Does glycosylation of lysosomal proteins show age-related changes in rat liver?


:We studied the pattern of lectins binding by liver lysosomal proteins from rats between 18 days of gestation and 72 weeks of age. An analysis of the carbohydrate structure was carried out after an electrophoresis and blotting, followed by a very sensitive detection system with highly specific digoxigenin-labelled lectins. The only age-related differences were observed in the reaction with sialic acid--(MAA; Macckia amurensis, SNA; Sambucus nigra) and fucose--(AAA; Aleuria aurantia) specific lectins. Sialylation increased and fucosylation decreased with age. We also observed a specific reaction with Galanthus nivalis (GNA), Phaseolus vulgaris (PHA-L) and peanut agglutinin (PNA), without any significant changes with age.


Mech Ageing Dev


Lityńska A,Przybyło M




Has Abstract


1998-05-01 00:00:00














  • Effect of dietary restriction on hepatic and renal phosphoenolpyruvate carboxykinase induction in young and old Fischer 344 rats.

    abstract::Food restriction is known to ameliorate many of the adverse physiologic effects of age. In this study, we have examined the effect of food restriction on the induction of the gluconeogenic enzyme, phosphoenolpyruvate carboxykinase (PEPCK) in liver and kidney following a 12-h fasting period in young (6 month) and old (...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Van Remmen H,Ward WF

    更新日期:1998-09-01 00:00:00

  • Related age changes in the elastase and lipid contents of normal and hemiplegic subjects of various ages.

    abstract::Elastase and lipid levels of the plasmas of subjects and of those who have suffered a stroke have been measured, and it has been shown that the normal age related fall in elastase content is mirrored more closely by the fall in high density lipoprotein cholesterol than by changes in total cholesterol. After a stroke a...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Hall DA,Elridi SS,Zajac A,Middleton RS

    更新日期:1980-11-01 00:00:00

  • Replicative potential and the duration of the cell cycle in human fibroblasts: coordinate stimulation by epidermal growth factor.

    abstract::The in vitro replicative potential of human diploid fibroblasts can be increased by polypeptide growth factors such as epidermal growth factor (EGF). Also, the cycle time of EGF-stimulated cells is, on average, decreased and their mitotic cell volume is reduced. Therefore, the regulation of cell size by the duration o...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Angello JC

    更新日期:1992-01-01 00:00:00

  • A comparative study of the Ca2+-Mg2+ dependent ATPase from skeletal muscles of young, adult and old rats.

    abstract::Sarcoplasmic reticulum (SR) vesicles isolated from skeletal muscle of Sprague-Dawley rats ranging in age from 4 months to 28 months were studied and compared. A marked decline, with age, was observed in the amount of (total) SR proteins isolated per gram of muscle tissue used. This decline is in line with the known lo...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Gafni A,Yuh KC

    更新日期:1989-08-01 00:00:00

  • Age changes of chromatin. A review.

    abstract::The age-related studies of chromatin and DNA has attracted significant interest in recent years. However, individual works describe only some and a few of the many changes of chromatin. It is often difficult to decide whether these changes have secondary or primary nature. The overview of these studies makes it possib...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Medvedev ZA

    更新日期:1984-12-01 00:00:00

  • Urinary hyaluronic acid elevation in Hutchinson-Gilford progeria syndrome.

    abstract::The basic genetic defect in the Hutchinson-Gilford Progeria Syndrome (progeria), a premature aging syndrome, is unknown. To investigate possible defects in hyaluronic acid (HA) metabolism in this disease, the urinary excretion of HA was studied. Urine specimens from 11 patients with this disorder were examined for HA ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Zebrower M,Kieras FJ,Brown WT

    更新日期:1986-06-01 00:00:00

  • Age-related changes of the human ciliary muscle. A quantitative morphometric study.

    abstract::The age-related changes of the ciliary muscle of human eyes (33-87 years) were studied on histological meridional sections. Eighty-five melanoma eyes and 10 eyes of normal donors were investigated. The total area and the length of the muscle, the area of the three main portions and the distance of the inner apex of th...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Tamm S,Tamm E,Rohen JW

    更新日期:1992-02-01 00:00:00

  • Integrated study on comparative transcriptome and skeletal muscle function in aged rats.

    abstract::The present study aimed to reveal aging-related changes in the skeletal muscle of SD rats by comparing transcriptome analysis, integrated with muscle physiological parameters. Ten rats aged 25 months were set as the old group (OG) and ten rats aged 6 months were set as the young group (YG). After 6 weeks of feeding, t...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Zhou J,Liao Z,Chen J,Zhao K,Xiao Q

    更新日期:2018-01-01 00:00:00

  • Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging.

    abstract::The tumor suppressors p16(INK4a) and p53 have been implicated as contributors to age-associated stem cell decline. Key functions of p53 are the induction of cell cycle arrest, senescence, or apoptosis in response to DNA damage. Here, we examine senescence, apoptosis, and DNA damage responses in a mouse accelerated agi...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Hinkal GW,Gatza CE,Parikh N,Donehower LA

