日期:2015-01-01 00:00:00

  • Hydrocortisone effects on nucleic acid and nuclear protein content and protein metabolism in aging WI-38 cells.

    abstract::Confluent late passage WI-38 human diploid fibroblast cultures grown in the presence or absence of hydrocortisone for fifteen population doublings were measured cytochemically for DNA, nuclear RNA, basic nuclear protein and acidic nuclear protein content during a 12-hour interval following a medium-change stimulation....

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(81)90059-2

    authors: Docherty PA,Anthony A,Mitchell RB

    更新日期:1981-11-01 00:00:00

  • Biphasic effects of dietary antioxidants on oxidative stress-mediated carcinogenesis.

    abstract::There is now strong evidence implicating the generation of reactive oxygen species (ROS) and the corresponding response to oxidative stress as key factors in the pathogenesis of several human diseases including cancer, atherosclerosis, and neurodegenerative disorders, and in ageing. The carcinogenicity of oxidative st...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审

    doi:10.1016/j.mad.2006.01.021

    authors: Lee KW,Lee HJ

    更新日期:2006-05-01 00:00:00

  • RETRACTED:A new function for the yeast trehalose-6P synthase (Tps1) protein, as key pro-survival factor during growth, chronological ageing, and apoptotic stress.

    abstract::This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of Marie-Ange Teste, Isabelle Léger-Silvestre, Jean M François and Jean-Luc Parrou. Marjorie Petitjean could not b...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,收录出版

    doi:10.1016/j.mad.2016.07.011

    authors: Petitjean M,Teste MA,Léger-Silvestre I,François JM,Parrou JL

    更新日期:2017-01-01 00:00:00

  • Cell-type specific codon usage and differentiation.

    abstract::This paper presents evidence derived from the selective use of codons in ca. 40 eukaryotic genes (or messages derived from them) that codon usage is one of the most conserved features of messages for specific cell products. The theory has been developed by several investigations that the kinds of products of many if n...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(82)90034-3

    authors: Strehler B,North D

    更新日期:1982-04-01 00:00:00

  • Hypersensitivity of hypoxia grown Mycobacterium smegmatis to DNA damaging agents: implications of the DNA repair deficiencies in attenuation of mycobacteria.

    abstract::Mycobacteria are an important group of pathogenic bacteria. We generated a series of DNA repair deficient strains of Mycobacterium smegmatis, a model organism, to understand the importance of various DNA repair proteins (UvrB, Ung, UdgB, MutY and Fpg) in survival of the pathogenic strains. Here, we compared tolerance ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2013.08.006

    authors: Rex K,Kurthkoti K,Varshney U

    更新日期:2013-10-01 00:00:00

  • Tropomyosin 2 heterozygous knockout in mice using CRISPR-Cas9 system displays the inhibition of injury-induced epithelial-mesenchymal transition, and lens opacity.

    abstract::The process of epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) after cataract surgery contributes to tissue fibrosis, wound healing and lens regeneration via a mechanism not yet fully understood. Here, we show that tropomyosin 2 (Tpm2) plays a critical role in wound healing and lens aging. Post...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2018.03.001

    authors: Shibata T,Shibata S,Ishigaki Y,Kiyokawa E,Ikawa M,Singh DP,Sasaki H,Kubo E

    更新日期:2018-04-01 00:00:00

  • Biosynthesis and operating mechanism of estrogens in ovariectomized animals under the effect of -SH groups.

    abstract::This paper is part of a series aimed to investigate the mechanism of the action of Folcysteine, a substance that has the capacity to release in the body active -SH groups and has been proved to be effective in the control of menopausal troubles. As an experimental model the ovariectomized rat, rather similar, from the...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(75)90043-3

    authors: Moldoveanu E,Klein R,Bartoc R,Bruhis S,Oeriu I

    更新日期:1975-09-01 00:00:00

  • Transplanted mammary epithelium grows in association with host stroma: aging of serially transplanted mammary gland is intrinsic to epithelial cells.

    abstract::Mouse mammary gland displays an irreversible decline in growth rate when propagated by serial transplantation in gland-free mammary fat pads of isogeneic mice. Because transplanted fragments of gland contain both mammary epithelial and stromal elements, the present study was undertaken to distinguish between two possi...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(83)90026-x

    authors: Daniel CW,Shannon JM,Cunha GR

    更新日期:1983-11-01 00:00:00

  • The complex interplay between depression and multimorbidity in late life: risks and pathways.

