Age-related cell surface changes in human diploid fibroblasts revealed by lectin-mediated red blood cell adsorption assay: a lectin survey.

abstract：:In a longitudinal design in which each animal was examined repeatedly throughout its life, we used flow cytometry to determine the numbers or proportions of a variety of T lymphocyte subsets in the peripheral blood of mice aged 8-20 months. Half of the 128 mice were given a low calorie diet which is known to extend li...

journal_title：Mechanisms of ageing and development

authors： Miller RA

更新日期：1997-06-01 00:00:00

abstract：:Chronic low-grade inflammation is involved in the pathogenesis of many disease conditions in humans and it is frequently quantified by measuring the blood concentration of C-reactive protein (CRP). Here we show that the CRP concentration in old people (nonagenarians) is, at least partially, genetically determined, and...

journal_title：Mechanisms of ageing and development

authors： Hurme M,Kivimäki M,Pertovaara M,Lehtimäki T,Karhunen PJ,Jylhä M,Hervonen A,Eklund C

更新日期：2007-10-01 00:00:00

abstract：:In order to determine whether the function of alveolar macrophages (AM) is modulated by aging, we measured the TNF-alpha production, phagocytic function, and surface antigen expression of AM from young and old mice. When AM were primed by IFN-gamma (500 units/ml) and triggered by LPS (100 micrograms/ml), TNF-alpha pro...

journal_title：Mechanisms of ageing and development

authors： Higashimoto Y,Fukuchi Y,Shimada Y,Ishida K,Ohata M,Furuse T,Shu C,Teramoto S,Matsuse T,Sudo E

更新日期：1993-07-01 00:00:00

abstract：:Survival characteristics of seven different populations of the mollusc Lymnaea stagnalis were studied under constant culture conditions. On the basis of these characteristics four populations were considered as healthy and three as infected. In the healthy populations senescence started at an age of about 200 days, 50...

journal_title：Mechanisms of ageing and development

authors： Janse C,Slob W,Popelier CM,Vogelaar JW

更新日期：1988-03-01 00:00:00

abstract：:Aging is a biological process associated with impairment of mitochondrial bioenergetic function, increased oxidative stress, attenuated ability to respond to stresses and increased risk in contracting age-associated diseases. When mitochondria are subjected to oxidative stress, accompanied by calcium overload and ATP ...

journal_title：Mechanisms of ageing and development

authors： Paradies G,Paradies V,Ruggiero FM,Petrosillo G

更新日期：2013-01-01 00:00:00

abstract：:A major cause of ageing is thought to be the accumulation of damage to macromolecules. Accumulation to DNA damage in cells therefore presupposes that aged cells are unable to repair this damage. We have used the in vitro model of cellular ageing to test the idea that senescent cells are deficient in some aspect of DNA...

journal_title：Mechanisms of ageing and development

authors： Al-Baker EA,Oshin M,Hutchison CJ,Kill IR

更新日期：2005-06-01 00:00:00

abstract：:The present review focuses on the effect of aging on flow-mediated outward remodeling (FMR) via alterations in estrogen metabolism, oxidative stress and inflammation. In ischemic disorders, the ability of the vasculature to adapt or remodel determines the quality of the recovery. FMR, which has a key role in revascula...

journal_title：Mechanisms of ageing and development

authors： Chehaitly A,Vessieres E,Guihot AL,Henrion D

更新日期：2020-12-14 00:00:00

abstract：:Hepatocyte morphology of the three zones of the liver lobule was evaluated by stereological analysis in 3-month-old and 35-month-old virgin female WAG/Rij rats. In the old rats, the volume of the nucleus and cytoplasm, and volume densities of smooth endoplasmic reticulum and lysosomes were increased in all areas of th...

journal_title：Mechanisms of ageing and development

authors： Meihuizen SP,Blansjaar N

更新日期：1980-06-01 00:00:00

abstract：:Alteration of T cell surface marker expression with a decrease of CD3 positive cells relative to the number of CD4 and CD8 positive cells, diminished in vitro proliferative response to mitogenic stimuli like PHA and antibodies to the CD3/Ti complex, and increase in serum IL-2 receptor levels, are among the changes in ...

journal_title：Mechanisms of ageing and development

authors： Hallgren HM,Bergh N,Rodysill KJ,O'Leary JJ

更新日期：1988-05-01 00:00:00

abstract：:In this investigation the effect of 4 months of 40% restriction of calories on defined markers of oxidative, glycoxidative or lipoxidative damage to heart mitochondrial proteins was studied. The protein markers assessed were N(epsilon)-(carboxyethyl)lysine (CEL), N(epsilon)-(carboxymethyl)lysine (CML), N(epsilon)-(mal...

