Control of lifespan by food bacteria, nutrient limitation and pathogenicity of food in C. elegans.

Abstract:

:The increased lifespan caused by food limitation has been observed in a wide range of animals including the nematode Caenorhabditis elegans. We show here that the lifespans of eat-2 and eat-5 feeding-defective mutants and a mutant of dbl-1 encoding a TGFβ ligand significantly change between the cultures fed on Escherichia coli strain OP50 or a more nutrient-rich strain HB101. On HB101 food, the eat-2, eat-5 and dbl-1 mutants show increased lifespan compared to that of the wild type. This result is probably due to nutrient limitation because the eat mutations reduce food uptake and the mutation of dbl-1 that regulates expression of several digestive enzymes leads to nutrient limitation. In contrast, the lifespans of the eat-2 and dbl-1 mutants decreased from that of the wild type on OP50 food. We found that live OP50 cells within a worm were markedly more in these mutants than in the wild type, which suggests that impaired digestion of pathogenic OP50 decreased lifespan in the eat-2 and dbl-1 mutants.

journal_name

Mech Ageing Dev

authors

So S,Tokumaru T,Miyahara K,Ohshima Y

doi

10.1016/j.mad.2011.02.005

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

210-2

issue

4

eissn

0047-6374

issn

1872-6216

pii

S0047-6374(11)00027-3

journal_volume

132

pub_type

杂志文章
  • Changes of the coronary arteries and cardiac microvasculature with aging: Implications for translational research and clinical practice.

    abstract::Aging results in functional and structural changes in the cardiovascular system, translating into a progressive increase of mechanical vessel stiffness, due to a combination of changes in micro-RNA expression patterns, autophagy, arterial calcification, smooth muscle cell migration and proliferation. The two pivotal m...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审

    doi:10.1016/j.mad.2019.111161

    authors: Piccirillo F,Carpenito M,Verolino G,Chello C,Nusca A,Lusini M,Spadaccio C,Nappi F,Di Sciascio G,Nenna A

    更新日期:2019-12-01 00:00:00

  • Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.

    abstract::The conserved SIR2 protein regulates life span in both yeast and worms: in both organisms overexpression of SIR2 can extend life span and in Caenorhabditis elegans this life span extension is dependent on the forkhead transcription factor, DAF-16. Here, we have done extensive genetic analysis with sir-2.1(ok434), a nu...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2005.09.005

    authors: Wang Y,Tissenbaum HA

    更新日期:2006-01-01 00:00:00

  • Decreased rates of protein synthesis by cell-free preparations from different organs of aging mice.

    abstract::Protein synthetic activity was determined in postmitochondrial preparations from heart, brain, kidney, liver and skeletal muscle of 5-26-month-old female C57B1/6J mice. An age-dependent decrease in the rate of protein synthesis was exhibited by all preparations except heart muscle. A 65% decrease in translational rate...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(83)90051-9

    authors: Blazejowski CA,Webster GC

    更新日期:1983-03-01 00:00:00

  • Mitogenic activity but not phenotype expression of rat osteoprogenitor cells in response to IGF-I is impaired in aged rats.

    abstract::The age-related deficit in the dose response of osteoprogenitor cells to IGF-I was further investigated. As expected, the effective dose, but not the maximal effect, was shifted two orders of magnitude higher in old cells. In this paper, we examined whether this age-deficit can be attributed to an alteration in the ex...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/s0047-6374(96)01793-9

    authors: Tanaka H,Liang CT

    更新日期:1996-11-29 00:00:00

  • Regulation of cytokine production in aging: use of recombinant cytokines to upregulate mitogen-stimulated spleen cells.

    abstract::We investigated the production of IL-2 and IFN-gamma (Th1 type) and IL-4 (Th2 type) cytokines by mitogen-activated spleen cells from young, adult and old mice. Cytokine production was evaluated in culture supernatants by CTLL proliferation (IL-2), ELISA (IFN-gamma), CT4.S proliferation (IL-4) and in mRNA extracted fro...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/s0047-6374(96)01825-8

    authors: Frasca D,Pucci S,Goso C,Barattini P,Barile S,Pioli C,Doria G

    更新日期:1997-02-01 00:00:00

  • Influence of long-term treatment with L-deprenyl on the age-dependent changes in rat brain microanatomy.