    abstract::Multimorbidity and depression are complex multifactorial conditions with major implications for older individuals, their families, and healthcare providers. In this scoping review, we aimed to 1) review findings from longitudinal epidemiological studies investigating the association between multimorbidity and depressi...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2020.111383

    authors: Triolo F,Harber-Aschan L,Belvederi Murri M,Calderón-Larrañaga A,Vetrano DL,Sjöberg L,Marengoni A,Dekhtyar S

    更新日期:2020-12-01 00:00:00

  • Gene expression and aging.

    abstract::Considerable amount of data has accumulated during the past few years showing several changes in gene expression as a function of age. However, the basic mechanism of aging still remains poorly understood. In this review, we have mainly analysed the data pertaining to the hypothesis that aging is associated with genet...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审

    doi:10.1016/0047-6374(93)90015-j

    authors: Thakur MK,Oka T,Natori Y

    更新日期:1993-01-01 00:00:00

  • Nuclear (DNA, RNA, histone and non-histone protein) and nucleolar changes during growth and senescence of may apple leaves.

    abstract::Quantitative interference microscopy was used to determine changes in nuclear and nucleolar indices (dry mass and cross-sectional area) in upper and lower epidermal cells and adjacent leaf-margin hair cells of the May apple (Podophyllum peltatum L.) leaves over a 42-day period (after leaves emerged above the ground li...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/s0047-6374(96)01804-0

    authors: Bhattacharya PK,Pappelis AJ,Lee SC,BeMiller JN,Karagiannis CS

    更新日期:1996-12-20 00:00:00

  • Endothelin-1 in monolayer cultures of articular chondrocytes from young and old rats: regulation by growth factors and cytokines.

    abstract::The endothelin-1 (ET-1) concentrations were measured by RIA in the media of confluent monolayer cultures of rat articular chondrocyte (RAC) exposed to fetal calf serum (FCS) and several growth factors and cytokines. The cells were obtained from 1- and 18-month-old rats. First passage cells were starved in Dulbecco's m...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/s0047-6374(99)00117-7

    authors: Messai H,Khatib AM,Lebrun G,Aubin P,Florina M,Jean F,Mitrovic DR

    更新日期:2000-02-22 00:00:00

  • Polyamine changes during senescence and tumorogenesis in plants.

    abstract::Putrescine, spermidine, spermine and two unknowns designated as A and B were detected in first seedling leaves of barley (Hordeum vulgare L. var. Wolfe). The levels of these polyamines in first seedling leaves from 4-day-old barley plants grown in darkness or in light were comparable and did not change significantly a...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(87)90031-5

    authors: Srivastava BI

    更新日期:1987-09-14 00:00:00

  • Nutritional influences on immune response in healthy aged persons.

    abstract::Healthy elderly (80+/-5 years) with different nutritional status were compared to young healthy adults (25+/-5 years) to quantify the relative influences of aging and nutrition on immune response. Aged persons, without alteration of their nutritional status, had lower CD3+, CD8+, and CD45RA+ as well as higher CD2+CD3-...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/s0047-6374(98)00047-5

    authors: Mazari L,Lesourd BM

    更新日期:1998-08-01 00:00:00

  • Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.

    abstract::There are multiple lines of evidence showing that oxidative stress and aberrant mitogenic signaling play an important role in the pathogenesis of Alzheimer disease. However, the chronological relationship between these and other events associated with disease pathogenesis is not known. Given the important role that mi...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/s0047-6374(01)00342-6

    authors: Zhu X,Castellani RJ,Takeda A,Nunomura A,Atwood CS,Perry G,Smith MA

    更新日期:2001-12-01 00:00:00

  • Kinetic studies of aflatoxin B1-glutathione conjugate formation in liver and kidneys of adult and weanling rats.

    abstract::Aflatoxin B1(AFB1)-glutathione(GSH) conjugation is the major pathway for the detoxification of aflatoxin metabolites. This reaction is catalysed by GSH S-transferase (GST) and play a major role in modulation of AFB1 adduct formation to nuclear DNA. Changes recorded in hepatic GST activity during development of rats ca...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/s0047-6374(00)00105-6

    authors: Allameh A,Farahani M,Zarghi A

    更新日期:2000-05-18 00:00:00

  • Role of lymphoid cells in age-related change of susceptibility to Friend leukemia virus-induced leukemia.

    abstract::Susceptibility for Friend leukemia virus (FLV)-induced leukemogenesis was examined in the C3H/He (C3H)-->C57BL/6 (B6) radiation bone marrow chimeras of various age groups, and the effect of aging of host mice on the susceptibility was determined. The bone marrow chimera system provided the various age of FLV-resistant...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/s0047-6374(00)00245-1

    authors: Yamaguchi S,Kitagawa M,Inoue M,Tejima Y,Kimura M,Aizawa S,Utsuyama M,Hirokawa K