journal_title：Mechanisms of ageing and development

authors： Pamplona R,Portero-Otín M,Requena J,Gredilla R,Barja G

更新日期：2002-09-01 00:00:00

abstract：:Motor neurons and ventral root motor fibres innervating extensor digitorum longus (EDL) muscle in rats of 0.5-3.5 months of age were studied by HRP-retrograde labelling and in vivo muscle tension recording, respectively. EDL nucleus size increased with age but motor neurons number and size did not change. Twitch and t...

journal_title：Mechanisms of ageing and development

authors： Cuppini R,Ambrogini P

更新日期：1996-12-20 00:00:00

abstract：:Aflatoxin B1(AFB1)-glutathione(GSH) conjugation is the major pathway for the detoxification of aflatoxin metabolites. This reaction is catalysed by GSH S-transferase (GST) and play a major role in modulation of AFB1 adduct formation to nuclear DNA. Changes recorded in hepatic GST activity during development of rats ca...

journal_title：Mechanisms of ageing and development

authors： Allameh A,Farahani M,Zarghi A

更新日期：2000-05-18 00:00:00

abstract：:Specific T-cell cytotoxic responses to allogeneic and hapten-modified syngeneic cells decrease with age. In order to determine the causes of these reduced T-cell cytotoxic responses, spleen cells from individual young and senescent C57BL/6J female mice were mixed in various proportions in culture with either X-irradia...

journal_title：Mechanisms of ageing and development

authors： Zharhary D,Segev Y,Gershon HE

更新日期：1984-04-01 00:00:00

abstract：:The plasma disappearance of endotoxin and endotoxin-induced hepatic injury were studied in two rat models: the aging rat and the subacutely hypervitaminotic A rat. The choice of these models was based on their respective association with a decreased or increased Kupffer cell endocytic activity. The half-life of endoto...

journal_title：Mechanisms of ageing and development

authors： Hendriks HF,Horan MA,Durham SK,Earnest DL,Brouwer A,Hollander CF,Knook DL

更新日期：1987-12-01 00:00:00

abstract：:In predicting the degree of brain atrophy as measured by CT, the AGP score and a few clinical variables were of some remarkable value. Especially the variables related to memory disorders and lack of insight are easily and reliably assessed during the course of the examination. In comparison to other more widely used ...

journal_title：Mechanisms of ageing and development

authors： Gutzmann H,Avdaloff W

更新日期：1980-11-01 00:00:00

abstract：:An age-related decline in blood-brain barrier transport of thyroid hormones may contribute to the central nervous system changes with aging. To test this hypothesis, the brain uptake index (BUI) of levo (L) and dextro (D) triiodothyronine (T3) was determined in male Fischer 344 rats at 6 months of age (young) and 26 m...

journal_title：Mechanisms of ageing and development

authors： Mooradian AD

更新日期：1990-03-15 00:00:00

abstract：:Hematopoietic stem cell performance and identity, crucial for homeostasis of the blood-forming system, is governed by extrinsic factors found in the bone marrow microenvironment. Communication within hematopoietic stem cell niches occurs via soluble factors or cell-to-cell contacts between niche and blood-forming cell...

journal_title：Mechanisms of ageing and development

authors： Böhm L,Helbing DL,Oraha N,Morrison H

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Our objective was to study the impact of an identical additional stress on male and female mortality with a quasi-experimental study design, using natural variations in summer mortality, including the massive heat wave that struck Europe in 2003. MATERIAL AND METHODS:The summer daily mortality rates of th...

journal_title：Mechanisms of ageing and development

authors： Robine JM,Michel JP,Herrmann FR

更新日期：2012-06-01 00:00:00

abstract：:Loss of telomere length homeostasis has been linked to age-related disease especially cancer. In this review, we discuss two major causes of telomere dysfunction that potentially lead to tumorigenesis: replicative aging and environmental assaults. Aging has long been recognized as a source for telomere dysfunction thr...

journal_title：Mechanisms of ageing and development

authors： Gilley D,Herbert BS,Huda N,Tanaka H,Reed T

更新日期：2008-01-01 00:00:00

abstract：:Extrachromosomal circular DNA complexes from peripheral blood lymphocytes from inbred mice of accelerated senescence, were detected by mica-press-adsorption method. In senescence-resistant series (SAM-R), polydisperse circular DNAs were observed at 7 weeks of age and a restricted size class of small circular forms of ...