    abstract::The present study was designed to assess whether treatment with the monoamine oxidase-B (MAO-B) inhibitor L-deprenyl, which has been documented to increase both mean and maximum survival in aged rats as well as sexual performance and cognitive function, has any effect on the age-related microanatomical changes occurri...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(94)90060-4

    authors: Zeng YC,Bongrani S,Bronzetti E,Cadel S,Ricci A,Valsecchi B,Amenta F

    更新日期:1994-02-01 00:00:00

  • Aged lymphocyte proliferation following incorporation and retention of dietary omega-3 fatty acids.

    abstract::T cell activation involves events at the plasma membrane; therefore, molecules such as long chain omega-3 fatty acids that alter the structure of the plasma membrane may affect the activation of aged T cells. In this project we investigated whether the incorporation of omega-3 fatty acids (from fish oil), in the prese...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(94)90079-5

    authors: VanMeter AR,Ehringer WD,Stillwell W,Blumenthal EJ,Jenski LJ

    更新日期:1994-08-01 00:00:00

  • Cellular dynamics and modulation of WRN protein is DNA damage specific.

    abstract::The human premature aging protein Werner (WRN), deficient in Werner syndrome (WS), is localized mainly to the nucleolus in many cell types. DNA damage or replication arrest causes WRN to redistribute from the nucleolus to the nucleoplasm into discrete foci. In this study, we have investigated DNA damage specific cellu...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2005.06.004

    authors: Karmakar P,Bohr VA

    更新日期:2005-11-01 00:00:00

  • Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing.

    abstract::Mitochondrial reactive oxygen species (ROS) and oxidative damage are associated with a range of age-related human pathologies. It is also likely that mitochondrial ROS generation is a factor in stress response and signal transduction pathways. However, current methods for measuring and influencing mitochondrial ROS pr...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审

    doi:10.1016/j.mad.2005.03.026

    authors: James AM,Cochemé HM,Murphy MP

    更新日期:2005-09-01 00:00:00

  • Immune parameters in a population of institutionalized elderly subjects: influence of depressive disorders and endocrinological correlations.

    abstract::Twenty-six institutionalized elderly subjects, selected as healthy according to the SENIEUR protocol, were compared to adult controls to establish correlations between affective disorders and immune abnormalities and to investigate underlying neuroendocrine mechanisms. After an extensive psychodiagnostic examination, ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(91)90104-8

    authors: Bartoloni C,Guidi L,Frasca D,Antico L,Pili R,Cursi F,Di Giovanni A,Rumi C,Menini E,Carbonin P

    更新日期:1991-09-01 00:00:00

  • The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature.

    abstract::The extracellular matrix (ECM) is an intricate network that provides structural and anchoring support to cells in order to stabilize cell morphology and tissue architecture. The ECM also controls many aspects of the cell's dynamic behavior and fate through its ongoing, bidirectional interaction with cells. These inter...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审

    doi:10.1016/j.mad.2018.04.002

    authors: De Luca M

    更新日期:2019-01-01 00:00:00

  • A return to time, cells, systems and aging: II. Relational and reliability theoretic approaches to the study of senescence in living systems.

    abstract::In this paper, we approach the problem of attempting to understand senescence by understanding the complexity and hierarchical structure of mammalian organisms. To do this, we make use of some concepts from abstract relational biology; in particular, graph theory. We subsequently utilize these concepts to develop the ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(84)90056-3

    authors: Witten M

    更新日期:1984-10-31 00:00:00

  • Effect of dietary high doses of vitamin E on lymphocyte subsets in young and old CBA mice.

    abstract::Different theories of ageing exist. Oxidative stress by generating neo-antigens and affecting cellular communications may precipitate immune disregulation, and both may concur in the whole ageing process. In the present study, we have analysed the effect of dietary high doses of vitamin E, a free radical scavenger, on...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(94)91593-8

    authors: Brohée D,Nève P

    更新日期:1994-10-20 00:00:00

  • Responses of mitochondrial superoxide dismutase, catalase and glutathione peroxidase activities to aging.

    abstract::The previous observation (Eur. J. Biochem., 82 (1978) 563--567) that age-dependent accumulation of lipid peroxides follows as a consequence of increased radical formation in mitochondria has prompted an examination of the response of a set of protective enzymes to the above situation. Levels of mitochondrial catalase ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(79)90050-2

    authors: Nohl H,Hegner D,Summer KH

    更新日期:1979-10-01 00:00:00

  • Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases.