    更新日期:2001-02-01 00:00:00

  • Chromosomal alterations and sister chromatid exchanges induced by zirconium oxychloride in human lymphocytes in vitro with relation to age of donors.

    abstract::Aqueous solutions of zirconium oxychloride were added to human peripheral blood lymphocyte culture. Cultures were set up from healthy donors of both sexes belonging to age groups of 0-10, 11-20, 21-30, 31-40, 41-50 and 51-60 years. Airdried Giemsa schedule was followed for preparation of chromosomal aberrations and mi...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(92)90110-y

    authors: Ghosh S,Talukder G,Sharma A

    更新日期:1992-03-01 00:00:00

  • Age-dependence of nuclear RNA processing.

    abstract::Following a 3 hour in vivo labelling of cytoplasmic RNA in rat liver with orotic acid-6-14C under conditions where ribosomal RNA synthesis was suppressed, the proportion of labelled messenger-like RNA released to the cytoplasm which contained polyadenylate (poly(A)) tracts was about 3.0 times higher in the livers of j...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(77)90026-4

    authors: Yannarell A,Schumm DE,Webb TE

    更新日期:1977-07-01 00:00:00

  • The influence of age on the hypothalamo-neurohypophyseal system of the mouse: a quantitative ultrastructural analysis of the posterior pituitary.

    abstract::A quantitative ultrastructural study of the posterior pituitary was undertaken. The posterior pituitary is the storage of the hormones vasopressin and oxytocin. Female C57BL/Icrfat mice which were under conditions of normal hydration were sampled at 8 and 32 months of age. There was a slight age-related decline in the...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(81)90069-5

    authors: Wilkinson A,Davies I

    更新日期:1981-02-01 00:00:00

  • Cycling patterns of hemopoietic stem cell subpopulations in young and old BDF1 mice.

    abstract::We have previously reported that two or more different subpopulations of bone marrow stem cells exist in mice as determined by cycling status of day-8 and day-14 CFU-S in long term bromodeoxyuridine (BrdU) infusion studies. In the present report, comparisons between cycling of stem cell subpopulations in old and young...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(89)90069-9

    authors: Pietrzyk ME,Wolf NS,Priestley GV

    更新日期:1989-07-01 00:00:00

  • Combined grafting of bone marrow and thymus, and sequential multiple thymus graftings in various strains of mice. The effect on immune functions and life span.

    abstract::The combined grafting of young bone marrow and newborn thymus performed in old mice was effective in restoring the impaired immune functions, but the same treatment performed in middle-aged adult mice had no effect on the life span of C3H/MTV female mice. Sequential multiple newborn thymus graftings starting at young ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(89)90067-5

    authors: Hirokawa K,Utsuyama M

    更新日期:1989-07-01 00:00:00

  • Regulation of cytokine production in aging: use of recombinant cytokines to upregulate mitogen-stimulated spleen cells.

    abstract::We investigated the production of IL-2 and IFN-gamma (Th1 type) and IL-4 (Th2 type) cytokines by mitogen-activated spleen cells from young, adult and old mice. Cytokine production was evaluated in culture supernatants by CTLL proliferation (IL-2), ELISA (IFN-gamma), CT4.S proliferation (IL-4) and in mRNA extracted fro...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/s0047-6374(96)01825-8

    authors: Frasca D,Pucci S,Goso C,Barattini P,Barile S,Pioli C,Doria G

    更新日期:1997-02-01 00:00:00

  • Growth hormone administration to long-living dwarf mice alters multiple components of the antioxidative defense system.

    abstract::Endocrine hormones are thought to be involved in processes that contribute to aging. Long-living dwarf mice are growth hormone (GH)-deficient and exhibit enhanced expression of antioxidative defense molecules when compared to normal, wild type littermates. In this study, 3- and 12-month-old Ames dwarf mice received wi...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2003.07.001

    authors: Brown-Borg HM,Rakoczy SG

    更新日期:2003-12-01 00:00:00

  • Effects of calorie restriction on the age-dependent accumulation of mutations in the small intestine of lacZ-transgenic mice.

    abstract::To understand the effect of calorie restriction on genome maintenance systems, the age-dependent accumulation of mutations in animals maintained on high and low calorie diets was examined using lacZ-transgenic mice. Mice were fed a diet of 95 kcal/w or 65 kcal/w from 2 to 17 months of age. The mutation frequencies in ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2011.01.004

    authors: He D,Uehara Y,Furuya M,Ikehata H,Komura J,Yamauchi K,Kakinuma S,Shang Y,Shimada Y,Ootsuyama A,Norimura T,Ono T

    更新日期:2011-03-01 00:00:00