Does glycosylation of lysosomal proteins show age-related changes in rat liver?

abstract：:Food restriction is known to ameliorate many of the adverse physiologic effects of age. In this study, we have examined the effect of food restriction on the induction of the gluconeogenic enzyme, phosphoenolpyruvate carboxykinase (PEPCK) in liver and kidney following a 12-h fasting period in young (6 month) and old (...

journal_title：Mechanisms of ageing and development

authors： Van Remmen H,Ward WF

更新日期：1998-09-01 00:00:00

abstract：:Elastase and lipid levels of the plasmas of subjects and of those who have suffered a stroke have been measured, and it has been shown that the normal age related fall in elastase content is mirrored more closely by the fall in high density lipoprotein cholesterol than by changes in total cholesterol. After a stroke a...

journal_title：Mechanisms of ageing and development

authors： Hall DA,Elridi SS,Zajac A,Middleton RS

更新日期：1980-11-01 00:00:00

abstract：:The in vitro replicative potential of human diploid fibroblasts can be increased by polypeptide growth factors such as epidermal growth factor (EGF). Also, the cycle time of EGF-stimulated cells is, on average, decreased and their mitotic cell volume is reduced. Therefore, the regulation of cell size by the duration o...

journal_title：Mechanisms of ageing and development

authors： Angello JC

更新日期：1992-01-01 00:00:00

abstract：:Sarcoplasmic reticulum (SR) vesicles isolated from skeletal muscle of Sprague-Dawley rats ranging in age from 4 months to 28 months were studied and compared. A marked decline, with age, was observed in the amount of (total) SR proteins isolated per gram of muscle tissue used. This decline is in line with the known lo...

journal_title：Mechanisms of ageing and development

authors： Gafni A,Yuh KC

更新日期：1989-08-01 00:00:00

abstract：:The age-related studies of chromatin and DNA has attracted significant interest in recent years. However, individual works describe only some and a few of the many changes of chromatin. It is often difficult to decide whether these changes have secondary or primary nature. The overview of these studies makes it possib...

journal_title：Mechanisms of ageing and development

authors： Medvedev ZA

更新日期：1984-12-01 00:00:00

abstract：:The basic genetic defect in the Hutchinson-Gilford Progeria Syndrome (progeria), a premature aging syndrome, is unknown. To investigate possible defects in hyaluronic acid (HA) metabolism in this disease, the urinary excretion of HA was studied. Urine specimens from 11 patients with this disorder were examined for HA ...

journal_title：Mechanisms of ageing and development

authors： Zebrower M,Kieras FJ,Brown WT

更新日期：1986-06-01 00:00:00

abstract：:The age-related changes of the ciliary muscle of human eyes (33-87 years) were studied on histological meridional sections. Eighty-five melanoma eyes and 10 eyes of normal donors were investigated. The total area and the length of the muscle, the area of the three main portions and the distance of the inner apex of th...

journal_title：Mechanisms of ageing and development

authors： Tamm S,Tamm E,Rohen JW

更新日期：1992-02-01 00:00:00

abstract：:The present study aimed to reveal aging-related changes in the skeletal muscle of SD rats by comparing transcriptome analysis, integrated with muscle physiological parameters. Ten rats aged 25 months were set as the old group (OG) and ten rats aged 6 months were set as the young group (YG). After 6 weeks of feeding, t...

journal_title：Mechanisms of ageing and development

authors： Zhou J,Liao Z,Chen J,Zhao K,Xiao Q

更新日期：2018-01-01 00:00:00

abstract：:The tumor suppressors p16(INK4a) and p53 have been implicated as contributors to age-associated stem cell decline. Key functions of p53 are the induction of cell cycle arrest, senescence, or apoptosis in response to DNA damage. Here, we examine senescence, apoptosis, and DNA damage responses in a mouse accelerated agi...

journal_title：Mechanisms of ageing and development

authors： Hinkal GW,Gatza CE,Parikh N,Donehower LA

更新日期：2009-04-01 00:00:00

abstract：:Neurons that degenerate in the brains of persons with Alzheimer's disease accumulate mitochondrial amyloid precursor protein (APP), which is thought to negatively affect mitochondrial function and cellular homeostasis. Because proteins that enter mitochondria require assistance from chaperone proteins, we hypothesized...