    abstract::Several laboratory animal models have shown that dietary energy restriction (ER) can promote longevity and improve various health aspects in old age. However, whether the entire spectrum of ER-induced short- and long-term physiological and metabolic adaptions is translatable to humans remains to be determined. In this...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2020.111364

    authors: Xie K,Kapetanou M,Sidiropoulou K,Bano D,Gonos ES,Djordjevic AM,Ehninger D

    更新日期:2020-12-01 00:00:00

  • Evolution of human longevity: a critical overview.

    abstract::Evolution of longevity of the ungulates, carnivores and primates is reviewed. Special emphasis is focused on recent evolutionary history of longevity along the hominid ancestral-descendant sequence leading to modern man. Maximum life span potential (MLP) or the change in MLP is predicted in extinct species by (1) a ph...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审

    doi:10.1016/0047-6374(79)90110-6

    authors: Cutler RG

    更新日期:1979-02-01 00:00:00

  • Modelling the actions of chaperones and their role in ageing.

    abstract::Many molecular chaperones are also known as heat shock proteins because they are synthesised in increased amounts after brief exposure of cells to elevated temperatures. They have many cellular functions and are involved in the folding of nascent proteins, the re-folding of denatured proteins, the prevention of protei...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2004.09.031

    authors: Proctor CJ,Soti C,Boys RJ,Gillespie CS,Shanley DP,Wilkinson DJ,Kirkwood TB

    更新日期:2005-01-01 00:00:00

  • Coenzyme Q content in synaptic and non-synaptic mitochondria from different brain regions in the ageing rat.

    abstract::We investigated the Coenzyme Q (CoQ) content of different mitochondrial fractions [free mitochondria (FM), synaptic heavy (HM) and light mitochondria (LM)] from three brain areas (cortex, striatum, hippocampus) of rats at different ages. In rats from 2 to 26 months of age, we observed only small differences in total C...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(94)01535-t

    authors: Battino M,Gorini A,Villa RF,Genova ML,Bovina C,Sassi S,Littarru GP,Lenaz G

    更新日期:1995-03-17 00:00:00

  • Age-associated changes in glutamine synthetase activity in WI-38 cells.

    abstract::The human fibroblast cell line WI-38 shows a gradual decline in glutamine synthetase specific activity with increasing age in culture. However, the level of functional enzyme per cell does not change with age. Heat inactivation profiles indicate that glutamine synthetase from younger cell cultures is more heat labile ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(78)90005-2

    authors: Viceps-Madore D,Cristofalo VJ

    更新日期:1978-07-01 00:00:00

  • Age related decline in cytokine induced nitric oxide synthase activation and apoptosis in cultured endothelial cells: minimal involvement of nitric oxide in the apoptosis.

    abstract::Nitric oxide synthase (NOS) activity was enhanced in human umbilical vein endothelial cells (HUVECs) by the combined stimulation with IFN-gamma plus IL-1beta, TNF-alpha and LPS which was accompanied by cell death. DNA analysis of the NOS induced dead HUVECs showed that internucleosomal DNA fragmentation had occurred, ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(94)01579-b

    authors: Sato I,Kaji K,Murota S

    更新日期:1995-06-30 00:00:00

  • Studying the cerebellar DNA damage response in the tissue culture dish.

    abstract::The cerebellum is exquisitely sensitive to deficiencies in the cellular response to specific DNA lesions. Genetic disorders caused by such deficiencies involve relentless, progressive cerebellar atrophy with striking loss of Purkinje and granule neurons. The reason for the extreme sensitivity of these cells to defecti...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2013.04.001

    authors: Tzur-Gilat A,Ziv Y,Mittelman L,Barzilai A,Shiloh Y

    更新日期:2013-10-01 00:00:00

  • Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs "in vitro" wound closure.

    abstract::Scavenger receptor B1 (SR-B1) is a trans-membrane protein, involved in tissue reverse cholesterol transport. Several studies have demonstrated that SR-B1 is also implicated in other physiological processes, such as bacteria and apoptotic cells recognition and regulation of intracellular tocopherol and carotenoids leve...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2017.11.006

    authors: Muresan XM,Sticozzi C,Belmonte G,Savelli V,Evelson P,Valacchi G

    更新日期:2018-06-01 00:00:00

  • Sleep disorders and late-onset epilepsy of unknown origin: Understanding new trajectories to brain amyloidopathy.