    更新日期:2009-04-01 00:00:00

  • Amyloid precursor protein, heat-shock proteins, and Bcl-2 form a complex in mitochondria and modulate mitochondria function and apoptosis in N2a cells.

    abstract::Neurons that degenerate in the brains of persons with Alzheimer's disease accumulate mitochondrial amyloid precursor protein (APP), which is thought to negatively affect mitochondrial function and cellular homeostasis. Because proteins that enter mitochondria require assistance from chaperone proteins, we hypothesized...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Yang TT,Hsu CT,Kuo YM

    更新日期:2009-09-01 00:00:00

  • Evolution of human longevity: a critical overview.

    abstract::Evolution of longevity of the ungulates, carnivores and primates is reviewed. Special emphasis is focused on recent evolutionary history of longevity along the hominid ancestral-descendant sequence leading to modern man. Maximum life span potential (MLP) or the change in MLP is predicted in extinct species by (1) a ph...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Cutler RG

    更新日期:1979-02-01 00:00:00

  • Effect of chronic vitamin E deficiency on the synapses of cerebellar glomeruli in young rats.

    abstract::A morphometric investigation has been carried out on the synaptic junctions in the cerebellar glomeruli of young-adult rats chronically deprived of vitamin E for 10 months and control animals of the same age. The following parameters were evaluated: the average length of the synapses (L), the numerical (NV) as well as...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Bertoni-Freddari C,Giuli C,Pieri C

    更新日期:1984-02-01 00:00:00

  • Effect of dietary high doses of vitamin E on lymphocyte subsets in young and old CBA mice.

    abstract::Different theories of ageing exist. Oxidative stress by generating neo-antigens and affecting cellular communications may precipitate immune disregulation, and both may concur in the whole ageing process. In the present study, we have analysed the effect of dietary high doses of vitamin E, a free radical scavenger, on...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Brohée D,Nève P

    更新日期:1994-10-20 00:00:00

  • Longevity-associated mitochondrial DNA 5178 A/C polymorphism influences effects of cigarette smoking on serum protein fraction levels in Japanese men.

    abstract::Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is reportedly associated with longevity and susceptibility to age-related diseases in Japanese individuals. We previously reported an association between mt5178 A/C polymorphism and serum protein fraction levels in healthy Japanese women. An association...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Kokaze A,Ishikawa M,Matsunaga N,Yoshida M,Sekine Y,Sekiguchi K,Satoh M,Harada M,Teruya K,Takeda N,Uchida Y,Takashima Y

    更新日期:2003-06-01 00:00:00

  • Telomere length in different tissues of elderly patients.

    abstract::Telomeres are supposed to play a role in cellular aging and might contribute to the genetic background of human aging and longevity. During the past few years telomere length has been measured in various human tissues. However, very little is known about the individual telomere loss in different tissues from the same ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Friedrich U,Griese E,Schwab M,Fritz P,Thon K,Klotz U

    更新日期:2000-11-15 00:00:00

  • The radiation-sensitive mutant rad-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development.

    abstract::A mutant of rad-8, originally isolated on the basis of its hypersensitivity to ultraviolet radiation, is also hypersensitive to oxygen and methyl viologen, a superoxide-anion generator. Oxygen also retarded development and reduced fecundity in a concentration-dependent fashion in rad-8 but not in wild type. In additio...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Ishi N,Suzuki N,Hartman PS,Suzuki K

    更新日期:1993-05-01 00:00:00

  • Relevance of oxidative stress to the limited replicative capacity of cultured human diploid cells: the limit of cumulative population doublings increases under low concentrations of oxygen and decreases in response to aminotriazole.

    abstract::Human diploid cells, TIG-7, were serially cultivated under 1%, 5% or 21% (air) oxygen. The limit of their cumulative population doublings was extended by 16% or 10% under 1% or 5% oxygen, respectively, as compared with that under 21% oxygen. When TIG-7 cells were serially cultivated in the presence of 10 mM or 20 mM 3...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Yuan H,Kaneko T,Matsuo M

    更新日期:1995-07-14 00:00:00

  • Spontaneous age-associated amyloidosis in senescence-accelerated mouse (SAM).

    abstract::Morphological studies on spontaneous systemic amyloidosis were conducted on 222 senescence-accelerated mice (SAM) (P) and on 150 mice in the senescence-resistant series (R). Among the pathologic findings, amyloidosis showed the highest incidence in both SAM (79.7%) and R (32.7%). Although an extensive deposition of am...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Takeshita S,Hosokawa M,Irino M,Higuchi K,Shimizu K,Yasuhira K,Takeda T

    更新日期:1982-09-01 00:00:00

  • Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution.

    abstract::Chronic oxidative stress is generally believed to be a major etiologic factor in the aging process. In addition to modulation of signaling processes and oxidation of cellular proteins and lipids, reactive oxygen species (ROS) induce multiple damages in both nuclear and mitochondrial genomes, most of which are repaired...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Szczesny B,Bhakat KK,Mitra S,Boldogh I

    更新日期:2004-10-01 00:00:00

  • Potential role of anti-oncogenes in aging.