journal_title：Mechanisms of ageing and development

authors： Yang TT,Hsu CT,Kuo YM

更新日期：2009-09-01 00:00:00

abstract：:Evolution of longevity of the ungulates, carnivores and primates is reviewed. Special emphasis is focused on recent evolutionary history of longevity along the hominid ancestral-descendant sequence leading to modern man. Maximum life span potential (MLP) or the change in MLP is predicted in extinct species by (1) a ph...

journal_title：Mechanisms of ageing and development

authors： Cutler RG

更新日期：1979-02-01 00:00:00

abstract：:A morphometric investigation has been carried out on the synaptic junctions in the cerebellar glomeruli of young-adult rats chronically deprived of vitamin E for 10 months and control animals of the same age. The following parameters were evaluated: the average length of the synapses (L), the numerical (NV) as well as...

journal_title：Mechanisms of ageing and development

authors： Bertoni-Freddari C,Giuli C,Pieri C

更新日期：1984-02-01 00:00:00

abstract：:Different theories of ageing exist. Oxidative stress by generating neo-antigens and affecting cellular communications may precipitate immune disregulation, and both may concur in the whole ageing process. In the present study, we have analysed the effect of dietary high doses of vitamin E, a free radical scavenger, on...

journal_title：Mechanisms of ageing and development

authors： Brohée D,Nève P

更新日期：1994-10-20 00:00:00

abstract：:Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is reportedly associated with longevity and susceptibility to age-related diseases in Japanese individuals. We previously reported an association between mt5178 A/C polymorphism and serum protein fraction levels in healthy Japanese women. An association...

journal_title：Mechanisms of ageing and development

authors： Kokaze A,Ishikawa M,Matsunaga N,Yoshida M,Sekine Y,Sekiguchi K,Satoh M,Harada M,Teruya K,Takeda N,Uchida Y,Takashima Y

更新日期：2003-06-01 00:00:00

abstract：:Telomeres are supposed to play a role in cellular aging and might contribute to the genetic background of human aging and longevity. During the past few years telomere length has been measured in various human tissues. However, very little is known about the individual telomere loss in different tissues from the same ...

journal_title：Mechanisms of ageing and development

authors： Friedrich U,Griese E,Schwab M,Fritz P,Thon K,Klotz U

更新日期：2000-11-15 00:00:00

abstract：:A mutant of rad-8, originally isolated on the basis of its hypersensitivity to ultraviolet radiation, is also hypersensitive to oxygen and methyl viologen, a superoxide-anion generator. Oxygen also retarded development and reduced fecundity in a concentration-dependent fashion in rad-8 but not in wild type. In additio...

journal_title：Mechanisms of ageing and development

authors： Ishi N,Suzuki N,Hartman PS,Suzuki K

更新日期：1993-05-01 00:00:00

abstract：:Human diploid cells, TIG-7, were serially cultivated under 1%, 5% or 21% (air) oxygen. The limit of their cumulative population doublings was extended by 16% or 10% under 1% or 5% oxygen, respectively, as compared with that under 21% oxygen. When TIG-7 cells were serially cultivated in the presence of 10 mM or 20 mM 3...

journal_title：Mechanisms of ageing and development

authors： Yuan H,Kaneko T,Matsuo M

更新日期：1995-07-14 00:00:00

abstract：:Morphological studies on spontaneous systemic amyloidosis were conducted on 222 senescence-accelerated mice (SAM) (P) and on 150 mice in the senescence-resistant series (R). Among the pathologic findings, amyloidosis showed the highest incidence in both SAM (79.7%) and R (32.7%). Although an extensive deposition of am...

journal_title：Mechanisms of ageing and development

authors： Takeshita S,Hosokawa M,Irino M,Higuchi K,Shimizu K,Yasuhira K,Takeda T

更新日期：1982-09-01 00:00:00

abstract：:Chronic oxidative stress is generally believed to be a major etiologic factor in the aging process. In addition to modulation of signaling processes and oxidation of cellular proteins and lipids, reactive oxygen species (ROS) induce multiple damages in both nuclear and mitochondrial genomes, most of which are repaired...

journal_title：Mechanisms of ageing and development

authors： Szczesny B,Bhakat KK,Mitra S,Boldogh I

更新日期：2004-10-01 00:00:00

abstract：:Some observations on cellular senescence are discussed regarding the possibility that the postulated genes, which bring about the DNA synthesis block of senescent fibroblasts, might be similar to those designated as anti-oncogenes or tumour suppressor genes. The latter genes have been defined by tumorogenicity tests o...