journal_title：Mechanisms of ageing and development

authors： Yamagishi H,Kunisada T,Takeda T

更新日期：1985-01-01 00:00:00

abstract：:Significant changes are observed in wet weight, microsomal protein content and enzymes of purified rough and smooth microsomes of liver during postnatal development and ageing of female Wistar rats. Protein content of total microsomes increases up to 15 days of age and remains steady during subsequent development, unl...

journal_title：Mechanisms of ageing and development

authors： Devasagayam TP,Pushpendran CK,Eapen J

更新日期：1983-03-01 00:00:00

abstract：:Calorie restriction (CR) extends life span and retards many age-related cellular and molecular changes in laboratory rodents. However, neither the breadth of its effects, its underlying mechanisms, nor the limits of its action is fully understood. Expression levels of 588 genes in livers from 3- and 24-month-old ad li...

journal_title：Mechanisms of ageing and development

authors： Han E,Hilsenbeck SG,Richardson A,Nelson JF

更新日期：2000-06-20 00:00:00

abstract：:In an interspecies comparison of seven primate species, the expression of the erbB proto oncogene was found to be higher in fibroblasts derived from three relatively long-lived species, the human, gorilla, and chimpanzee than in cells from the orangutan, pygmy chimpanzee, squirrel monkey, or red-bellied tamarin. No si...

journal_title：Mechanisms of ageing and development

authors： Nakamura KD,Hart RW

更新日期：1987-07-01 00:00:00

abstract：:Glucose phosphorylating activity of human erythrocytes quickly decreases during cell ageing; the electrophoretic pattern suggests that this fast decrease is due mainly to the isozyme II. We have shown that in the young cells only hexokinase I and II are responsible for the glucose phosphorylation, while in the old cel...

journal_title：Mechanisms of ageing and development

authors： Fornaini G,Magnani M,Dachà M,Bossú M,Stocchi V

更新日期：1978-10-01 00:00:00

abstract：:The release of cytokines is of crucial importance in the regulation of the type and magnitude of the immune response in the elderly. A number of studies have shown different levels of cytokine production in the elderly. In the present study, a range of polymorphisms were chosen within the genes of cytokines (IL-2, IL-...

journal_title：Mechanisms of ageing and development

authors： Ross OA,Curran MD,Meenagh A,Williams F,Barnett YA,Middleton D,Rea IM

更新日期：2003-02-01 00:00:00

abstract：:Telomeres are supposed to play a role in cellular aging and might contribute to the genetic background of human aging and longevity. During the past few years telomere length has been measured in various human tissues. However, very little is known about the individual telomere loss in different tissues from the same ...

journal_title：Mechanisms of ageing and development

authors： Friedrich U,Griese E,Schwab M,Fritz P,Thon K,Klotz U

更新日期：2000-11-15 00:00:00

abstract：:In this study, we proposed a hypothesis that chromatin of mouse hepatocytes exhibits age-related reduction of fractal dimension. This hypothesis was based on previously published works demonstrating that complexity of biological systems such as tissues, decreases during the process of physiological aging. Liver tissue...

journal_title：Mechanisms of ageing and development

authors： Pantic I,Petrovic D,Paunovic J,Vucevic D,Radosavljevic T,Pantic S

更新日期：2016-07-01 00:00:00

abstract：:Lipofuscin accumulation in cultured rat myocardial cells is considered an index of intra-lysosomal oxidative reactions and was registered by autofluorescence measurements. Lipofuscinogenesis in secondary lysosomes is thought to be a consequence of Fenton reactions, and is much enhanced by oxidative stress obtained by ...

journal_title：Mechanisms of ageing and development

authors： Marzabadi MR,Jones C,Rydström J

更新日期：1995-06-09 00:00:00

abstract：:Morphometric comparison of freeze-fractured mitochondria in flight muscles of adult (37-day-old) and old (68-day-old) houseflies revealed a 28% decrease of cristae in the old flies. The major membrane change with age was an increase in the 90-120-A particles in the inner membrane external face concomitant with a loss ...

journal_title：Mechanisms of ageing and development

authors： Turturro A,Shafiq SA

更新日期：1981-06-01 00:00:00

abstract：:Food restriction increases maximal life span in rodents. Male rats that exercise in voluntary running wheels do not have an increase in maximal longevity despite a relative caloric deficit. In contrast, sedentary rats that are food restricted so as to cause the same caloric deficit have an extension of maximal longevi...

journal_title：Mechanisms of ageing and development

authors： Holloszy JO

更新日期：1998-02-16 00:00:00