    abstract::Some observations on cellular senescence are discussed regarding the possibility that the postulated genes, which bring about the DNA synthesis block of senescent fibroblasts, might be similar to those designated as anti-oncogenes or tumour suppressor genes. The latter genes have been defined by tumorogenicity tests o...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Ferluga J

    更新日期:1990-04-30 00:00:00

  • Iron status in the elderly.

    abstract::Iron deficiency anaemia is prevalent in older age, particularly after the age of 80. Serum ferritin concentrations also decline, although there is no evidence to suggest that changes in iron stores are an inevitable consequence of ageing. Chronic inflammation is a common condition in older people, making the measureme...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Fairweather-Tait SJ,Wawer AA,Gillings R,Jennings A,Myint PK

    更新日期:2014-03-01 00:00:00

  • Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes.

    abstract::Older adults who are at risk of developing influenza illness, have a low level of influenza virus-stimulated cytotoxic T lymphocyte (CTL) activity as measured by an assay of granzyme B (GrB). The purpose of this study was to determine whether aging affected memory CTL populations identified by GrB expression in influe...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Xie D,McElhaney JE

    更新日期:2007-05-01 00:00:00

  • Vascular ageing in hypertension: Focus on mitochondria.

    abstract::Hypertension is a common age-related disease, along with vascular and neurodegenerative diseases. Vascular ageing increases during hypertension, but hypertension itself accelerates vascular ageing, thus creating a vicious circle. Vascular stiffening, endothelial dysfunction, impaired contractility and vasorelaxation a...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Forte M,Stanzione R,Cotugno M,Bianchi F,Marchitti S,Rubattu S

    更新日期:2020-07-01 00:00:00

  • Telomere length, oxidative stress, and antioxidant status in elderly men in Zutphen and Crete.

    abstract::The incidence of chronic diseases such as cardiovascular diseases is lower in Mediterranean Southern Europe than Northern Europe. This may be due to a lower level of oxidative stress and a higher antioxidant status in people living around the Mediterranean Sea. Oxidative stress may influence the rate of shortening of ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: de Vos-Houben JM,Ottenheim NR,Kafatos A,Buijsse B,Hageman GJ,Kromhout D,Giltay EJ

    更新日期:2012-06-01 00:00:00

  • Sarcopenia: the gliogenic perspective.

    abstract::It has been approximately 25 years since Dr. Rosenberg first brought attention to sarcopenia. To date, this aging-associated condition is recognized as a chronic loss of muscle mass and is usually accompanied by dynapenia. Despite its poly-etiological factors, sarcopenia has a strong neurogenic component underlying th...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Kwan P

    更新日期:2013-09-01 00:00:00

  • A new mutation in the timing of autogamy in Paramecium tetraurelia.

    abstract::We have isolated a new type of Paramecium tetraurelia mutant, named rie-2, that has a long immaturity period until autogamy. We previously isolated such an autogamy mutant, designated rie-1. These two mutants had some additional common features such as dependence of the occurrence of autogamy on the temperature, invol...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Komori R,Sato H,Harumoto T,Takagi Y

    更新日期:2005-06-01 00:00:00

  • Age-related cell surface changes in human diploid fibroblasts revealed by lectin-mediated red blood cell adsorption assay: a lectin survey.

    abstract::Two types of age-related cell surface changes could be demonstrated in human diploid fibroblasts with the two methods of the lectin-mediated red blood cell (RBC) adsorption assay: the fibroblast coating method (in which RBCs are adsorbed to lectin-coated fibroblasts) and the RBC coating method (in which lectin-coated ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Aizawa S,Kurimoto F

    更新日期:1979-11-01 00:00:00

  • Accumulation and identification of lipofuscin-like pigment in the neurons of Bulla gouldiana (Gastropoda: Opisthobranchia).

    abstract::A few reports suggest that pigmented granules found in molluscan neurons accumulate with age as do lipofuscin granules in vertebrate cells; however, no reports on molluscan neurons include detailed descriptions of granule accumulation or histochemical tests to identify the pigment as lipofuscin-like. In this study lig...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Robles LJ

    更新日期:1978-01-01 00:00:00

  • Combined grafting of bone marrow and thymus, and sequential multiple thymus graftings in various strains of mice. The effect on immune functions and life span.

    abstract::The combined grafting of young bone marrow and newborn thymus performed in old mice was effective in restoring the impaired immune functions, but the same treatment performed in middle-aged adult mice had no effect on the life span of C3H/MTV female mice. Sequential multiple newborn thymus graftings starting at young ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Hirokawa K,Utsuyama M

    更新日期:1989-07-01 00:00:00

  • Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers.

    abstract::Certain anatomic and functional parameters of the eye change with increasing chronological age. They may, therefore, serve as potential biomarkers of ageing. We investigated associations between four such ocular parameters (lens density, retinal vessel calibre, corneal endothelial cells and retinal nerve fibre layer t...

    journal_title:Mechanisms of ageing and development

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Pathai S,Gilbert CE,Lawn SD,Weiss HA,Peto T,Cook C,Wong TY,Shiels PG

    更新日期:2013-07-01 00:00:00