    abstract::The intertwining between epilepsy, sleep disorders and beta amyloid pathology has been progressively highlighted, as early identification and stratification of patients at high risk of cognitive decline is the need of the hour. Modification of the sleep-wake activity, such as sleep impairment or excessive daytime slee...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审

    doi:10.1016/j.mad.2021.111434

    authors: Liguori C,Spanetta M,Romoli M,Placidi F,Nardi Cesarini E,Mercuri NB,Costa C

    更新日期:2021-01-11 00:00:00

  • Calcium sensitivity of myocardial actomyosin ATPase in young and mature male Fischer rats. A brief note.

    abstract::Although myocardial actomyosin ATPase specific activity determined at Ca2+ levels of 1 x 10(-3) to 1 x 10(-2) M is consistently higher in two-month old male Fischer rats than in twelve-month old individuals, this difference can be eliminated if the enzyme is assayed at lower calcium concentrations. This suggests that ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(78)90040-4

    authors: Rockstein M,Chesky JA,Lopez T

    更新日期:1978-12-01 00:00:00

  • Replicative aging as a source of cell heterogeneity in budding yeast.

    abstract::While deviations from the optimal phenotype are deleterious, increased variation can prevent population extinction under severe stresses. Cell division asymmetry is an important source of microbial phenotypic heterogeneity. A consecutive set of asymmetric divisions can cause the gradual accumulation of deleterious fac...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审

    doi:10.1016/j.mad.2018.09.001

    authors: Knorre DA,Azbarova AV,Galkina KV,Feniouk BA,Severin FF

    更新日期:2018-12-01 00:00:00

  • Changes in immunological potential between juvenile and presenile in rabbit.

    abstract::To investigate the relationship between immunological potential and advance of age, patterns of humoral immune response in different aged rabbits were compared. In the primary response, the appearance of total antibody and the arrival to its peak level were retarded by advance of age. On the other hand, the appearance...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(76)90038-5

    authors: Nomaguchi T,Okuma-Sakurai Y,Kimura I

    更新日期:1976-01-01 00:00:00

  • The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity.

    abstract::An increasing body of data is progressively indicating that the comprehension of the epigenetic landscape, actively integrated with the genetic elements, is crucial to delineate the molecular basis of the inter-individual complexity of ageing process. Indeed, it has emerged that DNA methylation changes occur during ag...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审

    doi:10.1016/j.mad.2017.01.006

    authors: Bacalini MG,D'Aquila P,Marasco E,Nardini C,Montesanto A,Franceschi C,Passarino G,Garagnani P,Bellizzi D

    更新日期:2017-07-01 00:00:00

  • Strychnine-insensitive glycine binding to cerebral cortical membranes in developing and ageing mice.

    abstract::The strychnine-insensitive binding of [3H]glycine was characterized in purified cerebral cortical membranes from mice aged from 7 days to 22 months. The binding was saturable, exhibiting only one component during the whole life-span studied. The binding constant KD did not change during development and ageing, whereas...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/0047-6374(93)90131-a

    authors: Saransaari P,Oja SS

    更新日期:1993-11-01 00:00:00

  • Kinetic studies of aflatoxin B1-glutathione conjugate formation in liver and kidneys of adult and weanling rats.

    abstract::Aflatoxin B1(AFB1)-glutathione(GSH) conjugation is the major pathway for the detoxification of aflatoxin metabolites. This reaction is catalysed by GSH S-transferase (GST) and play a major role in modulation of AFB1 adduct formation to nuclear DNA. Changes recorded in hepatic GST activity during development of rats ca...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/s0047-6374(00)00105-6

    authors: Allameh A,Farahani M,Zarghi A

    更新日期:2000-05-18 00:00:00

  • Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells.

    abstract::Cellular senescence is a phenomenon of irreversible growth arrest in mammalian somatic cells in culture. Various stresses induce cellular senescence and indeed, we have found that excess thymidine effectively induces cellular senescence in human cells. Further, many reports indicate the implication of chromatin protei...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章

    doi:10.1016/j.mad.2019.01.001

    authors: Arai R,En A,Takauji Y,Maki K,Miki K,Fujii M,Ayusawa D

    更新日期:2019-03-01 00:00:00