journal_title：Mechanisms of ageing and development

authors： Ferluga J

更新日期：1990-04-30 00:00:00

abstract：:Iron deficiency anaemia is prevalent in older age, particularly after the age of 80. Serum ferritin concentrations also decline, although there is no evidence to suggest that changes in iron stores are an inevitable consequence of ageing. Chronic inflammation is a common condition in older people, making the measureme...

journal_title：Mechanisms of ageing and development

authors： Fairweather-Tait SJ,Wawer AA,Gillings R,Jennings A,Myint PK

更新日期：2014-03-01 00:00:00

abstract：:Older adults who are at risk of developing influenza illness, have a low level of influenza virus-stimulated cytotoxic T lymphocyte (CTL) activity as measured by an assay of granzyme B (GrB). The purpose of this study was to determine whether aging affected memory CTL populations identified by GrB expression in influe...

journal_title：Mechanisms of ageing and development

authors： Xie D,McElhaney JE

更新日期：2007-05-01 00:00:00

abstract：:Hypertension is a common age-related disease, along with vascular and neurodegenerative diseases. Vascular ageing increases during hypertension, but hypertension itself accelerates vascular ageing, thus creating a vicious circle. Vascular stiffening, endothelial dysfunction, impaired contractility and vasorelaxation a...

journal_title：Mechanisms of ageing and development

authors： Forte M,Stanzione R,Cotugno M,Bianchi F,Marchitti S,Rubattu S

更新日期：2020-07-01 00:00:00

abstract：:The incidence of chronic diseases such as cardiovascular diseases is lower in Mediterranean Southern Europe than Northern Europe. This may be due to a lower level of oxidative stress and a higher antioxidant status in people living around the Mediterranean Sea. Oxidative stress may influence the rate of shortening of ...

journal_title：Mechanisms of ageing and development

authors： de Vos-Houben JM,Ottenheim NR,Kafatos A,Buijsse B,Hageman GJ,Kromhout D,Giltay EJ

更新日期：2012-06-01 00:00:00

abstract：:It has been approximately 25 years since Dr. Rosenberg first brought attention to sarcopenia. To date, this aging-associated condition is recognized as a chronic loss of muscle mass and is usually accompanied by dynapenia. Despite its poly-etiological factors, sarcopenia has a strong neurogenic component underlying th...

journal_title：Mechanisms of ageing and development

authors： Kwan P

更新日期：2013-09-01 00:00:00

abstract：:We have isolated a new type of Paramecium tetraurelia mutant, named rie-2, that has a long immaturity period until autogamy. We previously isolated such an autogamy mutant, designated rie-1. These two mutants had some additional common features such as dependence of the occurrence of autogamy on the temperature, invol...

journal_title：Mechanisms of ageing and development

authors： Komori R,Sato H,Harumoto T,Takagi Y

更新日期：2005-06-01 00:00:00

abstract：:Two types of age-related cell surface changes could be demonstrated in human diploid fibroblasts with the two methods of the lectin-mediated red blood cell (RBC) adsorption assay: the fibroblast coating method (in which RBCs are adsorbed to lectin-coated fibroblasts) and the RBC coating method (in which lectin-coated ...

journal_title：Mechanisms of ageing and development

authors： Aizawa S,Kurimoto F

更新日期：1979-11-01 00:00:00

abstract：:A few reports suggest that pigmented granules found in molluscan neurons accumulate with age as do lipofuscin granules in vertebrate cells; however, no reports on molluscan neurons include detailed descriptions of granule accumulation or histochemical tests to identify the pigment as lipofuscin-like. In this study lig...

journal_title：Mechanisms of ageing and development

authors： Robles LJ

更新日期：1978-01-01 00:00:00

abstract：:The combined grafting of young bone marrow and newborn thymus performed in old mice was effective in restoring the impaired immune functions, but the same treatment performed in middle-aged adult mice had no effect on the life span of C3H/MTV female mice. Sequential multiple newborn thymus graftings starting at young ...

journal_title：Mechanisms of ageing and development

authors： Hirokawa K,Utsuyama M

更新日期：1989-07-01 00:00:00

abstract：:Certain anatomic and functional parameters of the eye change with increasing chronological age. They may, therefore, serve as potential biomarkers of ageing. We investigated associations between four such ocular parameters (lens density, retinal vessel calibre, corneal endothelial cells and retinal nerve fibre layer t...

journal_title：Mechanisms of ageing and development

authors： Pathai S,Gilbert CE,Lawn SD,Weiss HA,Peto T,Cook C,Wong TY,Shiels PG

更新日期：2013-07-01 00:00:00